IL98562A - )+(r-2- ]4-]טטרהידרו-2- פוראניל[ קרבוניל[- 1- פיפראזיניל[- 6, 7-דימתוקסי-4- קוינאזולינאמין ותכשירי רוקחות המכילים אותו - Google Patents
)+(r-2- ]4-]טטרהידרו-2- פוראניל[ קרבוניל[- 1- פיפראזיניל[- 6, 7-דימתוקסי-4- קוינאזולינאמין ותכשירי רוקחות המכילים אותוInfo
- Publication number
- IL98562A IL98562A IL9856291A IL9856291A IL98562A IL 98562 A IL98562 A IL 98562A IL 9856291 A IL9856291 A IL 9856291A IL 9856291 A IL9856291 A IL 9856291A IL 98562 A IL98562 A IL 98562A
- Authority
- IL
- Israel
- Prior art keywords
- tetrahydro
- quinazolinamine
- furanyl
- compound
- piperazinyl
- Prior art date
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/546,349 US5212176A (en) | 1990-06-29 | 1990-06-29 | R(+)-terazosin |
| CA002086974A CA2086974C (en) | 1990-06-29 | 1993-01-08 | R(+)-terazosin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL98562A true IL98562A (he) | 1995-12-31 |
Family
ID=25675811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9856291A IL98562A (he) | 1990-06-29 | 1991-06-19 | )+(r-2- ]4-]טטרהידרו-2- פוראניל[ קרבוניל[- 1- פיפראזיניל[- 6, 7-דימתוקסי-4- קוינאזולינאמין ותכשירי רוקחות המכילים אותו |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5212176A (he) |
| EP (1) | EP0536329B1 (he) |
| JP (1) | JPH07119222B2 (he) |
| AT (1) | ATE136779T1 (he) |
| AU (1) | AU654148B2 (he) |
| CA (1) | CA2086974C (he) |
| DE (1) | DE69118889T2 (he) |
| DK (1) | DK0536329T3 (he) |
| ES (1) | ES2089224T3 (he) |
| GR (1) | GR3020364T3 (he) |
| IE (1) | IE72967B1 (he) |
| IL (1) | IL98562A (he) |
| PT (1) | PT98148B (he) |
| WO (1) | WO1992000073A1 (he) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ241979A (en) * | 1991-03-20 | 1996-01-26 | Merck & Co Inc | Treatment of benign prostatic hyperplasia using 5alpha-reductase inhibitor and an alpha1-adrenergic recepter blocker |
| AU5546194A (en) * | 1992-11-04 | 1994-05-24 | Sepracor, Inc. | Methods and compositions of (+) doxazosin for the treatment of benign prostatic hyperplasia and atherosclerosis |
| EP0667776A1 (en) * | 1992-11-04 | 1995-08-23 | Sepracor, Inc. | Methods and compositions of (+) doxazosin for the treatment of hypertension |
| US5294615A (en) * | 1993-04-29 | 1994-03-15 | Abbott Laboratories | Terazosin polymorph and pharmaceutical composition |
| US5412095A (en) * | 1993-04-29 | 1995-05-02 | Abbott Laboratories | Terazosin monohydrochloride and processes and intermediate for its production |
| US5504207A (en) * | 1994-10-18 | 1996-04-02 | Abbott Laboratories | Process and intermediate for the preparation of terazosin hydrochloride dihydrate |
| US5587377A (en) * | 1995-10-24 | 1996-12-24 | Invamed, Inc. | Terazosin crystalline polymorph and pharmaceutical compositions thereof |
| JPH11507395A (ja) * | 1995-11-15 | 1999-06-29 | メルク エンド カンパニー インコーポレーテッド | アルファ１ａ アドレナリン受容体拮抗薬 |
| DE19546573A1 (de) * | 1995-12-13 | 1997-06-19 | Uetikon Chemie Gmbh | Kristallines Polymorph von Terazosin-Hydrochlorid, sowie Verfahren zu seiner Herstellung |
| US5952003A (en) * | 1996-08-01 | 1999-09-14 | Novartis Corporation | Terazosin capsules |
| US5922722A (en) * | 1996-11-12 | 1999-07-13 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonists |
| IT1286789B1 (it) * | 1996-11-29 | 1998-07-17 | Alfa Chem Ital | Processo per la produzione della forma i del terazosin monocloridato anidro |
| GB9708917D0 (en) * | 1997-05-01 | 1997-06-25 | Pfizer Ltd | Compounds useful in therapy |
| US6214832B1 (en) | 1997-06-18 | 2001-04-10 | Merck & Co., Inc. | Bis-piperidinyl-pyrimidin-2-ones as alpha 1a adrenergic receptor antagonists |
| US6057350A (en) * | 1997-06-18 | 2000-05-02 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonists |
| US6143750A (en) * | 1997-06-18 | 2000-11-07 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonists |
| US6080760A (en) * | 1997-06-18 | 2000-06-27 | Merck & Co., Inc. | Alpha 1A adrenergic receptor antagonists |
| US6376503B1 (en) | 1997-06-18 | 2002-04-23 | Merck & Co., Inc | Alpha 1a adrenergic receptor antagonists |
| US6037354A (en) | 1997-06-18 | 2000-03-14 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonists |
| US6248888B1 (en) | 1997-11-14 | 2001-06-19 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of terazosin hydrochloride dihydrate |
| AU5234899A (en) | 1998-07-30 | 2000-02-21 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonists |
| WO2000025782A1 (en) | 1998-10-29 | 2000-05-11 | Merck & Co., Inc. | Dihydropyridinones and pyrrolinones useful as alpha 1a adrenoceptor antagonists |
| US6319932B1 (en) | 1998-11-10 | 2001-11-20 | Merck & Co., Inc. | Oxazolidinones useful as alpha 1A adrenoceptor antagonists |
| US6228870B1 (en) | 1998-11-10 | 2001-05-08 | Merck & Co., Inc. | Oxazolidinones useful as alpha 1a adrenoceptor antagonists |
| WO2000029386A1 (en) | 1998-11-12 | 2000-05-25 | Merck & Co., Inc. | Pyrimidinedione derivatives useful as alpha 1a adrenoceptor antagonists |
| DE19861323B4 (de) * | 1998-12-08 | 2006-02-16 | Robert Bosch Gmbh | Verfahren zur Übertragung von Kurznachrichten |
| DE19856440C2 (de) * | 1998-12-08 | 2002-04-04 | Bosch Gmbh Robert | Übertragungsrahmen und Funkeinheit mit Übertragungsrahmen |
| US6358959B1 (en) | 1999-01-26 | 2002-03-19 | Merck & Co., Inc. | Polyazanaphthalenone derivatives useful as alpha 1a adrenoceptor antagonists |
| GB2355456A (en) | 1999-09-30 | 2001-04-25 | Merck & Co Inc | Novel arylhydantoin derivatives useful as alpha 1a adrenoceptor antagonists |
| GB2355264A (en) | 1999-09-30 | 2001-04-18 | Merck & Co Inc | Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists |
| GB2355263A (en) | 1999-09-30 | 2001-04-18 | Merck & Co Inc | Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists |
| GB2355457A (en) | 1999-09-30 | 2001-04-25 | Merck & Co Inc | Novel spirotricyclic substituted azacycloalkane derivatives useful as alpha 1a adrenoceptor antagonists |
| US6200573B1 (en) | 1999-12-03 | 2001-03-13 | Starcor Pharmaceuticals, Inc. | Method of medical management for lower urinary tract symptoms and benign prostatic hyperplasia |
| US7335803B2 (en) | 2001-10-19 | 2008-02-26 | Allergan, Inc. | Methods and compositions for modulating alpha adrenergic receptor activity |
| US6313172B1 (en) | 2000-04-13 | 2001-11-06 | Allergan Sales, Inc. | Methods and compositions for modulating alpha adrenergic receptor activity |
