IN2012DN01342A - - Google Patents
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- Publication number
- IN2012DN01342A IN2012DN01342A IN1342DEN2012A IN2012DN01342A IN 2012DN01342 A IN2012DN01342 A IN 2012DN01342A IN 1342DEN2012 A IN1342DEN2012 A IN 1342DEN2012A IN 2012DN01342 A IN2012DN01342 A IN 2012DN01342A
- Authority
- IN
- India
- Prior art keywords
- pyrimidines
- meanings
- iii
- formula
- making
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09167934 | 2009-08-14 | ||
| PCT/EP2010/061840 WO2011018518A1 (en) | 2009-08-14 | 2010-08-13 | Regioselective preparation of 2 -amino-5-trifluoromethylpyrimidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN01342A true IN2012DN01342A (ru) | 2015-06-05 |
Family
ID=42712695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1342DEN2012 IN2012DN01342A (ru) | 2009-08-14 | 2010-08-13 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8933227B2 (ru) |
| EP (1) | EP2464634B1 (ru) |
| JP (1) | JP5539519B2 (ru) |
| KR (1) | KR20120046248A (ru) |
| CN (1) | CN102471287A (ru) |
| AR (1) | AR077925A1 (ru) |
| AU (1) | AU2010283713A1 (ru) |
| BR (1) | BR112012002971A2 (ru) |
| CA (1) | CA2767965A1 (ru) |
| CL (1) | CL2012000278A1 (ru) |
| EA (1) | EA201200282A1 (ru) |
| IL (1) | IL217112A0 (ru) |
| IN (1) | IN2012DN01342A (ru) |
| MX (1) | MX2012001469A (ru) |
| NZ (1) | NZ597538A (ru) |
| TW (1) | TW201124385A (ru) |
| WO (1) | WO2011018518A1 (ru) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY31714A (es) * | 2008-03-20 | 2009-11-10 | Boehringer Ingelheim Int | Preparación selectiva de pirimidinas sustituidas |
| EP2268621A1 (en) * | 2008-03-20 | 2011-01-05 | Boehringer Ingelheim International GmbH | Regioselective preparation of substituted pyrimidines |
| US8729265B2 (en) | 2009-08-14 | 2014-05-20 | Boehringer Ingelheim International Gmbh | Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives |
| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
| CN102887860B (zh) * | 2012-09-29 | 2015-07-01 | 上海泰坦科技有限公司 | 4-氯-6-三氟甲基嘧啶类化合物的制备方法 |
| JP6391985B2 (ja) * | 2014-05-16 | 2018-09-19 | 東ソー・ファインケム株式会社 | ２−置換−４−（２，２，２−トリフルオロエトキシ）−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法 |
| JP6391988B2 (ja) * | 2014-05-21 | 2018-09-19 | 東ソー・ファインケム株式会社 | ５−（トリフルオロメチル）ピリミジン誘導体の製造方法及び新規５−（トリフルオロメチル）ピリミジン誘導体 |
| JP6262079B2 (ja) * | 2014-06-02 | 2018-01-17 | 東ソー・ファインケム株式会社 | ４−（２，２，２−トリフルオロエトキシ）−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法 |
| JP6431294B2 (ja) * | 2014-06-16 | 2018-11-28 | 東ソー・ファインケム株式会社 | ５−（トリフルオロメチル）ピリミジン誘導体及びその製造法 |
| JP6479486B2 (ja) * | 2015-01-16 | 2019-03-06 | 東ソー・ファインケム株式会社 | ４−アルコキシ−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法 |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6262A (ja) | 1986-03-05 | 1987-01-06 | Ishihara Sangyo Kaisha Ltd | ベンゾイルウレア系化合物の製造方法 |
| GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
| WO2003030909A1 (en) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
| UY27487A1 (es) | 2001-10-17 | 2003-05-30 | Boehringer Ingelheim Pharma | Derivados de pirimidina, medicamentos que contienen estos compuestos, su empleo y procedimiento para su preparación |
| DE10161763A1 (de) | 2001-12-15 | 2003-07-17 | Bayer Cropsience Ltd | Neues herbizides Verfahren |
| GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
