IS913B6 - Aðferð til framleiðslu á 1, 2, 4, - triazole nucleosides - Google Patents

Aðferð til framleiðslu á 1, 2, 4, - triazole nucleosides

Info

Publication number
IS913B6
IS913B6 IS2075A IS2075A IS913B6 IS 913 B6 IS913 B6 IS 913B6 IS 2075 A IS2075 A IS 2075A IS 2075 A IS2075 A IS 2075A IS 913 B6 IS913 B6 IS 913B6
Authority
IS
Iceland
Prior art keywords
production
triazole nucleosides
nucleosides
triazole
Prior art date
Application number
IS2075A
Other languages
English (en)
Icelandic (is)
Other versions
IS2075A7 (is
Inventor
Theodore Witkowski Joseph
Kenith Robins Roland
Original Assignee
International Chemical & Nuclear Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by International Chemical & Nuclear Corporation filed Critical International Chemical & Nuclear Corporation
Publication of IS2075A7 publication Critical patent/IS2075A7/is
Publication of IS913B6 publication Critical patent/IS913B6/is

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056Triazole or tetrazole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IS2075A 1971-06-01 1972-05-15 Aðferð til framleiðslu á 1, 2, 4, - triazole nucleosides IS913B6 (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14901771A 1971-06-01 1971-06-01
US24025272A 1972-03-31 1972-03-31

Publications (2)

Publication Number Publication Date
IS2075A7 IS2075A7 (is) 1973-01-02
IS913B6 true IS913B6 (is) 1975-09-15

Family

ID=26846393

Family Applications (1)

Application Number Title Priority Date Filing Date
IS2075A IS913B6 (is) 1971-06-01 1972-05-15 Aðferð til framleiðslu á 1, 2, 4, - triazole nucleosides

Country Status (28)

