IN2014DN10053A - - Google Patents
Download PDFInfo
- Publication number
- IN2014DN10053A IN2014DN10053A IN10053DEN2014A IN2014DN10053A IN 2014DN10053 A IN2014DN10053 A IN 2014DN10053A IN 10053DEN2014 A IN10053DEN2014 A IN 10053DEN2014A IN 2014DN10053 A IN2014DN10053 A IN 2014DN10053A
- Authority
- IN
- India
- Prior art keywords
- component
- nkx6
- endodermal cell
- noggin
- egf
- Prior art date
Links
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 229960003966 nicotinamide Drugs 0.000 abstract 2
- 235000005152 nicotinamide Nutrition 0.000 abstract 2
- 239000011570 nicotinamide Substances 0.000 abstract 2
- 102000045246 noggin Human genes 0.000 abstract 2
- 108700007229 noggin Proteins 0.000 abstract 2
- 210000000130 stem cell Anatomy 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/28—Vascular endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Developmental Biology & Embryology (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261640366P | 2012-04-30 | 2012-04-30 | |
| PCT/CA2013/000432 WO2013163739A1 (en) | 2012-04-30 | 2013-04-30 | METHODS AND COMPOSITIONS FOR GENERATING PANCREATIC PROGENITORS AND FUNCTIONAL BETA CELLS FROM hPSCs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN10053A true IN2014DN10053A (enrdf_load_stackoverflow) | 2015-08-14 |
Family
ID=49514141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN10053DEN2014 IN2014DN10053A (enrdf_load_stackoverflow) | 2012-04-30 | 2013-04-30 |
Country Status (17)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105358680B (zh) * | 2013-04-03 | 2019-06-25 | 富士费勒姆细胞动力学有限公司 | 用于悬浮培养内胚层祖细胞的方法和组合物 |
| CN106536718B (zh) * | 2014-05-21 | 2021-04-27 | 国立大学法人京都大学 | 胰芽细胞的制造方法及含有胰芽细胞的胰疾病治疗剂 |
| WO2016170069A1 (en) | 2015-04-24 | 2016-10-27 | University Of Copenhagen | Isolation of bona fide pancreatic progenitor cells |
| US20180119105A1 (en) * | 2015-04-24 | 2018-05-03 | University Of Copenhagen | Method for production of insulin-producing cells |
| EP3328404A4 (en) * | 2015-07-27 | 2018-12-26 | The Regents of The University of California | Methods and compositions for producing pancreatic beta cells |
| CN106554936B (zh) * | 2015-09-30 | 2020-05-05 | 海门雨霖细胞科技有限责任公司 | 诱导人干细胞向肝细胞定向分化的新方法 |
| WO2017144695A1 (en) * | 2016-02-24 | 2017-08-31 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| MA45329A (fr) * | 2016-04-08 | 2019-02-13 | Univ California | Production de cellules bêta matures pleinement fonctionnelles à partir de progénitrices pancréatiques humaines |
| WO2018021293A1 (ja) * | 2016-07-26 | 2018-02-01 | 国立大学法人京都大学 | Ｐｔｆ１ａ陽性細胞の製造方法 |
| EP3591040A4 (en) * | 2017-03-03 | 2020-11-11 | Kyoto University | METHOD OF PRODUCTION OF PANCREATIC PROGENITOR CELLS |
| EP4488363A3 (en) * | 2017-07-21 | 2025-03-26 | Vertex Pharmaceuticals Incorporated | Re-aggregation of stem cell-derived pancreatic beta cells |
| CA2983845C (en) | 2017-10-26 | 2024-01-30 | University Of Copenhagen | Generation of glucose-responsive beta cells |
| CN111630155B (zh) | 2017-11-15 | 2024-05-03 | 沃泰克斯药物股份有限公司 | 胰岛细胞制备性组合物和使用方法 |
| CN111630052B (zh) | 2018-01-18 | 2023-04-18 | 第一三共株式会社 | 二氢吲嗪酮衍生物 |
| JP2021525094A (ja) * | 2018-05-31 | 2021-09-24 | ユニバーシティー ヘルス ネットワーク | インスリン産生細胞を生成する、タンキラーゼ阻害剤を含む方法及び組成物 |
| AU2019320072A1 (en) | 2018-08-10 | 2021-02-25 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| US20210230554A1 (en) | 2018-08-30 | 2021-07-29 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| CN111848743B (zh) * | 2018-09-03 | 2021-05-11 | 吉林省汇融生物科技有限公司 | 表皮干细胞向胰腺细胞分化的改进方法 |
