IN2014KN01682A - - Google Patents
Info
- Publication number
- IN2014KN01682A IN2014KN01682A IN1682KON2014A IN2014KN01682A IN 2014KN01682 A IN2014KN01682 A IN 2014KN01682A IN 1682KON2014 A IN1682KON2014 A IN 1682KON2014A IN 2014KN01682 A IN2014KN01682 A IN 2014KN01682A
- Authority
- IN
- India
- Prior art keywords
- human
- receptor antagonist
- mammalian
- expression
- itr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10041—Use of virus, viral particle or viral elements as a vector
- C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10071—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10371—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/24—Vectors characterised by the absence of particular element, e.g. selectable marker, viral origin of replication
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20120000703 EP2623604B8 (en) | 2012-02-02 | 2012-02-02 | Adenoviral-based biological delivery and expression system for use in the treatment of osteoarthritis |
PCT/IB2013/000198 WO2013114199A1 (en) | 2012-02-02 | 2013-01-23 | Adenoviral-based biological delivery and expression system for use in the treatment of osteoarthritis |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014KN01682A true IN2014KN01682A (ja) | 2015-10-23 |
Family
ID=47891791
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN1682KON2014 IN2014KN01682A (ja) | 2012-02-02 | 2013-01-23 |
Country Status (12)
Country | Link |
---|---|
US (4) | US10301647B2 (ja) |
EP (1) | EP2623604B8 (ja) |
JP (2) | JP6340320B2 (ja) |
CN (1) | CN104245941B (ja) |
AU (1) | AU2013213873B2 (ja) |
CA (1) | CA2861408C (ja) |
DK (1) | DK2623604T3 (ja) |
EA (1) | EA033004B1 (ja) |
ES (1) | ES2534782T3 (ja) |
IN (1) | IN2014KN01682A (ja) |
PL (1) | PL2623604T3 (ja) |
WO (1) | WO2013114199A1 (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2948553B1 (en) * | 2013-01-25 | 2020-04-01 | Baylor College Of Medicine | A helper-dependent adenoviral gene therapy delivery and expression system |
GB201410314D0 (en) * | 2014-06-10 | 2014-07-23 | Advanced Risc Mach Ltd | Display controller |
CN107636146A (zh) * | 2015-03-02 | 2018-01-26 | 同生公司 | 被工程化为治疗受益于降低的消化道炎症和/或收紧的消化道粘膜屏障的疾病的细菌 |
WO2017123934A1 (en) | 2016-01-13 | 2017-07-20 | Merial, Inc. | Recombinant aav vectors expressing osteoprotective genes, including has2 and lubricin, useful in the treatment of osteoarthritis and related joint conditions in mammals |
AU2017313844B2 (en) | 2016-08-19 | 2023-10-12 | University Of Florida Research Foundation, Incorporated | Methods and compositions for treating conditions using recombinant self-complementary adeno-associated virus |
WO2018071295A1 (en) | 2016-10-10 | 2018-04-19 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for inducible production of anti-inflammatory cytokines |
CN110225923A (zh) * | 2016-12-07 | 2019-09-10 | 佛罗里达大学研究基金会有限公司 | IL-1Ra cDNA |
JP7260173B2 (ja) | 2017-04-21 | 2023-04-18 | ベイラー カレッジ オブ メディスン | 腫瘍溶解性ウイルス療法および免疫療法 |
EP4031192A4 (en) * | 2019-09-18 | 2023-10-25 | Pacira Therapeutics, Inc. | EFFECTIVE DOSAGE OF AN ADENOVIRUS BASED BIOLOGICAL DELIVERY AND EXPRESSION SYSTEM FOR USE IN THE TREATMENT OF OSTEOARTHRITIS IN HUMAN BEINGS AND COMPOSITIONS THEREOF |
JPWO2022234844A1 (ja) * | 2021-05-06 | 2022-11-10 | ||
KR20240052793A (ko) * | 2021-08-24 | 2024-04-23 | 파시라 테라퓨틱스, 인크. | 추간판 퇴행에 대한 IL-1Ra 유전자 요법 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5747072A (en) | 1993-07-30 | 1998-05-05 | University Of Michigan | Adenoviral-mediated gene transfer to synovial cells in vivo |
US20030091536A1 (en) | 1999-09-07 | 2003-05-15 | Colorado State University Research Foundation | In vivo treatment of joint disease using interleukin-1 |
FR2806418B1 (fr) * | 2000-03-14 | 2004-07-16 | Aventis Pharma Sa | Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations |
WO2002083080A2 (en) | 2001-04-17 | 2002-10-24 | Genetix Pharmaceuticals, Inc. | Method of treating arthritis using lentiviral vectors in gene therapy |
ES2569917T3 (es) * | 2005-06-21 | 2016-05-13 | Xoma (Us) Llc | Anticuerpos y fragmentos de los mismos que se unen a IL-1beta |
US8298533B2 (en) * | 2008-11-07 | 2012-10-30 | Medimmune Limited | Antibodies to IL-1R1 |
WO2010127275A1 (en) * | 2009-05-01 | 2010-11-04 | Oregon Health & Scince University | Method of expanding human hepatocytes in vivo |
CA2763161A1 (en) * | 2009-05-29 | 2010-12-02 | Xoma Technology Ltd. | Cardiovascular related uses of il-1.beta. antibodies and binding fragments thereof |
-
2012
- 2012-02-02 PL PL12000703T patent/PL2623604T3/pl unknown
- 2012-02-02 DK DK12000703.4T patent/DK2623604T3/da active
- 2012-02-02 ES ES12000703.4T patent/ES2534782T3/es active Active
