US5912347A
(en)
*
|
1996-09-30 |
1999-06-15 |
Mallinckrodt Inc. |
Process for preparing a morphinan derivative
|
AU4823900A
(en)
*
|
1999-05-05 |
2000-11-17 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
Direct c-14 oxidation of opioids
|
US6177567B1
(en)
|
1999-10-15 |
2001-01-23 |
Boehringer Ingelheim Chemicals, Inc. |
Method for preparing oxycodone
|
PL368732A1
(en)
*
|
2001-08-23 |
2005-04-04 |
Akzo Nobel N.V. |
C-14 oxidation of morphine derivatives
|
JP3961796B2
(ja)
*
|
2001-08-27 |
2007-08-22 |
ソニー株式会社 |
情報提供システム、情報処理装置および方法、情報提供装置および方法、記録媒体、並びにプログラム
|
US20040001889A1
(en)
|
2002-06-25 |
2004-01-01 |
Guohua Chen |
Short duration depot formulations
|
US20040058946A1
(en)
*
|
2002-07-05 |
2004-03-25 |
Buchwald Stephen L. |
Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
|
PT1562953E
(pt)
*
|
2002-11-08 |
2009-11-19 |
Mallinckrodt Inc |
Processo para a preparação de sais quaternários de n -alquilmorfinano
|
SI1575569T1
(sl)
|
2002-12-13 |
2010-12-31 |
Durect Corp |
Oralni sistem dostave zdravila, ki obsega visokoviskozne tekoče nosilne materiale
|
US6864370B1
(en)
*
|
2003-06-05 |
2005-03-08 |
Zhaiwei Lin |
Process for manufacturing oxycodone
|
US6790959B1
(en)
|
2003-06-05 |
2004-09-14 |
Halsey Drug Company, Inc. |
Process for manufacturing thebaine
|
PT1664061T
(pt)
|
2003-09-22 |
2017-06-22 |
Glaxosmithkline Australia Pty Ltd |
Processo para a síntese de compostos de morfinano e seus intermediários
|
US7875718B2
(en)
*
|
2003-09-22 |
2011-01-25 |
Johnson Matthey Public Limited Company |
Process for the synthesis of morphinane compounds and intermediates thereof
|
KR100921695B1
(ko)
*
|
2004-02-06 |
2009-10-15 |
유로-셀띠끄 소시에떼 아노님 |
3-o-보호된 모르피논 및 3-o-보호된 모르피논 디엔올카르복실레이트 제조방법
|
TW201509943A
(zh)
|
2004-03-30 |
2015-03-16 |
Euro Celtique Sa |
含有小於25ppm14-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
|
SK286047B6
(sk)
*
|
2004-04-13 |
2008-01-07 |
Zentiva, A. S. |
Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
|
US6946556B1
(en)
*
|
2004-05-21 |
2005-09-20 |
Acura Pharmaceuticals, Inc. |
Preparation of opioid analgesics by a one-pot process
|
AU2005254933B2
(en)
*
|
2004-06-08 |
2010-08-19 |
Mallinckrodt Inc. |
Extraction of alkaloids from opium
|
PT1765292T
(pt)
|
2004-06-12 |
2017-12-29 |
Collegium Pharmaceutical Inc |
Formulações de fármacos dissuasoras de abuso
|
EP2415484B1
(en)
|
2004-09-17 |
2014-06-18 |
Durect Corporation |
Sustained local anesthetic composition containing SAIB
|
GB0421149D0
(en)
*
|
2004-09-23 |
2004-10-27 |
Johnson Matthey Plc |
Preparation of oxycodone
|
GB0421687D0
(en)
*
|
2004-09-30 |
2004-11-03 |
Johnson Matthey Plc |
Preparation of opiate analgesics
|
WO2006084389A1
(de)
*
|
2005-02-11 |
2006-08-17 |
Cilag Ltd. |
Verfahren zur reinigung von noroxymorphon-verbindungen
|
WO2006094672A1
(en)
*
|
2005-03-04 |
2006-09-14 |
Euro-Celtique S.A. |
Method of reducing alpha, beta unsaturated ketones in opioid compositions
|
US8071768B2
(en)
*
|
2005-06-10 |
2011-12-06 |
Janssen Pharmaceutica, N.V. |
Alkylquinoline and alkylquinazoline kinase modulators
|
CA2610859C
(en)
*
|
2005-06-16 |
2013-11-12 |
Peter Xianqi Wang |
A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
|
US20070027105A1
(en)
|
2005-07-26 |
2007-02-01 |
Alza Corporation |
Peroxide removal from drug delivery vehicle
|
US20070117826A1
(en)
*
|
2005-11-23 |
2007-05-24 |
Forest Laboratories, Inc. |
Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone
|
EP1994034B1
(en)
|
2006-03-02 |
2009-11-11 |
Mallinckrodt, Inc. |
Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds
|
SA07280459B1
(ar)
|
2006-08-25 |
2011-07-20 |
بيورديو فارما إل. بي. |
أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
|
CA2663909A1
(en)
*
|
2006-09-20 |
2008-03-27 |
Mallinckrodt Inc. |
Preparation of substituted morphinan-6-ones and salts and intermediates thereof
|
US20080125592A1
(en)
*
|
2006-10-17 |
2008-05-29 |
Penick Corporation |
Process for preparing oxymorphone, naltrexone, and buprenorphine
|
AU2012216358B2
(en)
*
|
2006-10-17 |
2014-11-20 |
Penick Corporation |
Process For Preparing Oxymorphone, Naltrexone and Buprenorphine
|
EP2073636B1
(en)
*
|
2006-10-17 |
2012-09-05 |
Penick Corporation |
Process for preparing oxymorphone
|
CA2674915C
(en)
|
2006-10-17 |
2015-06-30 |
Penick Corporation |
Process for preparing oxymorphone
|
DK2117521T3
(da)
|
2006-11-03 |
2012-09-03 |
Durect Corp |
Transdermale indgivelsessystemer omfattende bupivacain
|
US7906647B2
(en)
*
|
2006-12-04 |
2011-03-15 |
Noramco, Inc. |
Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone
|
CN104761561A
(zh)
*
|
2006-12-04 |
2015-07-08 |
诺拉姆科有限公司 |
减少羟考酮碱中杂质的方法
|
GB0624880D0
(en)
*
|
2006-12-14 |
2007-01-24 |
Johnson Matthey Plc |
Improved method for making analgesics
|
US9040726B2
(en)
|
2007-03-06 |
2015-05-26 |
Mallinckrodt Llc |
Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
|
PL2137189T3
(pl)
*
|
2007-03-06 |
2015-12-31 |
SpecGx LLC |
Sposób wytwarzania czwartorzędowych N-alkilowych soli alkaloidu morfinanowego
|
CA2681740A1
(en)
*
|
2007-03-23 |
2008-10-02 |
Mallinckrodt Inc. |
Improved preparation of oxymorphone from oripavine
|
MX2009010931A
(es)
*
|
2007-04-16 |
2009-10-29 |
Mallinckrodt Inc |
Reduccion novedosa de opiaceos utilizando la reaccion de transferencia catalitica de hidrogeno.
|
WO2008144320A2
(en)
*
|
2007-05-17 |
2008-11-27 |
Endo Pharmaceuticals, Inc. |
Opioid and methods of making and using the same
|
CA2706931C
(en)
|
2007-12-06 |
2015-05-12 |
Durect Corporation |
Oral pharmaceutical dosage forms
|
AU2008338970B2
(en)
*
|
2007-12-17 |
2013-08-22 |
SpecGx LLC |
Sinomenine derivatives and processes for their synthesis
|
US8067596B2
(en)
|
2007-12-17 |
2011-11-29 |
Mallinckrodt Llc |
Processes for the production of (+)- “Nal” morphinan compounds
|
ATE519765T1
(de)
|
2008-02-29 |
2011-08-15 |
Mallinckrodt Inc |
Verfahren zur herstellung von 3-hydroxymorphinan- derivaten
|
JP6009764B2
(ja)
*
|
2008-04-24 |
2016-10-19 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプJanssen Pharmaceutica Naamloze Vennootschap |
ナルメフェンプロドラッグ
|
NZ589496A
(en)
*
|
2008-05-27 |
2013-02-22 |
Mallinckrodt Llc |
Processes and compounds for the preparation of normorphinans
|
WO2010028004A2
(en)
|
2008-09-03 |
2010-03-11 |
Mallinckrodt Inc. |
Substituted berbines and processes for their synthesis
|
EP2344506B1
(en)
*
|
2008-09-30 |
2016-02-10 |
Mallinckrodt LLC |
Processes for the alkylation of secondary amine groups of morphinan derivatives
|
US20100260844A1
(en)
|
2008-11-03 |
2010-10-14 |
Scicinski Jan J |
Oral pharmaceutical dosage forms
|
UA102916C2
(uk)
|
2009-07-02 |
2013-08-27 |
Кемфарм, Інк. |
Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
|
US10668060B2
(en)
|
2009-12-10 |
2020-06-02 |
Collegium Pharmaceutical, Inc. |
Tamper-resistant pharmaceutical compositions of opioids and other drugs
|
AU2011263417B2
(en)
|
2010-06-11 |
2014-03-27 |
Rhodes Technologies |
Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
