IN2014DN09529A - - Google Patents
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- Publication number
- IN2014DN09529A IN2014DN09529A IN9529DEN2014A IN2014DN09529A IN 2014DN09529 A IN2014DN09529 A IN 2014DN09529A IN 9529DEN2014 A IN9529DEN2014 A IN 9529DEN2014A IN 2014DN09529 A IN2014DN09529 A IN 2014DN09529A
- Authority
- IN
- India
- Prior art keywords
- coa
- dhb
- malate
- converting
- malyl
- Prior art date
Links
- IUNJCFABHJZSKB-UHFFFAOYSA-N 2,4-Dihydroxybenzaldehyde Natural products OC1=CC=C(C=O)C(O)=C1 IUNJCFABHJZSKB-UHFFFAOYSA-N 0.000 abstract 2
- HJQWLHMLMCDAEL-NALABAGVSA-N malyl-coa Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCSC(=O)C[C@H](O)C(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 HJQWLHMLMCDAEL-NALABAGVSA-N 0.000 abstract 2
- 101710138112 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase Proteins 0.000 abstract 1
- UFYGCFHQAXXBCF-UHFFFAOYSA-N 2,4-dihydroxybutanoic acid Chemical compound OCCC(O)C(O)=O UFYGCFHQAXXBCF-UHFFFAOYSA-N 0.000 abstract 1
- HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 abstract 1
- 229940049920 malate Drugs 0.000 abstract 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
- VNOYUJKHFWYWIR-FZEDXVDRSA-N succinyl-coa Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 VNOYUJKHFWYWIR-FZEDXVDRSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01002—Alcohol dehydrogenase (NADP+) (1.1.1.2), i.e. aldehyde reductase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01061—4-Hydroxybutyrate dehydrogenase (1.1.1.61)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01075—Malonyl CoA reductase (malonate semialdehyde-forming)(1.2.1.75)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01076—Succinate-semialdehyde dehydrogenase (acetylating) (1.2.1.76)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y208/00—Transferases transferring sulfur-containing groups (2.8)
- C12Y208/03—CoA-transferases (2.8.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/03—Oxo-acid-lyases (4.1.3)
- C12Y401/03024—Malyl-CoA lyase (4.1.3.24)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
- C12Y602/01—Acid-Thiol Ligases (6.2.1)
- C12Y602/01009—Malate--CoA ligase (6.2.1.9)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/52—Propionic acid; Butyric acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
- C12Y103/01028—2,3-Dihydro-2,3-dihydroxybenzoate dehydrogenase (1.3.1.28)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2012001123 | 2012-04-26 | ||
| PCT/IB2013/001071 WO2013160762A2 (en) | 2012-04-26 | 2013-04-25 | A method of production of 2,4-dihydroxybutyric acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN09529A true IN2014DN09529A (enExample) | 2015-07-17 |
Family
ID=48699857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN9529DEN2014 IN2014DN09529A (enExample) | 2012-04-26 | 2013-04-25 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9890400B2 (enExample) |
| EP (1) | EP2841584B1 (enExample) |
| JP (1) | JP6342385B2 (enExample) |
| KR (1) | KR102024109B1 (enExample) |
| CN (1) | CN104254612B (enExample) |
| BR (1) | BR112014026149A2 (enExample) |
| ES (1) | ES2875010T3 (enExample) |
| IN (1) | IN2014DN09529A (enExample) |
| MY (1) | MY175391A (enExample) |
| WO (1) | WO2013160762A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015000534B1 (pt) * | 2012-07-11 | 2023-02-28 | Adisseo France S.A.S | Método para a preparação de 2,4-dihidroxibutirato, microrganismo modificado e método de produção de 2,4-dhb |
| CN103642765B (zh) * | 2013-12-25 | 2015-11-18 | 南京工业大学 | 醇脱氢酶突变体及其应用 |
| MY180352A (en) * | 2014-04-11 | 2020-11-28 | String Bio Private Ltd | Recombinant methanotrophic bacterium and a method of production of succinic acid from methane or biogas thereof |
| WO2016162442A1 (en) | 2015-04-07 | 2016-10-13 | Metabolic Explorer | A modified microorganism for the optimized production of 2,4-dihydroxyburyrate with enhanced 2,4-dihydroxybutyrate efflux |
| BR112017021255A2 (pt) | 2015-04-07 | 2018-06-26 | Metabolic Explorer Sa | microrganismo modificado para a produção otimizada de 2,4-di-hidroxibutirato |
| CA2989434C (en) * | 2015-06-25 | 2023-10-03 | Dynamic Food Ingredients Corporation | Method for the production of 2,4-dihydroxybutyric acid |
| CN105441372A (zh) * | 2015-10-30 | 2016-03-30 | 清华大学 | 一种重组谷氨酸棒杆菌与应用 |