| WO2020080550A1 (ja) * | 2018-10-15 | 2020-04-23 | Cynity株式会社 | 低分子化合物による内胚葉組織又は器官由来細胞からの幹／前駆細胞の作製方法 |
| JP7385244B2 (ja) * | 2019-06-27 | 2023-11-22 | 国立大学法人 東京大学 | 膵前駆細胞の分離方法 |
| WO2021051256A1 (en) * | 2019-09-17 | 2021-03-25 | Center For Excellence In Molecular Cell Science, Chinese Academy Of Sciences | Pancreatic pro-endocrine progenitor cells and use thereof |
| US20240093154A1 (en) * | 2021-02-01 | 2024-03-21 | Cedars-Sinai Medical Center | Generation of functional human ipsc-derived pancreatic islets in co-culture with isogenic ipsc-derived vascular endothelial cells |
| CN113234664B (zh) * | 2021-05-11 | 2024-05-10 | 澳门大学 | 一种胰腺祖细胞的制备方法及其应用 |
| CN114634904B (zh) * | 2022-05-17 | 2022-09-13 | 天津外泌体科技有限公司 | 高纯度胰腺祖细胞的产生方法 |
| CN118345030B (zh) * | 2024-06-20 | 2024-08-16 | 羽铂精制生物技术(成都)有限公司 | iPSC诱导分化成为胰腺祖细胞修复胰腺的方法及应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| EP2264146A1 (en) * | 2001-12-07 | 2010-12-22 | Geron Corporation | Islet cells from human embryonic stem cells |
| JP5102030B2 (ja) | 2004-08-13 | 2012-12-19 | ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド | ヒト胚性幹細胞における自己再生および分化のための組成物および方法 |
| JP6110048B2 (ja) | 2006-03-02 | 2017-04-05 | ヴィアサイト，インコーポレイテッド | 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法 |
| WO2007127454A2 (en) | 2006-04-28 | 2007-11-08 | Cythera, Inc. | Hepatocyte lineage cells |
| US20080063628A1 (en) * | 2006-09-11 | 2008-03-13 | Davis Janet E | Methods to promote cell differentiation |
| US7695963B2 (en) | 2007-09-24 | 2010-04-13 | Cythera, Inc. | Methods for increasing definitive endoderm production |
| US8338170B2 (en) * | 2008-04-21 | 2012-12-25 | Viacyte, Inc. | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
| GB201111244D0 (en) * | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
| SG10201408552YA (en) * | 2009-12-23 | 2015-02-27 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
| WO2012070014A2 (en) * | 2010-11-26 | 2012-05-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells |
-
2013
- 2013-04-30 EP EP13784648.1A patent/EP2844739B1/en active Active
- 2013-04-30 AU AU2013255031A patent/AU2013255031C1/en active Active
- 2013-04-30 CA CA2871795A patent/CA2871795C/en active Active
- 2013-04-30 CN CN201380035022.5A patent/CN104411815B/zh active Active
- 2013-04-30 US US14/397,657 patent/US20150104430A1/en active Pending
- 2013-04-30 HR HRP20191677 patent/HRP20191677T1/hr unknown
- 2013-04-30 CN CN201711013526.3A patent/CN108004199B/zh active Active
- 2013-04-30 JP JP2015509270A patent/JP6397397B2/ja active Active
- 2013-04-30 HU HUE13784648A patent/HUE046271T2/hu unknown
- 2013-04-30 IN IN10053DEN2014 patent/IN2014DN10053A/en unknown
- 2013-04-30 DK DK13784648.1T patent/DK2844739T3/da active
- 2013-04-30 EP EP19181059.7A patent/EP3594323A1/en active Pending
- 2013-04-30 ES ES13784648T patent/ES2747967T3/es active Active
- 2013-04-30 SI SI201331572T patent/SI2844739T1/sl unknown
- 2013-04-30 PL PL13784648T patent/PL2844739T3/pl unknown
- 2013-04-30 WO PCT/CA2013/000432 patent/WO2013163739A1/en active Application Filing
- 2013-04-30 PT PT137846481T patent/PT2844739T/pt unknown
- 2013-04-30 LT LTEP13784648.1T patent/LT2844739T/lt unknown
-
2018
- 2018-08-30 JP JP2018162002A patent/JP6759293B2/ja active Active
-
2019
- 2019-09-13 CY CY20191100960T patent/CY1122058T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN108004199A (zh) | 2018-05-08 |
| EP2844739A4 (en) | 2015-12-02 |
| PL2844739T3 (pl) | 2019-12-31 |