Country Link
US (1) US3798209A (sv)
JP (5) JPS5527076B1 (sv)
AR (1) AR199463A1 (sv)
AU (1) AU461900B2 (sv)
BE (1) BE784195A (sv)
BG (1) BG22827A3 (sv)
CA (1) CA997756A (sv)
CH (1) CH614452A5 (sv)
DD (1) DD99791A5 (sv)
DE (1) DE2220246A1 (sv)
DK (2) DK143069C (sv)
EG (1) EG11406A (sv)
ES (1) ES403142A1 (sv)
FR (1) FR2140126B1 (sv)
GB (1) GB1353565A (sv)
HK (1) HK23876A (sv)
HU (1) HU167614B (sv)
IE (1) IE36478B1 (sv)
IL (1) IL39416A (sv)
IN (1) IN142290B (sv)
IS (1) IS913B6 (sv)
LU (1) LU65446A1 (sv)
MC (1) MC921A1 (sv)
MY (1) MY7600203A (sv)
NL (1) NL7207156A (sv)
NO (1) NO138805C (sv)
RO (1) RO62435A (sv)
SE (3) SE405604B (sv)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3984396A (en) * 1971-06-01 1976-10-05 Icn Pharmaceuticals, Inc. 1-(β,-D-ribofuranosyl)-1,2,4-triazole acid esters
DE2401449A1 (de) * 1973-01-16 1974-07-25 Voorhees Pharmazeutische zusammensetzung zur linderung von hautproliferationserkrankungen
US3888843A (en) * 1973-06-12 1975-06-10 Toyo Jozo Kk 4-carbamoyl-1-' -d-ribofuranosylimidazolium-5-olate
AR207138A1 (es) * 1974-03-18 1976-09-15 Icn Pharmaceuticals Metodo para la obtencion de 1,2,4-triazoles n-substituidos y sus sales de adicion
GB1482736A (en) * 1974-03-18 1977-08-10 Icn Pharmaceuticals 1-(beta-d-ribofuranosyl)-1,2,4-triazole acid derivatives
US3960836A (en) * 1974-07-22 1976-06-01 Eli Lilly And Company Acylated derivatives of pyrazofurin and process for their preparation
US4007198A (en) * 1975-05-01 1977-02-08 American Cyanamid Company Substituted 1,2,4-triazole carboxamide
US4138547A (en) * 1977-12-22 1979-02-06 Icn Pharmaceuticals, Inc. Process for preparing 1,2,4-triazole nucleosides
JPS57146593A (en) * 1981-03-09 1982-09-10 Ajinomoto Co Inc Preparation of ribofuranosyltriazole derivative
US4451648A (en) * 1981-08-19 1984-05-29 The United States Of America As Represented By The Department Of Health And Human Services Process for the production of 2-β-D-ribofuranosylthiazole-4-carboxamide
US4531001A (en) * 1982-03-23 1985-07-23 Brigham Young University 2-β-D-ribofuranosylselenazole-4-carboxamide compounds
US4446315A (en) * 1982-09-24 1984-05-01 The United States Of America As Represented By The Department Of Health And Human Services Adenosine 5'-triphosphate-4-carboxamide-ribofuranosylthiazole
JPS5964648U (ja) * 1982-10-22 1984-04-28 阿波野 政晴 日覆用骨格
BE902199A (fr) * 1984-10-29 1985-07-31 Vira Tek Inc Procede de traitement medical de maladies virales utilisant le 1-beta-d-ribofurannosyl-1, 2,4-triazole-3-carboxamide.
NZ213370A (en) * 1985-01-16 1989-03-29 Vira Tek Inc Method of treating viral infections of selected trees and field crops using ribavirin (1-b-d-ribofuranosyl-1,2,4-triazole-3-carboxamide) or the 2,3,5-triacetyl or 5'-butyryl derivative thereof
DE3606634A1 (de) * 1986-02-28 1987-09-03 Mack Chem Pharm Isohexid-nucleoside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
BR8607124A (pt) * 1986-03-27 1988-04-05 Harry Edward Gruber Um metodo de aumentar a excrecao de adenosina
US4925930A (en) * 1988-11-02 1990-05-15 Nucleic Acid Research Institute Synthesis and anti-leukemic activity of alkyl-1-(β-D-ribofuranosyl)[1,2,4]triazole-3-carboximidates
US5438131A (en) * 1992-09-16 1995-08-01 Bergstrom; Donald E. 3-nitropyrrole nucleoside
SI20976A (sl) * 1999-12-23 2003-02-28 Icn Pharmaceuticals, Inc. Sestavki in postopki za L-nukleozide, L-nukleotide in njihove analoge
US7638496B2 (en) * 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
US6495677B1 (en) 2000-02-15 2002-12-17 Kanda S. Ramasamy Nucleoside compounds
US6455508B1 (en) * 2000-02-15 2002-09-24 Kanda S. Ramasamy Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
KR20030036189A (ko) * 2000-05-26 2003-05-09 이데닉스(케이만)리미티드 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
US6815542B2 (en) * 2000-06-16 2004-11-09 Ribapharm, Inc. Nucleoside compounds and uses thereof
CN1460109A (zh) * 2000-08-22 2003-12-03 里巴药品公司 改善疾病治疗的特异性
US6878364B2 (en) * 2000-12-01 2005-04-12 Cornell Research Foundation, Inc. Animal model for flaviviridae infection
US20040014696A1 (en) * 2000-12-07 2004-01-22 Johnson Lau Specificity in treatment of diseases
US6720000B2 (en) * 2001-03-19 2004-04-13 Three Rivers Pharmaceutical, Llc Process for producing wet ribavirin pellets
ES2208540T3 (es) * 2001-07-30 2004-06-16 Clariant Life Science Molecules (Italia) Spa Procedimiento para la preparacion de ribavirina.
WO2003026589A2 (en) * 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
HUP0402364A2 (hu) * 2001-11-02 2005-02-28 Sandoz Ag Gyorsan oldódó, nagy koncentrációjú ribavirinkészítmények
KR100411398B1 (ko) 2001-12-06 2003-12-18 주식회사유한양행 베타-디-리보푸라노즈 유도체의 제조방법
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
DE14169110T1 (de) 2002-06-28 2022-05-12 Centre National De La Recherche Scientifique -Cnrs- Modifizierte 2'- und 3'-Nukleosid-Prodrugs zur Behandlung von Flaviridae-Infektionen
CN101172993A (zh) * 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′-c-甲基-3′-o-l-缬氨酸酯核糖呋喃基胞苷
AU2003248748A1 (en) * 2002-06-28 2004-01-19 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US20040067877A1 (en) * 2002-08-01 2004-04-08 Schinazi Raymond F. 2', 3'-Dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections
US7538094B2 (en) * 2002-09-19 2009-05-26 Three Rivers Pharmacueticals, Llc Composition containing ribavirin and use thereof
KR20050088079A (ko) 2002-11-15 2005-09-01 이데닉스 (케이만) 리미티드 2'-분지형 뉴클레오시드 및 플라비비리다에 돌연변이
EP2319853B1 (en) * 2002-12-12 2014-03-12 IDENIX Pharmaceuticals, Inc. Process for the production of 2'-branched nucleosides
