AT399722B - Verfahren zur herstellung von mevinolin - Google Patents

Verfahren zur herstellung von mevinolin

Info

Publication number
AT399722B
AT399722B AT0118993A AT118993A AT399722B AT 399722 B AT399722 B AT 399722B AT 0118993 A AT0118993 A AT 0118993A AT 118993 A AT118993 A AT 118993A AT 399722 B AT399722 B AT 399722B
Authority
AT
Austria
Prior art keywords
mevinolin
producing
producing mevinolin
Prior art date
Application number
AT0118993A
Other languages
English (en)
Other versions
ATA118993A (de
Inventor
Antonia Dr Jekkel
Eva Dr Ilkoey
Istvan Mihaly Dr Szabo
Gabor Dr Ambrus
Attila Andor
Ilona Varga
Imre Moravcsik
Istvan Szabo
Janos Dr Erdei
Kalman Dr Polya
Andras Kiss
Laszlo Cseke
Karoly Nagy
Mihaly Kaszas
Lajos Dr Kiss
Istvan Magyi
Edit Halasz
Gyoergy Dr Santha
Original Assignee
Biogal Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar
Publication of ATA118993A publication Critical patent/ATA118993A/de
Application granted granted Critical
Publication of AT399722B publication Critical patent/AT399722B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/66—Aspergillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT0118993A 1992-06-17 1993-06-17 Verfahren zur herstellung von mevinolin AT399722B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9202020A HU208997B (en) 1992-06-17 1992-06-17 Microbiological method for producing mevinoline

Publications (2)

Publication Number Publication Date
ATA118993A ATA118993A (de) 1994-11-15
AT399722B true AT399722B (de) 1995-07-25

Family

ID=10982069

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0118993A AT399722B (de) 1992-06-17 1993-06-17 Verfahren zur herstellung von mevinolin

Country Status (9)

Country Link
US (1) US5403728A (de)
AT (1) AT399722B (de)
CA (1) CA2098698C (de)
DE (1) DE4320023A1 (de)
ES (1) ES2064282B1 (de)
GR (1) GR1002573B (de)
HU (1) HU208997B (de)
IT (1) IT1264629B1 (de)
JO (1) JO1764B1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
US6812007B1 (en) * 1992-11-04 2004-11-02 Keri Vilmos Process for the isolation and purification of mevinolin
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US20060223150A1 (en) * 1993-09-08 2006-10-05 Vilmos Keri Process for the isolation and purification of mevinolin
SI9500238A (en) * 1995-07-27 1997-02-28 Krka Tovarna Zdravil Procedure for the production of lovastatin
EP0877089A1 (de) * 1997-05-07 1998-11-11 Gist-Brocades B.V. Verfahren zur Herstellung eines Inhibitors der Hmg-Coa Reduktase
KR100234976B1 (ko) * 1997-08-01 1999-12-15 김충환 세룰레닌 및 엘-메치오닌 유사체에 동시 내성을 갖는 아스퍼질 러스속 미생물 및 그를 이용한 메비놀린산의 제조방법
HU226966B1 (en) * 1998-03-20 2010-03-29 Teva Gyogyszergyar Zartkoeruee Fermentation process
NZ500870A (en) * 1998-03-20 2002-03-01 Biogal Gyogyszergyar Metabolic controlled fermentation process for preparing mevinolin (lovastatin)
KR100342789B1 (ko) * 1999-10-29 2002-07-04 김용규 니스타틴에 내성을 갖는 아스퍼질러스속 미생물 및 그를 이용한 트리올 헵타노익산의 제조방법
WO2001062949A1 (en) 2000-02-24 2001-08-30 Biogal Gyogyszergyar Rt Method of purifying a fermentation broth
IN192861B (de) * 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
EP1176208A1 (de) * 2000-07-28 2002-01-30 Société des Produits Nestlé S.A. Koji Pilze und ihre Anwendung zur Herstellung von hypercholesterolemische aktive Produkte
KR100379075B1 (en) * 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
US20070020554A1 (en) * 2005-07-25 2007-01-25 Xerox Corporation Toner process
TWI415619B (zh) * 2011-08-02 2013-11-21 Sunway Biotech Co Ltd 一種可降血脂且提升高密度脂蛋白膽固醇之組合物及其製造方法
CN112481139B (zh) * 2020-12-22 2022-08-05 华东理工大学 利用海洋真菌黄柄曲霉hn4-13生产大黄素的培养基及其制备方法
CN115232096B (zh) * 2022-06-15 2023-05-05 福建卫生职业技术学院 源于细曲霉的内酯类化合物及其制备方法和在抗人肝癌药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4319039A (en) * 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
EP0215665B1 (de) * 1985-09-13 1991-11-21 Sankyo Company Limited Hydroxy-ML-236B-Derivate, deren Herstellung und Anwendung
EP0337548A3 (de) * 1988-04-15 1991-08-14 Merck & Co. Inc. Inhibitoren von HMG-COA-Reduktase, hergestellt durch Nocardia SP.(MA6455)(ATCC 53695)
CA2009043A1 (en) * 1989-02-01 1990-08-01 Michael J. Ferris Process for the preparation of 6-alpha-hydroxymethyl lovastatin derivatives
US5250435A (en) * 1991-06-04 1993-10-05 Merck & Co., Inc. Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
''PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA'', VOL. 77, 1980, S 3957-3961 *

Also Published As

Publication number Publication date
GR930100259A (el) 1994-02-28
ES2064282A1 (es) 1995-01-16
GR1002573B (el) 1997-02-06
ATA118993A (de) 1994-11-15
CA2098698A1 (en) 1993-12-18
DE4320023A1 (de) 1993-12-23
US5403728A (en) 1995-04-04
ITMI931306A0 (it) 1993-06-17
HU208997B (en) 1994-02-28
HU9202020D0 (en) 1992-10-28
ITMI931306A1 (it) 1994-12-17
ES2064282B1 (es) 1995-08-01
JO1764B1 (en) 1994-05-15
IT1264629B1 (it) 1996-10-04
CA2098698C (en) 1998-05-19

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee