IN2013MN01438A - - Google Patents
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- Publication number
- IN2013MN01438A IN2013MN01438A IN1438MUN2013A IN2013MN01438A IN 2013MN01438 A IN2013MN01438 A IN 2013MN01438A IN 1438MUN2013 A IN1438MUN2013 A IN 1438MUN2013A IN 2013MN01438 A IN2013MN01438 A IN 2013MN01438A
- Authority
- IN
- India
- Prior art keywords
- heavy chains
- covalent link
- identical heavy
- region
- fab region
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161453591P | 2011-03-17 | 2011-03-17 | |
PCT/IL2012/050093 WO2012123949A1 (en) | 2011-03-17 | 2012-03-15 | Bi- and monospecific, asymmetric antibodies and methods of generating the same |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2013MN01438A true IN2013MN01438A (pl) | 2015-06-12 |
Family
ID=45999923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN1438MUN2013 IN2013MN01438A (pl) | 2011-03-17 | 2012-03-15 |
Country Status (11)
Country | Link |
---|---|
US (2) | US9624291B2 (pl) |
EP (1) | EP2686348B1 (pl) |
JP (1) | JP2014510084A (pl) |
KR (1) | KR20140019385A (pl) |
CN (1) | CN103429619B (pl) |
AU (1) | AU2012227883A1 (pl) |
BR (1) | BR112013023653A2 (pl) |
CA (1) | CA2827188C (pl) |
IN (1) | IN2013MN01438A (pl) |
MX (1) | MX342135B (pl) |
WO (1) | WO2012123949A1 (pl) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
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KR20130097156A (ko) | 2010-07-26 | 2013-09-02 | 트리아니, 인코포레이티드 | 트랜스제닉 동물 및 이의 사용 방법 |
US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
IN2013MN01438A (pl) | 2011-03-17 | 2015-06-12 | Univ Ramot | |
US9465889B2 (en) * | 2012-07-05 | 2016-10-11 | Physion Consulting, LLC | Method and system for identifying data and users of interest from patterns of user interaction with existing data |
CN104271602B (zh) | 2012-11-21 | 2020-08-21 | 武汉友芝友生物制药有限公司 | 双特异性抗体 |
CN104995341B (zh) * | 2013-01-24 | 2018-09-07 | 埃布特拉斯有限公司 | 基于蛋白结合的fv文库及其制备方法 |
AU2013378122B2 (en) * | 2013-02-15 | 2019-05-02 | R-Pharm International, Limited Liability Company | IL-1beta inhibitor composition and use thereof |
EP2975061A4 (en) * | 2013-03-13 | 2017-03-01 | Ibentrus Inc. | Protein in which electrical interaction is introduced within hydrophobic interaction site and preparation method therefor |
PT3083689T (pt) | 2013-12-17 | 2020-08-27 | Genentech Inc | Anticorpos anti-cd3 e métodos de utilização |
CN105992772A (zh) * | 2014-02-10 | 2016-10-05 | Igm生命科学股份有限公司 | IgA多特异性结合分子 |
CN111499753B (zh) * | 2014-03-03 | 2022-10-21 | 高雄医学大学 | 双功能抗体及其用途 |
US20170022291A1 (en) | 2014-04-01 | 2017-01-26 | Adimab, Llc | Multispecific antibody analogs comprising a common light chain, and methods of their preparation and use |
BR112016024780A2 (pt) | 2014-05-02 | 2017-10-10 | Momenta Pharmaceutical Inc | composições e métodos relacionados com construtos de fc manipulados |
RU2016151645A (ru) | 2014-07-01 | 2018-08-03 | Пфайзер Инк. | Биспецифические гетеродимерные диантитела и их применение |
WO2016080510A1 (ja) | 2014-11-21 | 2016-05-26 | アステラス製薬株式会社 | 新規二重特異的抗体フォーマット |
EP3916018A1 (en) | 2015-06-16 | 2021-12-01 | Genentech, Inc. | Anti-cd3 antibodies and methods of use |
JP2018525007A (ja) * | 2015-08-24 | 2018-09-06 | トリアンニ インコーポレイテッドTrianni,Inc. | 免疫グロブリンの産生増強 |
CN108602887B (zh) * | 2015-10-02 | 2022-06-21 | 豪夫迈·罗氏有限公司 | 对共刺激性tnf受体特异性的双特异性抗体 |
WO2017095939A1 (en) | 2015-12-03 | 2017-06-08 | Trianni, Inc. | Enhanced immunoglobulin diversity |
