IN2014DN09529A - - Google Patents

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Publication number
IN2014DN09529A
IN2014DN09529A IN9529DEN2014A IN2014DN09529A IN 2014DN09529 A IN2014DN09529 A IN 2014DN09529A IN 9529DEN2014 A IN9529DEN2014 A IN 9529DEN2014A IN 2014DN09529 A IN2014DN09529 A IN 2014DN09529A
Authority
IN
India
Prior art keywords
coa
dhb
malate
converting
malyl
Prior art date
Application number
Other languages
English (en)
Inventor
Thomas Walther
Clémentine Dressaire
Hélène CORDIER
Jean-Marie Francois
Original Assignee
Adisseo France Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Adisseo France Sas filed Critical Adisseo France Sas
Publication of IN2014DN09529A publication Critical patent/IN2014DN09529A/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0008Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/001Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/13Transferases (2.) transferring sulfur containing groups (2.8)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01002Alcohol dehydrogenase (NADP+) (1.1.1.2), i.e. aldehyde reductase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/010614-Hydroxybutyrate dehydrogenase (1.1.1.61)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y102/00Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01075Malonyl CoA reductase (malonate semialdehyde-forming)(1.2.1.75)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y102/00Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01076Succinate-semialdehyde dehydrogenase (acetylating) (1.2.1.76)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y208/00Transferases transferring sulfur-containing groups (2.8)
    • C12Y208/03CoA-transferases (2.8.3)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y401/00Carbon-carbon lyases (4.1)
    • C12Y401/03Oxo-acid-lyases (4.1.3)
    • C12Y401/03024Malyl-CoA lyase (4.1.3.24)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y602/00Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01Acid-Thiol Ligases (6.2.1)
    • C12Y602/01009Malate--CoA ligase (6.2.1.9)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/52Propionic acid; Butyric acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y103/00Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/01Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
    • C12Y103/010282,3-Dihydro-2,3-dihydroxybenzoate dehydrogenase (1.3.1.28)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
IN9529DEN2014 2012-04-26 2013-04-25 IN2014DN09529A (enExample)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2012001123 2012-04-26
PCT/IB2013/001071 WO2013160762A2 (en) 2012-04-26 2013-04-25 A method of production of 2,4-dihydroxybutyric acid

Publications (1)

Publication Number Publication Date
IN2014DN09529A true IN2014DN09529A (enExample) 2015-07-17

Family

ID=48699857

Family Applications (1)

Application Number Title Priority Date Filing Date
IN9529DEN2014 IN2014DN09529A (enExample) 2012-04-26 2013-04-25

Country Status (10)

Country Link
US (1) US9890400B2 (enExample)
EP (1) EP2841584B1 (enExample)
JP (1) JP6342385B2 (enExample)
KR (1) KR102024109B1 (enExample)
CN (1) CN104254612B (enExample)
BR (1) BR112014026149A2 (enExample)
ES (1) ES2875010T3 (enExample)
IN (1) IN2014DN09529A (enExample)
MY (1) MY175391A (enExample)
WO (1) WO2013160762A2 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10570422B2 (en) * 2012-07-11 2020-02-25 Adisseo France S.A.S. Method for the preparation of 2,4-dihydroxybutyrate
CN103642765B (zh) * 2013-12-25 2015-11-18 南京工业大学 醇脱氢酶突变体及其应用
WO2015155791A2 (en) * 2014-04-11 2015-10-15 String Bio Private Limited Production of succinic acid from organic waste or biogas or methane using recombinant methanotrophic bacterium
WO2016162712A1 (en) 2015-04-07 2016-10-13 Metabolic Explorer Modified microorganism for the optimized production of 2,4-dihydroxyburyrate
EP3280794B1 (en) 2015-04-07 2020-05-27 Metabolic Explorer A modified microorganism for the optimized production of 2,4-dihydroxyburyrate with enhanced 2,4-dihydroxybutyrate efflux
BR112017027815B1 (pt) 2015-06-25 2021-12-21 Dynamic Food Ingredients Corporation Método de produção de 2,4-dihidroxibutirato
CN105441372A (zh) * 2015-10-30 2016-03-30 清华大学 一种重组谷氨酸棒杆菌与应用
TWI773686B (zh) 2016-09-13 2022-08-11 美商愛力根公司 非蛋白梭菌毒素組成物
CN111778200B (zh) * 2019-04-04 2022-11-01 中国科学院微生物研究所 生产L-天冬氨酸的平台菌、基于该平台菌构建的生产β-丙氨酸的重组菌及其构建方法
CN112410389B (zh) * 2019-08-23 2023-07-18 中国科学院微生物研究所 支链α-酮酸脱氢酶复合体在制备丙二酸单酰辅酶A中的应用
CN110713962B (zh) * 2019-09-06 2022-06-21 南京农业大学 一株高产丙二酰辅酶a的基因工程菌及其构建方法和应用
DE102021101004B3 (de) 2021-01-19 2022-03-10 Technische Universität Dresden, Körperschaft des öffentlichen Rechts Verfahren zur Herstellung von 2,4-Dihydroxybutyrat oder L-Threonin unter Nutzung eines mikrobiellen Stoffwechselweges
CN115820616A (zh) * 2022-07-22 2023-03-21 昆明理工大学 一种带荧光标记的噬菌体裂解酶及其应用
US12519499B2 (en) * 2022-10-26 2026-01-06 Hewlett Packard Enterprise Development Lp Short detection and protection circuit for access point
CN115948482B (zh) * 2023-02-07 2024-02-09 中国科学院天津工业生物技术研究所 一种2,4-二羟基丁酸生物合成途径的构建方法及应用
KR102912666B1 (ko) * 2023-03-15 2026-01-15 씨제이제일제당 주식회사 Phb를 생산하는 메탄자화균 및 이를 이용한 phb의 생산방법

