IS6705A - Aðferð til að ákvarða stig metýleringar afmarkaðra sýtósína í genamengi DNA í raðasamhenginu 5'-CPG-3' - Google Patents

Aðferð til að ákvarða stig metýleringar afmarkaðra sýtósína í genamengi DNA í raðasamhenginu 5'-CPG-3'

Info

Publication number
IS6705A
IS6705A IS6705A IS6705A IS6705A IS 6705 A IS6705 A IS 6705A IS 6705 A IS6705 A IS 6705A IS 6705 A IS6705 A IS 6705A IS 6705 A IS6705 A IS 6705A
Authority
IS
Iceland
Prior art keywords
methylation
degree
determining
cpg
classes
Prior art date
Application number
IS6705A
Other languages
English (en)
Other versions
IS2566B (is
Inventor
Olek Alexander
Piepenbrock Christian
Berlin Kurt
Gütig David
Original Assignee
Epigenomics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10044543A external-priority patent/DE10044543C2/de
Application filed by Epigenomics Ag filed Critical Epigenomics Ag
Publication of IS6705A publication Critical patent/IS6705A/is
Publication of IS2566B publication Critical patent/IS2566B/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
IS6705A 2000-09-01 2003-01-31 Aðferð til að ákvarða stig metýleringar afmarkaðra sýtósína í genamengi DNA í raðasamhenginu 5'-CPG-3' IS2566B (is)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10043826 2000-09-01
DE10044543A DE10044543C2 (de) 2000-09-05 2000-09-05 Verfahren zur Bestimmung des Methylierungsgrades von bestimmten Cytosinen in genomischer DNA im Sequenzkontext 5'-CpG-3'
PCT/EP2001/010074 WO2002018632A2 (de) 2000-09-01 2001-09-01 Verfahren zur bestimmung des methylierungsgrades von bestimmten cytosinen in genomischer dna im sequenzkontext 5'-cpg-3'

Publications (2)

Publication Number Publication Date
IS6705A true IS6705A (is) 2003-01-31
IS2566B IS2566B (is) 2009-12-15

Family

ID=26006939

Family Applications (1)

Application Number Title Priority Date Filing Date
IS6705A IS2566B (is) 2000-09-01 2003-01-31 Aðferð til að ákvarða stig metýleringar afmarkaðra sýtósína í genamengi DNA í raðasamhenginu 5'-CPG-3'

Country Status (16)