IL260743B2 (en) | 2016-02-04 | 2024-03-01 | Trianni Inc | Advanced production of antibodies |
JP7045333B6 (ja) | 2016-05-23 | 2022-05-06 | モメンタ ファーマシューティカルズ インコーポレイテッド | 操作されたFcコンストラクトに関する組成物及び方法 |
WO2017205014A1 (en) | 2016-05-26 | 2017-11-30 | Qilu Puget Sound Biotherapeutics Corporation | Mixtures of antibodies |
AU2017293778B2 (en) * | 2016-07-07 | 2022-03-24 | Acceleron Pharma Inc. | TGF-beta superfamily heteromultimers and uses thereof |
US20230075499A1 (en) | 2016-07-19 | 2023-03-09 | Ibentrus, Inc. | Bispecific proteins and methods for preparing same |
WO2018089293A2 (en) | 2016-11-08 | 2018-05-17 | Qilu Puget Sound Biotherapeutics Corporation | Anti-pd1 and anti-ctla4 antibodies |
CN106496331B (zh) * | 2016-11-08 | 2020-03-13 | 北京智岭生物医药科技有限公司 | 一种FSH-Fc融合蛋白及其制备方法和用途 |
KR20240029119A (ko) | 2016-11-15 | 2024-03-05 | 제넨테크, 인크. | 항-cd20/항-cd3 이중특이적 항체에 의한 치료를 위한 투약 |
WO2018129255A1 (en) | 2017-01-06 | 2018-07-12 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered fc constructs |
UY37758A (es) | 2017-06-12 | 2019-01-31 | Novartis Ag | Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos |
AU2019218959A1 (en) | 2018-02-08 | 2020-09-03 | Genentech, Inc. | Bispecific antigen-binding molecules and methods of use |
TW202016151A (zh) | 2018-06-09 | 2020-05-01 | 德商百靈佳殷格翰國際股份有限公司 | 針對癌症治療之多特異性結合蛋白 |
WO2020135804A1 (zh) * | 2018-12-29 | 2020-07-02 | 上海一宸医药科技有限公司 | 异源二聚体融合蛋白 |
CN117417448A (zh) | 2019-12-13 | 2024-01-19 | 基因泰克公司 | 抗ly6g6d抗体及使用方法 |
CN113480645B (zh) * | 2021-07-16 | 2022-11-11 | 甘肃中科博瑞生物工程有限公司 | 一种抗幽门螺旋杆菌重组抗体、制备方法及用途 |
TW202406571A (zh) | 2022-04-13 | 2024-02-16 | 美商建南德克公司 | 莫蘇妥珠單抗之醫藥組成物及其使用方法 |
CN116789836B (zh) * | 2023-08-14 | 2024-01-05 | 浙江时迈药业有限公司 | 针对dll3的抗体及其用途 |
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IN2013MN01438A (pl) | 2011-03-17 | 2015-06-12 | Univ Ramot |
-
2012
- 2012-03-15 IN IN1438MUN2013 patent/IN2013MN01438A/en unknown
- 2012-03-15 AU AU2012227883A patent/AU2012227883A1/en not_active Abandoned
- 2012-03-15 CA CA2827188A patent/CA2827188C/en active Active
- 2012-03-15 US US14/005,580 patent/US9624291B2/en active Active
- 2012-03-15 WO PCT/IL2012/050093 patent/WO2012123949A1/en active Application Filing
- 2012-03-15 JP JP2013558572A patent/JP2014510084A/ja active Pending
- 2012-03-15 KR KR1020137027330A patent/KR20140019385A/ko not_active Application Discontinuation
- 2012-03-15 BR BR112013023653A patent/BR112013023653A2/pt not_active IP Right Cessation
- 2012-03-15 EP EP12716657.7A patent/EP2686348B1/en active Active
- 2012-03-15 MX MX2013010590A patent/MX342135B/es active IP Right Grant
- 2012-03-15 CN CN201280013666.XA patent/CN103429619B/zh active Active
-
2017
- 2017-03-02 US US15/447,244 patent/US10822428B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2827188A1 (en) | 2012-09-20 |
CN103429619B (zh) | 2017-07-28 |
AU2012227883A8 (en) | 2013-11-07 |
EP2686348A1 (en) | 2014-01-22 |
US10822428B2 (en) | 2020-11-03 |
CA2827188C (en) | 2020-02-11 |
MX342135B (es) | 2016-09-14 |
KR20140019385A (ko) | 2014-02-14 |
MX2013010590A (es) | 2014-05-27 |
US9624291B2 (en) | 2017-04-18 |
BR112013023653A2 (pt) | 2016-12-13 |
JP2014510084A (ja) | 2014-04-24 |
US20170174791A1 (en) | 2017-06-22 |
CN103429619A (zh) | 2013-12-04 |
US20140010814A1 (en) | 2014-01-09 |
EP2686348B1 (en) | 2015-12-30 |
AU2012227883A1 (en) | 2013-10-24 |
WO2012123949A8 (en) | 2013-03-14 |
WO2012123949A1 (en) | 2012-09-20 |
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