ITMI930456A0 - Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis - Google Patents

Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis

Info

Publication number
ITMI930456A0
ITMI930456A0 ITMI930456A ITMI930456A ITMI930456A0 IT MI930456 A0 ITMI930456 A0 IT MI930456A0 IT MI930456 A ITMI930456 A IT MI930456A IT MI930456 A ITMI930456 A IT MI930456A IT MI930456 A0 ITMI930456 A0 IT MI930456A0
Authority
IT
Italy
Prior art keywords
exocellular
antibodies
preparation
bacillus subtilis
recombinant vector
Prior art date
Application number
ITMI930456A
Other languages
English (en)
Inventor
Guido Grandi
Ferra Francesca De
Anna Cuzzoni
Original Assignee
Eniricerche Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eniricerche Spa filed Critical Eniricerche Spa
Publication of ITMI930456A0 publication Critical patent/ITMI930456A0/it
Priority to ITMI930456A priority Critical patent/IT1270866B/it
Priority to DK94200564T priority patent/DK0614982T3/da
Priority to ES94200564T priority patent/ES2149837T3/es
Priority to AT94200564T priority patent/ATE196317T1/de
Priority to DE69425843T priority patent/DE69425843T2/de
Priority to PT94200564T priority patent/PT614982E/pt
Priority to EP94200564A priority patent/EP0614982B1/en
Priority to US08/207,169 priority patent/US5674712A/en
Priority to JP6066642A priority patent/JPH0775581A/ja
Publication of ITMI930456A1 publication Critical patent/ITMI930456A1/it
Priority to US08/839,082 priority patent/US20020016446A1/en
Application granted granted Critical
Publication of IT1270866B publication Critical patent/IT1270866B/it
Priority to GR20000402393T priority patent/GR3034704T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/839—Bacillus subtilis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/867—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody produced via recombinant dna technology
ITMI930456A 1993-03-10 1993-03-10 Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis IT1270866B (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
ITMI930456A IT1270866B (it) 1993-03-10 1993-03-10 Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis
EP94200564A EP0614982B1 (en) 1993-03-10 1994-03-05 Recombinant vector for the exocellular preparation of single chain antibodies expressed in bacillus subtilis
ES94200564T ES2149837T3 (es) 1993-03-10 1994-03-05 Vector recombinante para la preparacion exocelular de anticuerpos monocatenarios expresados en bacillus subtilis.
AT94200564T ATE196317T1 (de) 1993-03-10 1994-03-05 Rekombinantes vektor für die exozelluläre verwendung von in bacillus subtilis exprimierten einkettigen antikörpern
DE69425843T DE69425843T2 (de) 1993-03-10 1994-03-05 Rekombinantes Vektor für die exozelluläre Verwendung von in Bacillus Subtilis exprimierten einkettigen Antikörpern
PT94200564T PT614982E (pt) 1993-03-10 1994-03-05 Vector recombinante e o seu uso para a preparacao exocelular de anticorpos sob a forma de molecula unica a partir de bacillus subtilis
DK94200564T DK0614982T3 (da) 1993-03-10 1994-03-05 Rekombinant vektor til exocellulær fremstilling af antistoffer i enkeltkædeform udtrykt i Bacillus subtilis
US08/207,169 US5674712A (en) 1993-03-10 1994-03-08 Recombinant vector and use thereof for exocellular preparation of antibodies in single molecule form from Bacillus subtilis
JP6066642A JPH0775581A (ja) 1993-03-10 1994-03-10 バチルス・ズブチリスの発現及び分泌組換えベクター
US08/839,082 US20020016446A1 (en) 1993-03-10 1997-04-23 Recombinant vector and use thereof for exocellular preparation of single molecula antibodies from bacillus subtilis
GR20000402393T GR3034704T3 (en) 1993-03-10 2000-10-30 Recombinant vector for the exocellular preparation of single chain antibodies expressed in bacillus subtilis.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI930456A IT1270866B (it) 1993-03-10 1993-03-10 Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis

Publications (3)

Publication Number Publication Date
ITMI930456A0 true ITMI930456A0 (it) 1993-03-10
ITMI930456A1 ITMI930456A1 (it) 1994-09-10
IT1270866B IT1270866B (it) 1997-05-13

Family

ID=11365305

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI930456A IT1270866B (it) 1993-03-10 1993-03-10 Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis

Country Status (10)

