IT1292437B1 - Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti - Google Patents

Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti

Info

Publication number
IT1292437B1
IT1292437B1 IT97MI001544A ITMI971544A IT1292437B1 IT 1292437 B1 IT1292437 B1 IT 1292437B1 IT 97MI001544 A IT97MI001544 A IT 97MI001544A IT MI971544 A ITMI971544 A IT MI971544A IT 1292437 B1 IT1292437 B1 IT 1292437B1
Authority
IT
Italy
Prior art keywords
synthesis
tetrazol
ortho
substituted benzenes
process useful
Prior art date
Application number
IT97MI001544A
Other languages
English (en)
Italian (it)
Inventor
Marco Villa
Pietro Allegrini
Katiuscia Arrighi
Maurizio Paiocchi
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of ITMI971544A0 publication Critical patent/ITMI971544A0/it
Priority to IT97MI001544A priority Critical patent/IT1292437B1/it
Priority to DE69808093T priority patent/DE69808093T2/de
Priority to IL13324998A priority patent/IL133249A/xx
Priority to AT98936398T priority patent/ATE224395T1/de
Priority to JP50630899A priority patent/JP4128633B2/ja
Priority to EP98936398A priority patent/EP0994881B1/en
Priority to US09/445,470 priority patent/US6271375B1/en
Priority to CA002294609A priority patent/CA2294609C/en
Priority to HU0004227A priority patent/HU226471B1/hu
Priority to CZ19994774A priority patent/CZ293277B6/cs
Priority to ES98936398T priority patent/ES2182349T3/es
Priority to PCT/EP1998/003969 priority patent/WO1999001459A1/en
Publication of ITMI971544A1 publication Critical patent/ITMI971544A1/it
Application granted granted Critical
Publication of IT1292437B1 publication Critical patent/IT1292437B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT97MI001544A 1997-06-30 1997-06-30 Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti IT1292437B1 (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IT97MI001544A IT1292437B1 (it) 1997-06-30 1997-06-30 Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
US09/445,470 US6271375B1 (en) 1997-06-30 1998-06-29 Ortho-metalation process for the synthesis of 2-substituted-1-(tetrazol-5-yl)benzenes
HU0004227A HU226471B1 (en) 1997-06-30 1998-06-29 Direct ortho-metalation process for the synthesis of 5-(2-substituted-phenyl)-tetrazol derivatives
AT98936398T ATE224395T1 (de) 1997-06-30 1998-06-29 Verfahren zur herstellung von 2-substituierten 1- (tetrazol-5-yl)benzenverbindungen durch ortho- metallierung
JP50630899A JP4128633B2 (ja) 1997-06-30 1998-06-29 ２−置換−１−（テトラゾール−５−イル）ベンゼン合成のためのオルトメタル化方法
EP98936398A EP0994881B1 (en) 1997-06-30 1998-06-29 Ortho-metalation process for the synthesis of 2-substituted-1-(tetrazol-5-yl)benzenes
DE69808093T DE69808093T2 (de) 1997-06-30 1998-06-29 Verfahren zur herstellung von 2-substituierten 1-(tetrazol-5-yl)benzenverbindungen durch ortho-metallierung
CA002294609A CA2294609C (en) 1997-06-30 1998-06-29 Ortho-metalation process for the synthesis of 2-substituted-1-(tetrazol-5-yl)benzenes
IL13324998A IL133249A (en) 1997-06-30 1998-06-29 Ortho-metalation process for the synthesis of 2-substituted-1- (tetrazol-5-yl) benzenes
CZ19994774A CZ293277B6 (cs) 1997-06-30 1998-06-29 Způsob přímé ortho-metalace
ES98936398T ES2182349T3 (es) 1997-06-30 1998-06-29 Procedimiento de orto-metalizacion para la sintesis de 1-(tetrazol-5-il)bencenos sustituidos en la posicion 2.
PCT/EP1998/003969 WO1999001459A1 (en) 1997-06-30 1998-06-29 Ortho-metalation process for the synthesis of 2-substituted-1-(tetrazol-5-yl)benzenes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI001544A IT1292437B1 (it) 1997-06-30 1997-06-30 Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti

Publications (3)

Publication Number Publication Date
ITMI971544A0 ITMI971544A0 (enExample) 1997-06-30
ITMI971544A1 ITMI971544A1 (it) 1998-12-30
IT1292437B1 true IT1292437B1 (it) 1999-02-08

Family

ID=11377464

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI001544A IT1292437B1 (it) 1997-06-30 1997-06-30 Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti

Country Status (12)

Country Link
US (1) US6271375B1 (enExample)
EP (1) EP0994881B1 (enExample)
JP (1) JP4128633B2 (enExample)
AT (1) ATE224395T1 (enExample)
CA (1) CA2294609C (enExample)
CZ (1) CZ293277B6 (enExample)
DE (1) DE69808093T2 (enExample)
ES (1) ES2182349T3 (enExample)
HU (1) HU226471B1 (enExample)
IL (1) IL133249A (enExample)
IT (1) IT1292437B1 (enExample)
WO (1) WO1999001459A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066161A1 (en) 1999-04-28 2000-11-09 Takeda Chemical Industries, Ltd. Preventives / remedies / progression inhibitors for simplex retinopathy or preproliferating retinopathy
WO2004014259A1 (en) 2002-07-26 2004-02-19 Pharmacia Groningen Bv Method and device for manipulation of an intraocular lens
WO2004065383A2 (en) * 2003-01-16 2004-08-05 Teva Pharmaceutical Industries Ltd. Novel synthesis of irbesartan
US7199144B2 (en) 2003-04-21 2007-04-03 Teva Pharmaceuticals Industries, Ltd. Process for the preparation of valsartan and intermediates thereof
EP1950204A1 (en) 2003-03-17 2008-07-30 Teva Pharmaceutical Industries Ltd. Amorphous form of valsartan
EP1511739B1 (en) * 2003-03-17 2008-04-30 Teva Pharmaceutical Industries Ltd. Polymorphs of valsartan
US7378531B2 (en) * 2003-04-21 2008-05-27 Teva Pharmaceutical Industries Ltd Process for the preparation of valsartan
EP1556363A2 (en) * 2003-04-21 2005-07-27 Teva Pharmaceutical Industries Limited Process for the preparation of valsartan and intermediates thereof
CA2534892A1 (en) * 2003-08-08 2005-02-17 Dipharma S.P.A. A process for the preparation of phenyltetrazole derivatives
WO2005049587A1 (en) * 2003-11-21 2005-06-02 Ranbaxy Laboratories Limited Process for preparation of biphenyl tetrazole
CA2568640C (en) 2004-06-04 2011-08-09 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
WO2006067216A2 (en) * 2004-12-22 2006-06-29 Enantia, S. L. Intermediate compounds for the preparation of an angiotensin ii receptor and process for the preparation of valsartan
EP1833801B9 (en) * 2004-12-22 2009-02-25 Algry Quimica, S.L Intermediate compounds for the preparation of angiotensin ii receptor antagonists
EP1812411A2 (en) * 2005-07-05 2007-08-01 Teva Pharmaceutical Industries Ltd. Process for preparing valsartan
EP2043607A2 (en) * 2006-06-23 2009-04-08 Usv Limited Process for the preparation of micronized valsartan
US7943794B2 (en) * 2008-02-13 2011-05-17 Ranbaxy Laboratories Limited Processes for the preparation of intermediates of valsartan
US8492577B2 (en) * 2008-04-07 2013-07-23 Hetero Research Foundation Process for preparation of valsartan intermediate
WO2012056294A1 (en) 2010-10-29 2012-05-03 Jubilant Life Sciences Ltd. An improved process for the preparation of n-pentanoyl-n-[[2'-(1h-tetrazol-5-yi)[1,1'-biphenyl]-4-yi]methyl]-l-valine
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
US12365654B2 (en) 2019-12-02 2025-07-22 Harman Finochem Limited Process for the preparation of highly pure valsartan

