JO2992B1 - عملية جديدة لتركيب أسيتونيتريل (7 - ميثوكسي - 1 - نافثي) والتطبيق في تركيب الأجوميلاتين) - Google Patents

عملية جديدة لتركيب أسيتونيتريل (7 - ميثوكسي - 1 - نافثي) والتطبيق في تركيب الأجوميلاتين)

Info

Publication number
JO2992B1
JO2992B1 JOP/2008/0348A JOP20080348A JO2992B1 JO 2992 B1 JO2992 B1 JO 2992B1 JO P20080348 A JOP20080348 A JO P20080348A JO 2992 B1 JO2992 B1 JO 2992B1
Authority
JO
Jordan
Prior art keywords
synthesis
agomelatine
application
naphthyl
acetonitrile
Prior art date
Application number
JOP/2008/0348A
Other languages
English (en)
Inventor
Dubuffet Thierry
- Paul HERMET Jean
- Pierre Lecouve Jean
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of JO2992B1 publication Critical patent/JO2992B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines

Abstract

عملية تصنيع مركب المعادلة (I): تطبيقات في صناعة الأجوميلاتين
JOP/2008/0348A 2007-08-03 2008-08-03 عملية جديدة لتركيب أسيتونيتريل (7 - ميثوكسي - 1 - نافثي) والتطبيق في تركيب الأجوميلاتين) JO2992B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0705688A FR2919606B1 (fr) 2007-08-03 2007-08-03 Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine.

Publications (1)

Publication Number Publication Date
JO2992B1 true JO2992B1 (ar) 2016-09-05

Family

ID=38926411

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2008/0348A JO2992B1 (ar) 2007-08-03 2008-08-03 عملية جديدة لتركيب أسيتونيتريل (7 - ميثوكسي - 1 - نافثي) والتطبيق في تركيب الأجوميلاتين)

Country Status (35)

Country Link
US (2) US8252951B2 (ar)
EP (1) EP2176214B1 (ar)
JP (1) JP5250626B2 (ar)
KR (1) KR101179173B1 (ar)
CN (1) CN101772484B (ar)
AP (1) AP2611A (ar)
AR (1) AR070642A1 (ar)
AU (1) AU2008316406B2 (ar)
BR (1) BRPI0815126A2 (ar)
CA (1) CA2695234C (ar)
CL (1) CL2008002272A1 (ar)
CY (1) CY1115094T1 (ar)
DK (1) DK2176214T3 (ar)
EA (1) EA016333B1 (ar)
ES (1) ES2467690T3 (ar)
FR (1) FR2919606B1 (ar)
GE (1) GEP20125586B (ar)
HK (1) HK1145830A1 (ar)
HR (1) HRP20140407T1 (ar)
JO (1) JO2992B1 (ar)
MA (1) MA31740B1 (ar)
MY (1) MY160226A (ar)
NZ (1) NZ583064A (ar)
PA (1) PA8792101A1 (ar)
PE (1) PE20090881A1 (ar)
PL (1) PL2176214T3 (ar)
PT (1) PT2176214E (ar)
RS (1) RS53250B (ar)
SA (1) SA08290480B1 (ar)
SI (1) SI2176214T1 (ar)
TW (1) TWI352074B (ar)
UA (1) UA94837C2 (ar)
UY (1) UY31229A1 (ar)
WO (1) WO2009053545A2 (ar)
ZA (1) ZA201001184B (ar)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2580183B1 (en) 2010-06-10 2014-07-23 Gador S.A. New process for the preparation of n-[2-(7-methoxy-1-naphthyl)-ethyl]acetamide
WO2013054273A2 (en) 2011-10-11 2013-04-18 Ranbaxy Laboratories Limited Process for the preparation of agomelatine
CN103130673B (zh) * 2011-11-28 2017-05-03 重庆医药工业研究院有限责任公司 一种阿戈美拉晶型i的制备方法
EP2785681A1 (en) 2011-12-01 2014-10-08 Ranbaxy Laboratories Limited Process for the preparation of agomelatine
ITMI20121444A1 (it) 2012-08-27 2014-02-28 Procos Spa Processo per la produzione di agomelatine
CN104788342A (zh) * 2015-04-07 2015-07-22 湖南大学 一种由芳香甲醇制备芳香腈类化合物的方法
CN107098828A (zh) * 2017-05-09 2017-08-29 枣阳市残联福利生物化工厂 一种高效合成甲氧基萘乙腈的工艺
CN107382773A (zh) * 2017-06-19 2017-11-24 太仓弘杉环保科技有限公司 一种合成7‑甲氧基萘乙腈的方法
CN107162933A (zh) * 2017-06-19 2017-09-15 太仓大唐化纤厂 一种合成阿戈美拉汀重要中间体7‑甲氧基萘乙腈的方法
CN107353229B (zh) * 2017-08-08 2019-04-30 许昌恒生制药有限公司 一种阿戈美拉汀中间体的制备方法
CN112574065B (zh) * 2020-12-30 2022-10-28 宁波职业技术学院 一种(苯-1,3,5-三酰基)三乙腈的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02202864A (ja) * 1989-01-31 1990-08-10 Hitachi Ltd ２，３―ジシアノ―６―ナフチルメタノール誘導体およびその製法
FR2658818B1 (fr) 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2696453B1 (fr) * 1992-10-02 1994-12-23 Adir Nouveaux arylalkyl(thio)amides, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent.
FR2726268B1 (fr) * 1994-10-26 1996-12-06 Adir Nouvelles o-arylmethyl n-(thio)acyl hydroxylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent
FR2784375B1 (fr) * 1998-10-12 2000-11-24 Adir Nouveaux derives cycliques a chaine cycloalkylenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2866335B1 (fr) * 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'agomelatine

