|
US5912347A
(en)
*
|
1996-09-30 |
1999-06-15 |
Mallinckrodt Inc. |
Process for preparing a morphinan derivative
|
|
AU4823900A
(en)
*
|
1999-05-05 |
2000-11-17 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
Direct c-14 oxidation of opioids
|
|
US6177567B1
(en)
|
1999-10-15 |
2001-01-23 |
Boehringer Ingelheim Chemicals, Inc. |
Method for preparing oxycodone
|
|
MXPA04001647A
(es)
*
|
2001-08-23 |
2004-05-31 |
Akzo Nobel Nv |
Proceso para la preparacion de un derivado de 14-hidroxinormorfinona.
|
|
JP3961796B2
(ja)
*
|
2001-08-27 |
2007-08-22 |
ソニー株式会社 |
情報提供システム、情報処理装置および方法、情報提供装置および方法、記録媒体、並びにプログラム
|
|
DE10161963A1
(de)
*
|
2001-12-17 |
2003-07-03 |
Johannes Schuetz |
6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
|
|
US20040001889A1
(en)
|
2002-06-25 |
2004-01-01 |
Guohua Chen |
Short duration depot formulations
|
|
US20040058946A1
(en)
*
|
2002-07-05 |
2004-03-25 |
Buchwald Stephen L. |
Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
|
|
RU2236412C2
(ru)
*
|
2002-07-18 |
2004-09-20 |
Власов Михаил Иванович |
Способ получения производных морфинона, способ получения производных 14-гидроксиморфинона, и способ получения производных оксиморфона
|
|
RU2215742C1
(ru)
*
|
2002-11-05 |
2003-11-10 |
Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" |
Способ получения сложных эфиров n-замещенных 14-гидроксиморфинанов
|
|
RU2215741C1
(ru)
*
|
2002-11-05 |
2003-11-10 |
Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" |
Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения
|
|
ES2332453T3
(es)
*
|
2002-11-08 |
2010-02-05 |
Mallinckrodt Inc. |
Proceso para la preparacion de sales de n-alquilo cuaternario de alcaloides de morfinano.
|
|
EP2959893A1
(en)
|
2002-12-13 |
2015-12-30 |
DURECT Corporation |
Oral drug delivery system comprising high viscosity liquid carrier materials
|
|
US6864370B1
(en)
*
|
2003-06-05 |
2005-03-08 |
Zhaiwei Lin |
Process for manufacturing oxycodone
|
|
US6790959B1
(en)
|
2003-06-05 |
2004-09-14 |
Halsey Drug Company, Inc. |
Process for manufacturing thebaine
|
|
ES2627995T3
(es)
|
2003-09-22 |
2017-08-01 |
Glaxosmithkline Australia Pty Ltd |
Procedimiento para la síntesis de compuestos de morfinano y productos intermedios de los mismos
|
|
US7875718B2
(en)
*
|
2003-09-22 |
2011-01-25 |
Johnson Matthey Public Limited Company |
Process for the synthesis of morphinane compounds and intermediates thereof
|
|
BRPI0506607B8
(pt)
*
|
2004-02-06 |
2021-05-25 |
Euro Celtique Sa |
métodos para produzir morfinonas protegidas por 3-o e carboxilatos de morfinona doenol protegidas por 3-o e composição
|
|
TWI483944B
(zh)
|
2004-03-30 |
2015-05-11 |
Euro Celtique Sa |
含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
|
|
SK286047B6
(sk)
*
|
2004-04-13 |
2008-01-07 |
Zentiva, A. S. |
Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
|
|
US6946556B1
(en)
*
|
2004-05-21 |
2005-09-20 |
Acura Pharmaceuticals, Inc. |
Preparation of opioid analgesics by a one-pot process
|
|
JP2008501797A
(ja)
*
|
2004-06-08 |
2008-01-24 |
マリンクロッド・インコーポレイテッド |
アヘンからのアルカロイド類の抽出
|
|
CA2569958C
(en)
|
2004-06-12 |
2016-03-22 |
Jane C. Hirsh |
Abuse-deterrent drug formulations
|
|
DK2415484T3
(da)
|
2004-09-17 |
2014-09-22 |
Durect Corp |
Sammensætning indeholdende saib til vedvarende lokalbedøvelse
|
|
GB0421149D0
(en)
*
|
2004-09-23 |
2004-10-27 |
Johnson Matthey Plc |
Preparation of oxycodone
|
|
GB0421687D0
(en)
†
|
2004-09-30 |
2004-11-03 |
Johnson Matthey Plc |
Preparation of opiate analgesics
|
|
WO2006084389A1
(de)
*
|
2005-02-11 |
2006-08-17 |
Cilag Ltd. |
Verfahren zur reinigung von noroxymorphon-verbindungen
|
|
CA2598774C
(en)
*
|
2005-03-04 |
2010-12-21 |
Euro-Celtique S.A. |
Method of reducing alpha, beta unsaturated ketones in opioid compositions
|
|
NZ563133A
(en)
*
|
2005-04-06 |
2010-07-30 |
Toray Industries |
Crystals of morphinan derivative and process for producing the same
|
|
US8071768B2
(en)
*
|
2005-06-10 |
2011-12-06 |
Janssen Pharmaceutica, N.V. |
Alkylquinoline and alkylquinazoline kinase modulators
|
|
EP1893616B1
(en)
*
|
2005-06-16 |
2010-12-29 |
Mallinckrodt, Inc. |
A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
|
|
US20070027105A1
(en)
|
2005-07-26 |
2007-02-01 |
Alza Corporation |
Peroxide removal from drug delivery vehicle
|
|
US20070117826A1
(en)
*
|
2005-11-23 |
2007-05-24 |
Forest Laboratories, Inc. |
Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone
|
|
US8871779B2
(en)
*
|
2006-03-02 |
2014-10-28 |
Mallinckrodt Llc |
Process for preparing morphinan-6-one products with low levels of α,β-unsaturated ketone compounds
|
|
SA07280459B1
(ar)
|
2006-08-25 |
2011-07-20 |
بيورديو فارما إل. بي. |
أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
|
|
RU2009112685A
(ru)
*
|
2006-09-20 |
2010-10-27 |
Маллинкродт Инк. (Us) |
Получение замещенных морфинан-6-онов и их солей и промежуточных соединений
|
|
US20080125592A1
(en)
*
|
2006-10-17 |
2008-05-29 |
Penick Corporation |
Process for preparing oxymorphone, naltrexone, and buprenorphine
|
|
AU2012216358B2
(en)
*
|
2006-10-17 |
2014-11-20 |
Penick Corporation |
Process For Preparing Oxymorphone, Naltrexone and Buprenorphine
|
|
CA2674915C
(en)
*
|
2006-10-17 |
2015-06-30 |
Penick Corporation |
Process for preparing oxymorphone
|
|
ES2392594T3
(es)
|
2006-10-17 |
2012-12-12 |
Penick Corporation |
Procedimiento para preparar oximorfona
|
|
EP2117521B1
(en)
|
2006-11-03 |
2012-06-27 |
Durect Corporation |
Transdermal delivery systems comprising bupivacaine
|
|
US7875719B2
(en)
*
|
2006-12-04 |
2011-01-25 |
Cox D Phillip |
Process for reducing impurities in oxycodone base
|
|
JP2010511726A
(ja)
*
|
2006-12-04 |
2010-04-15 |
ノランコ・インコーポレーテツド |
１４−ヒドロキシコデイノンの濃度が低いオキシコドンの製造方法
|
|
GB0624880D0
(en)
*
|
2006-12-14 |
2007-01-24 |
Johnson Matthey Plc |
Improved method for making analgesics
|
|
JP5875748B2
(ja)
*
|
2007-03-06 |
2016-03-02 |
マリンクロッド エルエルシー |
第４級ｎ−アルキルモルフィナンアルカロイド塩の調製のための方法
|
|
US9040726B2
(en)
|
2007-03-06 |
