IT1317356B1 - Derivati della cumarina e relativi sali, processo per la loropreparazione e loro impiego in campo farmaceutico. - Google Patents

Derivati della cumarina e relativi sali, processo per la loropreparazione e loro impiego in campo farmaceutico.

Info

Publication number
IT1317356B1
IT1317356B1 IT2000PD000193A ITPD20000193A IT1317356B1 IT 1317356 B1 IT1317356 B1 IT 1317356B1 IT 2000PD000193 A IT2000PD000193 A IT 2000PD000193A IT PD20000193 A ITPD20000193 A IT PD20000193A IT 1317356 B1 IT1317356 B1 IT 1317356B1
Authority
IT
Italy
Prior art keywords
salts
preparation
pharmaceutical field
cumarine
derivatives
Prior art date
Application number
IT2000PD000193A
Other languages
English (en)
Inventor
Marco Prosdocimi
Giampaolo Menon
Giovanni Monastra
Enrico Galbiati
Mario Finesso
Original Assignee
Fidia S P A Ora Fidia Farmaceu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia S P A Ora Fidia Farmaceu filed Critical Fidia S P A Ora Fidia Farmaceu
Publication of ITPD20000193A0 publication Critical patent/ITPD20000193A0/it
Priority to IT2000PD000193A priority Critical patent/IT1317356B1/it
Priority to JP2002515879A priority patent/JP2004505072A/ja
Priority to AU2001283959A priority patent/AU2001283959B8/en
Priority to ES01962875T priority patent/ES2247158T3/es
Priority to DE60113278T priority patent/DE60113278T2/de
Priority to PCT/EP2001/008642 priority patent/WO2002010148A1/en
Priority to US10/343,241 priority patent/US20040023893A1/en
Priority to AU8395901A priority patent/AU8395901A/xx
Priority to CA002417788A priority patent/CA2417788A1/en
Priority to EP01962875A priority patent/EP1307438B1/en
Publication of ITPD20000193A1 publication Critical patent/ITPD20000193A1/it
Application granted granted Critical
Publication of IT1317356B1 publication Critical patent/IT1317356B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/075—Benzo[b]pyran-2-ones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
IT2000PD000193A 2000-07-31 2000-07-31 Derivati della cumarina e relativi sali, processo per la loropreparazione e loro impiego in campo farmaceutico. IT1317356B1 (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT2000PD000193A IT1317356B1 (it) 2000-07-31 2000-07-31 Derivati della cumarina e relativi sali, processo per la loropreparazione e loro impiego in campo farmaceutico.
DE60113278T DE60113278T2 (de) 2000-07-31 2001-07-26 Cumarin-derivate und ihre salze, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
AU2001283959A AU2001283959B8 (en) 2000-07-31 2001-07-26 Novel coumarin derivatives and the salts thereof, a process for the preparation thereof and their use in the pharmaceutical field
ES01962875T ES2247158T3 (es) 2000-07-31 2001-07-26 Nuevos derivados de al coumarina y sales de los mismos, procedimiento para su preparacion y su uso en el campo farmaceutico.
JP2002515879A JP2004505072A (ja) 2000-07-31 2001-07-26 新規なクマリン誘導体及びそれらの塩類、それらの調製方法及び薬学分野におけるそれらの使用
PCT/EP2001/008642 WO2002010148A1 (en) 2000-07-31 2001-07-26 Novel coumarin derivatives and the salts thereof, a process for the preparation thereof and their use in the pharmaceutical field
US10/343,241 US20040023893A1 (en) 2000-07-31 2001-07-26 Novel coumarin derivatives and the salts thereof, a process for the preparation thereof and their use in the pharmaceutical field
AU8395901A AU8395901A (en) 2000-07-31 2001-07-26 Novel coumarin derivatives and the salts thereof, a process for the preparation thereof and their use in the pharmaceutical field
CA002417788A CA2417788A1 (en) 2000-07-31 2001-07-26 Novel coumarin derivatives and the salts thereof, a process for the preparation thereof and their use in the pharmaceutical field
EP01962875A EP1307438B1 (en) 2000-07-31 2001-07-26 Novel coumarin derivatives and the salts thereof, a process for the preparation thereof and their use in the pharmaceutical field

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000PD000193A IT1317356B1 (it) 2000-07-31 2000-07-31 Derivati della cumarina e relativi sali, processo per la loropreparazione e loro impiego in campo farmaceutico.

