AR108609A1 - Derivados de imidazolona y pirazolona como inhibidores de la elastasa de neutrófilos humana (hne) - Google Patents
Derivados de imidazolona y pirazolona como inhibidores de la elastasa de neutrófilos humana (hne)Info
- Publication number
- AR108609A1 AR108609A1 ARP170101443A ARP170101443A AR108609A1 AR 108609 A1 AR108609 A1 AR 108609A1 AR P170101443 A ARP170101443 A AR P170101443A AR P170101443 A ARP170101443 A AR P170101443A AR 108609 A1 AR108609 A1 AR 108609A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkylene
- alkyl
- heterocycloalkyl
- aryl
- heteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Derivados de imidazolona y pirazolona que tienen propiedades inhibitorias de la elastasa de neutrófilos humana, y su uso en terapia. Reivindicación 1: Un compuesto caracterizado porque es de fórmula (1), o una sal farmacéuticamente aceptable del mismo, donde X es -C o -N; Y es C o N, donde X e Y no son simultáneamente C o N; R¹ se selecciona entre el grupo que consiste en -C₁₋₆ alquilo lineal o ramificado, -C₃₋₆ cicloalquilo, -C₃₋₆ heterocicloalquilo y aril-C₁₋₆ alquileno-, donde cualquiera de dichos -C₃₋₆ cicloalquilo, -C₃₋₆ heterocicloalquilo y aril-C₁₋₆ alquileno- puede estar opcionalmente sustituido con -C₁₋₆ haloalquil-C(O)- lineal o ramificado, -C₁₋₆ alquilsulfonilo y aril-C₁₋₆ alquilen-OC(O)-; A se selecciona entre los restos del grupo de fórmulas (2), donde Q es -CH o N; R² se selecciona entre el grupo que consiste en -C₁₋₆ alquilo, aril-C₁₋₆ alquileno- y heteroaril-C₁₋₆ alquileno-; R³ es -C₁₋₆ alquilen-N⁺RᵃRᵇRᶜ o heteroaril-C₁₋₆ alquileno; Rᵃ es -C₁₋₆ alquilo; Rᵇ es -C₁₋₆ alquilo; Rᶜ se selecciona entre el grupo que consiste en -C₁₋₆ alquilo, aril-C₁₋₆ alquileno y heteroaril-C₁₋₆ alquileno- o Rᵃ y Rᵇ pueden formar un heterocicloalquilo con el átomo N⁺, donde dichos heterocicloalquilo y heteroarilo pueden estar opcionalmente sustituidos con uno o más C₁₋₆ alquilo; donde el átomo de nitrógeno en los grupos heterocicloalquilo y heteroarilo puede estar cuaternizado; y donde las líneas punteadas que conectan X al átomo de carbono en la posición 4 e Y, indican que cuando X es N, entonces el enlace doble se encuentra en la posición 4 - 5, y cuando Y es N, entonces el enlace doble se encuentra en la posición 3 - 4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16172199 | 2016-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR108609A1 true AR108609A1 (es) | 2018-09-05 |
Family
ID=56092842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170101443A AR108609A1 (es) | 2016-05-31 | 2017-05-26 | Derivados de imidazolona y pirazolona como inhibidores de la elastasa de neutrófilos humana (hne) |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9862706B2 (es) |
| EP (1) | EP3464269B1 (es) |
| AR (1) | AR108609A1 (es) |
| WO (1) | WO2017207433A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017185051A1 (en) | 2016-04-22 | 2017-10-26 | Pax Labs, Inc. | Aerosol devices having compartmentalized materials |
| WO2023118434A1 (en) * | 2021-12-22 | 2023-06-29 | Globachem Nv | Pesticidally active amide compounds |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU650953B2 (en) | 1991-03-21 | 1994-07-07 | Novartis Ag | Inhaler |
| GB201004179D0 (en) | 2010-03-12 | 2010-04-28 | Pulmagen Therapeutics Inflamma | Enzyme inhibitors |
| GB201004178D0 (en) | 2010-03-12 | 2010-04-28 | Pulmagen Therapeutics Inflamma | Enzyme inhibitors |