- 2012-02-02 EP EP20120000703 patent/EP2623604B8/en active Active
-
2013
- 2013-01-23 US US14/375,351 patent/US10301647B2/en active Active
- 2013-01-23 IN IN1682KON2014 patent/IN2014KN01682A/en unknown
- 2013-01-23 WO PCT/IB2013/000198 patent/WO2013114199A1/en active Application Filing
- 2013-01-23 CA CA2861408A patent/CA2861408C/en active Active
- 2013-01-23 EA EA201491457A patent/EA033004B1/ru unknown
- 2013-01-23 JP JP2014555328A patent/JP6340320B2/ja active Active
- 2013-01-23 AU AU2013213873A patent/AU2013213873B2/en active Active
- 2013-01-23 CN CN201380007814.1A patent/CN104245941B/zh active Active
-
2018
- 2018-02-01 JP JP2018016342A patent/JP2018075035A/ja active Pending
-
2019
- 2019-04-30 US US16/398,691 patent/US20190376080A1/en not_active Abandoned
-
2021
- 2021-10-08 US US17/497,045 patent/US20220073948A1/en not_active Abandoned
-
2022
- 2022-06-30 US US17/855,322 patent/US20220348963A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2623604B1 (en) | 2015-02-25 |
US20150031083A1 (en) | 2015-01-29 |
US20190376080A1 (en) | 2019-12-12 |
US20220348963A1 (en) | 2022-11-03 |
AU2013213873B2 (en) | 2018-06-21 |
ES2534782T3 (es) | 2015-04-28 |
PL2623604T3 (pl) | 2015-07-31 |
CA2861408C (en) | 2021-10-26 |
US10301647B2 (en) | 2019-05-28 |
EA201491457A1 (ru) | 2014-11-28 |
EP2623604B8 (en) | 2015-04-22 |
JP6340320B2 (ja) | 2018-06-06 |
DK2623604T3 (da) | 2015-06-01 |
CN104245941B (zh) | 2016-12-07 |
CA2861408A1 (en) | 2013-08-08 |
AU2013213873A1 (en) | 2014-09-25 |
EP2623604A1 (en) | 2013-08-07 |
JP2015506695A (ja) | 2015-03-05 |
US20220073948A1 (en) | 2022-03-10 |
WO2013114199A1 (en) | 2013-08-08 |
JP2018075035A (ja) | 2018-05-17 |
WO2013114199A8 (en) | 2014-09-25 |
EA033004B1 (ru) | 2019-08-30 |
CN104245941A (zh) | 2014-12-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IN2014KN01682A (ja) | ||
PH12019500694A1 (en) | Factor viii compositions and methods of making and using the same | |
Fayyad-Kazan et al. | Downregulation of microRNA-24 and-181 parallels the upregulation of IFN-γ secreted by activated human CD4 lymphocytes | |
BR112018005620A2 (pt) | método para transferência de gene estável e de nível elevado em linfócitos | |
MX337040B (es) | Moleculas de union a 4-1bb. | |
Chen et al. | Mesenchymal stem cells modified with heme oxygenase-1 have enhanced paracrine function and attenuate lipopolysaccharide-induced inflammatory and oxidative damage in pulmonary microvascular endothelial cells | |
NZ603813A (en) | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases | |
BR112016028023A2 (pt) | Composições e métodos de administração de tratamentos para infecções virais latentes | |
MX346923B (es) | Genes y proteinas para sintesis de alcanoil-coa. | |
MX362981B (es) | Moleculas artificiales de acido nucleico para la expresion mejorada de proteina o peptido. | |
EA201170506A1 (ru) | Генная терапия порфобилиногендезаминазой | |
BRPI1013877A2 (pt) | Sequências de aminoácidos melhoradas contra il-6r e polipeptídeos que compreendem os mesmos para o tratamento de doenças e distúrbios relacionados com il-6r | |
MX359953B (es) | Ácido nucleico que comprende o que codifica un tallo-rizo de histona y una secuencia poli (a) o una señal de poliadenilación para incrementar la expresión de una proteína terapéutica codificada. | |
IN2014DN03061A (ja) | ||
EA201692359A1 (ru) | Композиция на основе нового штамма prrsv или его белков, продукт, их применение, вирус prrsv, выделенная нк и рекомбинантный вектор экспрессии для получения этого вируса | |
MX354516B (es) | Vectores que codifican el factor de viabilidad de conos derivado de bastones. | |
BRPI0607119A2 (pt) | construção de ácido nucleico, população de construções de ácido nucleico, seqüência promotora quimérica isolada purificada, partìculas revestidas, receptáculo de dosagem para um dispositivo de liberação mediada por partìcula, dispositivo de liberação mediada por partìcula, composição farmacêutica, composição de vacina, e, método in vitro de obter a expressão em células de mamìfero de um polipeptìdeo da influenza de interesse | |
IN2014KN02823A (ja) | ||
IN2014CN04734A (ja) | ||
MX354016B (es) | Sistemas y metodos de suministro de agentes bioactivos mediante el uso de secuencias transportadoras derivadas de toxinas. | |
MX361434B (es) | Proteínas de fusión npp1. | |
WO2022038264A1 (en) | Modified lymphocytes | |
Peröbner et al. | LRP6 mediates Wnt/β-catenin signaling and regulates adipogenic differentiation in human mesenchymal stem cells | |
NZ709120A (en) | Beta-hexosyl-transferases and uses thereof | |
Locatelli et al. | Efficient plasmid-mediated gene transfection of ovine bone marrow mesenchymal stromal cells |