IL96398A0 - Therapeutically active chloro substituted benzimidazoles processes for their preparation as well as their use - Google Patents

Therapeutically active chloro substituted benzimidazoles processes for their preparation as well as their use

Info

Publication number
IL96398A0
IL96398A0 IL96398A IL9639890A IL96398A0 IL 96398 A0 IL96398 A0 IL 96398A0 IL 96398 A IL96398 A IL 96398A IL 9639890 A IL9639890 A IL 9639890A IL 96398 A0 IL96398 A0 IL 96398A0
Authority
IL
Israel
Prior art keywords
processes
preparation
well
therapeutically active
substituted benzimidazoles
Prior art date
Application number
IL96398A
Other languages
English (en)
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haessle Ab filed Critical Haessle Ab
Publication of IL96398A0 publication Critical patent/IL96398A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL96398A 1989-12-20 1990-11-19 Therapeutically active chloro substituted benzimidazoles processes for their preparation as well as their use IL96398A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/454,049 US4965269A (en) 1989-12-20 1989-12-20 Therapeutically active chloro substituted benzimidazoles

Publications (1)

Publication Number Publication Date
IL96398A0 true IL96398A0 (en) 1991-08-16

Family

ID=23803085

Family Applications (1)

Application Number Title Priority Date Filing Date
IL96398A IL96398A0 (en) 1989-12-20 1990-11-19 Therapeutically active chloro substituted benzimidazoles processes for their preparation as well as their use

Country Status (10)

Country Link
US (1) US4965269A (pt)
CN (1) CN1052671A (pt)
AU (1) AU6973991A (pt)
IE (1) IE904249A1 (pt)
IL (1) IL96398A0 (pt)
IS (1) IS3660A7 (pt)
PL (1) PL288336A1 (pt)
PT (1) PT96257A (pt)
WO (1) WO1991009029A1 (pt)
ZA (1) ZA909141B (pt)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5274099A (en) * 1989-12-20 1993-12-28 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
HUT62882A (en) * 1990-06-20 1993-06-28 Astra Ab Process for producing dialkoxy pyridylmethyl sulfinyl benzimidazole derivatives and pharmaceutical compositions comprising same
US6274591B1 (en) * 1997-11-03 2001-08-14 Joseph F. Foss Use of methylnaltrexone and related compounds
US20030158220A1 (en) * 1997-11-03 2003-08-21 Foss Joseph F. Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
YU10101A (sh) * 1998-08-10 2003-10-31 Partnership Of Michael E. Garst George Sachs And Jai Moo Shin Prolekovi inhibitori proton pumpe
US6093734A (en) * 1998-08-10 2000-07-25 Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin Prodrugs of proton pump inhibitors
WO2003027098A1 (fr) * 2001-09-25 2003-04-03 Takeda Chemical Industries, Ltd. Compose de benzymidazole, procede de production et d'utilisation de celui-ci
JPWO2003106429A1 (ja) * 2002-06-14 2005-10-13 武田薬品工業株式会社 プロドラッグおよびその製造法
MXPA05000657A (es) * 2002-07-19 2005-08-19 Winston Pharmaceuticals Llc Profarmacos de los inhibidores de bomba de protones.
MY148805A (en) 2002-10-16 2013-05-31 Takeda Pharmaceutical Controlled release preparation
US20050004155A1 (en) * 2003-04-08 2005-01-06 Boyd Thomas A. Use of methylnaltrexone to treat irritable bowel syndrome
SI1615646T2 (sl) 2003-04-08 2022-11-30 Progenics Pharmaceuticals, Inc. Farmacevtske formulacije vsebujoče metilnatrekson
MXPA05010821A (es) * 2003-04-08 2006-03-30 Progenics Pharm Inc Terapia de combinacion para constipacion que comprende un laxante y un antagonista opioide periferico.
CA2529984C (en) * 2003-06-26 2012-09-25 Isa Odidi Oral multi-functional pharmaceutical capsule preparations of proton pump inhibitors
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
WO2005039640A1 (en) * 2003-10-03 2005-05-06 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs
AU2005216862A1 (en) * 2004-02-18 2005-09-09 Allergan, Inc. Compositions comprising prodrugs of proton pump inhibitors
US20070161679A1 (en) * 2004-02-18 2007-07-12 Allergan, Inc. Method and compositions for the intravenous administration of compounds related to proton pump inhibitors
CA2561700A1 (en) * 2004-04-16 2005-12-15 Santarus, Inc. Combination of proton pump inhibitor, buffering agent, and prokinetic agent
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
CN101137378A (zh) * 2005-01-20 2008-03-05 普罗热尼奇制药公司 甲基纳曲酮和相关化合物治疗术后胃肠功能障碍的用途
CN104248763A (zh) 2005-03-07 2014-12-31 芝加哥大学 阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
US20080194611A1 (en) * 2005-06-03 2008-08-14 Alverdy John C Modulation of Cell Barrier Dysfunction
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
EP2007360B1 (en) 2006-04-03 2014-11-26 Isa Odidi Controlled release delivery device comprising an organosol coat
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
US20100317689A1 (en) * 2006-09-19 2010-12-16 Garst Michael E Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
CA2667682A1 (en) 2006-10-27 2008-05-15 The Curators Of The University Of Missouri Compositions comprising acid labile proton pump inhibiting agents, at least one other pharmaceutically active agent and methods of using same
US20080194307A1 (en) * 2007-02-13 2008-08-14 Jeff Sanger Sports-based game of chance
PT2139890E (pt) 2007-03-29 2014-09-03 Wyeth Llc Antagonistas do receptor opióide periférico e respectivas utilizações
MX2009010550A (es) 2007-03-29 2009-12-14 Progenics Pharm Inc Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas.
AR065877A1 (es) 2007-03-29 2009-07-08 Progenics Pharm Inc Antagonoistas del receptor opioide periferico y usos de los mismos
EP2240489A1 (en) 2008-02-06 2010-10-20 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
CA2716367C (en) 2008-02-20 2015-05-26 The Curators Of The University Of Missouri Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same
WO2009117669A2 (en) 2008-03-21 2009-09-24 The University Of Chicago Treatment with opioid antagonists and mtor inhibitors
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (pt) * 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
SE8204879D0 (sv) * 1982-08-26 1982-08-26 Haessle Ab Novel chemical intermediates
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
SE8301182D0 (sv) * 1983-03-04 1983-03-04 Haessle Ab Novel compounds
IL71664A (en) * 1983-05-03 1987-11-30 Byk Gulden Lomberg Chem Fab Fluoroalkoxy compounds,process for their preparation and pharmaceutical compositions containing the same
US4575554A (en) * 1983-12-05 1986-03-11 The Upjohn Company Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
GB2161160B (en) * 1984-07-06 1989-05-24 Fisons Plc Heterocyclic sulphinyl compounds
SE8404065D0 (sv) * 1984-08-10 1984-08-10 Haessle Ab Novel biologically active compounds
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS6150979A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
JPS62201884A (ja) * 1986-02-28 1987-09-05 Tokyo Tanabe Co Ltd ベンズイミダゾール誘導体及びその製造法
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
NZ234564A (en) * 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
JPS63183577A (ja) * 1987-01-23 1988-07-28 Grelan Pharmaceut Co Ltd ベンズイミダゾ−ル誘導体
US4839365A (en) * 1987-05-19 1989-06-13 Shinogi & Co., Ltd. Thienopyridine derivatives useful in treating gastric ulcers
FI96860C (fi) * 1987-06-17 1996-09-10 Eisai Co Ltd Analogiamenetelmä lääkeaineena käytettävän pyridiinijohdannaisen valmistamiseksi
WO1989005299A1 (en) * 1987-12-11 1989-06-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel benzimidazole derivatives

