IN2014MN02393A - - Google Patents

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Publication number
IN2014MN02393A
IN2014MN02393A IN2393MUN2014A IN2014MN02393A IN 2014MN02393 A IN2014MN02393 A IN 2014MN02393A IN 2393MUN2014 A IN2393MUN2014 A IN 2393MUN2014A IN 2014MN02393 A IN2014MN02393 A IN 2014MN02393A
Authority
IN
India
Prior art keywords
derivatives
intreating
diseases
modulation
processes
Prior art date
Application number
Other languages
English (en)
Inventor
Gerard M P Giblin
David T Macpherson
David R Witty
Steven J Stanway
Original Assignee
Convergence Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Convergence Pharmaceuticals filed Critical Convergence Pharmaceuticals
Publication of IN2014MN02393A publication Critical patent/IN2014MN02393A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IN2393MUN2014 2012-05-22 2013-05-22 IN2014MN02393A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261650325P 2012-05-22 2012-05-22
GB201209015A GB201209015D0 (en) 2012-05-22 2012-05-22 Novel compounds
US201361773710P 2013-03-06 2013-03-06
PCT/GB2013/051335 WO2013175205A1 (en) 2012-05-22 2013-05-22 Novel Compounds

Publications (1)

Publication Number Publication Date
IN2014MN02393A true IN2014MN02393A (ru) 2015-08-21

Family

ID=46546493

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2393MUN2014 IN2014MN02393A (ru) 2012-05-22 2013-05-22

Country Status (28)

Country Link
US (7) US9376445B2 (ru)
EP (3) EP2861594B1 (ru)
JP (3) JP2015517562A (ru)
KR (2) KR20200113027A (ru)
CN (2) CN107344942B (ru)
AU (3) AU2013265001B2 (ru)
BR (1) BR112014029280B1 (ru)
CA (1) CA2873956C (ru)
CY (2) CY1118274T1 (ru)
DK (2) DK3106464T3 (ru)
EA (1) EA025579B1 (ru)
ES (3) ES2782088T3 (ru)
GB (1) GB201209015D0 (ru)
HK (1) HK1209423A1 (ru)
HR (2) HRP20161349T1 (ru)
HU (2) HUE031664T2 (ru)
IL (4) IL235805A (ru)
IN (1) IN2014MN02393A (ru)
LT (2) LT2861602T (ru)
MX (1) MX355303B (ru)
PL (2) PL2861602T3 (ru)
PT (2) PT2861602T (ru)
RS (2) RS55415B1 (ru)
SG (2) SG10201703527WA (ru)
SI (2) SI2861602T1 (ru)
SM (1) SMT201600421B (ru)
WO (2) WO2013175206A1 (ru)
ZA (1) ZA201408253B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
AU2018338884A1 (en) * 2017-09-28 2020-04-16 Biogen Inc. Novel salts
KR20200068678A (ko) * 2017-10-10 2020-06-15 바이오젠 인크. 스피로 유도체를 제조하기 위한 공정
WO2022133097A1 (en) * 2020-12-17 2022-06-23 Biogen Ma Inc. Synthesis of compounds that modulate use-dependent voltage-gated sodium channels

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AU2003245753B2 (en) * 2002-07-05 2009-12-24 Targacept, Inc. N-aryl diazaspiracyclic compounds and methods of preparation and use thereof
US7855218B2 (en) 2005-10-10 2010-12-21 Convergence Pharmaceuticals Limited Compounds
TW200730494A (en) 2005-10-10 2007-08-16 Glaxo Group Ltd Novel compounds
TW200728258A (en) 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
US8143306B2 (en) 2005-10-10 2012-03-27 Convergence Pharmaceuticals Limited Methods of treating bipolar disorders
GB0520578D0 (en) * 2005-10-10 2005-11-16 Glaxo Group Ltd Novel compounds
CN101365690A (zh) * 2005-10-12 2009-02-11 沃泰克斯药物股份有限公司 作为电压门控离子通道调控剂的联苯衍生物
WO2007084314A2 (en) * 2006-01-12 2007-07-26 Incyte Corporation MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
WO2008046046A1 (en) 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Tricyclic spiro-oxindole derivatives and their uses as therapeutic agents
EP2076514A1 (en) 2006-10-12 2009-07-08 Xenon Pharmaceuticals Inc. Spiro (furo ý3, 2-c¨pyridine-3-3 ' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain
GB0701366D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
GB0701365D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
EP2129381A1 (en) 2007-01-24 2009-12-09 Glaxo Group Limited Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
GB0706630D0 (en) * 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds
AR077252A1 (es) * 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
PT2477964E (pt) 2009-09-14 2015-06-04 Convergence Pharmaceuticals Processo para a preparação de derivados de alfa-carboxamida
GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
JP6437911B2 (ja) * 2012-03-21 2018-12-12 インターデイジタル パテント ホールディングス インコーポレイテッド ワイヤレスネットワークにおいて移動局セッションを別の移動局によって資金援助すること
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
GB201209670D0 (en) 2012-05-31 2012-07-18 Convergence Pharmaceuticals Novel compounds

