IT951631B - Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi - Google Patents

Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi

Info

Publication number
IT951631B
IT951631B IT49167/71A IT4916771A IT951631B IT 951631 B IT951631 B IT 951631B IT 49167/71 A IT49167/71 A IT 49167/71A IT 4916771 A IT4916771 A IT 4916771A IT 951631 B IT951631 B IT 951631B
Authority
IT
Italy
Prior art keywords
geometric
separation
optical isomers
useful compounds
synthesis procedure
Prior art date
Application number
IT49167/71A
Other languages
English (en)
Italian (it)
Inventor
R Viterbo
Original Assignee
Richardson Merrell Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Spa filed Critical Richardson Merrell Spa
Priority to IT49167/71A priority Critical patent/IT951631B/it
Priority to ZA721297A priority patent/ZA721297B/xx
Priority to IL38860A priority patent/IL38860A/xx
Priority to AU39611/72A priority patent/AU462431B2/en
Priority to PH13312A priority patent/PH10768A/en
Priority to CA136,671A priority patent/CA961500A/en
Priority to GB1104172A priority patent/GB1360946A/en
Priority to US00233793A priority patent/US3848030A/en
Priority to SE7203303A priority patent/SE409323B/xx
Priority to DE2212660A priority patent/DE2212660C3/de
Priority to BE780887A priority patent/BE780887A/xx
Priority to JP2661472A priority patent/JPS5547013B1/ja
Priority to DK127372AA priority patent/DK139944B/da
Priority to NL7203574A priority patent/NL7203574A/xx
Priority to NO880/72A priority patent/NO136357C/no
Priority to ES400862A priority patent/ES400862A1/es
Priority to CH395572A priority patent/CH576921A5/xx
Priority to FR7209350A priority patent/FR2129741A5/fr
Application granted granted Critical
Publication of IT951631B publication Critical patent/IT951631B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Braiding, Manufacturing Of Bobbin-Net Or Lace, And Manufacturing Of Nets By Knotting (AREA)
IT49167/71A 1971-03-18 1971-03-18 Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi IT951631B (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT49167/71A IT951631B (it) 1971-03-18 1971-03-18 Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi
ZA721297A ZA721297B (en) 1971-03-18 1972-02-28 Process of separating optical,geometric,structural isomers and the compounds used for
IL38860A IL38860A (en) 1971-03-18 1972-02-29 Cyclic esters of phosphoric acid and their use for separating optical,geometric and structural isomers
AU39611/72A AU462431B2 (en) 1971-03-18 1972-03-03 Process of separating optical, geometric structural isomers andthe compounds usedfor
PH13312A PH10768A (en) 1971-03-18 1972-03-03 Optical isomers of binaphthyl phosphoric acids
CA136,671A CA961500A (en) 1971-03-18 1972-03-09 Process of separating optical, geometric, structural isomers and the compounds used therefor
GB1104172A GB1360946A (en) 1971-03-18 1972-03-09 Process of separating optical geometric structural isomers and the compounds used therefor
US00233793A US3848030A (en) 1971-03-18 1972-03-10 Optical isomers of binaphthyl-phosphoric acids
SE7203303A SE409323B (sv) 1971-03-18 1972-03-15 Anvendning av en optisk isomer av bi-(4,5,6,7-tetrahydronaftyl)-fosforsyraderivat for kemisk upplosning av basiska optiska cis- och trans-isomerer
DE2212660A DE2212660C3 (de) 1971-03-18 1972-03-16 Optische Einzelisomere von Binaphthylphosphorsäuren, Verfahren zur Trennung eines Racemats aus denselben und deren Verwenung zur Trennung von racemischen Basen
BE780887A BE780887A (fr) 1971-03-18 1972-03-17 Nouveaux agents de dedoublement et procede de leur utilisation
JP2661472A JPS5547013B1 (enExample) 1971-03-18 1972-03-17
DK127372AA DK139944B (da) 1971-03-18 1972-03-17 Optisk aktive syrer til anvendelse ved adskillelse af isomere af visse kemiske forbindelser.
NL7203574A NL7203574A (enExample) 1971-03-18 1972-03-17
NO880/72A NO136357C (no) 1971-03-18 1972-03-17 Anvendelse av optisisomerer av binafthylfosforsyre ved separasjon av basiske isomerer
ES400862A ES400862A1 (es) 1971-03-18 1972-03-17 Procedimiento para redisolver isomeros opticos.
CH395572A CH576921A5 (enExample) 1971-03-18 1972-03-17
FR7209350A FR2129741A5 (enExample) 1971-03-18 1972-03-17