Also Published As

Publication number Publication date
CN1052671A (zh) 1991-07-03
IE904249A1 (en) 1991-07-03
ZA909141B (en) 1991-08-28
US4965269A (en) 1990-10-23
WO1991009029A1 (en) 1991-06-27
PL288336A1 (en) 1991-12-02
PT96257A (pt) 1991-09-30
AU6973991A (en) 1991-07-18
IS3660A7 (is) 1991-06-21

Similar Documents

Publication Publication Date Title
IL96398A0 (en) Therapeutically active chloro substituted benzimidazoles processes for their preparation as well as their use
NO179584C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-acylaminotiazoler
NO180586C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte imidazoler
EP0444451A3 (en) 3-arylcarbonyl-1h-indoles useful as therapeutic agents
NO175978C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive bis-aza-bicykliske forbindelser
NO900032L (no) Fremgangsmaate for fremstilling av terapeutisk aktive tiazol-forbindelser.
NO174203C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive
NO174774C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive benzodiazepiner
ZA909629B (en) Anthelmintics
HU9401840D0 (en) Substituted benzimidazoles, process for their preparation as well as their use
ZA907638B (en) Anthelmintics
ZA905932B (en) 14,17alpha-etheno-and-ethanoestratrienes,processes for the preparation of these compounds,as well as their use for the production of medicinal agents
GB8314021D0 (en) Preparing therapeutically active dihydropyridines
ZA909142B (en) Therapeutically active fluoro substituted benzimidazoles,processes for their preparation as well as their use
NO175780C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte dibenzofuraner
ZA909630B (en) Anthelmintics
NO179367C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive fenoksy-heterocykliske forbindelser
ZA9010218B (en) Pharmaceutically active normanyl compounds
NO174927C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive benzopyraner
GB8925320D0 (en) Therapeutically active agent
GB8730191D0 (en) Pharmacologically active compounds & use
GB8730192D0 (en) Pharmacologically active compounds & use
SE8902170D0 (sv) Therapeutically active compounds
GB8910600D0 (en) Therapeutically useful compounds
GB8910602D0 (en) Therapeutically useful compounds