RU2005123395A (ru) * 2002-12-23 2006-01-27 Айденикс (Кайман) Лимитед (Ky) Способ получения 3-нуклеозидных пролекарств
RU2005133093A (ru) * 2003-03-28 2006-07-27 Фармассет, Инк. (Us) Соединения для лечения флавивирусных инфекций
US7429572B2 (en) 2003-05-30 2008-09-30 Pharmasset, Inc. Modified fluorinated nucleoside analogues
US20050075309A1 (en) * 2003-07-25 2005-04-07 Richard Storer Purine nucleoside analogues for treating Flaviviridae including hepatitis C
WO2005018330A1 (en) * 2003-08-18 2005-03-03 Pharmasset, Inc. Dosing regimen for flaviviridae therapy
US20050187192A1 (en) * 2004-02-20 2005-08-25 Kucera Pharmaceutical Company Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses
BRPI0512360A (pt) * 2004-06-23 2008-03-11 Idenix Cayman Ltd derivados de 5-aza-7-deazapurina para o tratamento de flaviviridae
CN101023094B (zh) * 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
WO2006031725A2 (en) 2004-09-14 2006-03-23 Pharmasset, Inc. Preparation of 2'­fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
EP2305697A3 (en) * 2005-07-25 2011-07-27 Intermune, Inc. Macrocyclic inhibitors of Hepatitis C virus replication
DE602006019323D1 (de) * 2005-10-11 2011-02-10 Intermune Inc Verbindungen und verfahren zur inhibierung der replikation des hepatitis-c-virus
US7781576B2 (en) * 2005-12-23 2010-08-24 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
JP5167244B2 (ja) 2006-04-11 2013-03-21 ノバルティス アーゲー Hcv/hiv阻害剤およびそれらの使用
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
EP2198870A4 (en) 2007-08-27 2011-08-03 Univ Nagoya Nat Univ Corp ACTIVATOR FOR BLOOD COAGULATION FACTOR VII PROMOTER AND USE THEREOF
US20110117054A1 (en) 2007-08-27 2011-05-19 National University Corporation Nagoya University Use of ribavirin in blood coagulation disorder
US20090082414A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched viramidine
WO2009105258A1 (en) 2008-02-22 2009-08-27 Nektar Therapeutics Al, Corporation Oligomer conjugates of heteropentacyclic nucleosides
TW200946541A (en) * 2008-03-27 2009-11-16 Idenix Pharmaceuticals Inc Solid forms of an anti-HIV phosphoindole compound
JP2011519364A (ja) * 2008-04-15 2011-07-07 インターミューン・インコーポレーテッド C型肝炎ウイルス複製の新規大環状阻害剤
US8173621B2 (en) * 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
AU2009303483A1 (en) * 2008-10-15 2010-04-22 Intermune, Inc. Therapeutic antiviral peptides
TWI432436B (zh) 2008-12-09 2014-04-01 Gilead Sciences Inc 類鐸受體的調節劑
EA019295B1 (ru) * 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Соединения пуриновых нуклеозидов и способ их получения
EP2376088B1 (en) 2008-12-23 2017-02-22 Gilead Pharmasset LLC 6-O-Substituted-2-amino-purine nucleoside phosphoramidates
US8551973B2 (en) * 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
US8512690B2 (en) 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
US20110182850A1 (en) 2009-04-10 2011-07-28 Trixi Brandl Organic compounds and their uses
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
CN102741270B (zh) * 2009-09-28 2015-07-22 英特穆恩公司 C型肝炎病毒复制的环肽抑制剂
TW201116540A (en) * 2009-10-01 2011-05-16 Intermune Inc Therapeutic antiviral peptides
WO2011076923A1 (en) 2009-12-23 2011-06-30 Institut National De La Sante Et De La Recherche Medicale Inhibitor for inosine monophosphate (imp) dehydrogenase and/or viral rna polymerase for treatment of hepatitis e
CA2787309A1 (en) * 2010-01-25 2011-07-28 Enanta Pharmaceuticals, Inc. Hepatitis c virus inhibitors
US8933110B2 (en) 2010-01-25 2015-01-13 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
JP2013527145A (ja) 2010-03-31 2013-06-27 ギリード・ファーマセット・エルエルシー リン含有活性化剤の立体選択的合成
PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
EP2624826B1 (en) 2010-10-08 2018-07-18 Novartis AG Vitamin e formulations of sulfamide ns3 inhibitors
AR084044A1 (es) 2010-11-30 2013-04-17 Pharmasset Inc Compuestos 2’-espiro-nucleosidos
WO2012087596A1 (en) 2010-12-20 2012-06-28 Gilead Sciences, Inc. Combinations for treating hcv
CA2752008A1 (en) 2011-09-13 2013-03-13 Universite De Montreal Combination therapy using ribavirin as elf4e inhibitor
JP6073897B2 (ja) 2011-09-16 2017-02-01 ギリアド ファーマセット エルエルシー Hcvを処置するための方法
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
CA2889903C (en) 2012-10-29 2021-03-09 Manjinder Singh Phull Antiviral phosphonate analogues and process for preparation thereof
US20140205566A1 (en) 2012-11-30 2014-07-24 Novartis Ag Cyclic nucleuoside derivatives and uses thereof
ES2771458T3 (es) 2013-01-31 2020-07-06 Gilead Pharmasset Llc Formulación de combinación de dos compuestos antivirales
PL3650014T3 (pl) 2013-08-27 2022-01-31 Gilead Pharmasset Llc Preparat złożony dwóch związków przeciwwirusowych
EA201692515A1 (ru) 2014-06-23 2017-05-31 Сановель Илач Санайи Ве Тиджарет А.Ш. Новая фармацевтическая композиция на основе софосбувира и рибавирина
EA201692514A1 (ru) 2014-06-23 2017-04-28 Сановель Илач Санайи Ве Тиджарет А.Ш. Фармацевтические композиции на основе софосбувира и рибавирина с модифицированным высвобождением
US20170112867A1 (en) 2014-06-23 2017-04-27 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Pharmaceutical combinations of sofosbuvir and ribavirin
EP3166607B1 (en) 2014-07-11 2022-08-31 Gilead Sciences, Inc. Modulators of toll-like receptors for the treatment of hiv
EA201790369A1 (ru) 2014-09-16 2017-10-31 Джилид Сайэнс, Инк. Твердые формы модулятора толл-подобного рецептора
TW201817714A (zh) 2016-08-30 2018-05-16 英商葛蘭素史密斯克藍智慧財產權有限公司 抑制3c及3cl蛋白酶之化合物及其使用方法
CN110713464B (zh) * 2019-10-31 2023-03-31 重庆大学 一种芳基1,2,4-三氮唑核苷化合物及其制备方法和应用
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Also Published As