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT49167/71A IT951631B (it) 1971-03-18 1971-03-18 Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi

Publications (1)

Publication Number Publication Date
IT951631B true IT951631B (it) 1973-07-10

Family

ID=11269830

Family Applications (1)

Application Number Title Priority Date Filing Date
IT49167/71A IT951631B (it) 1971-03-18 1971-03-18 Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi

Country Status (18)

Country Link
US (1) US3848030A (enExample)
JP (1) JPS5547013B1 (enExample)
AU (1) AU462431B2 (enExample)
BE (1) BE780887A (enExample)
CA (1) CA961500A (enExample)
CH (1) CH576921A5 (enExample)
DE (1) DE2212660C3 (enExample)
DK (1) DK139944B (enExample)
ES (1) ES400862A1 (enExample)
FR (1) FR2129741A5 (enExample)
GB (1) GB1360946A (enExample)
IL (1) IL38860A (enExample)
IT (1) IT951631B (enExample)
NL (1) NL7203574A (enExample)
NO (1) NO136357C (enExample)
PH (1) PH10768A (enExample)
SE (1) SE409323B (enExample)
ZA (1) ZA721297B (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4143028A (en) * 1977-12-05 1979-03-06 Ciba-Geigy Corporation Alkylated 1,1'-biphenyl-2,2'-diyl phosphonites and stabilized compositions
US5288914A (en) * 1984-08-27 1994-02-22 The Dow Chemical Company Poly(arylcyclobutenes)
NL8403224A (nl) * 1984-10-24 1986-05-16 Oce Andeno Bv Dioxafosforinanen, de bereiding ervan en de toepassing voor het splitsen van optisch actieve verbindingen.
DE3940765A1 (de) * 1989-12-09 1991-06-13 Hoechst Ag Verfahren zur herstellung reiner cyclischer phosphorsaeurediarylester
JPH10503752A (ja) * 1994-05-16 1998-04-07 メリル・フアーマシユウテイカルズ・インコーポレイテツド ラセミ形α−〔４−（１，１−ジメチルエチル）フェニル〕−４−（ヒドロキシジフェニルメチル）−１−ピペリジンブタノールおよび誘導体化合物の光学分割に有用な方法およびジアステレオマー塩
JP4725757B2 (ja) * 1999-03-24 2011-07-13 東ソー株式会社 ビナフトールリン酸誘導体及びその利用
DE60008807T2 (de) * 1999-03-24 2005-01-13 Tosoh Corp., Shinnanyo Binaphtol-monophosphorsäurederivate und deren Verwendung
WO2001030763A1 (en) * 1999-10-22 2001-05-03 Takeda Chemical Industries, Ltd. Process for producing optically active naphthalene derivative and optical resolver therefor
EP1229019A4 (en) * 1999-11-10 2004-08-18 Takeda Chemical Industries Ltd METHOD FOR THE PRODUCTION OF OPTICALLY ACTIVE, CYCLIC ENAMINONE DERIVATIVES
US6391926B2 (en) * 2000-03-13 2002-05-21 Tosoh Corporation Optically active phosphate derivative
AU2002318225B2 (en) 2001-07-09 2007-12-13 Repros Therapeutics Inc. Methods and materials for the treatment of testosterone deficiency in men
JP4556869B2 (ja) * 2003-04-25 2010-10-06 東亞合成株式会社 キラルなブレンステッド酸を触媒として用いる不斉合成方法
US7229557B2 (en) * 2004-02-04 2007-06-12 Konec, Inc. Method to separate stereoisomers
