IN2012DN06631A - - Google Patents
Info
- Publication number
- IN2012DN06631A IN2012DN06631A IN6631DEN2012A IN2012DN06631A IN 2012DN06631 A IN2012DN06631 A IN 2012DN06631A IN 6631DEN2012 A IN6631DEN2012 A IN 6631DEN2012A IN 2012DN06631 A IN2012DN06631 A IN 2012DN06631A
- Authority
- IN
- India
- Prior art keywords
- yloxy
- methyl
- isoxazol
- pyran
- piperidin
- Prior art date
Links
- WLLOFQROROXOMO-GOSISDBHSA-N 4-[[4-[[4-[(3r)-oxolan-3-yl]oxy-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxan-4-ol Chemical compound C1CC(COC=2C3=C(O[C@H]4COCC4)C=CC=C3ON=2)CCN1CC1(O)CCOCC1 WLLOFQROROXOMO-GOSISDBHSA-N 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30492110P | 2010-02-16 | 2010-02-16 | |
| PCT/IB2011/050548 WO2011101774A1 (en) | 2010-02-16 | 2011-02-09 | (r)-4-((4-((4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2h-pyran-4-ol, a partial agonist of 5-ht4 receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN06631A true IN2012DN06631A (cs) | 2015-10-23 |
Family
ID=43904611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN6631DEN2012 IN2012DN06631A (cs) | 2010-02-16 | 2011-02-09 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20120041026A1 (cs) |
| EP (1) | EP2536713A1 (cs) |
| JP (1) | JP2013519722A (cs) |
| KR (1) | KR20120123089A (cs) |
| CN (1) | CN102762554A (cs) |
| AR (1) | AR080172A1 (cs) |
| AU (1) | AU2011216950A1 (cs) |
| CA (1) | CA2788656A1 (cs) |
| IN (1) | IN2012DN06631A (cs) |
| MX (1) | MX2012008721A (cs) |
| SG (1) | SG183111A1 (cs) |
| TW (1) | TW201141856A (cs) |
| UY (1) | UY33225A (cs) |
| WO (1) | WO2011101774A1 (cs) |
| ZA (1) | ZA201206469B (cs) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| US10583138B2 (en) | 2012-07-12 | 2020-03-10 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| CA2836372C (en) * | 2011-05-18 | 2020-09-22 | Raqualia Pharma Inc. | Polymorph form of 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}-tetrahydro-2h-pyran-4-carboxylic acid |
| CN104837836B (zh) * | 2012-11-21 | 2018-07-03 | 拉夸里亚创药株式会社 | 多晶型物 |
| MX364929B (es) | 2013-03-20 | 2019-05-14 | Suven Life Sciences Ltd | Derivados de la 5-amino-quinolina-8-carboxamida como agonistas del receptor 5-ht4. |
| CA2932428C (en) | 2013-12-16 | 2017-10-24 | Suven Life Sciences Limited | Indazole compounds as 5-ht4 receptor agonists |
| ES2747989T3 (es) * | 2014-05-20 | 2020-03-12 | Raqualia Pharma Inc | Sal de derivado de benzisoxazol |
| EP3265459B1 (en) | 2015-02-13 | 2019-05-15 | Suven Life Sciences Limited | Amide compounds as 5-ht4 receptor agonists |
| CN117796401A (zh) * | 2023-12-25 | 2024-04-02 | 江苏万隆化学有限公司 | 一种含2-羟基-6-氟苯甲酸甲酯中间体抗菌剂的制备工艺 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0573562B1 (en) | 1991-02-27 | 1996-04-24 | Merrell Pharmaceuticals Inc. | Dihydroquinoline NMDA antagonists |
| US5750542A (en) * | 1993-09-28 | 1998-05-12 | Pfizer | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors |
| NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| JP3462501B2 (ja) * | 1992-11-23 | 2003-11-05 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | 置換された３−（アミノアルキルアミノ）−１，２−ベンゾイソキサゾールおよび関連化合物 |
| US5889006A (en) | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
| IL117149A0 (en) | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
| KR100464895B1 (ko) | 1995-09-29 | 2005-05-16 | 글락소 웰컴 에스피에이 | Nmda길항제로서의테트라히드로퀴놀린 |