Publication number Publication date
DD99791A5 (sv) 1973-08-20
IL39416A0 (en) 1972-07-26
SE7801925L (sv) 1978-02-20
RO62435A (fr) 1978-03-15
AU4215772A (en) 1973-12-20
MC921A1 (fr) 1973-01-25
JPS5519238B2 (sv) 1980-05-24
EG11406A (en) 1981-06-30
JPS5519239B2 (sv) 1980-05-24
FR2140126A1 (sv) 1973-01-12
CH614452A5 (en) 1979-11-30
AR199463A1 (es) 1974-09-09
IS2075A7 (is) 1973-01-02
JPS53124271A (en) 1978-10-30
MY7600203A (en) 1976-12-31
NO138805B (no) 1978-08-07
IE36478B1 (en) 1976-11-10
JPS5395974A (en) 1978-08-22
AU461900B2 (en) 1975-06-12
DK509876A (da) 1976-11-12
NO138805C (no) 1978-11-15
BE784195A (fr) 1972-11-30
FR2140126B1 (sv) 1976-04-16
SE405604B (sv) 1978-12-18
IL39416A (en) 1975-07-28
HU167614B (sv) 1975-11-28
CA997756A (en) 1976-09-28
US3798209A (en) 1974-03-19
JPS5387356A (en) 1978-08-01
IE36478L (en) 1972-12-01
BG22827A3 (sv) 1977-04-20
NL7207156A (sv) 1972-12-05
GB1353565A (en) 1974-05-22
ES403142A1 (es) 1975-05-01
DE2220246A1 (de) 1972-12-14
LU65446A1 (sv) 1972-10-05
JPS5527076B1 (sv) 1980-07-17
HK23876A (en) 1976-04-30
SE7801926L (sv) 1978-02-20
JPS53108973A (en) 1978-09-22
DK143069B (da) 1981-03-23
IN142290B (sv) 1977-06-18
DK143069C (da) 1981-11-02