Also Published As

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PT3106464T (pt) 2020-04-03
IL271330A (en) 2020-01-30
US20150166551A1 (en) 2015-06-18
JP6169687B2 (ja) 2017-07-26
EA201492169A1 (ru) 2015-04-30
IL280595A (en) 2021-03-25
AU2013265001A1 (en) 2014-12-18
HUE049445T2 (hu) 2020-09-28
IL235805A (en) 2017-05-29
US9376445B2 (en) 2016-06-28
CN104640867A (zh) 2015-05-20
HUE031664T2 (en) 2017-07-28
US20200289508A1 (en) 2020-09-17
KR20200113027A (ko) 2020-10-05
EP2861602A1 (en) 2015-04-22
US20170304303A1 (en) 2017-10-26
SG11201407755UA (en) 2014-12-30
KR20150023401A (ko) 2015-03-05
IL252033A0 (en) 2017-06-29
CN104640867B (zh) 2017-07-21
WO2013175205A1 (en) 2013-11-28
US10485801B2 (en) 2019-11-26
CY1123044T1 (el) 2021-10-29
MX2014014274A (es) 2015-06-17
KR102161101B1 (ko) 2020-10-20
EP2861602B1 (en) 2016-08-10
IL252033B (en) 2019-12-31
IL235805A0 (en) 2015-02-01
LT3106464T (lt) 2020-04-10
DK2861602T3 (en) 2016-11-28
PL2861602T3 (pl) 2017-05-31
US10010551B2 (en) 2018-07-03
AU2017201421B2 (en) 2017-12-07
RS55415B1 (sr) 2017-04-28
DK3106464T3 (da) 2020-03-23
JP2015517562A (ja) 2015-06-22
AU2013265001B2 (en) 2016-12-01
JP6378404B2 (ja) 2018-08-22
LT2861602T (lt) 2016-11-10
US20160184306A1 (en) 2016-06-30
WO2013175206A1 (en) 2013-11-28
CN107344942B (zh) 2020-09-25
EP2861594A1 (en) 2015-04-22
CA2873956A1 (en) 2013-11-28
AU2018201653A1 (en) 2018-03-29
EA025579B1 (ru) 2017-01-30
US9309254B2 (en) 2016-04-12
US20180360833A1 (en) 2018-12-20
EP2861594B1 (en) 2016-08-24
IL271330B (en) 2021-02-28
ES2602193T3 (es) 2017-02-20
US9737536B2 (en) 2017-08-22
SI2861602T1 (sl) 2017-03-31
AU2018201653B2 (en) 2019-05-02
HRP20161349T1 (hr) 2017-01-27
BR112014029280B1 (pt) 2022-10-04
ES2782088T3 (es) 2020-09-10
PT2861602T (pt) 2016-11-14
GB201209015D0 (en) 2012-07-04
RS60368B1 (sr) 2020-07-31
JP2017206534A (ja) 2017-11-24
JP2015517561A (ja) 2015-06-22
US20150119404A1 (en) 2015-04-30
EP3106464A1 (en) 2016-12-21
SG10201703527WA (en) 2017-06-29
EP3106464B1 (en) 2020-01-08
HK1209423A1 (en) 2016-04-01
BR112014029280A2 (pt) 2017-06-27
AU2017201421A1 (en) 2017-03-23
MX355303B (es) 2018-04-12
CY1118274T1 (el) 2017-06-28
SI3106464T1 (sl) 2020-12-31
ES2602308T3 (es) 2017-02-20
CN107344942A (zh) 2017-11-14
US20160263115A1 (en) 2016-09-15
ZA201408253B (en) 2015-12-23
PL3106464T3 (pl) 2020-11-16
HRP20200580T1 (hr) 2020-10-02
CA2873956C (en) 2021-03-23
SMT201600421B (it) 2017-01-10

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