IN2014MN02069A - - Google Patents
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- Publication number
- IN2014MN02069A IN2014MN02069A IN2069MUN2014A IN2014MN02069A IN 2014MN02069 A IN2014MN02069 A IN 2014MN02069A IN 2069MUN2014 A IN2069MUN2014 A IN 2069MUN2014A IN 2014MN02069 A IN2014MN02069 A IN 2014MN02069A
- Authority
- IN
- India
- Prior art keywords
- compounds
- cancer
- diseases
- processes
- preparation
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- -1 pteridine derivative compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261653081P | 2012-05-30 | 2012-05-30 | |
| GBGB1209613.7A GB201209613D0 (en) | 2012-05-30 | 2012-05-30 | New compounds |
| US201361782233P | 2013-03-14 | 2013-03-14 | |
| PCT/GB2013/051427 WO2013179033A1 (en) | 2012-05-30 | 2013-05-30 | Pteridines as fgfr inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014MN02069A true IN2014MN02069A (member.php) | 2015-08-21 |
Family
ID=46546195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2069MUN2014 IN2014MN02069A (member.php) | 2012-05-30 | 2013-05-30 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US9447098B2 (member.php) |
| EP (1) | EP2855480B1 (member.php) |
| JP (1) | JP6363068B2 (member.php) |
| KR (1) | KR102149759B1 (member.php) |
| CN (1) | CN104507944B (member.php) |
| AU (1) | AU2013269316C1 (member.php) |
| BR (1) | BR112014029709B1 (member.php) |
| CA (1) | CA2874967C (member.php) |
| DK (1) | DK2855480T3 (member.php) |
| ES (1) | ES2739348T3 (member.php) |
| GB (1) | GB201209613D0 (member.php) |
| HR (1) | HRP20191202T1 (member.php) |
| HU (1) | HUE045663T2 (member.php) |
| IN (1) | IN2014MN02069A (member.php) |
| LT (1) | LT2855480T (member.php) |
| MX (1) | MX359418B (member.php) |
| RU (1) | RU2702906C2 (member.php) |
| SI (1) | SI2855480T1 (member.php) |
| WO (1) | WO2013179033A1 (member.php) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
| GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
| GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
| GB2504177B (en) | 2012-05-14 | 2014-12-10 | Thoratec Corp | Sheath system for catheter pump |
| GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
| GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
| GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
| BR112016022062B1 (pt) | 2014-03-26 | 2023-04-11 | Astex Therapeutics Limited | Combinação, composição farmacêutica, uso de uma combinação ou de uma composição farmacêutica, e, produto farmacêutico |
| JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
| HRP20210338T1 (hr) | 2014-03-26 | 2021-04-30 | Astex Therapeutics Ltd. | Kombinacije fgfr-i cmet-inhibitora za liječenje raka |
| WO2015160980A1 (en) | 2014-04-15 | 2015-10-22 | Thoratec Corporation | Heart pump providing adjustable out flow |
| CN103992262B (zh) * | 2014-06-12 | 2015-11-11 | 苏州明锐医药科技有限公司 | 塞瑞替尼及其中间体的制备方法 |
| JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| RU2747645C2 (ru) * | 2015-09-23 | 2021-05-11 | Янссен Фармацевтика Нв | Новые соединения |
| AU2016328693B2 (en) * | 2015-09-23 | 2021-03-11 | Janssen Pharmaceutica Nv | Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer |
| MX382526B (es) | 2015-10-23 | 2025-03-13 | Array Biopharma Inc | Compuestos de 2-piridazin-3(2h)-ona 2-aril sustituidas y 2-heteroaril sustituidas como inhibidores de las tirosina quinasas fgfr |
| IL307931A (en) * | 2016-04-15 | 2023-12-01 | Epizyme Inc | Amine-substituted aryl or heteroaryl compounds as ehmt1 and ehmt2 inhibitors |
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| EP3722282B1 (en) * | 2017-12-07 | 2024-09-11 | Harbin Zhenbao Pharmaceutical Co., Ltd. | Salt form and crystal form serving as fgfr and vegfr inhibitor compounds, and preparation method therefor |
| EP3745979B1 (en) | 2018-01-29 | 2025-11-19 | Bard Access Systems, Inc. | Connection system for establishing an electrical connection through a drape and methods thereof |