| AU2003231231A1 (en) | 2002-05-06 | 2003-11-11 | Bayer Pharmaceuticals Corporation | Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders |
| AR037647A1 (es) | 2002-05-29 | 2004-12-01 | Novartis Ag | Derivados de diarilurea utiles para el tratamiento de enfermedades dependientes de la cinasa de proteina |
| MXPA05005547A (es) | 2002-11-28 | 2005-07-26 | Schering Ag | Pirimidinas inhibidoras de chk, pdk y akt, su produccion y uso como agentes farmaceuticos. |
| UA80767C2 (en) | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| ES2338545T3 (es) | 2002-12-20 | 2010-05-10 | Pfizer Products Inc. | Derivados de pirimidina para el tratamiento del crecimiento celular anormal. |
| PL1663991T3 (pl) * | 2003-09-05 | 2007-04-30 | Pfizer Prod Inc | Selektywna synteza CF3 – podstawionych pirymidyn |
| JP2007505858A (ja) | 2003-09-18 | 2007-03-15 | ノバルティス アクチエンゲゼルシャフト | 増殖性障害の処置に有用な２，４−ジ（フェニルアミノ）ピリミジン |
| MY141220A (en) | 2003-11-17 | 2010-03-31 | Astrazeneca Ab | Pyrazole derivatives as inhibitors of receptor tyrosine kinases |
| CN102127058A (zh) | 2004-05-14 | 2011-07-20 | 辉瑞产品有限公司 | 治疗异常细胞生长的嘧啶衍生物 |
| EP1598343A1 (de) | 2004-05-19 | 2005-11-23 | Boehringer Ingelheim International GmbH | 2-Arylaminopyrimidine als PLK Inhibitoren |
| WO2006014482A1 (en) | 2004-07-08 | 2006-02-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Pyrimidine derivatives useful as inhibitors of pkc-theta |
| US7521457B2 (en) | 2004-08-20 | 2009-04-21 | Boehringer Ingelheim International Gmbh | Pyrimidines as PLK inhibitors |
| US7776869B2 (en) | 2004-10-18 | 2010-08-17 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
| JP5208516B2 (ja) | 2004-12-30 | 2013-06-12 | エグゼリクシス， インコーポレイテッド | キナーゼモジュレーターとしてのピリミジン誘導体および使用方法 |
| US7323447B2 (en) | 2005-02-08 | 2008-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2006091737A1 (en) | 2005-02-24 | 2006-08-31 | Kemia, Inc. | Modulators of gsk-3 activity |
| EP1705177A1 (en) | 2005-03-23 | 2006-09-27 | Schering Aktiengesellschaft | N-aryl-sulfoximine-substituted pyrimidines as CDK- and/or VEGF inhibitors, their production and use as pharmaceutical agents |
| US20080194606A1 (en) | 2005-05-05 | 2008-08-14 | Astrazeneca | Pyrazolyl-Amino-Substituted Pyrimidines and Their Use in the Treatment of Cancer |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| US20070032514A1 (en) | 2005-07-01 | 2007-02-08 | Zahn Stephan K | 2,4-diamino-pyrimidines as aurora inhibitors |
| PT1945631E (pt) | 2005-10-28 | 2012-10-15 | Astrazeneca Ab | Derivados de 4-(3-aminopirazole)pirimidina para utilização como inibidores da tirosina-cinase no tratamento do cancro |
| US8722884B2 (en) | 2005-12-01 | 2014-05-13 | Verastem, Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| EA014551B1 (ru) | 2005-12-21 | 2010-12-30 | Пфайзер Продактс Инк. | Пиримидиновые производные для лечения аномального клеточного роста |
| TW200804364A (en) | 2006-02-22 | 2008-01-16 | Boehringer Ingelheim Int | New compounds |
| CA2648170A1 (en) | 2006-04-10 | 2007-10-18 | Boehringer Ingelheim International Gmbh | 2, 4-diaminopyrimidine derivatives and their use for the treatment of cancer |
| US8623887B2 (en) * | 2006-05-15 | 2014-01-07 | Boehringer Ingelheim International Gmbh | Compounds |
| US8466318B2 (en) | 2006-05-18 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Method of preparing chiral cyclic β-aminocarboxamides |
| DE102006027156A1 (de) | 2006-06-08 | 2007-12-13 | Bayer Schering Pharma Ag | Sulfimide als Proteinkinaseinhibitoren |
| WO2008003766A2 (en) | 2006-07-06 | 2008-01-10 | Boehringer Ingelheim International Gmbh | 4-heter0cycl0alkylpyri(mi)dines, process for the preparation thereof and their use as medicaments |
| DE102006041382A1 (de) | 2006-08-29 | 2008-03-20 | Bayer Schering Pharma Ag | Carbamoyl-Sulfoximide als Proteinkinaseinhibitoren |
| WO2008040951A1 (en) | 2006-10-03 | 2008-04-10 | Astrazeneca Ab | Compounds |
| US8097630B2 (en) | 2006-10-10 | 2012-01-17 | Rigel Pharmaceuticals, Inc. | Pinane-substituted pyrimidinediamine derivatives useful as Axl inhibitors |
| US20080255155A1 (en) | 2006-10-18 | 2008-10-16 | Stephane Raeppel | Kinase inhibitors and uses thereof |
| CA2666762C (en) | 2006-10-19 | 2014-12-30 | F. Hoffmann-La Roche Ag | Aminomethyl-4-imidazoles |
| US8148391B2 (en) | 2006-10-23 | 2012-04-03 | Cephalon, Inc. | Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-Met inhibitors |
| CA2671478C (en) * | 2006-12-13 | 2015-02-17 | F. Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
| CA2670645A1 (en) | 2006-12-19 | 2008-07-03 | Genentech, Inc. | Pyrimidine kinase inhibitors |
| EP1939185A1 (de) | 2006-12-20 | 2008-07-02 | Bayer Schering Pharma Aktiengesellschaft | Neuartige Hetaryl-Phenylendiamin-Pyrimidine als Proteinkinaseinhibitoren zur Behandlung von Krebs |
| WO2008079346A1 (en) | 2006-12-21 | 2008-07-03 | Vertex Pharmaceuticals Incorporated | 5-cyan0-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors |
| US20100144706A1 (en) | 2006-12-22 | 2010-06-10 | Boehringer Ingelheim International Gmbh | Compounds |
| CL2008000197A1 (es) | 2007-01-26 | 2008-08-01 | Smithkline Beecham Corp | Compuestos derivados de 2,4-diamino pirimidina, inhibidores de antranilamida de cinasa aurora; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer. |
| US7947698B2 (en) | 2007-03-23 | 2011-05-24 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
| CN101678215B (zh) | 2007-04-18 | 2014-10-01 | 辉瑞产品公司 | 用于治疗异常细胞生长的磺酰胺衍生物 |
| CA2693594A1 (en) | 2007-07-17 | 2009-01-22 | Rigel Pharmaceuticals, Inc. | Cyclic amine substituted pyrimidinediamines as pkc inhibitors |
| WO2009017838A2 (en) | 2007-08-01 | 2009-02-05 | Exelixis, Inc. | Combinations of jak-2 inhibitors and other agents |
| EA017252B1 (ru) | 2007-08-28 | 2012-11-30 | Айрм Ллк | Производные 2-бифениламино-4-аминопиримидина в качестве ингибиторов киназ |
| WO2009063240A1 (en) | 2007-11-16 | 2009-05-22 | Arrow Therapeutics Limited | 2,4-diaminopyrimidine derivatives useful as inhibitors of aurora kinase |
| JP2011505407A (ja) | 2007-12-03 | 2011-02-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 過剰な又は異常な細胞増殖を特徴とする疾患を治療するためのジアミノピリジン |
| WO2009079412A2 (en) | 2007-12-14 | 2009-06-25 | Ardea Biosciences Inc. | Reverse transcriptase inhibitors |
| UY31714A (es) * | 2008-03-20 | 2009-11-10 | Boehringer Ingelheim Int | Preparación selectiva de pirimidinas sustituidas |
| EP2268621A1 (en) * | 2008-03-20 | 2011-01-05 | Boehringer Ingelheim International GmbH | Regioselective preparation of substituted pyrimidines |
| UY31929A (es) | 2008-06-25 | 2010-01-05 | Irm Llc | Compuestos y composiciones como inhibidores de cinasa |
| UA101057C2 (en) | 2008-06-25 | 2013-02-25 | Айерем Элелси | Pyrimidine derivatives as kinase inhibitors |
| ES2711249T3 (es) | 2008-06-27 | 2019-04-30 | Celgene Car Llc | Compuestos de heteroarilo y usos de los mismos |
| EP2179991A1 (de) | 2008-10-21 | 2010-04-28 | Bayer Schering Pharma Aktiengesellschaft | Sulfoximinsubstituierte Anilino-Pyrimidinderivate als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
| EP2179992A1 (de) | 2008-10-21 | 2010-04-28 | Bayer Schering Pharma Aktiengesellschaft | Sulfonsubstituierte Anlinopyrimidinderivative als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
| UY32240A (es) | 2008-11-14 | 2010-06-30 | Boeringer Ingelheim Kg | Nuevas 2,4-diaminopirimidinas, sus sales farmacéuticamente aceptables, composiciones conteniéndolas y aplicaciones. |
| TWI491605B (zh) | 2008-11-24 | 2015-07-11 | Boehringer Ingelheim Int | 新穎化合物 |
| AR074209A1 (es) | 2008-11-24 | 2010-12-29 | Boehringer Ingelheim Int | Derivados de pirimidina utiles para el tratamiento del cancer |
| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
| US8729265B2 (en) * | 2009-08-14 | 2014-05-20 | Boehringer Ingelheim International Gmbh | Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives |
-
2010
- 2010-08-10 US US12/853,732 patent/US8933227B2/en active Active
- 2010-08-13 EP EP10744917.5A patent/EP2464634B1/en active Active
- 2010-08-13 WO PCT/EP2010/061840 patent/WO2011018518A1/en active Application Filing
- 2010-08-13 AR ARP100103001A patent/AR077925A1/es unknown
- 2010-08-13 JP JP2012524242A patent/JP5539519B2/ja active Active
- 2010-08-13 AU AU2010283713A patent/AU2010283713A1/en not_active Abandoned
- 2010-08-13 MX MX2012001469A patent/MX2012001469A/es not_active Application Discontinuation
- 2010-08-13 EA EA201200282A patent/EA201200282A1/ru unknown
- 2010-08-13 KR KR1020127003436A patent/KR20120046248A/ko not_active Application Discontinuation
- 2010-08-13 CN CN2010800346368A patent/CN102471287A/zh active Pending
- 2010-08-13 BR BR112012002971A patent/BR112012002971A2/pt not_active IP Right Cessation
- 2010-08-13 IN IN1342DEN2012 patent/IN2012DN01342A/en unknown
- 2010-08-13 TW TW099127176A patent/TW201124385A/zh unknown
- 2010-08-13 CA CA2767965A patent/CA2767965A1/en not_active Abandoned
- 2010-08-13 NZ NZ597538A patent/NZ597538A/en not_active IP Right Cessation
-
2011
- 2011-12-21 IL IL217112A patent/IL217112A0/en unknown
-
2012
- 2012-02-02 CL CL2012000278A patent/CL2012000278A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2012001469A (es) | 2012-02-22 |
| CA2767965A1 (en) | 2011-02-17 |
| CL2012000278A1 (es) | 2012-10-12 |
| AR077925A1 (es) | 2011-10-05 |
| JP5539519B2 (ja) | 2014-07-02 |
| TW201124385A (en) | 2011-07-16 |
| IL217112A0 (en) | 2012-02-29 |
| EP2464634B1 (en) | 2016-11-30 |
| EA201200282A1 (ru) | 2012-09-28 |
| EP2464634A1 (en) | 2012-06-20 |
| KR20120046248A (ko) | 2012-05-09 |
| CN102471287A (zh) | 2012-05-23 |
| US20110190499A1 (en) | 2011-08-04 |
| WO2011018518A1 (en) | 2011-02-17 |
| US8933227B2 (en) | 2015-01-13 |
| JP2013501759A (ja) | 2013-01-17 |
| BR112012002971A2 (pt) | 2015-10-13 |
| NZ597538A (en) | 2014-05-30 |
| AU2010283713A1 (en) | 2012-02-02 |
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