Publications (3)

Publication Number Publication Date
ITPD20000193A0 ITPD20000193A0 (it) 2000-07-31
ITPD20000193A1 ITPD20000193A1 (it) 2002-01-31
IT1317356B1 true IT1317356B1 (it) 2003-06-16

Family

ID=11452041

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2000PD000193A IT1317356B1 (it) 2000-07-31 2000-07-31 Derivati della cumarina e relativi sali, processo per la loropreparazione e loro impiego in campo farmaceutico.

Country Status (9)

Country Link
US (1) US20040023893A1 (it)
EP (1) EP1307438B1 (it)
JP (1) JP2004505072A (it)
AU (2) AU8395901A (it)
CA (1) CA2417788A1 (it)
DE (1) DE60113278T2 (it)
ES (1) ES2247158T3 (it)
IT (1) IT1317356B1 (it)
WO (1) WO2002010148A1 (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1281599C (zh) * 2003-05-15 2006-10-25 中国科学院上海有机化学研究所 香豆素类化合物和合成方法
US20050054586A1 (en) * 2003-06-30 2005-03-10 Bartels Stephen P. Treatment of ophthalmic disorders
GB0611115D0 (en) * 2006-06-06 2006-07-19 Novabiotics Ltd Compounds and their use
CN108727447B (zh) * 2017-04-21 2021-01-12 中国医学科学院药物研究所 一种香豆素衍生物代谢产物的制备及其在防治脑缺血和阿尔茨海默病中的应用
CN114920722B (zh) * 2021-06-02 2024-03-08 何黎琴 一种7-羟基-3-乙酰基香豆素肟类化合物、其制备方法及医药用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE621327A (it) *
DE1210883B (de) * 1961-11-09 1966-02-17 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von Derivaten des 7-Oxycumarins
US3243441A (en) * 1962-07-26 1966-03-29 Cassella Farbwerke Mainkur Ag 7-hydroxy coumarin derivative
US3259635A (en) * 1962-07-26 1966-07-05 Cassella Farbwerke Mainkur Ag 7-hydroxy coumarin derivative
FR1451667A (fr) * 1964-10-17 1966-01-07 Cassella Farbwerke Mainkur Ag Nouvelles 3-aminoalkyl-4-alkyl-coumarines et leur préparation
IT1247476B (it) * 1991-06-14 1994-12-17 Fidia Spa Derivati della cumarina.
IT1265665B1 (it) * 1993-06-21 1996-11-22 Fidia Spa Composizioni farmaceutiche comprendenti 8-cloro-3-(beta- dietilaminoetil)-4-metil-7-etossicarbonilmetossi cumarina base e
DE4337906A1 (de) * 1993-11-08 1995-05-11 Cassella Ag Verwendung von Cumarinderivaten

Also Published As

Publication number Publication date
CA2417788A1 (en) 2002-02-07
DE60113278T2 (de) 2006-04-27
WO2002010148A1 (en) 2002-02-07
ITPD20000193A0 (it) 2000-07-31
EP1307438A1 (en) 2003-05-07
ES2247158T3 (es) 2006-03-01
AU2001283959B8 (en) 2006-01-19
JP2004505072A (ja) 2004-02-19
US20040023893A1 (en) 2004-02-05
EP1307438B1 (en) 2005-09-07
AU8395901A (en) 2002-02-13
DE60113278D1 (de) 2005-10-13
ITPD20000193A1 (it) 2002-01-31
AU2001283959B2 (en) 2006-01-05

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