IN2015DN00202A - - Google Patents
Download PDFInfo
- Publication number
- IN2015DN00202A IN2015DN00202A IN202DEN2015A IN2015DN00202A IN 2015DN00202 A IN2015DN00202 A IN 2015DN00202A IN 202DEN2015 A IN202DEN2015 A IN 202DEN2015A IN 2015DN00202 A IN2015DN00202 A IN 2015DN00202A
- Authority
- IN
- India
- Prior art keywords
- mula
- inhibitors
- compounds
- formula
- neutrophil elastase
- Prior art date
Links
- 235000013350 formula milk Nutrition 0.000 abstract 2
- 108010028275 Leukocyte Elastase Proteins 0.000 abstract 1
- 102000016799 Leukocyte elastase Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12176079 | 2012-07-12 | ||
| EP13158756 | 2013-03-12 | ||
| PCT/EP2013/064603 WO2014009425A1 (en) | 2012-07-12 | 2013-07-10 | Inhibition of enzymes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN00202A true IN2015DN00202A (oth) | 2015-06-12 |
Family
ID=48953361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN202DEN2015 IN2015DN00202A (oth) | 2012-07-12 | 2013-07-10 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9199984B2 (oth) |
| EP (1) | EP2872509B1 (oth) |
| KR (1) | KR20150031318A (oth) |
| CN (1) | CN104428300B (oth) |
| AR (1) | AR091737A1 (oth) |
| BR (1) | BR112015000507A2 (oth) |
| CA (1) | CA2878792A1 (oth) |
| IN (1) | IN2015DN00202A (oth) |
| RU (1) | RU2638537C2 (oth) |
| WO (1) | WO2014009425A1 (oth) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2933725A1 (en) | 2013-12-16 | 2015-06-25 | Chiesi Farmaceutici S.P.A. | Tetrahydrotriazolopyrimidine derivatives as human neutrophil elastase inhibitors |
| US9487528B2 (en) | 2014-06-09 | 2016-11-08 | Chiesi Farmaceutici S.P.A. | Compounds |
| US9440930B2 (en) | 2014-07-31 | 2016-09-13 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9475779B2 (en) | 2014-07-31 | 2016-10-25 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9657015B2 (en) | 2014-07-31 | 2017-05-23 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9409870B2 (en) * | 2014-12-15 | 2016-08-09 | Chiesi Farmaceutici S.P.A. | Compounds |
| EP3464268B1 (en) * | 2016-05-31 | 2020-03-11 | Chiesi Farmaceutici S.p.A. | Novel compounds |
| AR108609A1 (es) * | 2016-05-31 | 2018-09-05 | Chiesi Farm Spa | Derivados de imidazolona y pirazolona como inhibidores de la elastasa de neutrófilos humana (hne) |
| AR108610A1 (es) * | 2016-05-31 | 2018-09-05 | Chiesi Farm Spa | Derivados de imidazolona inhibidores de la elastasa de neutrófilos humana |
| CA3053719A1 (en) | 2017-02-27 | 2018-08-30 | Geza Balint | Smart device with a display that enables simultaneous multi-functional handling of the displayed information and/or data |
| CN118496198A (zh) | 2019-07-23 | 2024-08-16 | 拜耳公司 | 作为农药的新的杂芳基-三唑化合物 |
| CA3148209A1 (en) | 2019-07-23 | 2021-01-28 | Bayer Aktiengesellschaft | Novel heteroaryl-triazole compounds as pesticides |
| CN114650819A (zh) | 2019-09-17 | 2022-06-21 | 美莱奥生物制药第四有限公司 | 用于治疗移植物排斥、闭塞性细支气管炎综合征和移植物抗宿主病的阿维来司他 |