| US10369190B2 (en) | 2016-09-13 | 2019-08-06 | Allergan, Inc. | Non-protein clostridial toxin compositions |
| CN111778200B (zh) * | 2019-04-04 | 2022-11-01 | 中国科学院微生物研究所 | 生产L-天冬氨酸的平台菌、基于该平台菌构建的生产β-丙氨酸的重组菌及其构建方法 |
| CN112410389B (zh) * | 2019-08-23 | 2023-07-18 | 中国科学院微生物研究所 | 支链α-酮酸脱氢酶复合体在制备丙二酸单酰辅酶A中的应用 |
| CN110713962B (zh) * | 2019-09-06 | 2022-06-21 | 南京农业大学 | 一株高产丙二酰辅酶a的基因工程菌及其构建方法和应用 |
| DE102021101004B3 (de) | 2021-01-19 | 2022-03-10 | Technische Universität Dresden, Körperschaft des öffentlichen Rechts | Verfahren zur Herstellung von 2,4-Dihydroxybutyrat oder L-Threonin unter Nutzung eines mikrobiellen Stoffwechselweges |
| CN115820616A (zh) * | 2022-07-22 | 2023-03-21 | 昆明理工大学 | 一种带荧光标记的噬菌体裂解酶及其应用 |
| CN115948482B (zh) * | 2023-02-07 | 2024-02-09 | 中国科学院天津工业生物技术研究所 | 一种2，4-二羟基丁酸生物合成途径的构建方法及应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| DE3788764T2 (de) | 1986-09-16 | 1994-06-23 | Gist Brocades Nv | Penicilliumtransformanten und Verfahren zu ihrer Herstellung. |
| HU218465B (hu) | 1989-08-09 | 2000-09-28 | Dekalb Genetics Corporation | Eljárások és kompozíciók stabilan transzformált, termő egyszikű növények és sejtjeik előállítására |
| US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US5693781A (en) | 1991-06-03 | 1997-12-02 | Mitsubishi Chemical Corporation | Promoter DNA fragment from coryneform bacteria |
| CA2142602A1 (en) | 1992-08-19 | 1994-03-03 | Tiina Hannele Nakari | Fungal promoters active in the presence of glucose |
| FR2734842B1 (fr) | 1995-06-02 | 1998-02-27 | Rhone Poulenc Agrochimie | Sequence adn d'un gene de l'hydroxy-phenyl pyruvate dioxygenase et obtention de plantes contenant un gene de l'hydroxy-phenyl pyruvate dioxygenase, tolerantes a certains herbicides |
| FR2736926B1 (fr) | 1995-07-19 | 1997-08-22 | Rhone Poulenc Agrochimie | 5-enol pyruvylshikimate-3-phosphate synthase mutee, gene codant pour cette proteine et plantes transformees contenant ce gene |
| FR2780416B1 (fr) | 1998-06-10 | 2002-12-20 | Rhone Poulenc Nutrition Animal | Procede industriel de production de proteines heterologues chez e. coli et souches utiles pour le procede |
| FR2787121B1 (fr) | 1998-12-11 | 2003-09-12 | Aventis Cropscience Sa | Nouvelle methode d'isolement et de selection de genes codant pour des enzymes, et milieu de culture approprie |
| CA2372983A1 (en) | 1999-05-06 | 2000-11-16 | Aventis Animal Nutrition S.A. | Recombinant penicillium funiculosum for homologous and heterologous protein production |
| JP3687497B2 (ja) * | 2000-06-28 | 2005-08-24 | ダイソー株式会社 | 微生物培養法による光学活性１，２−ジオール類の製造法 |
| DE102006025821A1 (de) * | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
| JP2010501516A (ja) | 2006-08-24 | 2010-01-21 | エボニック デグサ ゲーエムベーハー | Ｄ，ｌ−２−ヒドロキシ−４−アルキルチオ酪酸の製造方法 |
| CN1935977B (zh) * | 2006-10-19 | 2010-06-09 | 华东理工大学 | 左旋内酯水解酶产生菌及其用于制备手性羟基酸的方法 |
| VN29801A1 (enExample) | 2009-06-04 | 2012-05-25 | ||
| RU2626531C2 (ru) * | 2010-10-28 | 2017-07-28 | Адиссео Франс С.А.С. | Способ получения 2,4-дигидроксимасляной кислоты |
-
2013
- 2013-04-25 IN IN9529DEN2014 patent/IN2014DN09529A/en unknown
- 2013-04-25 KR KR1020147033085A patent/KR102024109B1/ko active Active
- 2013-04-25 CN CN201380022158.2A patent/CN104254612B/zh active Active
- 2013-04-25 JP JP2015507618A patent/JP6342385B2/ja active Active
- 2013-04-25 ES ES13731871T patent/ES2875010T3/es active Active
- 2013-04-25 US US14/397,315 patent/US9890400B2/en active Active
- 2013-04-25 BR BR112014026149A patent/BR112014026149A2/pt not_active Application Discontinuation
- 2013-04-25 EP EP13731871.3A patent/EP2841584B1/en active Active
- 2013-04-25 WO PCT/IB2013/001071 patent/WO2013160762A2/en not_active Ceased
- 2013-04-25 MY MYPI2014002952A patent/MY175391A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015514433A (ja) | 2015-05-21 |
| WO2013160762A2 (en) | 2013-10-31 |
| JP6342385B2 (ja) | 2018-06-13 |
| WO2013160762A3 (en) | 2014-01-23 |
| KR102024109B1 (ko) | 2019-09-23 |
| BR112014026149A2 (pt) | 2017-07-18 |
| CN104254612B (zh) | 2018-06-01 |
| ES2875010T3 (es) | 2021-11-08 |
| EP2841584B1 (en) | 2021-03-17 |
| EP2841584A2 (en) | 2015-03-04 |
| KR20150013607A (ko) | 2015-02-05 |
| MY175391A (en) | 2020-06-23 |
| US20150159182A1 (en) | 2015-06-11 |
| CN104254612A (zh) | 2014-12-31 |
| US9890400B2 (en) | 2018-02-13 |
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