| JP2002121188A (ja) * | 2000-07-18 | 2002-04-23 | Toray Ind Inc | ピペラジンアミド化合物の製造法およびピペラジンテトラヒドロフラン−２−カルボン酸アミド誘導体 |
| WO2002054996A2 (en) * | 2000-10-23 | 2002-07-18 | Euro Celtique Sa | Terazosin transdermal device and methods |
| US6534542B2 (en) | 2001-02-27 | 2003-03-18 | Allergen Sales, Inc. | (2-hydroxy)ethyl-thioureas useful as modulators of α2B adrenergic receptors |
| AU2003217676B2 (en) | 2002-02-22 | 2009-06-11 | Takeda Pharmaceutical Company Limited | Active agent delivery systems and methods for protecting and administering active agents |
| US7091232B2 (en) | 2002-05-21 | 2006-08-15 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
| US7276522B2 (en) | 2002-05-21 | 2007-10-02 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones, 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
| US7323485B2 (en) | 2002-05-21 | 2008-01-29 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
| US7358269B2 (en) | 2002-05-21 | 2008-04-15 | Allergan, Inc. | 2-((2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronapthalen-1(2H)-one |
| JP5165242B2 (ja) | 2003-09-12 | 2013-03-21 | アラーガン、インコーポレイテッド | 疼痛およびα２アドレナリン受容体が関与する他の状態の処置のための方法および組成物 |
| US7390829B2 (en) | 2005-06-29 | 2008-06-24 | Allergan, Inc. | Alpha-2 adrenergic agonists |
| US7323477B2 (en) | 2006-02-02 | 2008-01-29 | Allergan, Inc. | 7-((1H-imidazol-4-yl)methyl)-5,6,7,8-tetrahydroquinoline |
| CA2660659A1 (en) * | 2006-08-08 | 2008-02-21 | Auspex Pharmaceuticals, Inc. | Preparation and utility of substituted quinazoline compounds with alpha-adrenergic blocking effects |
| US7598417B2 (en) | 2007-04-12 | 2009-10-06 | Allergan, Inc. | Substituted fluoroethyl ureas as alpha 2 adrenergic agents |
| WO2008147788A1 (en) | 2007-05-23 | 2008-12-04 | Allergan, Inc. | Therapeutic ((phenyl)imidazolyl)methylquinolinyl compounds |
| CA2688897A1 (en) | 2007-05-23 | 2008-11-23 | Allergan, Inc. | Cyclic lactams for the treatment of glaucoma or elevated intraocular pressure |
| US7902247B2 (en) | 2008-01-09 | 2011-03-08 | Allergan, Inc. | Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors |
| US7829587B2 (en) | 2008-01-09 | 2010-11-09 | Allergan, Inc. | Substituted 2-aminotetralin derivatives as selective alpha 2B agonist |
| US8809379B2 (en) | 2008-01-18 | 2014-08-19 | Allergan, Inc. | Selective subtype alpha 2 adrenergic agents and methods for use thereof |
| WO2009091759A1 (en) | 2008-01-18 | 2009-07-23 | Allergan, Inc. | Selective subtype alpha 2 adrenergic agents and methods for use thereof |
| US20090239918A1 (en) * | 2008-03-24 | 2009-09-24 | Allergan, Inc. | Selective subtype alpha 2 adrenergic agents and methods for use thereof |
| US8420114B2 (en) | 2008-04-18 | 2013-04-16 | Warsaw Orthopedic, Inc. | Alpha and beta adrenergic receptor agonists for treatment of pain and / or inflammation |
| US9072727B2 (en) | 2008-04-18 | 2015-07-07 | Warsaw Orthopedic, Inc. | Alpha adrenergic receptor agonists for treatment of degenerative disc disease |
| EP2280707A1 (en) | 2008-05-05 | 2011-02-09 | Allergan, Inc. | Alpha2b and alpha2c agonists |
| WO2009140204A2 (en) | 2008-05-16 | 2009-11-19 | Allergan, Inc. | Selective subtype alpha 2 adrenergic agents and methods for use thereof |