2015-05-26 |
Mallinckrodt Llc |
Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
|
|
CA2681740A1
(en)
*
|
2007-03-23 |
2008-10-02 |
Mallinckrodt Inc. |
Improved preparation of oxymorphone from oripavine
|
|
CA2684458A1
(en)
*
|
2007-04-16 |
2008-10-30 |
Mallinckrodt Inc. |
Novel opiate reduction utilizing catalytic hydrogen transfer reaction
|
|
WO2008144320A2
(en)
*
|
2007-05-17 |
2008-11-27 |
Endo Pharmaceuticals, Inc. |
Opioid and methods of making and using the same
|
|
JP2011506318A
(ja)
|
2007-12-06 |
2011-03-03 |
デュレクト コーポレーション |
経口医薬製剤
|
|
EP2222678B1
(en)
*
|
2007-12-17 |
2016-03-09 |
Mallinckrodt LLC |
Processes for the production of (+)-'nal' morphinan compounds
|
|
EP2222643B1
(en)
*
|
2007-12-17 |
2019-03-20 |
SpecGx LLC |
Sinomenine derivatives and processes for their synthesis
|
|
EP2250175B1
(en)
*
|
2008-02-29 |
2011-08-10 |
Mallinckrodt Inc. |
Process for the preparation of 3-hydroxymorphinan derivatives
|
|
ES2373364T3
(es)
*
|
2008-04-24 |
2012-02-02 |
Janssen Pharmaceutica N.V. |
Profármacos de nalmefeno.
|
|
AU2009251427B2
(en)
*
|
2008-05-27 |
2014-05-22 |
SpecGx LLC |
Processes and compounds for the preparation of normorphinans
|
|
WO2010028004A2
(en)
|
2008-09-03 |
2010-03-11 |
Mallinckrodt Inc. |
Substituted berbines and processes for their synthesis
|
|
CN102227433B
(zh)
*
|
2008-09-30 |
2015-01-07 |
马林克罗特有限公司 |
烷基化吗啡喃衍生物的仲胺基团的方法
|
|
US20100260844A1
(en)
|
2008-11-03 |
2010-10-14 |
Scicinski Jan J |
Oral pharmaceutical dosage forms
|
|
UA102916C2
(uk)
|
2009-07-02 |
2013-08-27 |
Кемфарм, Інк. |
Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
|
|
US10668060B2
(en)
|
2009-12-10 |
2020-06-02 |
Collegium Pharmaceutical, Inc. |
Tamper-resistant pharmaceutical compositions of opioids and other drugs
|
|
CA2802294C
(en)
|
2010-06-11 |
2016-05-10 |
Rhodes Technologies |
Process for n-dealkylation of tertiary amines
|
|
EP2995614B8
(en)
|
2010-06-11 |
2018-03-28 |
Rhodes Technologies Inc. |
Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
|
|
ES2659168T3
(es)
|
2010-07-02 |
2018-03-14 |
Johnson Matthey Public Limited Company |
Proceso para la síntesis y purificación de oxicodona
|
|
RU2448709C1
(ru)
*
|
2011-02-01 |
2012-04-27 |
Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) |
Способ получения налтрексона
|
|
TWI560170B
(en)
*
|
2011-12-06 |
2016-12-01 |
Lundbeck & Co As H |
Process for recovery of nalmefene hydrochloride
|
|
US9315514B2
(en)
|
2012-08-27 |
2016-04-19 |
Rhodes Technologies |
1,3-dioxanomorphides and 1,3-dioxanocodides
|
|
EP2931724B1
(en)
|
2012-12-14 |
2017-01-25 |
Purdue Pharma LP |
Pyridonemorphinan analogs and biological activity on opioid receptors
|
|
US8937084B2
(en)
|
2012-12-14 |
2015-01-20 |
Purdue Pharma L.P. |
Nitrogen containing morphinan derivatives and the use thereof
|
|
JP6141444B2
(ja)
|
2012-12-14 |
2017-06-07 |
パーデュー、ファーマ、リミテッド、パートナーシップ |
スピロ環式モルフィナンおよびこれらの使用
|
|
CA2896202A1
(en)
|
2012-12-28 |
2014-07-03 |
Purdue Pharma L.P. |