| CN117567338A (zh) | 2019-10-09 | 2024-02-20 | 拜耳公司 | 作为农药的新的杂芳基三唑化合物 |
| US20220386611A1 (en) | 2019-10-09 | 2022-12-08 | Bayer Aktiengesellschaft | Novel heteroaryl-triazole compounds as pesticides |
| JP7652772B2 (ja) * | 2019-11-01 | 2025-03-27 | ブリストル－マイヤーズ スクイブ カンパニー | 置換ピラゾール化合物 |
| TW202134226A (zh) | 2019-11-18 | 2021-09-16 | 德商拜耳廠股份有限公司 | 作為殺蟲劑之新穎雜芳基-三唑化合物 |
| PT4106757T (pt) | 2020-04-16 | 2023-11-17 | Mereo Biopharma 5 Inc | Métodos que envolvem o inibidor da elastase neutrofílica alvelestat para o tratamento de doenças respiratórias mediadas pela deficiência de alfa 1 antitripsina |
| US20230303562A1 (en) * | 2020-09-28 | 2023-09-28 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Pyrazole compound and preparation method therefor and use thereof |
| CN113480486B (zh) * | 2021-07-30 | 2022-05-24 | 赣南师范大学 | 一种3-胺基-1,2,4-三唑类衍生物及其制备方法和应用 |
| JP2024540952A (ja) | 2021-10-20 | 2024-11-06 | メレオ バイオファーマ ４ リミテッド | 線維化の治療における使用のための好中球エラスターゼ阻害剤 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4259504A (en) | 1979-08-27 | 1981-03-31 | American Cyanamid Company | Substituted 1H-1,2,4-triazoles |
| US4451471A (en) | 1981-03-18 | 1984-05-29 | Ciba-Geigy Corporation | Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same |
| US4576958A (en) | 1984-01-23 | 1986-03-18 | E. I. Du Pont De Nemours And Company | Antihypertensive 4,5-diaryl-1H-imidazole-2-methanol derivatives |
| AU650953B2 (en) | 1991-03-21 | 1994-07-07 | Novartis Ag | Inhaler |
| ES2184633B1 (es) | 2001-08-07 | 2004-08-01 | J. URIACH & CIA, S.A. | Procedimiento para la preparacion de derivados de 4-(imidazol-1-il) bencenosulfonamida. |
| US6693116B2 (en) * | 2001-10-08 | 2004-02-17 | Hoffmann-La Roche Inc. | Adenosine receptor ligands |
| EP1799680A2 (en) | 2004-10-07 | 2007-06-27 | Warner-Lambert Company LLC | Triazolopyridine derivatives as antibacterial agents |
| US7902374B2 (en) | 2005-05-06 | 2011-03-08 | Universal Display Corporation | Stability OLED materials and devices |
| US20080125587A1 (en) | 2006-05-25 | 2008-05-29 | Chimmanamada Dinesh U | Synthesis of triazole compounds that modulate HSP90 activity |
| KR20100096131A (ko) * | 2007-11-06 | 2010-09-01 | 아스트라제네카 아베 | 특정 2-피라지논 유도체 및 호중구 엘라스타제의 억제제로서의 이의 용도 |
| PE20091953A1 (es) | 2008-05-08 | 2010-01-09 | Du Pont | Azoles sustituidos como fungicidas |
| JP2011525183A (ja) * | 2008-06-20 | 2011-09-15 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼ阻害剤として有用なイミダゾピリジンおよびイミダゾピラジン化合物 |
| EP2307411B1 (en) * | 2008-06-20 | 2014-01-01 | Bristol-Myers Squibb Company | Triazolopyridine compounds useful as kinase inhibitors |
| DE102009004197A1 (de) * | 2009-01-09 | 2010-07-15 | Bayer Schering Pharma Aktiengesellschaft | Heterocyclisch anellierte Diaryldihydropyrimidin-Derivate und ihre Verwendung |
| KR20120099639A (ko) * | 2009-10-02 | 2012-09-11 | 아스트라제네카 아베 | 호중구 엘라스타제의 억제제로서 사용되는 2-피리돈 화합물 |