Country Link
US (2) US5674712A (it)
EP (1) EP0614982B1 (it)
JP (1) JPH0775581A (it)
AT (1) ATE196317T1 (it)
DE (1) DE69425843T2 (it)
DK (1) DK0614982T3 (it)
ES (1) ES2149837T3 (it)
GR (1) GR3034704T3 (it)
IT (1) IT1270866B (it)
PT (1) PT614982E (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69426527T2 (de) * 1993-06-09 2001-08-30 Unilever Nv Verfahren zur herstellung von fusionsproteinen, die scfv fragmente enthalten, in transformierten schimmelpilzen
US5665570A (en) * 1994-02-10 1997-09-09 Takeda Chemical Industries, Ltd. Antibody-encoding recombinant DNA and its use
US5891680A (en) * 1995-02-08 1999-04-06 Whitehead Institute For Biomedical Research Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12
US5801064A (en) * 1995-12-04 1998-09-01 Foresman; Mark D. Assay methods and reagents for detecting autoantibodies
CA2213512A1 (en) * 1995-12-22 1997-07-03 Toray Industries, Inc. Method for producing bioactive fusion protein
EP0909277B2 (en) 1996-06-07 2008-12-24 Poniard Pharmaceuticals, Inc. Humanized antibodies that bind to the same antigen as bound by antibody nr-lu-13, and their use in pretargeting methods
JP2002502977A (ja) 1998-02-04 2002-01-29 インビトロジェン コーポレイション マイクロアレイとその使用
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
WO2001083827A1 (en) 2000-05-04 2001-11-08 Yale University High density protein arrays for screening of protein activity
JP2004520011A (ja) * 2000-08-21 2004-07-08 スミスクライン・ビーチャム・コーポレイション Ｒａｎｋリガンド介在障害の治療において有用な抗−ｒａｎｋリガンドモノクローナル抗体
AU2003210996A1 (en) * 2002-02-11 2003-09-04 Zymogenetics, Inc. Materials and methods for preparing dimeric growth factors
US20070148166A1 (en) * 2002-05-13 2007-06-28 Wu Madeline C S Scfvs in photosynthetic microbes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
IT1228925B (it) * 1987-08-07 1991-07-10 Eniricerche Spa Procedimento per la preparazione dell'ormone della crescita umano
IT1223577B (it) * 1987-12-22 1990-09-19 Eniricerche Spa Procedimento migliorato per la preparazione dell'ormone della crescita umano naturale in forma pura
IT1231156B (it) * 1989-07-19 1991-11-19 Eniricerche Spa Espressione e secrezione di interleuchina 1 beta umana matura in bacillus subtilis e mezzi e metodi per il suo ottenimento.

Also Published As

Publication number Publication date
IT1270866B (it) 1997-05-13
ES2149837T3 (es) 2000-11-16
EP0614982A1 (en) 1994-09-14
JPH0775581A (ja) 1995-03-20
GR3034704T3 (en) 2001-01-31
EP0614982B1 (en) 2000-09-13
US5674712A (en) 1997-10-07
ATE196317T1 (de) 2000-09-15
US20020016446A1 (en) 2002-02-07
PT614982E (pt) 2001-01-31
DK0614982T3 (da) 2000-12-18
DE69425843T2 (de) 2001-03-29
ITMI930456A1 (it) 1994-09-10
DE69425843D1 (de) 2000-10-19

Similar Documents

Publication Publication Date Title
IL122910A0 (en) Stable isotonic lyophilized protein formulation
BR9610048A (pt) Acil amino salicilamidas
DE69523791T2 (de) Peptid-mischung und produkte davon
BR9607317A (pt) Peptídios e composição farmacêutica
BR9607318A (pt) Peptidos e composição farmacêutica
IL133830A0 (en) Vertebrate tolomerase genes and proteins and uses thereof
IT1292841B1 (it) Metodo e dispositivo per l'allineamento di prodotti.
EP0948343A4 (en) ALKYL PEPTIDE AMIDES AND APPLICATIONS
FI943389A (fi) Bacillus-lajista saatu ksylanaasi, tällaisen ksylanaasin ja muiden proteiinien ekspressiovektori, niiden isäntäorganismit ja käyttö
ITMI930456A0 (it) Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis
IL158126A0 (en) Peptides and antibodies to muc 1 proteins
AU5894900A (en) Novel molecules of the card-related protein family and uses thereof
IT1310880B1 (it) Metodo per il controllo statico e dinamico della planarita'di prodotti piani laminati
IT1274168B (it) Vettore plasmidico e suo impiego per la produzione di proteine eterologhe
IT1269385B (it) Impianto di stoccaggio di prodotti, in particolare di piastrelle ceramiche e simili
FR2769022B1 (fr) Vecteurs d'antigenes et compositions therapeutiques contenant des antigenes
GB9721494D0 (en) Abrasive articles and their preparations
EP1226162A4 (en) NEW MOLECULES OF THE "CARD-LIKE" PROTEIN FAMILY AND THEIR USES
AU1162499A (en) Use of polysiloxanes comprising polyether and/or amine units as demisting agents
AU2001229697A1 (en) Novel molecules of the card-related protein family and uses thereof
ATE311440T1 (de) Bacillus-proteasen
DE69635608D1 (de) Bacillus proteasen
ITMI931036A0 (it) Supporto per la sintesi di peptidi carbossammidici e suo uso
BR1101121A (pt) Vetor adenovirótico recombinante e processos de uso
AU1209797A (en) Novel antigenic proteins of mycoplasmata, genes thereof, and recombinant vector and use of the same

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970313