IT1264629B1 - Procedimento microbico per la preparazione di mevinolina - Google Patents

Procedimento microbico per la preparazione di mevinolina

Info

Publication number
IT1264629B1
IT1264629B1 IT93MI001306A ITMI931306A IT1264629B1 IT 1264629 B1 IT1264629 B1 IT 1264629B1 IT 93MI001306 A IT93MI001306 A IT 93MI001306A IT MI931306 A ITMI931306 A IT MI931306A IT 1264629 B1 IT1264629 B1 IT 1264629B1
Authority
IT
Italy
Prior art keywords
formula
delta
methylbutyryloxy
naphthalen
hexahydro
Prior art date
Application number
IT93MI001306A
Other languages
English (en)
Inventor
Antonia Nata Bokany Jekkel
Eva Ilkoy
Istavan Mihaly Szabo
Gabor Ambrus
Attilia Andor
Ilona Nata Bosinger Varga
Imre Moravcsik
Istvan Szabo
Janos Erdei
Kalman Polya
Andras Kiss
Laszlo Cseke
Karoly Nagy
Mihaly Kaszas
Lajos Kiss
Istvan Magyi
Edit Halasz
Gyorgy Santha
Original Assignee
Biogal Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar
Publication of ITMI931306A0 publication Critical patent/ITMI931306A0/it
Publication of ITMI931306A1 publication Critical patent/ITMI931306A1/it
Application granted granted Critical
Publication of IT1264629B1 publication Critical patent/IT1264629B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/66—Aspergillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invenzione riguarda un procedimento microbico per preparare delta-lattone dell'acido beta, delta-diidrossi-7-[1, 2, 6, 7, 8, 8a-esaidro-2, 6-dimetil-8-(2-metilbutirrilossi)-naftalen-1-il]-attanoico della formula (I) ad acido beta, delta-diidrossi-7-[1, 2, 6, 7, 8a-esaidro-2, 6-dimetil-8-(2-metilbutirrilossi)naftalen-1-il-]ettanoico della formula (II) (FORMULA I E II) mediante la fermentazione aerobica della coltura sommersa di un ceppo di fungo imperfetto, biosintetizzando i suddetti composti in un mezzo nutriente contenente sorgenti utilizzabili di carbonio ad azoto nonché sali minerali, ed isolando il prodotto della formula (I) che comprende il fatto di coltivare un ceppo della nuova specie di fungo Aspergillus obscurus producendo i suddetti composti delle formule (I) e/o (II) in una gamma di temperatura da 25° a 30°C e se lo si desidera separare i prodotti formati dal modo di fermentazione, quindi isolandoli in forma di lattone della formula (I) e se lo si desidera purificandoli.
IT93MI001306A 1992-06-17 1993-06-17 Procedimento microbico per la preparazione di mevinolina IT1264629B1 (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9202020A HU208997B (en) 1992-06-17 1992-06-17 Microbiological method for producing mevinoline

Publications (3)

Publication Number Publication Date
ITMI931306A0 ITMI931306A0 (it) 1993-06-17
ITMI931306A1 ITMI931306A1 (it) 1994-12-17
IT1264629B1 true IT1264629B1 (it) 1996-10-04

Family

ID=10982069

Family Applications (1)

Application Number Title Priority Date Filing Date
IT93MI001306A IT1264629B1 (it) 1992-06-17 1993-06-17 Procedimento microbico per la preparazione di mevinolina

Country Status (9)

Country Link
US (1) US5403728A (it)
AT (1) AT399722B (it)
CA (1) CA2098698C (it)
DE (1) DE4320023A1 (it)
ES (1) ES2064282B1 (it)
GR (1) GR1002573B (it)
HU (1) HU208997B (it)
IT (1) IT1264629B1 (it)
JO (1) JO1764B1 (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
US6812007B1 (en) * 1992-11-04 2004-11-02 Keri Vilmos Process for the isolation and purification of mevinolin
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US20060223150A1 (en) * 1993-09-08 2006-10-05 Vilmos Keri Process for the isolation and purification of mevinolin
SI9500238A (en) * 1995-07-27 1997-02-28 Krka Tovarna Zdravil Procedure for the production of lovastatin
EP0877089A1 (en) * 1997-05-07 1998-11-11 Gist-Brocades B.V. HMG-CoA reductase inhibitor preparation process
KR100234976B1 (ko) * 1997-08-01 1999-12-15 김충환 세룰레닌 및 엘-메치오닌 유사체에 동시 내성을 갖는 아스퍼질 러스속 미생물 및 그를 이용한 메비놀린산의 제조방법
NZ500870A (en) * 1998-03-20 2002-03-01 Biogal Gyogyszergyar Metabolic controlled fermentation process for preparing mevinolin (lovastatin)
HU226966B1 (en) * 1998-03-20 2010-03-29 Teva Gyogyszergyar Zartkoeruee Fermentation process
KR100342789B1 (ko) * 1999-10-29 2002-07-04 김용규 니스타틴에 내성을 갖는 아스퍼질러스속 미생물 및 그를 이용한 트리올 헵타노익산의 제조방법
EP1263979A4 (en) 2000-02-24 2003-05-21 Biogal Gyogyszergyar METHOD FOR CLEANING FERMENTATION BREW
IN192861B (it) * 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
EP1176208A1 (en) * 2000-07-28 2002-01-30 Société des Produits Nestlé S.A. Koji molds and use thereof for preparing cholesterol-lowering products
KR100379075B1 (en) * 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
US20070020554A1 (en) * 2005-07-25 2007-01-25 Xerox Corporation Toner process
TWI415619B (zh) * 2011-08-02 2013-11-21 Sunway Biotech Co Ltd 一種可降血脂且提升高密度脂蛋白膽固醇之組合物及其製造方法
CN112481139B (zh) * 2020-12-22 2022-08-05 华东理工大学 利用海洋真菌黄柄曲霉hn4-13生产大黄素的培养基及其制备方法
CN115232096B (zh) * 2022-06-15 2023-05-05 福建卫生职业技术学院 源于细曲霉的内酯类化合物及其制备方法和在抗人肝癌药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4319039A (en) * 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
DE3682557D1 (de) * 1985-09-13 1992-01-02 Sankyo Co Hydroxy-ml-236b-derivate, deren herstellung und anwendung.
EP0337548A3 (en) * 1988-04-15 1991-08-14 Merck & Co. Inc. HMG-COA reductase inhibitors produced by nocardia SP. (MA6455)(ATCC 53695)
EP0381478A1 (en) * 1989-02-01 1990-08-08 Merck & Co. Inc. Process for the preparation of 6-alpha-hydroxymethyl lovastatin derivatives
US5250435A (en) * 1991-06-04 1993-10-05 Merck & Co., Inc. Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)

Also Published As

Publication number Publication date
ATA118993A (de) 1994-11-15
GR930100259A (el) 1994-02-28
HU208997B (en) 1994-02-28
AT399722B (de) 1995-07-25
CA2098698C (en) 1998-05-19
DE4320023A1 (de) 1993-12-23
GR1002573B (el) 1997-02-06
JO1764B1 (en) 1994-05-15
ITMI931306A0 (it) 1993-06-17
ES2064282A1 (es) 1995-01-16
CA2098698A1 (en) 1993-12-18
US5403728A (en) 1995-04-04
ITMI931306A1 (it) 1994-12-17
ES2064282B1 (es) 1995-08-01
HU9202020D0 (en) 1992-10-28

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970627