US8420822B2 (en) * 2009-10-09 2013-04-16 Hetero Research Foundation Optical resolution of substituted 2-(2-pyridinylmethylsulphinyl)-1H-benzimidazoles
UA113291C2 (xx) 2011-08-04 2017-01-10 Метаболіти транскломіфену і їх застосування
KR20150041793A (ko) 2012-08-21 2015-04-17 레프로스 쎄라피우틱스 아이엔씨. 트랜스-클로미펜 제형 및 그의 용도
HK1216502A1 (zh) 2012-11-02 2016-11-18 Repros Therapeutics Inc. 用於癌症治療的反式-克羅米芬
MX2016011567A (es) * 2014-03-11 2016-12-07 Repros Therapeutics Inc Sintesis de clomifeno usando un solvente unico.
CN107072969B (zh) 2014-07-24 2020-04-21 艾森潘帕克制药股份有限公司 使用顺式氯米芬治疗雄激素剥夺疗法诱导的热潮红和骨丢失
EP3015454A1 (en) * 2014-10-28 2016-05-04 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Stable solid form of trans-Clomiphene citrate
EP3015453B1 (en) 2014-10-28 2016-10-12 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of Clomiphene
EP3368506B1 (en) 2016-04-22 2023-09-06 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of enclomiphene citrate having needle shaped crystal habit.
IL304863B2 (en) 2017-09-11 2025-08-01 Atossa Therapeutics Inc Methods for making and using endoxifen
FR3082842A1 (fr) * 2018-06-21 2019-12-27 Veru Inc. Polymorphe de cis-clomiphene (zuclomiphene) et procedes d'utilisation de celui-ci
JP7662204B2 (ja) 2019-07-03 2025-04-15 アトッサ・セラピューティクス・インコーポレイテッド エンドキシフェンの徐放性組成物
CA3098552A1 (en) 2019-11-14 2021-05-14 Apotex Inc. Processes for the preparation of zuclomiphene and intermediates thereof
CA3098725A1 (en) 2019-11-14 2021-05-14 Apotex Inc. Zuclpomiphene salts and crystalline forms thereof
CA3105944A1 (en) 2020-01-22 2021-07-22 Apotex Inc. Crystalline forms of zuclomiphene citrate
EP3907213A1 (en) 2020-05-04 2021-11-10 Pcas Processes for the production of isomerically pure or enriched cis-clomiphene
US11578025B2 (en) 2020-10-19 2023-02-14 Apotex Inc. Processes for the preparation of zuclomiphene intermediates

Also Published As

Publication number Publication date
CH576921A5 (enExample) 1976-06-30
IL38860A0 (en) 1972-04-27
NL7203574A (enExample) 1972-09-20
CA961500A (en) 1975-01-21
SE409323B (sv) 1979-08-13
PH10768A (en) 1977-09-05
JPS5547013B1 (enExample) 1980-11-27
DK139944C (enExample) 1979-10-22
ES400862A1 (es) 1976-04-16
BE780887A (fr) 1972-07-17
AU3961172A (en) 1973-09-06
FR2129741A5 (enExample) 1972-10-27
DE2212660A1 (de) 1972-09-28
NO136357C (no) 1977-08-24
GB1360946A (en) 1974-07-24
US3848030A (en) 1974-11-12
DE2212660B2 (de) 1980-07-10
DK139944B (da) 1979-05-21
IL38860A (en) 1975-06-25
NO136357B (enExample) 1977-05-16
DE2212660C3 (de) 1981-09-24
AU462431B2 (en) 1975-06-09
ZA721297B (en) 1973-03-28

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