| CA2746295A1 (en) | 2008-12-08 | 2010-07-08 | Allergan, Inc. | N-(1-phenyl-2-arylethyl)-4,5-dihydro-3h-pyrrol-2-amine compounds as subtype selective modulators of alpha2b or alpha2b and alpha2c adrenoceptors |
| EP2393800B1 (en) | 2009-02-06 | 2014-10-08 | Allergan, Inc. | Pyridine compounds as subtype selective modulators of alpha2b and/or alpha 2c adrenergic receptors |
| CA2769449A1 (en) | 2009-07-30 | 2011-02-03 | Allergan, Inc. | Selective alpha 2b/2c agonists |
| ES2756499T3 (es) | 2009-10-06 | 2020-04-27 | Allergan Inc | Derivados de 2H-pirrol-5-amina como moduladores de receptor alfa adrenérgico |
| US20160361380A1 (en) | 2015-06-12 | 2016-12-15 | Nymox Corporation | Combination compositions for treating disorders requiring removal or destruction of unwanted cellular proliferations |
| US11224572B1 (en) * | 2020-08-17 | 2022-01-18 | Novitium Pharma LLC | Stable oral liquid composition of terazosin |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4026894A (en) * | 1975-10-14 | 1977-05-31 | Abbott Laboratories | Antihypertensive agents |
| GB1591490A (en) * | 1977-08-04 | 1981-06-24 | Abbott Lab | 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate |
| JPH01216983A (ja) * | 1988-02-26 | 1989-08-30 | Hiroyuki Nohira | （±）−テトラヒドロフラン−２−カルボン酸の光学分割方法 |
-
1990
- 1990-06-29 US US07/546,349 patent/US5212176A/en not_active Expired - Fee Related
-
1991
- 1991-06-18 IE IE208691A patent/IE72967B1/en not_active IP Right Cessation
- 1991-06-19 IL IL9856291A patent/IL98562A/he not_active IP Right Cessation
- 1991-06-26 EP EP91914562A patent/EP0536329B1/en not_active Expired - Lifetime
- 1991-06-26 AT AT91914562T patent/ATE136779T1/de not_active IP Right Cessation
- 1991-06-26 ES ES91914562T patent/ES2089224T3/es not_active Expired - Lifetime
- 1991-06-26 DK DK91914562.3T patent/DK0536329T3/da active
- 1991-06-26 DE DE69118889T patent/DE69118889T2/de not_active Expired - Fee Related
- 1991-06-26 AU AU83231/91A patent/AU654148B2/en not_active Ceased
- 1991-06-26 JP JP3513458A patent/JPH07119222B2/ja not_active Expired - Fee Related
- 1991-06-26 WO PCT/US1991/004562 patent/WO1992000073A1/en not_active Ceased
- 1991-06-28 PT PT98148A patent/PT98148B/pt not_active IP Right Cessation
-
1993
- 1993-01-08 CA CA002086974A patent/CA2086974C/en not_active Expired - Fee Related
-
1996
- 1996-06-27 GR GR960401733T patent/GR3020364T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0536329T3 (da) | 1996-08-12 |
| DE69118889T2 (de) | 1996-11-07 |
| EP0536329A1 (en) | 1993-04-14 |
| AU8323191A (en) | 1992-01-23 |
| IE72967B1 (en) | 1997-05-07 |
| CA2086974A1 (en) | 1994-07-09 |
| EP0536329B1 (en) | 1996-04-17 |
| ES2089224T3 (es) | 1996-10-01 |
| US5212176A (en) | 1993-05-18 |
| IE912086A1 (en) | 1992-01-01 |
| PT98148B (pt) | 1998-12-31 |
| PT98148A (pt) | 1993-08-31 |
| JPH05507280A (ja) | 1993-10-21 |
| EP0536329A4 (en) | 1993-05-19 |
| JPH07119222B2 (ja) | 1995-12-20 |
| WO1992000073A1 (en) | 1992-01-09 |
| AU654148B2 (en) | 1994-10-27 |
| CA2086974C (en) | 2001-04-10 |
| ATE136779T1 (de) | 1996-05-15 |
| GR3020364T3 (en) | 1996-09-30 |
| DE69118889D1 (en) | 1996-05-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |