IN2012DN01938A - - Google Patents

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Publication number
IN2012DN01938A
IN2012DN01938A IN1938DEN2012A IN2012DN01938A IN 2012DN01938 A IN2012DN01938 A IN 2012DN01938A IN 1938DEN2012 A IN1938DEN2012 A IN 1938DEN2012A IN 2012DN01938 A IN2012DN01938 A IN 2012DN01938A
Authority
IN
India
Application number
Other languages
English (en)
Inventor
Carmen Boix Bernardini Maria
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of IN2012DN01938A publication Critical patent/IN2012DN01938A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79Acids; Esters
    • C07D213/80Acids; Esters in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79Acids; Esters
    • C07D213/803Processes of preparation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IN1938DEN2012 2009-10-16 2012-03-05 IN2012DN01938A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09382212A EP2314577A1 (en) 2009-10-16 2009-10-16 Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid
PCT/EP2010/006283 WO2011045059A1 (en) 2009-10-16 2010-10-14 Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid

Publications (1)

Publication Number Publication Date
IN2012DN01938A true IN2012DN01938A (es) 2015-08-21

Family

ID=41402565

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1938DEN2012 IN2012DN01938A (es) 2009-10-16 2012-03-05

Country Status (32)

Country Link
US (1) US8598363B2 (es)
EP (2) EP2314577A1 (es)
JP (1) JP5809630B2 (es)
KR (1) KR101699999B1 (es)
CN (2) CN102574800B (es)
AU (1) AU2010306098B2 (es)
BR (1) BR112012008464B1 (es)
CA (1) CA2776328C (es)
CL (1) CL2012000739A1 (es)
CO (1) CO6430508A2 (es)
CR (1) CR20120185A (es)
CY (1) CY1115161T1 (es)
DK (1) DK2488497T3 (es)
EA (1) EA022805B1 (es)
ES (1) ES2467165T3 (es)
HK (1) HK1168101A1 (es)
HR (1) HRP20140523T1 (es)
IL (1) IL218446A (es)
IN (1) IN2012DN01938A (es)
ME (1) ME01812B (es)
MX (1) MX2012004033A (es)
MY (1) MY160308A (es)
NZ (1) NZ598429A (es)
PE (1) PE20121173A1 (es)
PL (1) PL2488497T3 (es)
PT (1) PT2488497E (es)
RS (1) RS53319B (es)
SI (1) SI2488497T1 (es)
SM (1) SMT201400064B (es)
UA (1) UA107811C2 (es)
WO (1) WO2011045059A1 (es)
ZA (1) ZA201201563B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2319596B1 (es) 2006-12-22 2010-02-08 Laboratorios Almirall S.A. Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.
UY31272A1 (es) 2007-08-10 2009-01-30 Almirall Lab Nuevos derivados de ácido azabifenilaminobenzoico
EP2135610A1 (en) 2008-06-20 2009-12-23 Laboratorios Almirall, S.A. Combination comprising DHODH inhibitors and methotrexate
EP2239256A1 (en) 2009-03-13 2010-10-13 Almirall, S.A. Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor
JP7343373B2 (ja) * 2019-12-02 2023-09-12 花王株式会社 香料組成物