|
ES2537610T3
(es)
|
2010-06-11 |
2015-06-10 |
Rhodes Technologies |
Proceso para la N-desalquilación de aminas terciarias
|
AU2011274361B2
(en)
|
2010-07-02 |
2014-09-18 |
Macfarlan Smith Limited |
Process for the synthesis and purification of oxycodone
|
RU2448709C1
(ru)
*
|
2011-02-01 |
2012-04-27 |
Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) |
Способ получения налтрексона
|
TWI560170B
(en)
*
|
2011-12-06 |
2016-12-01 |
Lundbeck & Co As H |
Process for recovery of nalmefene hydrochloride
|
US9315514B2
(en)
|
2012-08-27 |
2016-04-19 |
Rhodes Technologies |
1,3-dioxanomorphides and 1,3-dioxanocodides
|
TW201434837A
(zh)
|
2012-12-14 |
2014-09-16 |
Purdue Pharma Lp |
螺環嗎啡喃及其用途
|
JP6163210B2
(ja)
|
2012-12-14 |
2017-07-12 |
パーデュー、ファーマ、リミテッド、パートナーシップ |
窒素含有モルフィナン誘導体およびその使用
|
US8980906B2
(en)
|
2012-12-14 |
2015-03-17 |
Purdue Pharma L.P. |
Pyridonemorphinan analogs and biological activity on opioid receptors
|
JP6159416B2
(ja)
|
2012-12-28 |
2017-07-05 |
パーデュー、ファーマ、リミテッド、パートナーシップ |
7,8−環式モルフィナン類似体
|
CA2896202A1
(en)
|
2012-12-28 |
2014-07-03 |
Purdue Pharma L.P. |
Substituted morphinans and the use thereof
|
JP6181770B2
(ja)
|
2012-12-31 |
2017-08-16 |
ローズ テクノロジーズ |
7β−置換6α,14α−エテノモルフィナンおよび7β−置換6α,14α−エタノモルフィナンを調製するための方法
|
EP2983468A4
(en)
|
2013-03-15 |
2016-09-07 |
Durect Corp |
COMPOSITIONS WITH RHEOLOGY MODIFIER TO REDUCE RESOLUTION VARIABILITY
|
EP2829541A1
(en)
|
2013-07-26 |
2015-01-28 |
Siegfried AG |
Novel synthesis of noroxymorphone from morphine
|
WO2015015146A1
(en)
|
2013-08-02 |
2015-02-05 |
Johnson Matthey Public Limited Company |
Process for the preparation of oxymorphone
|
EP3087079B1
(en)
|
2013-12-26 |
2019-04-03 |
Purdue Pharma LP |
Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
|
US9340542B2
(en)
|
2013-12-26 |
2016-05-17 |
Purdue Pharma L.P. |
Propellane-based compounds and the use thereof
|
EP3087078B1
(en)
|
2013-12-26 |
2019-05-15 |
Purdue Pharma LP |
7-beta-alkyl analogs of orvinols
|
US9994571B2
(en)
|
2013-12-26 |
2018-06-12 |
Purdue Pharma L.P. |
10-substituted morphinan hydantoins
|
US9902726B2
(en)
|
2013-12-30 |
2018-02-27 |
Purdue Pharma L.P. |
Pyridone-sulfone morphinan analogs as opioid receptor ligands
|
NZ731591A
(en)
|
2014-11-25 |
2018-06-29 |
Kempharm Inc |
Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone
|
ES2701855T3
(es)
|
2016-05-31 |
2019-02-26 |
Alcaliber Investig Desarrollo E Innovacion Slu |
Proceso para la obtención de 3,14-diacetiloximorfona a partir de oripavina
|
WO2017222575A1
(en)
|
2016-06-23 |
2017-12-28 |
Collegium Pharmaceutical, Inc. |
Process of making more stable abuse-deterrent oral formulations
|
MX2019007327A
(es)
|
2016-12-23 |
2019-09-02 |
Minoryx Therapeutics S L |
Proceso para preparar 5-[[4-[2-[5-(1-hidroxietil)-2-piridinil] etoxi]fenil]metil]-2,4-tiazolidindiona y sus sales.
|
SK592017A3
(sk)
|
2017-07-04 |
2019-01-08 |
Saneca Pharmaceuticals A. S. |
Spôsob prípravy morfínanových zlúčenín
|
EP3755704A1
(en)
|
2018-02-23 |
2020-12-30 |
Rhodes Technologies Inc. |
Novel opioid compounds and uses thereof
|
CN110054656B
(zh)
*
|
2019-05-28 |
2021-02-02 |
宜昌人福药业有限责任公司 |
一种10-羰基/羟基吗啡-6-葡萄糖苷酸的合成方法
|
CA3146163A1
(en)
*
|
2019-07-08 |
2021-01-14 |
University Of Health Sciences & Pharmacy In St. Louis |
G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment
|
CA3167217A1
(en)
|
2020-01-13 |
2021-07-22 |
Durect Corporation |
Sustained release drug delivery systems with reduced impurities and related methods
|