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039814A (en) * 1990-05-02 1991-08-13 Merck & Co., Inc. Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes
US5149699A (en) 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists
TW226375B (enExample) * 1991-10-24 1994-07-11 American Home Prod
US5256654A (en) 1991-10-24 1993-10-26 American Home Products Corporation Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
EP0550313A1 (fr) * 1991-12-30 1993-07-07 Synthelabo Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse
US5310929A (en) 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
FR2696746B1 (fr) 1992-10-12 1994-11-18 Synthelabo Dérivés de l'acide benzèneborinique, leur préparation et leur utilisation comme intermédiaires de synthèse.
US5760220A (en) 1995-06-07 1998-06-02 American Home Products Corporation Process for preparation of biphenyl derivatives
WO1996040684A1 (en) * 1995-06-07 1996-12-19 American Home Products Corporation Process for preparation of biphenyl derivatives

Also Published As

Publication number Publication date
ITMI971544A1 (it) 1998-12-30
CA2294609C (en) 2008-08-19
US6271375B1 (en) 2001-08-07
DE69808093D1 (de) 2002-10-24
HUP0004227A2 (hu) 2001-06-28
CA2294609A1 (en) 1999-01-14
CZ477499A3 (cs) 2000-07-12
IL133249A (en) 2003-12-10
JP4128633B2 (ja) 2008-07-30
DE69808093T2 (de) 2003-06-05
EP0994881A1 (en) 2000-04-26
WO1999001459A1 (en) 1999-01-14
CZ293277B6 (cs) 2004-03-17
HUP0004227A3 (en) 2003-03-28
JP2002510314A (ja) 2002-04-02
ATE224395T1 (de) 2002-10-15
HU226471B1 (en) 2008-12-29
IL133249A0 (en) 2001-04-30
ES2182349T3 (es) 2003-03-01
EP0994881B1 (en) 2002-09-18
ITMI971544A0 (enExample) 1997-06-30

Similar Documents

Publication Publication Date Title
IL133249A0 (en) Ortho-metalation process for the synthesis of 2-substituted-1-(tetrazol-5-yl) benzenes
ES2088839T1 (es) Compuestos inhibidores de la proteasa retroviral.
CY1111759T1 (el) Ενδιαμεσες ενωσεις για την παρασκευη συγκεκριμενων τριαζολοπυριμιδινων ως ρ2τ ανταγωνιστων
BG106340A (en) Substituted oxoazaheterocyclyl compounds
ATE297203T1 (de) Antithrombotische mitteln
PT1312609E (pt) Compostos de acido e ester boronico, sinteses e utilizacoes
SE0100903D0 (sv) Compounds
IS6614A (is) Ný tríasólpýrimídínefnasambönd
YU47600A (sh) SUPSTITUISANI OKSOAZAHETEROCIKLIL INHIBITORI FAKTORA Xa
CY1107634T1 (el) Φαρμακευτικη συνθεση
YU25497A (sh) Postupak za dobijanje sildenafila
TR200800474T2 (tr) Florfenikole aracı maddelerin hazırlanmasına ilişkin işlem.
GB0127903D0 (en) Improvements relating to organic compounds
DE69812634D1 (de) Metalloproteinase-inhibitoren
IT1293778B1 (it) 1,4,7,10-tetraazabiciclo(8.2.2.)tetradecan-2 one, sua preparazione e suo uso per la preparazione di tetraazamacrocicli
ATE411287T1 (de) Neue metallproteinaseinhibitoren
EA200000094A1 (ru) Способ получения замещенного пергидроизоиндола
TR200000786T2 (tr) Vitronektin reseptör antagonisti
NO20016151L (no) Fremstilling av substituerte piperidin-4-oner
DE60041001D1 (de) Substituierte homopiperidylbenzimidazolanaloga als fundusrelaxantien
DK1206452T3 (da) Fremgangsmåde til fremstilling af benzoperhydro-isoindolforbindelser
CY1107481T1 (el) Εναντιοεκλεκτικη αλκυλιωση τρικυκλικων ενωσεων
MXPA03002493A (es) Proceso eficiente para preparacion de un inhibidor del factor xa.
ATE280776T1 (de) Medizinische verwendung von mechanismus- orientierten inhibitoren der dipeptidylpeptidase i
DE69703115D1 (de) Zwischenprodukte um 2-imidazolin-5onederivate herzustellen.

Legal Events

Date Code Title Description
0001 Granted