Also Published As

Publication number Publication date
RS53250B (en) 2014-08-29
HRP20140407T1 (hr) 2014-06-06
TW200925141A (en) 2009-06-16
JP2010535746A (ja) 2010-11-25
CY1115094T1 (el) 2016-12-14
EA201000257A1 (ru) 2010-08-30
US20120330062A1 (en) 2012-12-27
FR2919606B1 (fr) 2010-09-17
NZ583064A (en) 2011-07-29
US8252951B2 (en) 2012-08-28
WO2009053545A3 (fr) 2009-07-23
CA2695234A1 (fr) 2009-04-30
PT2176214E (pt) 2014-04-14
US20100137628A1 (en) 2010-06-03
WO2009053545A2 (fr) 2009-04-30
AP2611A (en) 2013-03-05
KR20100039899A (ko) 2010-04-16
JP5250626B2 (ja) 2013-07-31
EP2176214A2 (fr) 2010-04-21
EA016333B1 (ru) 2012-04-30
DK2176214T3 (da) 2014-06-10
PE20090881A1 (es) 2009-07-18
CN101772484A (zh) 2010-07-07
CL2008002272A1 (es) 2009-02-06
FR2919606A1 (fr) 2009-02-06
AU2008316406A1 (en) 2009-04-30
ZA201001184B (en) 2011-04-28
UA94837C2 (ru) 2011-06-10
TWI352074B (en) 2011-11-11
UY31229A1 (es) 2008-09-30
US8436206B2 (en) 2013-05-07
CA2695234C (fr) 2013-02-05
SA08290480B1 (ar) 2012-02-07
CN101772484B (zh) 2013-09-18
SI2176214T1 (sl) 2014-06-30
AP2010005145A0 (en) 2010-02-28
GEP20125586B (en) 2012-07-25
AU2008316406B2 (en) 2011-04-07
HK1145830A1 (en) 2011-05-06
MA31740B1 (fr) 2010-10-01
ES2467690T3 (es) 2014-06-12
BRPI0815126A2 (pt) 2015-02-03
MY160226A (en) 2017-02-28
KR101179173B1 (ko) 2012-09-03
AR070642A1 (es) 2010-04-28
EP2176214B1 (fr) 2014-03-05
PL2176214T3 (pl) 2014-06-30
PA8792101A1 (es) 2009-09-17

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