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE209518T1 (de) 1995-06-21 2001-12-15 Asta Medica Ag Arzneipulverkartusche mit integrierter dosiereinrichtung, sowie pulverinhalator
DE19547648A1 (de) 1995-12-20 1997-06-26 Hoechst Ag Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate
DE19610955A1 (de) 1996-03-20 1997-09-25 Hoechst Ag Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid
GB9804343D0 (en) 1998-02-27 1998-04-22 Univ Cardiff Chemical compounds
EP1225886A2 (en) 1999-06-10 2002-07-31 Warner-Lambert Company Method of inhibiting amyloid protein aggregation and imaging amyloid deposits
SI1381356T1 (sl) 2001-04-05 2008-12-31 Aventis Pharma Inc Uporaba (Z)-2-ciano-3-hidroksi-but-2-enojska kislina-(4'-trifluorometilfenil)-amida za zdravljenje multiple skleroze
WO2002102374A1 (en) 2001-06-19 2002-12-27 Merck & Co., Inc. Amine salt of an integrin receptor antagonist
DE10129703A1 (de) 2001-06-22 2003-01-02 Sofotec Gmbh & Co Kg Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren
WO2003006424A1 (en) 2001-07-10 2003-01-23 4Sc Ag Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
DE10202940A1 (de) 2002-01-24 2003-07-31 Sofotec Gmbh & Co Kg Patrone für einen Pulverinhalator
US7258118B2 (en) 2002-01-24 2007-08-21 Sofotec Gmbh & Co, Kg Pharmaceutical powder cartridge, and inhaler equipped with same
KR20040081201A (ko) * 2002-02-13 2004-09-20 글락소 그룹 리미티드 항정신병제로서 벤젠술폰아미드 유도체
US20070135488A1 (en) * 2002-04-13 2007-06-14 Chung You S Amlodipine nicotinate and process for the preparation thereof
AR042206A1 (es) * 2002-11-26 2005-06-15 Novartis Ag Acidos fenilaceticos y derivados
WO2004056747A1 (en) 2002-12-23 2004-07-08 4Sc Ag Dhodh-inhibitors and method for their identification
US7071355B2 (en) 2002-12-23 2006-07-04 4 Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
SE0400234D0 (sv) 2004-02-06 2004-02-06 Active Biotech Ab New compounds, methods for their preparation and use thereof
CN1993125A (zh) 2004-05-21 2007-07-04 Uab研究基金会 涉及嘧啶合成抑制剂的组合物和方法
WO2006022442A1 (ja) 2004-08-24 2006-03-02 Santen Pharmaceutical Co., Ltd. ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体
EP1804782A1 (en) 2004-10-19 2007-07-11 Aventis Pharmaceuticals Inc. Use of (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating inflammatory bowel disease
ES2265276B1 (es) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
CN1696100B (zh) * 2005-06-01 2010-11-24 黑龙江福和华星制药集团股份有限公司 痤疮治疗药阿达帕林的新型简捷合成方法
ES2319596B1 (es) 2006-12-22 2010-02-08 Laboratorios Almirall S.A. Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.
ATE508108T1 (de) 2007-02-06 2011-05-15 Chelsea Therapeutics Inc Neue verbindungen, verfahren zu deren herstellung und deren verwendung
UY31272A1 (es) 2007-08-10 2009-01-30 Almirall Lab Nuevos derivados de ácido azabifenilaminobenzoico
EP2135610A1 (en) 2008-06-20 2009-12-23 Laboratorios Almirall, S.A. Combination comprising DHODH inhibitors and methotrexate
EP2210615A1 (en) 2009-01-21 2010-07-28 Almirall, S.A. Combinations comprising methotrexate and DHODH inhibitors
EP2230232A1 (en) 2009-03-13 2010-09-22 Almirall, S.A. Addition salts of tromethamine with azabiphenylaminobenzoic acid derivatives as DHODH inhibitors
EP2239256A1 (en) 2009-03-13 2010-10-13 Almirall, S.A. Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor
EP2228367A1 (en) 2009-03-13 2010-09-15 Almirall, S.A. Addition salts of amines containing hydroxyl and/or carboxylic groups with amino nicotinic acid derivatives as DHODH inhibitors

Also Published As

Publication number Publication date
EP2488497B1 (en) 2014-03-12
DK2488497T3 (da) 2014-06-10
BR112012008464A2 (pt) 2015-09-22
RS53319B (en) 2014-10-31
JP2013507407A (ja) 2013-03-04
IL218446A0 (en) 2012-04-30
PL2488497T3 (pl) 2014-07-31
CA2776328C (en) 2017-08-08
EA022805B1 (ru) 2016-03-31
PT2488497E (pt) 2014-05-28
MX2012004033A (es) 2012-05-08
HRP20140523T1 (hr) 2014-07-04
CY1115161T1 (el) 2016-12-14
UA107811C2 (en) 2015-02-25
ES2467165T3 (es) 2014-06-12
SMT201400064B (it) 2014-07-07
AU2010306098B2 (en) 2015-10-15
CN102574800A (zh) 2012-07-11
PE20121173A1 (es) 2012-08-30
US20120245359A1 (en) 2012-09-27
CN103936668A (zh) 2014-07-23
CL2012000739A1 (es) 2012-10-12
HK1168101A1 (en) 2012-12-21
CO6430508A2 (es) 2012-04-30
WO2011045059A1 (en) 2011-04-21
IL218446A (en) 2014-08-31
EP2488497A1 (en) 2012-08-22
KR20120087131A (ko) 2012-08-06
SI2488497T1 (sl) 2014-08-29
NZ598429A (en) 2014-02-28
CN102574800B (zh) 2014-09-17
CA2776328A1 (en) 2011-04-21
MY160308A (en) 2017-02-28
EP2314577A1 (en) 2011-04-27
EA201200594A1 (ru) 2012-11-30
AU2010306098A1 (en) 2012-03-15
BR112012008464B1 (pt) 2021-08-24
ZA201201563B (en) 2012-11-28
KR101699999B1 (ko) 2017-01-26
JP5809630B2 (ja) 2015-11-11
CR20120185A (es) 2012-06-11
ME01812B (me) 2014-09-20
US8598363B2 (en) 2013-12-03

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