IL96723A0 - Novel platelet-derived growth factor b chain analogs and method for homogeneous production thereof - Google Patents

Novel platelet-derived growth factor b chain analogs and method for homogeneous production thereof

Info

Publication number
IL96723A0
IL96723A0 IL96723A IL9672390A IL96723A0 IL 96723 A0 IL96723 A0 IL 96723A0 IL 96723 A IL96723 A IL 96723A IL 9672390 A IL9672390 A IL 9672390A IL 96723 A0 IL96723 A0 IL 96723A0
Authority
IL
Israel
Prior art keywords
analogs
pdgf
present
growth factor
novel
Prior art date
Application number
IL96723A
Other languages
English (en)
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/454,794 external-priority patent/US5149792A/en
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of IL96723A0 publication Critical patent/IL96723A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
IL96723A 1989-12-19 1990-12-19 Novel platelet-derived growth factor b chain analogs and method for homogeneous production thereof IL96723A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/454,794 US5149792A (en) 1989-12-19 1989-12-19 Platelet-derived growth factor B chain analogs
US07/624,451 US5272064A (en) 1989-12-19 1990-12-13 DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof

Publications (1)

Publication Number Publication Date
IL96723A0 true IL96723A0 (en) 1991-09-16

Family

ID=27037609

Family Applications (1)

Application Number Title Priority Date Filing Date
IL96723A IL96723A0 (en) 1989-12-19 1990-12-19 Novel platelet-derived growth factor b chain analogs and method for homogeneous production thereof

Country Status (17)

Country Link
US (1) US5272064A (es)
EP (1) EP0458959B1 (es)
JP (1) JPH04504064A (es)
AT (1) ATE123949T1 (es)
AU (1) AU646014B2 (es)
CA (1) CA2032675A1 (es)
DE (1) DE69020335T2 (es)
DK (1) DK0458959T3 (es)
ES (1) ES2073735T3 (es)
FI (1) FI913892A0 (es)
GR (1) GR3017317T3 (es)
IE (1) IE904608A1 (es)
IL (1) IL96723A0 (es)
NO (1) NO913232L (es)
NZ (1) NZ236549A (es)
PT (1) PT96272A (es)
WO (1) WO1991008761A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2130748A1 (en) * 1992-02-26 1993-09-02 Michael E. Stern Use of platelet derived growth factor in ophthalmic wound healing
AU3816593A (en) * 1992-03-30 1993-11-08 Schering Corporation Monomeric platelet-derived growth factor and prevention of stenosis or restenosis
WO2003083066A2 (en) 2002-03-27 2003-10-09 Immunex Corporation Methods for increasing polypeptide production
JP2006517586A (ja) * 2003-02-04 2006-07-27 ラドウィグ インスティテュート フォー キャンサー リサーチ 幹細胞のｖｅｇｆ−ｂ及びｐｄｇｆ調節
WO2011008904A1 (en) 2009-07-17 2011-01-20 Tabor Aaron T Compositions and methods for genetic modification of cells having cosmetic function to enhance cosmetic appearance
WO2012019160A1 (en) 2010-08-05 2012-02-09 Amgen Inc. Dipeptides to enhance yield and viability from cell cultures
ES2725785T3 (es) 2011-04-20 2019-09-27 Amgen Inc Aparato autoinyector
US9133493B2 (en) 2011-04-21 2015-09-15 Amgen Inc. Method for culturing mammalian cells to improve recombinant protein production
IL310968A (en) 2011-07-01 2024-04-01 Amgen Inc Mammalian cell culture
KR20140058669A (ko) 2011-09-02 2014-05-14 암젠 인크 의약품 및 의약품의 광 노출을 분석하는 방법
AR089231A1 (es) 2011-12-15 2014-08-06 Amgen Inc Metodo de floculacion
WO2014109858A1 (en) 2013-01-14 2014-07-17 Amgen Inc. Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
TWI625390B (zh) 2013-03-14 2018-06-01 安美基公司 用於增加重組蛋白質之甘露糖含量之方法
SI2969099T2 (sl) 2013-03-14 2022-04-29 Amgen Inc. Odstranjevanje izluženega afinitetnega purifikacijskega liganda
ES2973257T3 (es) 2013-03-15 2024-06-19 Amgen Inc Casete de fármaco, autoinyector y sistema de autoinyector
TWI580452B (zh) 2013-03-15 2017-05-01 安美基公司 用於注射器之匣盒、注射器及使用包括自動注射器及匣盒之設備之方法
BR112015022042B1 (pt) 2013-03-15 2023-01-10 Amgen Inc Injetor para injetar um produto terapêutico
US9481901B2 (en) 2013-05-30 2016-11-01 Amgen Inc. Methods for increasing mannose content of recombinant proteins
EP3063287A1 (en) 2013-10-31 2016-09-07 Amgen Inc. Use of monensin to regulate glycosylation of recombinant proteins
AU2014376225C1 (en) 2014-01-13 2019-02-21 Amgen Inc. Regulating ornithine metabolism to manipulate the high mannose glycoform content of recombinant proteins
IL282517B (en) 2014-01-29 2022-07-01 Amgen Inc Overexpression of n-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
US10106829B2 (en) 2014-01-29 2018-10-23 Amgen Inc. Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
EA039148B1 (ru) 2014-06-04 2021-12-10 Эмджен Инк. Способ сбора рекомбинантного белка
EP3221465B1 (en) 2014-11-19 2019-03-13 Amgen Inc. Quantitation of glycan moiety in recombinant glycoproteins
PL3227454T3 (pl) 2014-12-01 2020-07-27 Amgen Inc. Sposób manipulowania poziomem zawartości glikanów w glikoproteinie
MX2020005066A (es) 2017-11-16 2020-08-20 Amgen Inc Autoinyector con deteccion de detencion y punto final.
EP3788076A1 (en) 2018-05-01 2021-03-10 Amgen Inc. Antibodies with modulated glycan profiles
WO2023079058A1 (en) 2021-11-05 2023-05-11 Yokogawa Insilico Biotechnology Gmbh Cell culture with reduced production of lactate
WO2023129974A1 (en) 2021-12-29 2023-07-06 Bristol-Myers Squibb Company Generation of landing pad cell lines

