IN2014MN02175A - - Google Patents

Info

Publication number
IN2014MN02175A
IN2014MN02175A IN2175MUN2014A IN2014MN02175A IN 2014MN02175 A IN2014MN02175 A IN 2014MN02175A IN 2175MUN2014 A IN2175MUN2014 A IN 2175MUN2014A IN 2014MN02175 A IN2014MN02175 A IN 2014MN02175A
Authority
IN
India
Prior art keywords
nme
coh
double bond
independently
single bond
Prior art date
Application number
Other languages
English (en)
Inventor
Philip Wilson Howard
David Edwin Thurston
Khondaker Mirazur Rahman
Peter William Taylor
Original Assignee
Ucl Business Plc
Spirogen Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucl Business Plc, Spirogen Sarl filed Critical Ucl Business Plc
Publication of IN2014MN02175A publication Critical patent/IN2014MN02175A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IN2175MUN2014 2012-04-30 2013-04-30 IN2014MN02175A (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261640316P 2012-04-30 2012-04-30
PCT/GB2013/051097 WO2013164592A1 (en) 2012-04-30 2013-04-30 Pyrrolobenzodiazepines

Publications (1)

Publication Number Publication Date
IN2014MN02175A true IN2014MN02175A (pl) 2015-08-28

Family

ID=48289484

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2175MUN2014 IN2014MN02175A (pl) 2012-04-30 2013-04-30

Country Status (14)

Country Link
US (1) US9321774B2 (pl)
EP (1) EP2855481A1 (pl)
JP (1) JP6125614B2 (pl)
KR (1) KR101960130B1 (pl)
CN (1) CN104540827B (pl)
AU (1) AU2013255612B2 (pl)
BR (1) BR112014027190B1 (pl)
CA (1) CA2872205C (pl)
HK (1) HK1208217A1 (pl)
IN (1) IN2014MN02175A (pl)
MX (1) MX2014013144A (pl)
NZ (1) NZ701478A (pl)
WO (1) WO2013164592A1 (pl)
ZA (1) ZA201408043B (pl)

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KR101961976B1 (ko) 2011-10-14 2019-03-25 시애틀 지네틱스, 인크. 피롤로벤조디아제핀 및 표적 접합체
ES2945932T3 (es) 2011-10-14 2023-07-10 Seagen Inc Pirrolobenzodiazepinas y conjugados dirigidos
AU2012322932B2 (en) 2011-10-14 2016-11-10 Medimmune Limited Pyrrolobenzodiazepines
EP2751111B1 (en) 2011-10-14 2017-04-26 MedImmune Limited Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative or autoimmune diseases
CA3060520C (en) 2012-10-12 2022-05-17 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
WO2014057072A1 (en) 2012-10-12 2014-04-17 Spirogen Sàrl Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
LT2839860T (lt) 2012-10-12 2019-07-10 Medimmune Limited Pirolobenzodiazepinai ir jų konjugatai
NZ707534A (en) 2012-10-12 2018-08-31 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
EA032986B1 (ru) 2012-12-21 2019-08-30 Медимьюн Лимитед Пирролобензодиазепины
AU2013366493B2 (en) 2012-12-21 2017-08-24 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
JP6340019B2 (ja) 2013-03-13 2018-06-06 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ ピロロベンゾジアゼピン及びそのコンジュゲート
TWI680766B (zh) 2013-03-13 2020-01-01 英商梅迪繆思有限公司 吡咯并苯并二氮呯及其共軛物
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
CN107148285B (zh) 2014-11-25 2022-01-04 Adc治疗股份有限公司 吡咯并苯并二氮杂䓬-抗体缀合物
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GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
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WO2017201132A2 (en) 2016-05-18 2017-11-23 Mersana Therapeutics, Inc. Pyrrolobenzodiazepines and conjugates thereof
CN109641910A (zh) * 2016-06-24 2019-04-16 梅尔莎纳医疗公司 吡咯并苯二氮*及其缀合物
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
PT3544636T (pt) 2017-02-08 2021-05-04 Medimmune Ltd Conjugados de anticorpos-pirrolobenzodiazepinas
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
HUE059828T2 (hu) 2017-04-18 2023-01-28 Medimmune Ltd Pirrolobenzodiazepin konjugátumok
CA3057748A1 (en) 2017-04-20 2018-10-25 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
BR112019026564A2 (pt) 2017-06-14 2020-06-30 Adc Therapeutics Sa regimes de dosagem para a administração de um adc anti-cd19
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WO2019065964A1 (ja) 2017-09-29 2019-04-04 第一三共株式会社 抗体－ピロロベンゾジアゼピン誘導体コンジュゲート
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GB201900929D0 (en) * 2019-01-23 2019-03-13 King S College London Nf-kappa b inhibitors
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GB2597532A (en) 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
WO2024127332A1 (en) 2022-12-14 2024-06-20 Pheon Therapeutics Ltd Cytotoxic compounds

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Also Published As

Publication number Publication date
BR112014027190A2 (pt) 2017-06-27
AU2013255612A1 (en) 2014-11-20
MX2014013144A (es) 2015-05-11
CA2872205A1 (en) 2013-11-07
ZA201408043B (en) 2017-08-30
CN104540827A (zh) 2015-04-22
JP6125614B2 (ja) 2017-05-10
CA2872205C (en) 2020-07-21
AU2013255612B2 (en) 2017-06-22
US20150126495A1 (en) 2015-05-07
JP2015516987A (ja) 2015-06-18
KR101960130B1 (ko) 2019-03-19
KR20150014935A (ko) 2015-02-09
BR112014027190B1 (pt) 2020-03-03
US9321774B2 (en) 2016-04-26
NZ701478A (en) 2016-08-26
WO2013164592A1 (en) 2013-11-07
HK1208217A1 (en) 2016-02-26
CN104540827B (zh) 2018-03-23
EP2855481A1 (en) 2015-04-08

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