IL98133A - 2-alkyl-1, 2, 3, 4, 4a, 10b-hexahydro-6-(sulfonamidophenyl)-benzo-(c)-1, 6-naphthyridine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same - Google Patents

2-alkyl-1, 2, 3, 4, 4a, 10b-hexahydro-6-(sulfonamidophenyl)-benzo-(c)-1, 6-naphthyridine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same

Info

Publication number
IL98133A
IL98133A IL9813391A IL9813391A IL98133A IL 98133 A IL98133 A IL 98133A IL 9813391 A IL9813391 A IL 9813391A IL 9813391 A IL9813391 A IL 9813391A IL 98133 A IL98133 A IL 98133A
Authority
IL
Israel
Prior art keywords
compounds
denotes
alkyl
salts
methyl
Prior art date
Application number
IL9813391A
Other languages
English (en)
Other versions
IL98133A0 (en
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of IL98133A0 publication Critical patent/IL98133A0/xx
Publication of IL98133A publication Critical patent/IL98133A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heat Treatment Of Steel (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL9813391A 1990-05-16 1991-05-14 2-alkyl-1, 2, 3, 4, 4a, 10b-hexahydro-6-(sulfonamidophenyl)-benzo-(c)-1, 6-naphthyridine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same IL98133A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH165890 1990-05-16

Publications (2)

Publication Number Publication Date
IL98133A0 IL98133A0 (en) 1992-06-21
IL98133A true IL98133A (en) 1994-11-11

Family

ID=4215610

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9813391A IL98133A (en) 1990-05-16 1991-05-14 2-alkyl-1, 2, 3, 4, 4a, 10b-hexahydro-6-(sulfonamidophenyl)-benzo-(c)-1, 6-naphthyridine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same

Country Status (23)

Country Link
US (1) US5346904A (da)
EP (1) EP0528922B1 (da)
JP (1) JP3238397B2 (da)
CN (1) CN1027507C (da)
AT (1) ATE181330T1 (da)
AU (1) AU651592B2 (da)
CA (1) CA2082923C (da)
CS (1) CS144791A3 (da)
DE (3) DE4191109D2 (da)
DK (1) DK0528922T3 (da)
ES (1) ES2134777T3 (da)
FI (1) FI925005A (da)
GR (1) GR3031098T3 (da)
HU (2) HUT62895A (da)
IE (1) IE911625A1 (da)
IL (1) IL98133A (da)
MY (1) MY105344A (da)
NO (1) NO924414L (da)
NZ (1) NZ238141A (da)
PT (1) PT97680B (da)
WO (1) WO1991017991A1 (da)
YU (1) YU85691A (da)
ZA (1) ZA913627B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0612247A1 (de) * 1991-11-15 1994-08-31 Byk Gulden Lomberg Chemische Fabrik GmbH Verwendung von sulfonylverbindungen
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
DK0937074T3 (da) * 1996-11-11 2003-06-23 Altana Pharma Ag Benzonaphthyridiner som bronkiale terapeutiske midler
PT968211E (pt) * 1997-03-07 2004-01-30 Altana Pharma Ag Derivados de tetrazoles
DK0988302T3 (da) * 1997-06-03 2003-06-02 Altana Pharma Ag Benzonaphthyridiner
EP0997462B1 (en) 1997-06-30 2004-12-22 Nippon Kayaku Kabushiki Kaisha Novel naphthyridine derivatives or salts thereof
MXPA02001830A (es) 1999-08-21 2002-08-12 Byk Gulden Lomberg Chem Fab Combinacion sinergica de inhibidores de pde y agonista de beta 2 adrenoceptor.
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EA200501548A1 (ru) 2003-04-01 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. Ингибиторы фосфодиэстераз при бесплодии
DK2170930T3 (da) 2007-06-04 2012-11-05 Synergy Pharmaceuticals Inc Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US8196556B2 (en) * 2009-09-17 2012-06-12 Delphi Technologies, Inc. Apparatus and method for setting mechanical lash in a valve-deactivating hydraulic lash adjuster
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
ES2664873T3 (es) 2011-03-01 2018-04-23 Synergy Pharmaceuticals Inc. Proceso de preparación de agonistas de guanilato ciclasa C
EP2958577A2 (en) 2013-02-25 2015-12-30 Synergy Pharmaceuticals Inc. Guanylate cyclase receptor agonists for use in colonic cleansing
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
KR102272746B1 (ko) 2013-06-05 2021-07-08 보슈 헬스 아일랜드 리미티드 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법
KR20220147691A (ko) 2013-08-09 2022-11-03 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899494A (en) * 1970-05-13 1975-08-12 Sandoz Ltd Substituted 6-phenyl benzo-naphthyridines
FI750205A (da) * 1974-02-05 1975-08-06 Sandoz Ag
US4087530A (en) * 1974-02-05 1978-05-02 Sandoz Ltd. Substituted 6-phenyl-octahydrobenzo [c] [1,6] naphthyridines
EP0247971A3 (en) * 1986-05-29 1990-01-17 Sandoz Ag Novel pharmaceutical compositions comprising and use of cis-6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin

Also Published As

Publication number Publication date
NZ238141A (en) 1993-07-27
WO1991017991A1 (de) 1991-11-28
AU651592B2 (en) 1994-07-28
EP0528922A1 (de) 1993-03-03
IE911625A1 (en) 1991-11-20
YU85691A (sh) 1994-06-24
PT97680B (pt) 1998-09-30
JP3238397B2 (ja) 2001-12-10
US5346904A (en) 1994-09-13
NO924414D0 (no) 1992-11-16
GR3031098T3 (en) 1999-12-31
ES2134777T3 (es) 1999-10-16
HUT62895A (en) 1993-06-28
DE4191109A1 (da) 1993-04-01
DE4191109D2 (en) 1993-04-01
EP0528922B1 (de) 1999-06-16
CN1027507C (zh) 1995-01-25
DE59109135D1 (de) 1999-07-22
IL98133A0 (en) 1992-06-21
PT97680A (pt) 1992-02-28
JPH05507081A (ja) 1993-10-14
HU9203557D0 (en) 1993-03-29
NO924414L (no) 1992-11-16
CN1056691A (zh) 1991-12-04
MY105344A (en) 1994-09-30
AU7870191A (en) 1991-12-10
CS144791A3 (en) 1992-03-18
ATE181330T1 (de) 1999-07-15
CA2082923A1 (en) 1991-11-17
CA2082923C (en) 2001-12-18
ZA913627B (en) 1992-01-29
DK0528922T3 (da) 1999-11-22
FI925005A0 (fi) 1992-11-05
FI925005A (fi) 1992-11-05

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