| IL126003A0 (en) | 1996-04-10 | 1999-04-11 | Hoechst Marion Roussel Inc | Spiro [cyclopent [b] indole-piperidines] and n-[phenyl-hydrazon intermediates for their preparation both being acetyl cholinesterase and mao inhibitors |
| CA2252039C (en) | 1996-04-12 | 2002-12-24 | Hoechst Marion Roussel, Inc. | Isatin derivatives as acetylcholinesterase inhibitors and analgesics |
| NZ333322A (en) | 1996-07-01 | 2000-06-23 | Schering Corp | Di-N-substituted piperazines and 1,4-di-substituted piperidines as muscarinic antagonists |
| CA2263167C (en) | 1996-08-15 | 2006-02-14 | Schering Corporation | Ether muscarinic antagonists |
| IL129187A0 (en) | 1996-09-30 | 2000-02-17 | Hoechst Marion Roussel Inc | NMDA (N-methyl-D-aspartate) antagonists |
| CN1535682A (zh) | 1998-09-30 | 2004-10-13 | ����ҩƷ��ҵ��ʽ���� | 改善膀胱排泄能力的药物 |
| ES2299561T3 (es) | 2001-01-26 | 2008-06-01 | Btg International Limited | Analogo de bencilamina. |
| AU2002250256B2 (en) | 2001-03-08 | 2008-04-03 | Emory University | pH-dependent NMDA receptor antagonists |
| WO2002080928A1 (en) | 2001-04-03 | 2002-10-17 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists |
| JP4322113B2 (ja) | 2001-07-24 | 2009-08-26 | リチュテル・ゲデオン・ヴェジェーセティ・ジャール・ニュイルヴァーノシャン・ミューコェデー・レースヴェーニュタールシャシャーグ | 新規カルボン酸アミド化合物 |
| KR20060017839A (ko) | 2003-06-04 | 2006-02-27 | 머크 앤드 캄파니 인코포레이티드 | Ｎｍｄａ／ｎｒ2ｂ 길항제로서 3-플루오로-피페리딘 |
| GB0316094D0 (en) | 2003-07-09 | 2003-08-13 | Neuropharma Sa | Acetylcholinesterase dual inhibitors |
| MXPA06009898A (es) * | 2004-03-03 | 2008-02-07 | Revance Therapeutics Inc | Composiciones y metodos para la aplicacion topica y suministro transdermico de toxinas botulinicas. |
| HU227119B1 (en) | 2004-07-29 | 2010-07-28 | Richter Gedeon Nyrt | Indole and benzimidazole carboxylic acid amide derivatives and pharmaceutical compositions containing them |
| HU227000B1 (en) | 2004-07-29 | 2010-04-28 | Richter Gedeon Nyrt | Nmda receptor antagonist benzoyl urea derivatives, and pharmaceutical compositions containing them |
| HUP0401522A2 (en) | 2004-07-29 | 2006-04-28 | Richter Gedeon Vegyeszet | New 4-benzylidene-piperidine derivatives, pharmaceutical compositions containing the same and process for their preparation |
| HUP0401523A3 (en) | 2004-07-29 | 2007-05-02 | Richter Gedeon Vegyeszet | Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them |
| HU226977B1 (en) | 2004-07-29 | 2010-04-28 | Richter Gedeon Nyrt | Kynurenic acid amide derivatives, pharmaceutical compositions containing them and process for producing them |
| TW200621677A (en) | 2004-09-21 | 2006-07-01 | Astellas Pharma Inc | Cyclic amine derivative or salt thereof |
| AU2004324030B2 (en) | 2004-10-15 | 2012-09-06 | Universidade Estadual Paulista-Unesp | Piperidinic derivatives, pharmaceutic compositions containing the same and preparation processes |
| ES2523459T3 (es) * | 2005-02-25 | 2014-11-26 | Raqualia Pharma Inc | Derivados de benzisoxazol |
| US20090124600A1 (en) | 2005-04-19 | 2009-05-14 | Layton Mark E | N-Alkyl-Azacycloalkyl NMDA/NR2B Antagonists |
| WO2007016357A1 (en) | 2005-07-29 | 2007-02-08 | Regents Of The University Of Minnesota | Amyloid beta receptor and uses thereof |
| CN101437510B (zh) | 2006-03-20 | 2012-12-05 | 科学与工业研究会 | 用作乙酰胆碱酯酶抑制剂的药物组合物 |
| ES2288406B1 (es) | 2006-04-20 | 2008-12-16 | Universidad De Barcelona | Compuestos inhibidores de acetilcolinesterasa para el tratamiento de la enfermedad de alzheimer. |