Country Link
US (2) US20040234960A1 (is)
EP (2) EP1942197A1 (is)
JP (1) JP2004516821A (is)
KR (1) KR100870486B1 (is)
AT (1) ATE382711T1 (is)
AU (2) AU1218802A (is)
CA (1) CA2420840A1 (is)
DE (1) DE50113454D1 (is)
DK (1) DK1423528T3 (is)
EA (1) EA007028B1 (is)
ES (1) ES2299520T3 (is)
IL (2) IL154663A0 (is)
IS (1) IS2566B (is)
MX (1) MXPA03001834A (is)
NZ (1) NZ524229A (is)
WO (1) WO2002018632A2 (is)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
DE19951189C2 (de) * 1999-10-15 2003-11-06 Epigenomics Ag Verfahren zur Unterscheidung von 5-Position-Methylierungsänderungen von Cytosin-Basen und Cytosin-zu-Thymin-Mutationen und zum Nachweis von single nucleotide polymorphisms (SNPs) oder Punktmutation in genomischer DNA
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
DE10061338A1 (de) * 2000-12-06 2002-06-20 Epigenomics Ag Diagnose von mit Angiogenese assoziierten Krankheiten
DE10061348C2 (de) * 2000-12-06 2002-10-24 Epigenomics Ag Verfahren zur Quantifizierung von Cytosin-Methylierungen in komplex amplifizierter genomischer DNA
AU2002246708A1 (en) 2000-12-15 2002-08-12 Agensys, Inc. Nucleic acid and encoded zinc transporter protein entitled 108p5h8 useful in treatment and detection of cancer
WO2002083921A2 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
JP2003144172A (ja) * 2001-11-16 2003-05-20 Nisshinbo Ind Inc メチル化検出用オリゴヌクレオチド固定化基板
AU2002349383A1 (en) * 2002-02-13 2003-09-04 Terukatsu Arima Dna sequence useful in diagnosing hepatitis and polypeptide encoded thereby
EP1340818A1 (en) * 2002-02-27 2003-09-03 Epigenomics AG Method and nucleic acids for the analysis of a colon cell proliferative disorder
DE10214232A1 (de) * 2002-03-25 2003-10-23 Epigenomics Ag Verfahren und Vorrichtung für die DNA Methylierungsanalyse
EP1488003A1 (en) * 2002-03-25 2004-12-22 Epigenomics AG Method for the analysis of methylation patterns within nucleic acids by means of mass spectrometry
US20060099581A1 (en) * 2002-04-09 2006-05-11 Kurt Berlin Method for analysis of methylated nucleic acids
WO2003104427A2 (en) 2002-06-05 2003-12-18 Case Western Reserve University Methods and compositions for detecting cancers
US7569553B2 (en) * 2002-07-03 2009-08-04 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
EP1551221A4 (en) * 2002-07-03 2007-08-01 Coley Pharm Group Inc NUCLEIC ACID COMPOSITIONS FOR STIMULATING IMMUNE RESPONSES
WO2004016733A2 (en) 2002-08-16 2004-02-26 Agensys, Inc. Nucleic acid and corresponding protein entitled 251p5g2 useful in treatment and detection of cancer
WO2004018668A1 (ja) * 2002-08-23 2004-03-04 Sumitomo Chemical Company, Limited ヒト由来の検体の癌化度を評価する方法
AU2003284967A1 (en) * 2002-11-15 2004-06-15 Five Prime Therapeutics, Inc. Novel mouse polypeptides encoded by polynucleotides and methods of their use
WO2004048565A1 (ja) * 2002-11-22 2004-06-10 Takeda Pharmaceutical Company Limited アポトーシス関連蛋白質およびその用途
JP4488720B2 (ja) * 2002-11-22 2010-06-23 武田薬品工業株式会社 アポトーシス関連蛋白質およびその用途
US20060094016A1 (en) * 2002-12-02 2006-05-04 Niall Gormley Determination of methylation of nucleic acid sequences
WO2004059007A2 (en) * 2002-12-25 2004-07-15 National Institute Of Advanced Industrial Science And Technology Nucleic acid methylation detection process using an internal reference sample
EP1604013A4 (en) * 2003-03-17 2009-02-11 Univ Johns Hopkins METHYL GENES ABERRANTY IN PANCREATIC CANCER
EP1636386B1 (en) * 2003-06-23 2015-08-05 Epigenomics AG Methods and nucleic acids for analyses of colorectal cell proliferative disorders
ES2546644T3 (es) * 2003-06-23 2015-09-25 Epigenomics Ag Métodos y ácidos nucleicos para el análisis de trastornos proliferativos de células colorrectales
EP1660683B1 (en) 2003-08-14 2017-04-19 Case Western Reserve University Methods and compositions for detecting colon cancers
US8415100B2 (en) 2003-08-14 2013-04-09 Case Western Reserve University Methods and compositions for detecting gastrointestinal and other cancers
JP2005087050A (ja) * 2003-09-16 2005-04-07 National Cancer Center-Japan 哺乳動物由来の検体の癌化度を評価する方法
JP5116935B2 (ja) * 2003-09-16 2013-01-09 独立行政法人国立がん研究センター 哺乳動物由来の検体の癌化度を評価する方法
JP5116938B2 (ja) * 2003-09-16 2013-01-09 独立行政法人国立がん研究センター 哺乳動物由来の検体の癌化度を評価する方法
US7910296B2 (en) 2003-10-21 2011-03-22 Orion Genomics Llc Methods for quantitative determination of methylation density in a DNA locus
EP3269826B1 (en) * 2003-12-01 2020-03-11 Epigenomics AG Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
