IT1283782B1 - Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo - Google Patents

Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo

Info

Publication number
IT1283782B1
IT1283782B1 IT96MI001732A ITMI961732A IT1283782B1 IT 1283782 B1 IT1283782 B1 IT 1283782B1 IT 96MI001732 A IT96MI001732 A IT 96MI001732A IT MI961732 A ITMI961732 A IT MI961732A IT 1283782 B1 IT1283782 B1 IT 1283782B1
Authority
IT
Italy
Prior art keywords
alkyl
amides
treatment
hydroxybutyric acid
halo
Prior art date
Application number
IT96MI001732A
Other languages
English (en)
Italian (it)
Inventor
Roberto Cacciaglia
Antonella Loche
Vincenzo Perlini
Lorenza Guano
Original Assignee
Ct Lab Farm Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Lab Farm Srl filed Critical Ct Lab Farm Srl
Publication of ITMI961732A0 publication Critical patent/ITMI961732A0/it
Priority to IT96MI001732A priority Critical patent/IT1283782B1/it
Priority to PCT/EP1997/004309 priority patent/WO1998006690A1/en
Priority to DK97941921T priority patent/DK0932597T3/da
Priority to JP50937298A priority patent/JP4259615B2/ja
Priority to EP97941921A priority patent/EP0932597B1/en
Priority to SI9730343T priority patent/SI0932597T1/xx
Priority to CA002263328A priority patent/CA2263328C/en
Priority to US09/242,048 priority patent/US6436998B1/en
Priority to AU43790/97A priority patent/AU4379097A/en
Priority to ES97941921T priority patent/ES2174287T3/es
Priority to AT97941921T priority patent/ATE215065T1/de
Priority to HU9902437A priority patent/HU228595B1/hu
Priority to DE69711411T priority patent/DE69711411T2/de
Priority to PT97941921T priority patent/PT932597E/pt
Publication of ITMI961732A1 publication Critical patent/ITMI961732A1/it
Application granted granted Critical
Publication of IT1283782B1 publication Critical patent/IT1283782B1/it
Priority to US10/013,971 priority patent/US6770784B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Addiction (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
IT96MI001732A 1996-08-09 1996-08-09 Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo IT1283782B1 (it)

Priority Applications (15)

Application Number Priority Date Filing Date Title
IT96MI001732A IT1283782B1 (it) 1996-08-09 1996-08-09 Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo
AU43790/97A AU4379097A (en) 1996-08-09 1997-08-07 Use of gamma-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism
AT97941921T ATE215065T1 (de) 1996-08-09 1997-08-07 Verwendung von gamma-hydroxybuttersäureamiden in der behandlung von drogenabhängigkeit und insbesondere von alcoholismus
JP50937298A JP4259615B2 (ja) 1996-08-09 1997-08-07 薬物常用および特にアルコール中毒の治寮へのγ―ヒドロキシ酪酸アミドの使用
EP97941921A EP0932597B1 (en) 1996-08-09 1997-08-07 Use of gamma-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism
SI9730343T SI0932597T1 (en) 1996-08-09 1997-08-07 Use of gamma-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism
CA002263328A CA2263328C (en) 1996-08-09 1997-08-07 Use of .gamma.-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism
US09/242,048 US6436998B1 (en) 1996-08-09 1997-08-07 Use of gamma-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism
PCT/EP1997/004309 WO1998006690A1 (en) 1996-08-09 1997-08-07 USE OF η-HYDROXYBUTYRIC ACID AMIDES IN THE TREATMENT OF DRUG ADDICTION AND IN PARTICULAR OF ALCOHOLISM
ES97941921T ES2174287T3 (es) 1996-08-09 1997-08-07 Empleo de las amidas del acido gamma-hidroxibutarico en el tratamiento de drogadicciones y en particular del alcoholismo.
DK97941921T DK0932597T3 (da) 1996-08-09 1997-08-07 Anvendelse af gamma-hydroxysmørsyreamider til behandling af lægemiddelafhængighed og især alkoholisme
HU9902437A HU228595B1 (en) 1996-08-09 1997-08-07 Gamma-hydroxybutyric acid amides, process to prepare them, use gamma-hydroxybutyric acid amides, and pharmaceuticals contg. them for the treatmant of drug abusing
DE69711411T DE69711411T2 (de) 1996-08-09 1997-08-07 Verwendung von gamma-hydroxybuttersäureamiden in der behandlung von drogenabhängigkeit und insbesondere von alcoholismus
PT97941921T PT932597E (pt) 1996-08-09 1997-08-07 Utilizacao de amidas do acido gama-hidroxibutirico no tratamento da toxicodependencia e particularmente do alcoolismo
US10/013,971 US6770784B2 (en) 1996-08-09 2001-12-11 Use of γ-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI001732A IT1283782B1 (it) 1996-08-09 1996-08-09 Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo

Publications (3)

Publication Number Publication Date
ITMI961732A0 ITMI961732A0 (enExample) 1996-08-09
ITMI961732A1 ITMI961732A1 (it) 1998-02-09
IT1283782B1 true IT1283782B1 (it) 1998-04-30

Family

ID=11374795

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96MI001732A IT1283782B1 (it) 1996-08-09 1996-08-09 Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo

Country Status (13)

Country Link
US (2) US6436998B1 (enExample)
EP (1) EP0932597B1 (enExample)
JP (1) JP4259615B2 (enExample)
AT (1) ATE215065T1 (enExample)
AU (1) AU4379097A (enExample)
CA (1) CA2263328C (enExample)
DE (1) DE69711411T2 (enExample)
DK (1) DK0932597T3 (enExample)
ES (1) ES2174287T3 (enExample)
HU (1) HU228595B1 (enExample)
IT (1) IT1283782B1 (enExample)
PT (1) PT932597E (enExample)
WO (1) WO1998006690A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
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ATE238783T1 (de) 1998-12-23 2003-05-15 Orphan Medical Inc Mikrobenbeständige und stabilisierte lösungen, die gamma-hydroxybuttersäuresalze zur behandlung von narkolepsie enthalten
FR2827859B1 (fr) 2001-07-30 2005-09-23 Lipha Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete
AU2003295393A1 (en) * 2002-11-01 2004-06-07 Baylor Research Institute Ghb treatment methods
US7838556B2 (en) * 2006-02-21 2010-11-23 University Of Maryland, Baltimore Ethers of 3-hydroxyphenylacetic acid as selective gamma-hydroxybutyric acid receptor ligands
EP2062875A1 (en) * 2007-11-13 2009-05-27 LABORATORIO FARMACEUTICO C.T. S.r.l. New polymorphic forms of n-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide
US8771735B2 (en) * 2008-11-04 2014-07-08 Jazz Pharmaceuticals, Inc. Immediate release dosage forms of sodium oxybate
US8778398B2 (en) * 2008-11-04 2014-07-15 Jazz Pharmaceuticals, Inc. Immediate release formulations and dosage forms of gamma-hydroxybutyrate
CN102917697B (zh) 2010-03-24 2016-01-20 爵士制药有限公司 用于高剂量的水溶性和吸湿性药物的控释剂型
US8591922B1 (en) 2012-12-14 2013-11-26 Jazz Pharmacuticals, Inc. Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
ITMI20132041A1 (it) * 2013-12-06 2015-06-07 Ct Lab Farm Srl Derivati dell'acido gamma-idrossibutirrico, loro preparazione e loro uso medico.
US10398662B1 (en) 2015-02-18 2019-09-03 Jazz Pharma Ireland Limited GHB formulation and method for its manufacture
ITUB20152860A1 (it) * 2015-08-04 2017-02-04 Laboratorio Farm C T S R L Selezionata amide dell?acido ?-idrossibutirrico e suoi usi nel trattamento dell?abuso da alcool
ITUA20164040A1 (it) * 2016-06-01 2017-12-01 Laboratorio Farm C T S R L Procedimento per la preparazione di polimorfo a