| JP2018198620A (ja) | 2018-12-20 |
| DK2844739T3 (da) | 2019-09-30 |
| AU2013255031C1 (en) | 2018-12-06 |
| HK1254968A1 (zh) | 2019-08-02 |
| JP6759293B2 (ja) | 2020-09-23 |
| JP2015519048A (ja) | 2015-07-09 |
| CA2871795C (en) | 2023-03-14 |
| CN104411815B (zh) | 2017-11-28 |
| EP2844739B1 (en) | 2019-06-19 |
| CN108004199B (zh) | 2022-03-18 |
| SI2844739T1 (sl) | 2019-11-29 |
| LT2844739T (lt) | 2019-10-10 |
| HRP20191677T1 (hr) | 2019-12-13 |
| CA2871795A1 (en) | 2013-11-07 |
| HUE046271T2 (hu) | 2020-02-28 |
| EP3594323A1 (en) | 2020-01-15 |
| WO2013163739A1 (en) | 2013-11-07 |
| AU2013255031B2 (en) | 2018-09-06 |
| AU2013255031A1 (en) | 2014-12-04 |
| CN104411815A (zh) | 2015-03-11 |
| EP2844739A1 (en) | 2015-03-11 |
| US20150104430A1 (en) | 2015-04-16 |
| JP6397397B2 (ja) | 2018-09-26 |
| ES2747967T3 (es) | 2020-03-12 |
| HK1208047A1 (en) | 2016-02-19 |
| CY1122058T1 (el) | 2020-11-25 |
| PT2844739T (pt) | 2019-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2014DN10053A (enrdf_load_stackoverflow) | ||
| GB2549822B (en) | A method of differentiating or promoting the differentiation of NKX6.1/PDX1+pancreatic progenitor cells into non-native pancreatic ß cells in vitro | |
| PH12018501295A1 (en) | Differentiation of human embryonic stem cells into pancreatic endocrine cells | |
| PH12013500349A1 (en) | Differentiation of pluripotent stem cells | |
| WO2012135621A3 (en) | Priming of pluripotent stem cells for neural differentiation | |
| PH12014501429A1 (en) | Differentiation of human embryonic stem cells into single hormonal insulin positive cells | |
| WO2014201015A3 (en) | Methods and compositions for target dna modification | |
| HK1217109A1 (zh) | 使用hb9調節子使人胚胎幹細胞分化為胰腺內分泌細胞的方法 | |
| PH12015501477A1 (en) | Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells | |
| SG10201807292YA (en) | Improved reprogramming methods and cell culture platforms | |
| SG10201810830UA (en) | Cell culture compositions and methods for polypeptide production | |
| MX2013002406A (es) | Diferenciacion de celulas madre embrionarias humanas. | |
| SG10201809452RA (en) | Cell culture compositions with antioxidants and methods for polypeptide production | |
| AU2014300650B2 (en) | Cell populations, methods of transdifferention and methods of use thereof | |
| AU2016250905A8 (en) | Generation of muscle-lineage cells from stem cells | |
| PH12013500367A1 (en) | Differentiation of human embryonic stem cells | |
| EP4527921A3 (en) | Renal cell populations and uses thereof | |
| EP3031905A4 (en) | Method for producing pancreatic hormone-producing cell | |
| GB2523696A (en) | Methods of differentiating stem cells by modulating miR-124 | |
| BR112018010946A2 (pt) | método para enriquecimento de células endócrinas pancreáticas, população enriquecida de células endócrinas pancreáticas, método de tratamento de diabetes e método de preparação de células beta de produção de insulina | |
| MX2010012730A (es) | Metodo para diferenciacion de celulas progenitoras de mamifero en celulas de islote pancreaticas que producen insulina. | |
| SG10201808061WA (en) | Method for the clarification of high density crude cell culture harvest | |
| IN2014DN10762A (enrdf_load_stackoverflow) | ||
| EP3064572A4 (en) | Method for producing induced pluripotent stem cell from mesenchymal stem cell and induced pluripotent stem cell produced by the method | |
| TH148730A (th) | การเปลี่ยนแปลงของสเต็มเซลล์จากตัวอ่อนมนุษย์ไปเป็นเซลล์ที่ทำหน้าที่จำเพาะ |