Similar Documents

Publication Publication Date Title
IS913B6 (is) Aðferð til framleiðslu á 1, 2, 4, - triazole nucleosides
BE792789A (fr) Procede de preparation de 1,2,3-trichloropropene
DK128854B (da) Analogifremgangsmåde til fremstilling af adenosinderivater.
FI49503C (sv) Analogiförfarande för framställning av 1,2,3,4-tetrahydro-4-fenyl-isok inolinderivat.
SU435611A3 (ru) Способ получения производных 5-циннамоилбензофурана
BE779572A (fr) Procede de production de 4-amino-1,2,4-triazine-5-
SU474150A3 (ru) Способ получени производных окса-1-диаза-3,8-спиро-(4,5)-декана
DK139264B (da) Fremgangsmåde til fremstilling af olefiner.
AR200117A1 (es) Procedimiento para la produccion de pirazolo (3,4-b) piridina
BE788444A (fr) Procede de production de 2,5-dimethyl-2,4-hexadiene
FI56176C (fi) Foerfarande foer framstaellning av 2,4-diamino-5-bensylpyrimidiner
BE772194A (fr) Procede de regulation.
IT966300B (it) Procedimento per la produzione di i, i diantrachinonili
DK132221B (da) Fremgangsmåde til fremstilling af 2,4-diamino-5-benzylpyrimider.
DK130308B (da) Fremgangsmåde til fremstilling af 13β-alkylgona-4,9,11-triener.
CH552620A (fr) Procede de preparation de nouvelles quinoleines substittuees.
SU474147A3 (ru) Способ получени 1,2-дигидро-2оксо-4-диалкиламино-пиримидо(4,5- )-хиноксалин-5,10-двуокисей
DK131189B (da) Analogifremgangsmåde til fremstilling af 16-hydroxylerede 17alfa-ethynyl-17beta-hydroxy-13beta-alkylgona-4,9,11-trien-3-oner.
RO67383A (ro) Procedeu pentru prepararea unor 2,4-diamino-5-benzilpirimidine
DK127110B (da) Fremgangsmåde til fremstilling af pyranosider af 3β-hydroxy-4-chlor-carda-4,20(22)-dienolider.
SU444357A3 (ru) Способ получения 1,1-дигалоид3-арилпропена-1
SU443856A1 (ru) Способ получени 2,3-дигидробензодиазепинов
DK131185B (da) Fremgangsmåde til fremstilling af bis-chromoner.
SU430554A3 (ru) Способ получения производных 2,3-бензоксазепина
IS1998A7 (is) Endurbætt aðferð til framleiðslu á 2,3- Dihydro- lh-Pyrido- [2,3-b] [1,4]- Thiazin -2-Ones