ITMI931306A0 - Procedimento microbico per la preparazione di mevinolina - Google Patents
Procedimento microbico per la preparazione di mevinolinaInfo
- Publication number
- ITMI931306A0 ITMI931306A0 IT93MI1306A ITMI931306A ITMI931306A0 IT MI931306 A0 ITMI931306 A0 IT MI931306A0 IT 93MI1306 A IT93MI1306 A IT 93MI1306A IT MI931306 A ITMI931306 A IT MI931306A IT MI931306 A0 ITMI931306 A0 IT MI931306A0
- Authority
- IT
- Italy
- Prior art keywords
- mevinolin
- preparation
- microbial
- procedure
- microbial procedure
- Prior art date
Links
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 title 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 title 1
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 title 1
- 230000000813 microbial effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/66—Aspergillus
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9202020A HU208997B (en) | 1992-06-17 | 1992-06-17 | Microbiological method for producing mevinoline |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI931306A0 true ITMI931306A0 (it) | 1993-06-17 |
ITMI931306A1 ITMI931306A1 (it) | 1994-12-17 |
IT1264629B1 IT1264629B1 (it) | 1996-10-04 |
Family
ID=10982069
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT93MI001306A IT1264629B1 (it) | 1992-06-17 | 1993-06-17 | Procedimento microbico per la preparazione di mevinolina |
Country Status (9)
Country | Link |
---|---|
US (1) | US5403728A (it) |
AT (1) | AT399722B (it) |
CA (1) | CA2098698C (it) |
DE (1) | DE4320023A1 (it) |
ES (1) | ES2064282B1 (it) |
GR (1) | GR1002573B (it) |
HU (1) | HU208997B (it) |
IT (1) | IT1264629B1 (it) |
JO (1) | JO1764B1 (it) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU210867B (en) * | 1992-11-04 | 1995-10-30 | Biogal Gyogyszergyar | Method for extraction and purification of mevinolin from culture medium |
US6812007B1 (en) * | 1992-11-04 | 2004-11-02 | Keri Vilmos | Process for the isolation and purification of mevinolin |
SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
US20060223150A1 (en) * | 1993-09-08 | 2006-10-05 | Vilmos Keri | Process for the isolation and purification of mevinolin |
SI9500238A (en) * | 1995-07-27 | 1997-02-28 | Krka Tovarna Zdravil | Procedure for the production of lovastatin |
EP0877089A1 (en) * | 1997-05-07 | 1998-11-11 | Gist-Brocades B.V. | HMG-CoA reductase inhibitor preparation process |
KR100234976B1 (ko) * | 1997-08-01 | 1999-12-15 | 김충환 | 세룰레닌 및 엘-메치오닌 유사체에 동시 내성을 갖는 아스퍼질 러스속 미생물 및 그를 이용한 메비놀린산의 제조방법 |
UA73074C2 (en) * | 1998-03-20 | 2005-06-15 | Method of controlled fermentation for production of lovastatin as hydroxy-acid | |
HU226966B1 (en) * | 1998-03-20 | 2010-03-29 | Teva Gyogyszergyar Zartkoeruee | Fermentation process |
KR100342789B1 (ko) * | 1999-10-29 | 2002-07-04 | 김용규 | 니스타틴에 내성을 갖는 아스퍼질러스속 미생물 및 그를 이용한 트리올 헵타노익산의 제조방법 |
CZ20022779A3 (cs) | 2000-02-24 | 2003-02-12 | Biogal Gyogyszergyar Rt. | Způsob purifikace fermentačního bujónu |
IN192861B (it) * | 2000-06-30 | 2004-05-22 | Ranbaxy Lab Ltd | |
EP1176208A1 (en) * | 2000-07-28 | 2002-01-30 | Société des Produits Nestlé S.A. | Koji molds and use thereof for preparing cholesterol-lowering products |
KR100379075B1 (en) * | 2002-03-07 | 2003-04-08 | Jinis Biopharmaceuticals Co | Method for producing low cholesterol animal food product and food product therefrom |
US20070020554A1 (en) * | 2005-07-25 | 2007-01-25 | Xerox Corporation | Toner process |
TWI415619B (zh) * | 2011-08-02 | 2013-11-21 | Sunway Biotech Co Ltd | 一種可降血脂且提升高密度脂蛋白膽固醇之組合物及其製造方法 |
CN112481139B (zh) * | 2020-12-22 | 2022-08-05 | 华东理工大学 | 利用海洋真菌黄柄曲霉hn4-13生产大黄素的培养基及其制备方法 |
CN115232096B (zh) * | 2022-06-15 | 2023-05-05 | 福建卫生职业技术学院 | 源于细曲霉的内酯类化合物及其制备方法和在抗人肝癌药物中的应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
US4319039A (en) * | 1979-06-15 | 1982-03-09 | Merck & Co., Inc. | Preparation of ammonium salt of hypocholesteremic fermentation product |
DE3682557D1 (de) * | 1985-09-13 | 1992-01-02 | Sankyo Co | Hydroxy-ml-236b-derivate, deren herstellung und anwendung. |
EP0337548A3 (en) * | 1988-04-15 | 1991-08-14 | Merck & Co. Inc. | HMG-COA reductase inhibitors produced by nocardia SP. (MA6455)(ATCC 53695) |
CA2009043A1 (en) * | 1989-02-01 | 1990-08-01 | Michael J. Ferris | Process for the preparation of 6-alpha-hydroxymethyl lovastatin derivatives |
US5250435A (en) * | 1991-06-04 | 1993-10-05 | Merck & Co., Inc. | Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I) |
-
1992
- 1992-06-17 HU HU9202020A patent/HU208997B/hu not_active IP Right Cessation
-
1993
- 1993-06-17 GR GR930100259A patent/GR1002573B/el not_active IP Right Cessation
- 1993-06-17 JO JO19931764A patent/JO1764B1/en active
- 1993-06-17 AT AT0118993A patent/AT399722B/de not_active IP Right Cessation
- 1993-06-17 ES ES09301350A patent/ES2064282B1/es not_active Expired - Fee Related
- 1993-06-17 US US08/077,364 patent/US5403728A/en not_active Expired - Fee Related
- 1993-06-17 CA CA002098698A patent/CA2098698C/en not_active Expired - Fee Related
- 1993-06-17 IT IT93MI001306A patent/IT1264629B1/it active IP Right Grant
- 1993-06-17 DE DE4320023A patent/DE4320023A1/de not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JO1764B1 (en) | 1994-05-15 |
ATA118993A (de) | 1994-11-15 |
ES2064282B1 (es) | 1995-08-01 |
ES2064282A1 (es) | 1995-01-16 |
GR930100259A (el) | 1994-02-28 |
HU9202020D0 (en) | 1992-10-28 |
CA2098698A1 (en) | 1993-12-18 |
CA2098698C (en) | 1998-05-19 |
IT1264629B1 (it) | 1996-10-04 |
DE4320023A1 (de) | 1993-12-23 |
GR1002573B (el) | 1997-02-06 |
ITMI931306A1 (it) | 1994-12-17 |
US5403728A (en) | 1995-04-04 |
HU208997B (en) | 1994-02-28 |
AT399722B (de) | 1995-07-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970627 |