US7157281B2 (en) * 2003-12-11 2007-01-02 Monsanto Technology Llc High lysine maize compositions and event LY038 maize plants
EP1961827A3 (en) * 2004-07-18 2008-09-17 Epigenomics AG Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders
KR20060026595A (ko) 2004-09-21 2006-03-24 (주)지노믹트리 제한효소와 ｄｎａ 칩을 이용한 프로모터의 메틸화 검출방법
EP3061833B1 (en) 2004-09-30 2018-03-14 Epigenomics AG Method for providing dna fragments derived from an archived sample
US20060134650A1 (en) * 2004-12-21 2006-06-22 Illumina, Inc. Methylation-sensitive restriction enzyme endonuclease method of whole genome methylation analysis
WO2006084699A1 (en) * 2005-02-11 2006-08-17 Roche Diagnostics Gmbh New methylation marker
WO2006088978A1 (en) 2005-02-16 2006-08-24 Epigenomics, Inc. Method for determining the methylation pattern of a polynucleic acid
US7932027B2 (en) 2005-02-16 2011-04-26 Epigenomics Ag Method for determining the methylation pattern of a polynucleic acid
JP5133238B2 (ja) 2005-04-15 2013-01-30 エピゲノミックス アクチェンゲゼルシャフト 遠隔サンプル由来のｄｎａ断片を提供する方法
SG183708A1 (en) * 2005-04-15 2012-09-27 Epigenomics Ag Methods and nucleic acids for analyses of cellular proliferative disorders
US8110361B2 (en) * 2005-05-02 2012-02-07 University of Southern California USC Stevens Center for Innovation DNA methylation markers associated with the CpG island methylator phenotype (CIMP) in human colorectal cancer
EP1885919B1 (en) * 2005-05-27 2013-02-13 Dana-Farber Cancer Institute, Inc. Gene methylation and expression
US20060292585A1 (en) * 2005-06-24 2006-12-28 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
WO2007019670A1 (en) * 2005-07-01 2007-02-22 Graham, Robert Method and nucleic acids for the improved treatment of breast cancers
WO2007032748A1 (en) * 2005-09-15 2007-03-22 Agency For Science, Technology & Research Method for detecting dna methylation
EP3095878A1 (en) 2005-11-17 2016-11-23 Epigenomics AG Method for the determination of the dna methylation level of a cpg position in identical cells within a tissue sample
KR100817444B1 (ko) * 2006-03-10 2008-03-27 포천중문의과대학교 산학협력단 5'-말단 ｘｉｓｔ 유전자 서열에 존재하는 메틸화 정도측정방법과 이를 이용한 암 진단 방법, 항암활성을측정하는 방법 및 메틸화 측정 키트
US7901882B2 (en) * 2006-03-31 2011-03-08 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
KR100761031B1 (ko) * 2006-05-27 2007-10-04 김연수 디엔에이 메틸화 현상을 이용한 암 진단용 키트
WO2007143037A2 (en) * 2006-05-31 2007-12-13 Orion Genomics Llc Gene methylation in cancer diagnosis
GB0700374D0 (en) * 2007-01-09 2007-02-14 Oncomethylome Sciences S A NDRG family methylation markers
US20090170082A1 (en) 2007-02-02 2009-07-02 Orion Genomics Llc Gene methylation in renal cancer diagnosis
WO2008096146A1 (en) 2007-02-07 2008-08-14 Solexa Limited Preparation of templates for methylation analysis
WO2008102002A2 (en) * 2007-02-21 2008-08-28 Oslo Universitetssykehus Hf New markers for cancer
EP2152902A2 (en) 2007-06-08 2010-02-17 Epigenomics AG Method for methylation analysis
US20100279879A1 (en) * 2007-09-17 2010-11-04 Koninklijke Philips Electronics N.V. Method for the analysis of breast cancer disorders
KR200449398Y1 (ko) * 2007-11-22 2010-07-07 고영길 컴퓨터 책상
WO2009108917A2 (en) * 2008-02-29 2009-09-03 Oncomethylome Sciences, S.A. Markers for improved detection of breast cancer
EP2108705A1 (en) * 2008-04-08 2009-10-14 Universität Duisburg-Essen Method for analysing the epigenetic status of the HtrA 1 gene in a biological sample
KR100986960B1 (ko) * 2008-07-23 2010-10-11 재단법인 아산사회복지재단 유전자의 메틸화 여부 및 비율의 분석방법
EP2340314B8 (en) * 2008-10-22 2015-02-18 Illumina, Inc. Preservation of information related to genomic dna methylation
ES2572563T3 (es) * 2008-12-09 2016-06-01 Coley Pharmaceutical Group, Inc. Oligonucleótidos inmunoestimulantes
EP3327139A1 (en) * 2009-04-06 2018-05-30 The Johns Hopkins University Digital quantification of dna methylation
US20120184447A1 (en) * 2009-06-26 2012-07-19 Reinhold Wasserkort Methods and Nucleic Acids for Analysis of Bladder Cell Proliferative Disorders
WO2011028533A2 (en) * 2009-08-24 2011-03-10 Perkinelmer Health Sciences, Inc. Methods for detecting dna methylation using encoded particles
US10428388B2 (en) * 2009-11-05 2019-10-01 Genomictree, Inc. Method for detecting the methylation of colorectal-cancer-specific methylation marker genes for colorectal cancer diagnosis
WO2011119934A2 (en) 2010-03-26 2011-09-29 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal neoplasm
BR112014002252A2 (pt) * 2011-07-29 2018-04-24 Cambridge Epigenetix Ltd métodos para a detecção de modificação de nucleotídeo
CN102618645B (zh) * 2012-03-30 2014-07-09 中国人民解放军第四军医大学 基于荧光偏振的egfr基因启动子甲基化状态均相检测法
CA2882185A1 (en) * 2012-08-28 2014-03-06 Istat Biomedical Co., Ltd. Test composition for screening cancers
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
WO2014159650A2 (en) 2013-03-14 2014-10-02 Mayo Foundation For Medical Education And Research Detecting neoplasm
ES2524194B1 (es) * 2013-06-03 2015-09-09 Universitat De Barcelona Métodos y kits para el diagnóstico de la diabetes tipo 2
EP3839071A1 (en) 2014-03-31 2021-06-23 Mayo Foundation for Medical Education and Research Detecting colorectal neoplasm
US11352672B2 (en) * 2014-09-15 2022-06-07 Garvan Institute Of Medical Research Methods for diagnosis, prognosis and monitoring of breast cancer and reagents therefor
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
CN113981057A (zh) * 2014-12-12 2022-01-28 精密科学公司 用于进行甲基化检测测定的组合物和方法
CN113897432A (zh) * 2014-12-12 2022-01-07 精密科学公司 用于进行甲基化检测测定的组合物和方法
US20190136325A1 (en) * 2014-12-31 2019-05-09 Case Western Reserve University Methods and compositions for detecting esophageal neoplasias and/or metaplasias in the esophagus
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
CN115927612A (zh) 2015-03-27 2023-04-07 精密科学公司 检测食管疾病
CA2992790A1 (en) 2015-08-31 2017-03-09 Mayo Foundation For Medical Education And Research Detecting gastric neoplasm
CN108350485A (zh) 2015-10-30 2018-07-31 精密科学发展有限责任公司 血浆dna的多重扩增检测测定以及分离和检测
EP3408407B1 (en) * 2016-01-29 2021-01-06 Epigenomics AG Methods for detecting cpg methylation of tumor-derived dna in blood samples
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
CA3020628A1 (en) 2016-04-14 2017-10-19 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia
CA3022911A1 (en) 2016-05-05 2017-11-09 Exact Sciences Development Company, Llc Detection of lung neoplasia by analysis of methylated dna
KR101883631B1 (ko) * 2016-05-27 2018-08-01 전남대학교산학협력단 심장 질환 후 우울증 진단을 위한 정보 제공 방법 및 진단용 키트
CN109804086B (zh) 2016-08-10 2023-06-13 格里尔公司 制备双标签dna库用于亚硫酸盐转化定序的方法
EP3336197B1 (en) 2016-12-16 2022-04-06 Eurofins Genomics Europe Sequencing GmbH Epigenetic markers and related methods and means for the detection and management of ovarian cancer
US11118228B2 (en) 2017-01-27 2021-09-14 Exact Sciences Development Company, Llc Detection of colon neoplasia by analysis of methylated DNA
CA3054836A1 (en) 2017-02-28 2018-09-07 Mayo Foundation For Medical Education And Research Detecting prostate cancer
US20190092817A1 (en) * 2017-03-13 2019-03-28 Base Pair Biotechnologies, Inc. Functional ligands to peptides
EP3717644A4 (en) 2017-11-30 2021-12-29 Mayo Foundation for Medical Education and Research Detecting breast cancer
EP3744858A4 (en) * 2017-12-01 2021-04-14 Biochain (Beijing) Science & Technology, Inc. COMPOSITION FOR DETECTING CANCER FROM SOPHAGE AND ASSOCIATED USE
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
JP2021520809A (ja) * 2018-04-12 2021-08-26 シングレラ ジェノミクス， インコーポレイテッド がんまたは新生物評価のための組成物および方法
CN110511997A (zh) * 2018-05-22 2019-11-29 广州市康立明生物科技有限责任公司 肿瘤标志物、甲基化试剂、试剂盒及其应用
CN112752763A (zh) * 2018-05-23 2021-05-04 杭州诺辉健康科技有限公司 筛查结直肠癌和晚期腺瘤的试剂盒及其应用
CN108660209B (zh) * 2018-05-23 2020-01-14 杭州诺辉健康科技有限公司 基于bmp3基因甲基化制备结直肠癌早期检测的产品
EP3850083A4 (en) * 2018-09-14 2022-06-29 Shinozaki, Gen Systems and methods for detection of delirium risk using epigenetic markers
CN112195243A (zh) * 2020-09-22 2021-01-08 北京华大吉比爱生物技术有限公司 一种检测多基因甲基化的试剂盒及其应用
EP4234720A1 (en) * 2022-02-25 2023-08-30 Consejo Superior de Investigaciones Cientificas Epigenetic biomarkers for the diagnosis of thyroid cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US6027880A (en) 1995-08-02 2000-02-22 Affymetrix, Inc. Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis
WO1995011995A1 (en) * 1993-10-26 1995-05-04 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
EP0963443B1 (en) 1996-12-10 2006-03-08 Sequenom, Inc. Releasable nonvolatile mass-label molecules
DE19754482A1 (de) * 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
DE19817948A1 (de) * 1998-04-17 1999-10-21 Metagen Gesellschaft Fuer Genomforschung Mbh Menschliche Nukleinsäuresequenzen aus Endometrium-Tumor
DE19853398C1 (de) * 1998-11-19 2000-03-16 Epigenomics Gmbh Verfahren zur Identifikation von Cytosin-Methylierungsmustern in genomischer DNA
DE19905082C1 (de) * 1999-01-29 2000-05-18 Epigenomics Gmbh Verfahren zur Identifikation von Cytosin-Methylierungsmustern in genomischen DNA-Proben
JP2004507214A (ja) * 2000-03-15 2004-03-11 エピゲノミクス　アーゲー 腫瘍抑制遺伝子と腫瘍遺伝子に関連する疾患の診断