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4479896A (en) * 1981-12-11 1984-10-30 Antoniades Harry N Method for extraction localization and direct recovery of platelet derived growth factor
US4801542A (en) * 1984-10-12 1989-01-31 Zymogenetics, Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US4766073A (en) * 1985-02-25 1988-08-23 Zymogenetics Inc. Expression of biologically active PDGF analogs in eucaryotic cells
EP0487116B1 (en) * 1984-10-12 1999-12-29 ZymoGenetics, Inc. Biologically active PDGF analogs in eucaryotic cells
US4769328A (en) * 1984-10-12 1988-09-06 Zymogenetics Inc. Expression of biologically active PDGF analogs in yeast
DE3751632T2 (de) * 1986-08-13 1996-06-13 Zymogenetics Inc Expression von biologisch-aktiven PDGF-Analogen in eukaryotischen Zellen
DE3834079A1 (de) * 1988-10-06 1990-04-12 Biotechnolog Forschung Gmbh Wachstumstimulierendes pdgf-bb und dessen verwendung sowie ein verfahren zu seiner herstellung und der des monomeren
IL96682A0 (en) * 1989-12-15 1991-09-16 Amgen Inc Production of biologically active platelet-derived growth factor from high expression host cell systems

Also Published As

Publication number Publication date
DK0458959T3 (da) 1995-08-14
DE69020335D1 (de) 1995-07-27
US5272064A (en) 1993-12-21
WO1991008761A1 (en) 1991-06-27
NO913232D0 (no) 1991-08-19
EP0458959A1 (en) 1991-12-04
EP0458959B1 (en) 1995-06-21
PT96272A (pt) 1991-09-30
IE904608A1 (en) 1991-06-19
EP0458959A4 (en) 1993-06-16
ATE123949T1 (de) 1995-07-15
CA2032675A1 (en) 1991-06-20
JPH04504064A (ja) 1992-07-23
AU646014B2 (en) 1994-02-03
AU7153491A (en) 1991-07-18
ES2073735T3 (es) 1995-08-16
NO913232L (no) 1991-08-19
DE69020335T2 (de) 1995-11-02
NZ236549A (en) 1993-03-26
GR3017317T3 (en) 1995-12-31
FI913892A0 (fi) 1991-08-16

Similar Documents

Publication Publication Date Title
IL96723A0 (en) Novel platelet-derived growth factor b chain analogs and method for homogeneous production thereof
CA2032153A1 (fr) Application de nouveaux fragments d'adn en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
HUT46061A (en) Dna sequences encoding hirudin-like protein and process for producing such proteins
PH30889A (en) Dna encoding equuine-gamma interferon and recombination production of equine ifn-polypeptides.
DE3584579D1 (de) Herstellung von polypeptiden mit human-gammainterferon-aktivitaet.
TW275066B (es)
NO895028D0 (no) Ny chimerisk transformerende vekstfaktor-beta.
IL80562A0 (en) Recombinant human lysozyme,its preparation by recombinant dna technology and pharmaceutical compositions containing it
GB8821795D0 (en) New derivatives of human/bovine basic fibroplast growth factor
ATE145939T1 (de) Mitogen für die glatte muskulatur und dessen kodierende dns
DE69219242D1 (de) Muteine des menschlichen Parathormons und ihre Herstellung
EP0613946A3 (en) Hst-2 mutein, dna coding for the same and preparation thereof.
DE60138885D1 (de) Polypeptide mit aktivität der stimulierung von neutrophilen