| EP3793464A4 (en) | 2018-05-18 | 2021-07-21 | Bard Access Systems, Inc. | CONNECTION SYSTEM AND METHOD FOR MAKING AN ELECTRICAL CONNECTION THROUGH A COVERING CLOTH |
| CN113474337A (zh) | 2018-12-19 | 2021-10-01 | 奥瑞生物药品公司 | 作为fgfr抑制剂用于治疗癌症的7-((3，5-二甲氧基苯基)氨基)喹喔啉衍生物 |
| WO2020131627A1 (en) | 2018-12-19 | 2020-06-25 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases |
| EP3942045A1 (en) | 2019-03-21 | 2022-01-26 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| CA3146657A1 (en) | 2019-07-12 | 2021-01-21 | Bard Access Systems, Inc. | Catheter tracking and placement system including light emitting diode array |
| EP4007932B1 (en) | 2019-08-08 | 2025-12-31 | Bard Access Systems, Inc. | Optical fiber connector modules including shape detection systems and associated processes |
| WO2021089791A1 (en) | 2019-11-08 | 2021-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021138392A1 (en) | 2019-12-30 | 2021-07-08 | Tyra Biosciences, Inc. | Aminopyrimidine compounds |
| BE1027936B1 (nl) | 2019-12-30 | 2021-08-03 | Kreco Nv | Coccolitisch krijtproduct voor toepassing in landbouw en waterbeheer |
| WO2021138391A1 (en) | 2019-12-30 | 2021-07-08 | Tyra Biosciences, Inc. | Indazole compounds |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| IL304014A (en) | 2020-12-30 | 2023-08-01 | Tyra Biosciences Inc | Indazole compounds as kinase inhibitors |
| US20240190849A1 (en) | 2021-02-26 | 2024-06-13 | Tyra Biosciences, Inc. | Aminopyrimidine compounds and methods of their use |
| CA3260633A1 (en) | 2022-06-29 | 2024-01-04 | Tyra Biosciences, Inc. | POLYMORPHIC COMPOUNDS AND THEIR USES |
| EP4547656A1 (en) | 2022-06-29 | 2025-05-07 | Tyra Biosciences, Inc. | Indazole compounds |
| CN114984019B (zh) * | 2022-07-15 | 2023-08-22 | 山东中医药大学 | 一种铁死亡抑制剂化合物及在肝损伤修复领域的应用 |
| WO2024138112A1 (en) | 2022-12-22 | 2024-06-27 | Tyra Biosciences, Inc. | Indazole compounds |
| TW202504611A (zh) | 2023-03-30 | 2025-02-01 | 美商銳新醫藥公司 | 用於誘導ｒａｓ ｇｔｐ水解之組合物及其用途 |
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| WO2025034702A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 for use in the treatment of ras protein-related disease or disorder |
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| WO2025129014A1 (en) | 2023-12-15 | 2025-06-19 | Tyra Biosciences, Inc. | Indazole compounds for the treatment of cancer |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025222097A1 (en) | 2024-04-19 | 2025-10-23 | Tyra Biosciences, Inc. | Indazole-based protac degraders and their anticancer activity |
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| US20250375445A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
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| HRP20191202T1 (hr) | 2019-10-18 |
| GB201209613D0 (en) | 2012-07-11 |
| MX2014014110A (es) | 2015-06-17 |
| AU2013269316A1 (en) | 2014-10-30 |
| US9447098B2 (en) | 2016-09-20 |
| CA2874967A1 (en) | 2013-12-05 |
| CN104507944A (zh) | 2015-04-08 |
| EP2855480B1 (en) | 2019-06-26 |
| US20150291589A1 (en) | 2015-10-15 |
| BR112014029709A2 (pt) | 2017-06-27 |
| RU2702906C2 (ru) | 2019-10-14 |
| CN104507944B (zh) | 2017-04-12 |
| AU2013269316C1 (en) | 2018-04-12 |
| DK2855480T3 (da) | 2019-07-22 |
| JP6363068B2 (ja) | 2018-07-25 |
| JP2015518039A (ja) | 2015-06-25 |
| MX359418B (es) | 2018-09-27 |
| ES2739348T3 (es) | 2020-01-30 |
| SI2855480T1 (sl) | 2019-09-30 |
| RU2014153050A (ru) | 2016-07-20 |
| AU2013269316B2 (en) | 2017-10-19 |
| LT2855480T (lt) | 2019-08-12 |
| US10272087B2 (en) | 2019-04-30 |
| BR112014029709B1 (pt) | 2022-03-22 |
| CA2874967C (en) | 2021-11-09 |
| KR20150016595A (ko) | 2015-02-12 |
| HUE045663T2 (hu) | 2020-01-28 |
| KR102149759B1 (ko) | 2020-08-31 |
| EP2855480A1 (en) | 2015-04-08 |
| US20170000796A1 (en) | 2017-01-05 |
| WO2013179033A1 (en) | 2013-12-05 |
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