WO2018093223A3 - 엘더칼시톨의 제조방법 및 그를 위한 중간체 - Google Patents

엘더칼시톨의 제조방법 및 그를 위한 중간체 Download PDF

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Publication number
WO2018093223A3
WO2018093223A3 PCT/KR2017/013209 KR2017013209W WO2018093223A3 WO 2018093223 A3 WO2018093223 A3 WO 2018093223A3 KR 2017013209 W KR2017013209 W KR 2017013209W WO 2018093223 A3 WO2018093223 A3 WO 2018093223A3
Authority
WO
WIPO (PCT)
Prior art keywords
eldecalcitol
preparing
intermediate therefor
present
therefor
Prior art date
Application number
PCT/KR2017/013209
Other languages
English (en)
French (fr)
Other versions
WO2018093223A2 (ko
Inventor
이승종
문형욱
고은정
신현익
이기영
오창영
Original Assignee
연성정밀화학(주)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 연성정밀화학(주) filed Critical 연성정밀화학(주)
Priority to CN201780071892.6A priority Critical patent/CN109982992B/zh
Priority to JP2019542342A priority patent/JP6775809B2/ja
Publication of WO2018093223A2 publication Critical patent/WO2018093223A2/ko
Publication of WO2018093223A3 publication Critical patent/WO2018093223A3/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/196—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 엘더칼시톨의 제조방법 및 그에 사용되는 중간체에 관한 것이다, 본 발명의 제조방법에 따르면, 엘더칼시톨을 복잡하고 긴 제조 과정을 거치지 않고, 효율적이고 경제적으로 제조할 수 있다.
PCT/KR2017/013209 2016-11-21 2017-11-20 엘더칼시톨의 제조방법 및 그를 위한 중간체 WO2018093223A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201780071892.6A CN109982992B (zh) 2016-11-21 2017-11-20 艾地骨化醇的制备方法及用于其的中间体
JP2019542342A JP6775809B2 (ja) 2016-11-21 2017-11-20 エルデカルシトールの製造方法及びそのための中間体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020160155127A KR101884729B1 (ko) 2016-11-21 2016-11-21 엘더칼시톨의 제조방법 및 그를 위한 중간체
KR10-2016-0155127 2016-11-21

Publications (2)

Publication Number Publication Date
WO2018093223A2 WO2018093223A2 (ko) 2018-05-24
WO2018093223A3 true WO2018093223A3 (ko) 2018-07-12

Family

ID=62146692

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2017/013209 WO2018093223A2 (ko) 2016-11-21 2017-11-20 엘더칼시톨의 제조방법 및 그를 위한 중간체

Country Status (4)

Country Link
JP (2) JP6775809B2 (ko)
KR (1) KR101884729B1 (ko)
CN (1) CN109982992B (ko)
WO (1) WO2018093223A2 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7421573B2 (ja) 2019-05-13 2024-01-24 ファエス・ファルマ・ソシエダッド・アノニマ エルデカルシトールを調製するための方法および中間体
CN113105495A (zh) * 2020-01-09 2021-07-13 成都必凯科技有限公司 一种艾尔骨化醇a环中间体的制备方法
CN112094291A (zh) * 2020-08-14 2020-12-18 甘肃皓天医药科技有限责任公司 一种艾地骨化醇a环中间体的合成方法
CN113651845A (zh) * 2021-08-03 2021-11-16 甘肃皓天医药科技有限责任公司 一种骨化二醇中间体a环的制备方法
CN114656384A (zh) * 2022-04-20 2022-06-24 正大制药（青岛）有限公司 一种艾地骨化醇20s异构体的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5334740A (en) * 1991-03-13 1994-08-02 Kurary Co., Ltd. Cyclohexanetriol derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009013154A (ja) 2006-09-29 2009-01-22 Teijin Pharma Ltd ２−置換−１４−エピ−プレビタミンｄ３誘導体
AU2014257745B2 (en) 2013-04-22 2018-10-04 Ascendis Pharma A/S Hydrogel-linked prodrugs releasing modified drugs
JP6946182B2 (ja) 2014-10-22 2021-10-06 エクステンド バイオサイエンシズ インコーポレーテッドＥｘｔｅｎｄ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ 治療用ビタミンｄコンジュゲート

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5334740A (en) * 1991-03-13 1994-08-02 Kurary Co., Ltd. Cyclohexanetriol derivatives

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HATAKEYAMA S. ET AL.: "Synthesis and Biological Evaluation of a 3-positon Epimer of 1alpha,25-Dihydroxy-2beta-(3-hydroxypropoxy)vitamine D3 (ED-71)", JOURNAL OF STEROID BIOCHEMISTRY & MOLECULAR BIOLOGY, vol. 103, no. 3-5, 15 March 2007 (2007-03-15), pages 222 - 226, XP005924317 *
KUBODERA, N.: "Search for and Development of Active Vitamin D3 Analogues", CHEMINFORM, vol. 63, no. 7, 13 December 2005 (2005-12-13), pages 728 - 738, XP055511004 *
MAEYAMA, J. ET AL.: "Two Convergent Approaches to the Synthesis of 1alpha,25-Dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 (ED-71) by the Lythgoe and the Trost Coupling Reactions", HETEROCYCLES, vol. 70, no. 1, 2006, pages 295 - 307 *
ZHAO, G.-D. ET AL.: "Structural Revisions of the Reported A-ring Phosphine Oxide Synthon for ED-71 (Eldecalcitol) and a New Synthesis", TETRAHEDRON, vol. 71, no. 42, 1 October 2015 (2015-10-01), pages 8033 - 8040, XP055511011 *

Also Published As

Publication number Publication date
JP6775809B2 (ja) 2020-10-28
JP2020189844A (ja) 2020-11-26
JP2019536814A (ja) 2019-12-19
KR101884729B1 (ko) 2018-08-02
KR20180057033A (ko) 2018-05-30
JP7072273B2 (ja) 2022-05-20
WO2018093223A2 (ko) 2018-05-24
CN109982992A (zh) 2019-07-05
CN109982992B (zh) 2022-05-17

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