IT1054101B - Processo per la preparazione di iomega i oxoalchil 3, 7 oppure 7 obega 1 oxoalchil 1, 3 dimetilxantine - Google Patents

Processo per la preparazione di iomega i oxoalchil 3, 7 oppure 7 obega 1 oxoalchil 1, 3 dimetilxantine

Info

Publication number
IT1054101B
IT1054101B IT19813/65A IT1981365A IT1054101B IT 1054101 B IT1054101 B IT 1054101B IT 19813/65 A IT19813/65 A IT 19813/65A IT 1981365 A IT1981365 A IT 1981365A IT 1054101 B IT1054101 B IT 1054101B
Authority
IT
Italy
Prior art keywords
oxoalchil
obega
dimethylxantine
iomega
preparation
Prior art date
Application number
IT19813/65A
Other languages
English (en)
Original Assignee
Albert Ag Chem Werke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DEC33812A external-priority patent/DE1235320B/de
Priority claimed from DEC33811A external-priority patent/DE1233405B/de
Application filed by Albert Ag Chem Werke filed Critical Albert Ag Chem Werke
Application granted granted Critical
Publication of IT1054101B publication Critical patent/IT1054101B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/60—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT19813/65A 1964-09-05 1965-09-04 Processo per la preparazione di iomega i oxoalchil 3, 7 oppure 7 obega 1 oxoalchil 1, 3 dimetilxantine IT1054101B (it)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DEC33812A DE1235320B (de) 1964-09-05 1964-09-05 Verfahren zur Herstellung von 1-(Oxoalkyl)-3, 7-dimethylxanthinen
DEC33811A DE1233405B (de) 1964-09-05 1964-09-05 Verfahren zur Herstellung von 7-(Oxoalkyl)-1, 3-dimethylxanthinen
DEC0036289 1965-07-02
DEC0036362 1965-07-10
DEC0036493 1965-07-24

Publications (1)

Publication Number Publication Date
IT1054101B true IT1054101B (it) 1981-11-10

Family

ID=27511962

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19813/65A IT1054101B (it) 1964-09-05 1965-09-04 Processo per la preparazione di iomega i oxoalchil 3, 7 oppure 7 obega 1 oxoalchil 1, 3 dimetilxantine

Country Status (7)