| EP2740728A4 (en) | 2011-08-01 | 2015-04-01 | Sumitomo Dainippon Pharma Co Ltd | URACIL DERIVATIVE AND ITS USE FOR MEDICAL PURPOSES |
| BR112015000507A2 (pt) | 2012-07-12 | 2017-06-27 | Chiesi Farm Spa | inibição de enzimas |
| EA028507B1 (ru) | 2012-12-18 | 2017-11-30 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Соединения |
| CN105873933A (zh) | 2013-12-16 | 2016-08-17 | 奇斯药制品公司 | 作为人中性白细胞弹性蛋白酶抑制剂的四氢三唑并嘧啶衍生物 |
| US9221807B2 (en) | 2014-02-21 | 2015-12-29 | Boehringer Ingelheim International Gmbh | Substituted pyridones and pyrazinones and their use as inhibitors of neutrophil elastase activity |
| US9409870B2 (en) | 2014-12-15 | 2016-08-09 | Chiesi Farmaceutici S.P.A. | Compounds |
-
2017
- 2017-05-26 WO PCT/EP2017/062757 patent/WO2017207433A1/en unknown
- 2017-05-26 AR ARP170101443A patent/AR108609A1/es unknown
- 2017-05-26 US US15/606,064 patent/US9862706B2/en active Active
- 2017-05-26 EP EP17728093.0A patent/EP3464269B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20170342056A1 (en) | 2017-11-30 |
| US9862706B2 (en) | 2018-01-09 |
| WO2017207433A1 (en) | 2017-12-07 |
| EP3464269B1 (en) | 2020-04-01 |
| WO2017207433A9 (en) | 2018-03-01 |
| EP3464269A1 (en) | 2019-04-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR109349A1 (es) | Compuestos y usos | |
| AR095426A1 (es) | Inhibidores tripeptídicos de la epoxicetona proteasa | |
| CY1119714T1 (el) | Ενωσεις αναστολεων | |
| BR112017012755A2 (pt) | compostos de heteroarila de anel fundido e seu uso como inibidores de trk | |
| AR099788A1 (es) | Derivados de nucleósidos sustituidos en 4 como inhibidores de la transcriptasa inversa del vih | |
| AR091628A1 (es) | 7h-pirrolo[2,3-d]pirimidinas 4-(amino-substituidas) como inhibidores de lrrk2 | |
| AR091146A1 (es) | Composiciones herbicidas que contienen amidas de acido n-(tetrazol-5-il)- y n-(triazol-5-il)arilcarboxilico | |
| AR107170A1 (es) | Compuestos heterocíclicos tricíclicos condesados como inhibidores de integrasa del vih | |
| AR099228A1 (es) | Inhibidores macrocíclicos de fxia que tienen grupos heterocíclicos | |
| AR089774A1 (es) | Derivados de indolizina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
| PE20160501A1 (es) | Derivados de quinolizina sustituidos utiles como inhibidores de integrasa del vih | |
| AR090474A1 (es) | Compuestos de tetrahidropirrolotiazina | |
| AR094876A1 (es) | Derivados de ácido betulínico modificados con alquilo c-3 y alquenilo | |
| AR091939A1 (es) | 4-metil-2,3,5,9,9b-pentaaza-ciclopenta[a]naftalenos | |
| AR100073A1 (es) | Sulfonas heterocíclicas sustituidas con heteroarilos | |
| AR097199A1 (es) | Inhibidores de rorc2 y sus métodos de uso | |
| AR094790A1 (es) | Derivados sustituidos del ácido bisfenil butanóico fosfónico como inhibidores de la nep | |
| AR094496A1 (es) | Compuestos tetracíclicos sustituidos con heterociclo y métodos de uso de los mismos para el tratamiento de enfermedades víricas | |
| TR201908265T4 (tr) | Isı şok transkripsiyon faktörü 1 in inhibitörleri olarak kaynaşık 1,4-dihidrodioksin türevleri. | |
| AR116022A1 (es) | Compuestos heteroaromáticos como inhibidores de vanina | |
| AR108610A1 (es) | Derivados de imidazolona inhibidores de la elastasa de neutrófilos humana | |
| AR093035A1 (es) | Derivados de pirrolotriazinona como inhibidores de pi3k | |
| AR096153A1 (es) | Derivados de pirrolo[2,3-d]pirimidina | |
| AR098723A1 (es) | Derivados de pirazolopirimidin-2-ilo como inhibidores de jak | |
| AR117229A1 (es) | Compuestos heteroaromáticos como inhibidores de vanina |