Also Published As

Publication number Publication date
ATE382711T1 (de) 2008-01-15
MXPA03001834A (es) 2003-08-01
KR100870486B1 (ko) 2008-12-11
DK1423528T3 (da) 2008-05-13
NZ524229A (en) 2006-01-27
AU2002212188B2 (en) 2008-02-28
AU1218802A (en) 2002-03-13
EP1423528A2 (de) 2004-06-02
US9719131B2 (en) 2017-08-01
JP2004516821A (ja) 2004-06-10
KR20040015705A (ko) 2004-02-19
US20040234960A1 (en) 2004-11-25
US20110136687A1 (en) 2011-06-09
IL154663A0 (en) 2003-09-17
DE50113454D1 (de) 2008-02-14
ES2299520T3 (es) 2008-06-01
CA2420840A1 (en) 2003-02-27
EP1423528B1 (de) 2008-01-02
EA007028B1 (ru) 2006-06-30
WO2002018632A2 (de) 2002-03-07
IL154663A (en) 2009-12-24
IS2566B (is) 2009-12-15
EA200300330A1 (ru) 2004-06-24
EP1942197A1 (de) 2008-07-09
WO2002018632A3 (de) 2004-02-05

Similar Documents

Publication Publication Date Title
IS6705A (is) Aðferð til að ákvarða stig metýleringar afmarkaðra sýtósína í genamengi DNA í raðasamhenginu 5'-CPG-3'
CN107849603B (zh) 利用有限核苷酸组成的引物扩增
CA2226542C (en) Glycosylase mediated detection of nucleotide sequences at candidate loci
US5744308A (en) Chimera oligonucleotide and its utilization for obtaining transcripts of a nucleic acid
US8673567B2 (en) Method and kit for nucleic acid sequence detection
EP1322782B1 (en) Method of nucleic acid typing or sequencing
CA2662837C (en) Methods and substances for isolation and detection of small polynucleotides
US7846693B2 (en) Nucleic acid detection assay
US20100209932A1 (en) MicroRNA and Messenger RNA Detection On Arrays
US20060211030A1 (en) Methods and compositions for assay readouts on multiple analytical platforms
NZ506333A (en) An assay for detecting and quantifying the presence of particular nucleic acid (DNA or RNA) sequences
US20020127575A1 (en) Partially double-stranded nucleic acids, methods of making, and use thereof
CN106574304B (zh) 基于链侵入的dna扩增方法
AU6981800A (en) Method for relative quantification of methylation of cytosin-type bases in DNA samples
KR20100124705A (ko) 핵산 하이브리드화 방법
JP2003517303A (ja) 複合ｐｃｒ増幅の制御可能な実施方法
WO2015014759A1 (en) Compositions and methods for bisulfite converted sequence capture
WO2002061124A3 (en) Analysis of methylation patterns in genomic dna using bisulfite treatment and fluorescence polarisation assay techniques
US20020031776A1 (en) Enzymatic labeling and detection of DNA hybridization probes
WO2002034937A2 (en) Methods for detection of differences in nucleic acids
AU2004270756B2 (en) Nucleic acid detection assay