ITMI920162A0 - Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole - Google Patents
Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicoleInfo
- Publication number
- ITMI920162A0 ITMI920162A0 IT92MI162A ITMI920162A ITMI920162A0 IT MI920162 A0 ITMI920162 A0 IT MI920162A0 IT 92MI162 A IT92MI162 A IT 92MI162A IT MI920162 A ITMI920162 A IT MI920162A IT MI920162 A0 ITMI920162 A0 IT MI920162A0
- Authority
- IT
- Italy
- Prior art keywords
- activity
- maintaining
- polyethylene glycol
- proteolytic enzymes
- enzymes modified
- Prior art date
Links
- 102000035195 Peptidases Human genes 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 title 1
- 239000002202 Polyethylene glycol Substances 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 229920001223 polyethylene glycol Polymers 0.000 title 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI920162A IT1260468B (it) | 1992-01-29 | 1992-01-29 | Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole |
PCT/EP1993/000205 WO1993015189A1 (en) | 1992-01-29 | 1993-01-29 | A method to maintain the activity in polyethylene glycol-modified proteolytic enzymes |
JP5512940A JPH07502900A (ja) | 1992-01-29 | 1993-01-29 | ポリエチレングリコール変性タンパク分解酵素の活性を持続させる方法 |
CA002129134A CA2129134A1 (en) | 1992-01-29 | 1993-01-29 | A method to maintain the activity in polyethylene glycol-modified proteolytic enzymes |
EP93914525A EP0624191A1 (en) | 1992-01-29 | 1993-01-29 | A method to maintain the activity in polyethylene glycol-modified proteolytic enzymes |
US08/256,834 US5514572A (en) | 1992-01-29 | 1993-01-29 | Method to maintain the activity in polyethylene glycol-modified proteolytic enzymes |
AU34522/93A AU665982B2 (en) | 1992-01-29 | 1993-01-29 | A method to maintain the activity in polyethylene glycol-modified proteolytic enzymes |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI920162A IT1260468B (it) | 1992-01-29 | 1992-01-29 | Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI920162A0 true ITMI920162A0 (it) | 1992-01-29 |
ITMI920162A1 ITMI920162A1 (it) | 1993-07-30 |
IT1260468B IT1260468B (it) | 1996-04-09 |
Family
ID=11361713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI920162A IT1260468B (it) | 1992-01-29 | 1992-01-29 | Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole |
Country Status (7)
Country | Link |
---|---|
US (1) | US5514572A (it) |
EP (1) | EP0624191A1 (it) |
JP (1) | JPH07502900A (it) |
AU (1) | AU665982B2 (it) |
CA (1) | CA2129134A1 (it) |
IT (1) | IT1260468B (it) |
WO (1) | WO1993015189A1 (it) |
Families Citing this family (99)
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US6461849B1 (en) | 1998-10-13 | 2002-10-08 | Novozymes, A/S | Modified polypeptide |
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MXPA02000840A (es) | 1999-07-22 | 2002-07-30 | Procter & Gamble | Variantes de proteasa de subtilisina que tienen substituciones de aminoacidos en regiones de epitopes definidas. |
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CA3111576A1 (en) | 2018-09-11 | 2020-03-19 | Ambrx, Inc. | Interleukin-2 polypeptide conjugates and their uses |
US20220096608A1 (en) * | 2019-01-25 | 2022-03-31 | Council Of Scientific And Industrial Research | Fibrinolytic composition and method of its preparation |
KR20220151202A (ko) | 2020-03-11 | 2022-11-14 | 암브룩스, 인코포레이티드 | 인터류킨-2 폴리펩타이드 접합체 및 그의 사용 방법 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4002531A (en) * | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
JPS5896026A (ja) * | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
US4610879A (en) * | 1984-01-06 | 1986-09-09 | University Of Southern California | Fibrinolytic enzyme from snake vernom |
US4847325A (en) * | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
US5162430A (en) * | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
US5219995A (en) * | 1992-07-14 | 1993-06-15 | Alpha Therapeutic Corporation | Plasma fraction purification |
-
1992
- 1992-01-29 IT ITMI920162A patent/IT1260468B/it active IP Right Grant
-
1993
- 1993-01-29 CA CA002129134A patent/CA2129134A1/en not_active Abandoned
- 1993-01-29 JP JP5512940A patent/JPH07502900A/ja active Pending
- 1993-01-29 AU AU34522/93A patent/AU665982B2/en not_active Ceased
- 1993-01-29 US US08/256,834 patent/US5514572A/en not_active Expired - Fee Related
- 1993-01-29 EP EP93914525A patent/EP0624191A1/en not_active Ceased
- 1993-01-29 WO PCT/EP1993/000205 patent/WO1993015189A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2129134A1 (en) | 1993-08-05 |
US5514572A (en) | 1996-05-07 |
JPH07502900A (ja) | 1995-03-30 |
AU3452293A (en) | 1993-09-01 |
EP0624191A1 (en) | 1994-11-17 |
ITMI920162A1 (it) | 1993-07-30 |
WO1993015189A1 (en) | 1993-08-05 |
AU665982B2 (en) | 1996-01-25 |
IT1260468B (it) | 1996-04-09 |
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Legal Events
Date | Code | Title | Description |
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0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19960130 |