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12478604B1 (en) 2016-07-22 2025-11-25 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12186296B1 (en) 2016-07-22 2025-01-07 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US20180263936A1 (en) 2017-03-17 2018-09-20 Jazz Pharmaceuticals Ireland Limited Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
BR112021006027A2 (pt) 2018-11-19 2021-06-29 Jazz Pharmaceuticals Ireland Limited formulações de fármaco resistente a álcool
WO2020178695A1 (en) 2019-03-01 2020-09-10 Flamel Ireland Limited Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state
TW202139986A (zh) 2020-02-21 2021-11-01 愛爾蘭商爵士製藥愛爾蘭有限責任公司 治療原發性嗜睡症之方法
WO2023126076A1 (en) 2022-01-03 2023-07-06 Laboratorio Farmaceutico C.T. S.R.L. Medical use of an amide of y-hydroxybutyric acid in the treatment of fragile x syndrome
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3940258A (en) * 1971-11-26 1976-02-24 Gaf Corporation Method for controlling aquatic weeds with N-phenylalkyl-γ-hydroxybutyramide
JPS6016432B2 (ja) * 1977-07-26 1985-04-25 グレラン製薬株式会社 複素環式化合物類およびその製造法
DE3855875T2 (de) * 1987-02-23 1997-08-28 Ono Pharmaceutical Co Thiazolidin-Derivate
IT1217783B (it) * 1988-06-03 1990-03-30 Farmaceutico Ct S R L Lab Impiego di salo dell,acido gamma idrossi butirrico per la preparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell,alcolismo e composizioni relative
IT1248588B (it) * 1991-06-28 1995-01-19 Gaetano Crepaldi Composizioni farmaceutiche per la terapia dell'astinenza, del " craving", della dipendenza da sostanze stupefacenti, da sostanze psicoattive, da nicotina e dei disturbi alimentari.
ATE189211T1 (de) * 1994-06-01 2000-02-15 Axys Pharm Inc Zusammensetzungen und verfahren zur behandlung von durch mast-zellen verursachten krankheiten
AU712467B2 (en) * 1995-09-18 1999-11-04 Sankyo Company Limited New urea derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use
RU2199534C2 (ru) * 1997-10-14 2003-02-27 Мицубиси Фарма Корпорейшн СОЕДИНЕНИЕ ПИПЕРАЗИНА, ИНГИБИТОР ПРОДУЦИРОВАНИЯ TNF-α И /ИЛИ ПРОМОТОР ПРОДУЦИРОВАНИЯ IL-10 И СРЕДСТВО ДЛЯ ПРОФИЛАКТИКИ ИЛИ ЛЕЧЕНИЯ БОЛЕЗНЕЙ НА ЕГО ОСНОВЕ

Also Published As

Publication number Publication date
AU4379097A (en) 1998-03-06
JP4259615B2 (ja) 2009-04-30
HUP9902437A2 (hu) 1999-12-28
WO1998006690A1 (en) 1998-02-19
CA2263328A1 (en) 1998-02-19
EP0932597A1 (en) 1999-08-04
JP2000516225A (ja) 2000-12-05
EP0932597B1 (en) 2002-03-27
CA2263328C (en) 2006-07-25
DE69711411T2 (de) 2002-11-07
US6770784B2 (en) 2004-08-03
ATE215065T1 (de) 2002-04-15
ES2174287T3 (es) 2002-11-01
US6436998B1 (en) 2002-08-20
HU228595B1 (en) 2013-04-29
DK0932597T3 (da) 2002-06-24
PT932597E (pt) 2002-09-30
ITMI961732A0 (enExample) 1996-08-09
ITMI961732A1 (it) 1998-02-09
HUP9902437A3 (en) 2001-07-30
DE69711411D1 (de) 2002-05-02
US20020165224A1 (en) 2002-11-07

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