| ATE502026T1 (de) | 2006-12-20 | 2011-04-15 | Abbott Healthcare Products Bv | Verbindungen mit kombinierten cannabinoid-cb1- antagonismus und acetylcholinesterasehemmung |
| US7605265B2 (en) | 2007-01-22 | 2009-10-20 | Biotechnology Research Corporation Ltd. | Heterodimers and methods of using them |
| MX370608B (es) | 2007-05-01 | 2019-12-18 | Concert Pharmaceuticals Inc | Compuestos de morfinano. |
| CN101730706B (zh) | 2007-05-11 | 2015-04-15 | 生物科技研究有限公司 | 具有神经保护和增强记忆活性的受体拮抗剂 |
| WO2009006437A1 (en) | 2007-06-29 | 2009-01-08 | Emory University | Nmda receptor antagonists for neuroprotection |
| US8129428B2 (en) | 2007-09-12 | 2012-03-06 | Virginia Tech Intellectual Properties, Inc. | Insecticidal carbamates exhibiting species-selective inhibition of acetylcholinesterase (AChE) |
| WO2009092324A1 (en) | 2008-01-16 | 2009-07-30 | Hong Kong University Of Science And Technology | Oxazolidine derivatives as nmda antagonists |
| EA014100B1 (ru) | 2008-02-21 | 2010-08-30 | Общество С Ограниченной Ответственностью "Валексфарм" | Производные 2,4-диаминопиридина, фармацевтическая композиция, лекарственное средство на их основе для лечения или предупреждения заболеваний и нарушений, вызванных гиперактивацией nmda-рецепторов и/или в качестве стимуляторов когнитивных функций и способ лечения |
| CN101440061B (zh) | 2008-04-08 | 2010-12-08 | 温州医学院 | 一类具有抑制乙酰胆碱酯酶活性的芳基吡啶酮类衍生物 |
| WO2009129181A1 (en) | 2008-04-14 | 2009-10-22 | Concert Pharmaceuticals Inc. | Propanediol-dicarbamate derivatives |
| JP2011520815A (ja) | 2008-05-09 | 2011-07-21 | エモリー・ユニバーシテイ | 精神神経障害治療のためのｎｍｄａ受容体拮抗薬 |
-
2011
- 2011-02-09 IN IN6631DEN2012 patent/IN2012DN06631A/en unknown
- 2011-02-09 WO PCT/IB2011/050548 patent/WO2011101774A1/en not_active Ceased
- 2011-02-09 KR KR1020127021310A patent/KR20120123089A/ko not_active Ceased
- 2011-02-09 CN CN2011800099647A patent/CN102762554A/zh active Pending
- 2011-02-09 CA CA2788656A patent/CA2788656A1/en not_active Abandoned
- 2011-02-09 AU AU2011216950A patent/AU2011216950A1/en not_active Abandoned
- 2011-02-09 JP JP2012553423A patent/JP2013519722A/ja not_active Withdrawn
- 2011-02-09 EP EP11710564A patent/EP2536713A1/en not_active Withdrawn
- 2011-02-09 MX MX2012008721A patent/MX2012008721A/es not_active Application Discontinuation
- 2011-02-09 SG SG2012053906A patent/SG183111A1/en unknown
- 2011-02-14 AR ARP110100443A patent/AR080172A1/es not_active Application Discontinuation
- 2011-02-14 UY UY0001033225A patent/UY33225A/es not_active Application Discontinuation
- 2011-02-15 TW TW100104942A patent/TW201141856A/zh unknown
- 2011-02-16 US US13/028,368 patent/US20120041026A1/en not_active Abandoned
-
2012
- 2012-08-28 ZA ZA2012/06469A patent/ZA201206469B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20120123089A (ko) | 2012-11-07 |
| CN102762554A (zh) | 2012-10-31 |
| UY33225A (es) | 2011-09-30 |
| AR080172A1 (es) | 2012-03-21 |
| EP2536713A1 (en) | 2012-12-26 |
| TW201141856A (en) | 2011-12-01 |
| MX2012008721A (es) | 2012-08-17 |
| AU2011216950A1 (en) | 2012-08-23 |
| SG183111A1 (en) | 2012-09-27 |
| JP2013519722A (ja) | 2013-05-30 |
| WO2011101774A1 (en) | 2011-08-25 |
| ZA201206469B (en) | 2013-05-29 |
| CA2788656A1 (en) | 2011-08-25 |
| US20120041026A1 (en) | 2012-02-16 |
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