-
2013
- 2013-07-10 CN CN201380036973.4A patent/CN104428300B/zh not_active Expired - Fee Related
- 2013-07-10 BR BR112015000507A patent/BR112015000507A2/pt not_active IP Right Cessation
- 2013-07-10 IN IN202DEN2015 patent/IN2015DN00202A/en unknown
- 2013-07-10 KR KR20157002129A patent/KR20150031318A/ko not_active Withdrawn
- 2013-07-10 EP EP13747801.2A patent/EP2872509B1/en active Active
- 2013-07-10 CA CA2878792A patent/CA2878792A1/en not_active Abandoned
- 2013-07-10 RU RU2015104644A patent/RU2638537C2/ru not_active IP Right Cessation
- 2013-07-10 WO PCT/EP2013/064603 patent/WO2014009425A1/en not_active Ceased
- 2013-07-11 AR ARP130102470 patent/AR091737A1/es unknown
- 2013-07-12 US US13/940,555 patent/US9199984B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2638537C2 (ru) | 2017-12-14 |
| CA2878792A1 (en) | 2014-01-16 |
| BR112015000507A2 (pt) | 2017-06-27 |
| AR091737A1 (es) | 2015-02-25 |
| KR20150031318A (ko) | 2015-03-23 |
| WO2014009425A1 (en) | 2014-01-16 |
| HK1207078A1 (en) | 2016-01-22 |
| EP2872509A1 (en) | 2015-05-20 |
| RU2015104644A (ru) | 2016-08-27 |
| CN104428300B (zh) | 2016-11-09 |
| US20140018345A1 (en) | 2014-01-16 |
| CN104428300A (zh) | 2015-03-18 |
| US9199984B2 (en) | 2015-12-01 |
| EP2872509B1 (en) | 2016-09-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2015DN00202A (oth) | ||
| UY34092A (es) | Nuevos compuestos como inhibidores de jak | |
| AU2013291345B2 (en) | Composition for controlling plant disease and application therefor | |
| UY34051A (es) | Derivados de pirrolotriazinona como inhibidores de pi3k | |
| MY163187A (en) | Novel imidazo-oxazine compound or salt thereof | |
| CR20140024A (es) | Compuestos inhibidores de metaloenzimas | |
| UY34156A (es) | Compuestos inhibidores de metaloenzimas | |
| PH12014502169A1 (en) | N-cyclylamides as nematicides | |
| UY34145A (es) | Compuestos inhibidores de metaloenzimas | |
| PH12012501650B1 (en) | Heterocyclic compound | |
| MX341456B (es) | Amino-quinolinas como inhibidores de cinasa. | |
| UY33958A (es) | Inhibidores de la glucosilceramida sintasa | |
| IL228239A0 (en) | 3,4-dihydro--pyrrolo[1,2-a]pyrazin-1-ylamine derivatives useful as inhibitors of beta-secretase (bace) | |
| UY33930A (es) | Inhibidores novedosos de quinasas | |
| UY33929A (es) | Compuestos de ciclohexilo tetrasustituido como inhibidores de quinasas | |
| UA111744C2 (uk) | ЗАМІЩЕНІ ПІРИДОПІРАЗИНИ ЯК ІНГІБІТОРИ Syk | |
| UY34523A (es) | Derivados de betulina | |
| IN2015DN00598A (oth) | ||
| IN2015DN01061A (oth) | ||
| CR20130539A (es) | Triazolopiridinas | |
| TN2013000400A1 (en) | Imidazopyridazines as akt kinase inhibitors | |
| IN2014MN01637A (oth) | ||
| JO3063B1 (ar) | مركب مبتكر وطرق لانتاجه | |
| NZ711192A (en) | Process for making benzoxazepin compounds | |
| UY34329A (es) | Compuestos de triazolopiridina |