Country Link
US (1) US3422107A (it)
BE (1) BE668977A (it)
CH (2) CH540275A (it)
FR (1) FR4791M (it)
GB (1) GB1079267A (it)
IT (1) IT1054101B (it)
NL (1) NL6511581A (it)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2366501C2 (de) * 1973-06-16 1983-11-24 Hoechst Ag, 6230 Frankfurt 1-Alkyl-3-methyl-7-oxoalkylxanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE2330742C2 (de) 1973-06-16 1982-07-29 Hoechst Ag, 6000 Frankfurt 1-(Oxoalkyl)-3-methyl-7-alkylxanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE2507555A1 (de) * 1975-02-21 1976-09-02 Wuelfing J A Fa 7-(oxoalkyl)-1,3-dialkylxanthine, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel
JPS5275920U (it) * 1975-12-05 1977-06-07
US4156736A (en) * 1976-05-28 1979-05-29 Sanol Schwarz-Monheim Gmbh Supersaturated isosorbide dinitrate solution, process for its production and its use
BE863935A (fr) * 1977-02-26 1978-08-14 Basf Ag Utilisation de l'ether 1,2-propylene-glycol-1-n-propylique comme solvant pour preparations pharmaceutiques
US4636507A (en) * 1984-04-30 1987-01-13 Hoechst-Roussel Pharmaceuticals Inc. Host defense mechanism enhancement
DE3604149A1 (de) * 1986-02-10 1987-08-13 Rentschler Arzneimittel Arzneimittelkombination
CA2030112A1 (en) * 1989-11-24 1991-05-25 Yasuo Ito Xanthine compound, method for preparing thereof, and a pharmaceutical composition comprising the same
US6420374B1 (en) 1990-11-30 2002-07-16 Fred Hutchinson Cancer Research Center Use of xanthines as immunosuppressants and to inhibit allograft reactions
US5856115A (en) * 1991-05-24 1999-01-05 Fred Hutchinson Cancer Research Center Assay for identification therapeutic agents
US5648357A (en) * 1992-03-04 1997-07-15 Cell Therapeutics, Inc. Enatiomerically pure hydroxylated xanthine compounds
WO1993017684A2 (en) * 1992-03-04 1993-09-16 Cell Therapeutics, Inc. Enantiomeric hydroxylated xanthine compounds
US5580874A (en) * 1992-03-04 1996-12-03 Cell Therapeutics, Inc. Enatiomerically pure hydroxylated xanthine compounds
US5288721A (en) * 1992-09-22 1994-02-22 Cell Therapeutics, Inc. Substituted epoxyalkyl xanthines
US5817662A (en) * 1992-11-09 1998-10-06 Cell Therapeutics, Inc. Substituted amino alkyl compounds
US5780476A (en) * 1992-11-16 1998-07-14 Cell Therapeutics, Inc. Hydroxyl-containing xanthine compounds
US6693105B1 (en) 1992-11-16 2004-02-17 Cell Therapeutics, Inc. Hydroxyl-containing compounds
US5795897A (en) * 1992-11-18 1998-08-18 Cell Therapeutics, Inc. Oxohexyl methylxanthine compounds
US5866576A (en) * 1992-12-16 1999-02-02 Cell Therapeutics, Inc. Epoxide-containing compounds
WO1994015605A1 (en) * 1993-01-14 1994-07-21 Cell Therapeutics, Inc. Acetal or ketal substituted therapeutic compounds
AU6092794A (en) * 1993-01-19 1994-08-15 Cell Therapeutics, Inc. Oxime-substituted therapeutic compounds
US5837703A (en) * 1993-03-31 1998-11-17 Cell Therapeutics, Inc. Amino-alcohol substituted cyclic compounds
US5641783A (en) * 1993-11-12 1997-06-24 Cell Therapeutics, Inc. Substituted amino alcohol compounds
US6020337A (en) * 1993-04-05 2000-02-01 Cell Therapeutics, Inc. Electronegative-substituted long chain xanthine compounds
US5532003A (en) * 1994-01-18 1996-07-02 Alza Corporation Pentoxifylline therapy
WO1995022546A1 (en) * 1994-02-18 1995-08-24 Cell Therapeutics, Inc. Intracellular signalling mediators
US5801182A (en) * 1994-03-24 1998-09-01 Cell Therapeutics, Inc. Amine substituted compounds
US5807861A (en) * 1994-03-24 1998-09-15 Cell Therapeutics, Inc. Amine substituted xanthinyl compounds
US20030207901A1 (en) * 1999-07-27 2003-11-06 Cell Therapeutics, Inc. Hydroxyl-containing compounds
ATE502635T1 (de) 2002-08-19 2011-04-15 Pfizer Kombinationstherapie gegen hyperproliferative erkrankungen
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
US20060063803A1 (en) * 2004-09-23 2006-03-23 Pfizer Inc 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
CN102781927B (zh) * 2010-03-02 2016-02-03 Spc生命科学私人有限公司 甲基-甲基-3, 4-二氢-2h-吡喃-5-羧酸酯的制备工艺
ES2395801B1 (es) 2011-06-23 2014-06-06 María Carmen PARDINA PALLEJÀ "pentoxifilina por vía transvaginal para el tratamiento de la infertilidad"
KR101695582B1 (ko) 2013-04-17 2017-01-13 화이자 인코포레이티드 심혈관 질환을 치료하기 위한 n-피페리딘-3-일벤즈아미드 유도체
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN119060040A (zh) 2019-01-18 2024-12-03 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法
WO2024161377A1 (en) 2023-02-04 2024-08-08 Lavender Laboratories Private Limited Process for the preparation of halo alkyl ketone

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776300A (en) * 1951-08-31 1957-01-01 Searle & Co Basic esters of substituted 3, 4-dihydro-1, 2-pyran-5-carboxylic acids and salts thereof
GB759981A (en) * 1953-09-09 1956-10-24 Roche Products Ltd Process for the manufacture of xanthine derivatives
US3029239A (en) * 1954-04-17 1962-04-10 Chemiewerk Homburg Zweignieder Basic substituted 1-and 7-alkylxanthines or salts thereof
US2815379A (en) * 1954-09-13 1957-12-03 Hoffmann La Roche Alicyclic ketone and intermediates for the preparation thereof
AT216011B (de) * 1958-08-16 1961-07-10 Chemiewerk Homburg Verfahren zur Herstellung von neuen Oxygruppen tragenden 1-bzw. 7-Aminoalkylxanthinderivaten
US3030363A (en) * 1959-06-10 1962-04-17 Boehringer Sohn Ingelheim Derivatives of xanthine
US3122587A (en) * 1959-11-13 1964-02-25 Union Carbide Corp Process of producing 6-halo-2, 5-dimethylhexanone-3

Also Published As

Publication number Publication date
NL6511581A (it) 1966-03-07
FR4791M (it) 1967-01-30
CH555352A (de) 1974-10-31
US3422107A (en) 1969-01-14
CH540275A (de) 1973-08-15
GB1079267A (en) 1967-08-16
BE668977A (it) 1966-02-28

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