Substituted morphinans and the use thereof
|
|
EP2941430B1
(en)
|
2012-12-28 |
2017-04-26 |
Purdue Pharma LP |
7,8-cyclicmorphinan analogs
|
|
AU2013369037C1
(en)
|
2012-12-31 |
2017-06-08 |
Rhodes Technologies |
Process for preparing 7beta-substituted 6alpha,14alpha -ethenomorphinans and 7beta-substituted 6alpha,14alpha-ethanomorphinans
|
|
TW201521769A
(zh)
|
2013-03-15 |
2015-06-16 |
Durect Corp |
具有流變改質劑以減少溶解變異性之組成物
|
|
EP2829541A1
(en)
*
|
2013-07-26 |
2015-01-28 |
Siegfried AG |
Novel synthesis of noroxymorphone from morphine
|
|
EP3027622B8
(en)
|
2013-08-02 |
2019-06-12 |
Johnson Matthey Public Limited Company |
Process for the preparation of oxymorphone
|
|
WO2015097546A1
(en)
|
2013-12-26 |
2015-07-02 |
Purdue Pharma L.P. |
Propellane-based compounds and their use as opioid receptor modulators
|
|
EP3087079B1
(en)
|
2013-12-26 |
2019-04-03 |
Purdue Pharma LP |
Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
|
|
EP3087078B1
(en)
|
2013-12-26 |
2019-05-15 |
Purdue Pharma LP |
7-beta-alkyl analogs of orvinols
|
|
WO2015097547A1
(en)
|
2013-12-26 |
2015-07-02 |
Purdue Pharma L.P. |
10-substituted morphinan hydantoins
|
|
US9902726B2
(en)
|
2013-12-30 |
2018-02-27 |
Purdue Pharma L.P. |
Pyridone-sulfone morphinan analogs as opioid receptor ligands
|
|
MX2017006520A
(es)
|
2014-11-25 |
2017-08-09 |
Kempharm Inc * |
Acido benzoico, derivados de acido benzoico y conjugados de oxicodona de acido heteroaril carboxilico.
|
|
ES2701855T3
(es)
|
2016-05-31 |
2019-02-26 |
Alcaliber Investig Desarrollo E Innovacion Slu |
Proceso para la obtención de 3,14-diacetiloximorfona a partir de oripavina
|
|
WO2017222575A1
(en)
|
2016-06-23 |
2017-12-28 |
Collegium Pharmaceutical, Inc. |
Process of making more stable abuse-deterrent oral formulations
|
|
SG11201811760VA
(en)
|
2016-07-06 |
2019-01-30 |
Durect Corp |
Oral dosage form with drug composition, barrier layer and drug layer
|
|
SI3559010T1
(sl)
|
2016-12-23 |
2022-10-28 |
Minoryx Therapeutics S. L. |
Postopek za pripravo 5-((4-(2-(5-(1-hidroksietil)-2-piridinil)etoksi) fenil)metil)-2,4-tiazolidindiona in soli le-tega
|
|
SK592017A3
(sk)
|
2017-07-04 |
2019-01-08 |
Saneca Pharmaceuticals A. S. |
Spôsob prípravy morfínanových zlúčenín
|
|
MX2020008706A
(es)
|
2018-02-23 |
2020-09-25 |
Rhodes Tech |
Nuevos compuestos de opioides y sus usos.
|
|
CN110054656B
(zh)
*
|
2019-05-28 |
2021-02-02 |
宜昌人福药业有限责任公司 |
一种10-羰基/羟基吗啡-6-葡萄糖苷酸的合成方法
|
|
US11613547B2
(en)
|
2019-07-08 |
2023-03-28 |
University Of Health Sciences & Pharmacy In St. Louis |
G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment
|
|
WO2021146215A1
(en)
|
2020-01-13 |
2021-07-22 |
Durect Corporation |
Sustained release drug delivery systems with reduced impurities and related methods
|
|
CN114621239A
(zh)
*
|
2020-12-10 |
2022-06-14 |
鲁南制药集团股份有限公司 |
一种纳曲酮的制备方法
|
|
CA3200832A1
(en)
*
|
2020-12-28 |
2022-07-07 |
Navin Saxena Research & Technology Pvt. Ltd. |
Novel process for the synthesis of noroxymorphone from morphine
|