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US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
DE3788764T2 (de) 1986-09-16 1994-06-23 Gist Brocades Nv Penicilliumtransformanten und Verfahren zu ihrer Herstellung.
ES2110417T3 (es) 1989-08-09 1998-02-16 Dekalb Genetics Corp Metodos y composiciones para la produccion de plantas de maiz fertiles, transformadas establemente y de sus celulas.
US7705215B1 (en) 1990-04-17 2010-04-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US5693781A (en) 1991-06-03 1997-12-02 Mitsubishi Chemical Corporation Promoter DNA fragment from coryneform bacteria
AU4712193A (en) 1992-08-19 1994-03-15 Alko Group Limited Fungal promoters active in the presence of glucose
FR2734842B1 (fr) 1995-06-02 1998-02-27 Rhone Poulenc Agrochimie Sequence adn d'un gene de l'hydroxy-phenyl pyruvate dioxygenase et obtention de plantes contenant un gene de l'hydroxy-phenyl pyruvate dioxygenase, tolerantes a certains herbicides
FR2736926B1 (fr) 1995-07-19 1997-08-22 Rhone Poulenc Agrochimie 5-enol pyruvylshikimate-3-phosphate synthase mutee, gene codant pour cette proteine et plantes transformees contenant ce gene
FR2780416B1 (fr) 1998-06-10 2002-12-20 Rhone Poulenc Nutrition Animal Procede industriel de production de proteines heterologues chez e. coli et souches utiles pour le procede
FR2787121B1 (fr) 1998-12-11 2003-09-12 Aventis Cropscience Sa Nouvelle methode d'isolement et de selection de genes codant pour des enzymes, et milieu de culture approprie
AU777674B2 (en) 1999-05-06 2004-10-28 Adisseo France S.A.S. Recombinant Penicillium Funiculosum for homologous and heterologous protein production
JP3687497B2 (ja) * 2000-06-28 2005-08-24 ダイソー株式会社 微生物培養法による光学活性1,2−ジオール類の製造法
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US20090318715A1 (en) 2006-08-24 2009-12-24 Patrick Deck Method for the Production of D,L-2-Hydroxy-4-Alkylthio Butyric Acid
CN1935977B (zh) * 2006-10-19 2010-06-09 华东理工大学 左旋内酯水解酶产生菌及其用于制备手性羟基酸的方法
MY187676A (en) 2009-06-04 2021-10-08 Genomatica Inc Microorganisms for the production of 1,4-butanediol and related methods
KR101990014B1 (ko) * 2010-10-28 2019-06-17 아디쎄오 프랑스 에스에이에스 2,4-디하이드록시부티르산의 제조 방법

Also Published As

Publication number Publication date
US20150159182A1 (en) 2015-06-11
US9890400B2 (en) 2018-02-13
JP6342385B2 (ja) 2018-06-13
CN104254612B (zh) 2018-06-01
WO2013160762A3 (en) 2014-01-23
EP2841584B1 (en) 2021-03-17
JP2015514433A (ja) 2015-05-21
MY175391A (en) 2020-06-23
EP2841584A2 (en) 2015-03-04
ES2875010T3 (es) 2021-11-08
CN104254612A (zh) 2014-12-31
BR112014026149A2 (pt) 2017-07-18
WO2013160762A2 (en) 2013-10-31
KR20150013607A (ko) 2015-02-05
KR102024109B1 (ko) 2019-09-23

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