IL95511A - Neurotrophin-3 a novel neurotrophic factor related to nerve growth and brain derived neurotrophic factor - Google Patents

Neurotrophin-3 a novel neurotrophic factor related to nerve growth and brain derived neurotrophic factor

Info

Publication number
IL95511A
IL95511A IL9551190A IL9551190A IL95511A IL 95511 A IL95511 A IL 95511A IL 9551190 A IL9551190 A IL 9551190A IL 9551190 A IL9551190 A IL 9551190A IL 95511 A IL95511 A IL 95511A
Authority
IL
Israel
Prior art keywords
neurotrophic factor
neurotrophin
nerve growth
brain derived
protein
Prior art date
Application number
IL9551190A
Other languages
English (en)
Other versions
IL95511A0 (en
Original Assignee
Max Planck Gesellschaft
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/400,591 external-priority patent/US5180820A/en
Application filed by Max Planck Gesellschaft, Regeneron Pharma filed Critical Max Planck Gesellschaft
Publication of IL95511A0 publication Critical patent/IL95511A0/xx
Publication of IL95511A publication Critical patent/IL95511A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
    • F02B—INTERNAL-COMBUSTION PISTON ENGINES; COMBUSTION ENGINES IN GENERAL
    • F02B75/00—Other engines
    • F02B75/02—Engines characterised by their cycles, e.g. six-stroke
    • F02B2075/022—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle
    • F02B2075/027—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle four
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL9551190A 1989-08-30 1990-08-28 Neurotrophin-3 a novel neurotrophic factor related to nerve growth and brain derived neurotrophic factor IL95511A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/400,591 US5180820A (en) 1989-08-30 1989-08-30 Brain-derived neurotrophic factor
US49000490A 1990-03-07 1990-03-07
US57018990A 1990-08-20 1990-08-20

Publications (2)

Publication Number Publication Date
IL95511A0 IL95511A0 (en) 1991-06-30
IL95511A true IL95511A (en) 2000-10-31

Family

ID=27410411

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9551190A IL95511A (en) 1989-08-30 1990-08-28 Neurotrophin-3 a novel neurotrophic factor related to nerve growth and brain derived neurotrophic factor

Country Status (21)

Country Link
EP (1) EP0441947B1 (fi)
KR (1) KR100196203B1 (fi)
CN (1) CN1124342C (fi)
AT (1) ATE153074T1 (fi)
AU (1) AU643705B2 (fi)
CA (1) CA2040437C (fi)
CZ (1) CZ286015B6 (fi)
DE (1) DE69030719T2 (fi)
ES (1) ES2100891T3 (fi)
FI (1) FI105343B (fi)
GR (1) GR1000980B (fi)
HK (1) HK1006579A1 (fi)
IE (1) IE903129A1 (fi)
IL (1) IL95511A (fi)
LV (1) LV10792B (fi)
NO (1) NO303694B1 (fi)
NZ (1) NZ235086A (fi)
PT (1) PT95153B (fi)
SG (1) SG70560A1 (fi)
SK (1) SK423090A3 (fi)
WO (1) WO1991003569A1 (fi)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor
US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
US5606031A (en) * 1990-04-06 1997-02-25 Lile; Jack Production and purification of biologically active recombinant neurotrophic protein in bacteria
US5235043A (en) * 1990-04-06 1993-08-10 Synergen, Inc. Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins
US5986070A (en) * 1990-04-06 1999-11-16 Amgen Inc. Production of biologically active NGF proteins
DK0499993T3 (da) * 1991-02-18 1997-12-01 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af human nervevækstfaktor-2
US5389529A (en) * 1991-06-12 1995-02-14 Regeneron Pharmaceuticals, Inc. Modified lamβ signal sequence and processes for producing recombinant neurotrophins
PT100501A (pt) * 1991-07-10 1993-09-30 Regeneron Pharma Composicoes farmaceuticas a base de um membro da familia de moleculas de bdnf/nt-3/ngf, processo para promover a sobrevivencia,crescimentoe/ou diferenciacao de neuronios motores in vitro e de diagnostico, e processo de ensaio de um agente de teste.
DE4237047A1 (en) * 1991-11-04 1993-05-06 I N R O Handels-Gmbh, 8750 Aschaffenburg, De Drug contg. polypeptide homologous to nerve growth factor and slow virus sequence - for treating amyotrophic lateral sclerosis, spinal muscle atrophy or Parkinson's disease
EP0573904B1 (en) * 1992-06-08 2001-09-26 Takeda Chemical Industries, Ltd. Therapeutic agent for neutropenia
EP0644937A4 (en) * 1992-06-12 1995-05-03 Regeneron Pharmaceuticals, Inc. Therapeutic and diagnostic methods based on neurotrophin-4 expression.
ATE194658T1 (de) * 1992-09-03 2000-07-15 Univ California Das dorsalgewebe beeinflussender faktor
DK0669929T3 (da) * 1992-11-13 2007-01-29 Immunex Corp Elk-ligand, et cytokin
AU5891394A (en) * 1993-02-11 1994-08-29 Erziehungsdirektion Of The Canton Zurich A combination of neurotrophin and antibody directed toward myelin-associated neurite growth inhibitory protein promotes central nervous system regeneration
JPH07246040A (ja) * 1993-07-06 1995-09-26 Takeda Chem Ind Ltd ニューロトロフィン−３遺伝子が不活性化された胚幹細胞および該遺伝子発現不全動物
EP0753013A1 (en) * 1994-03-29 1997-01-15 Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V. Neurotrophin-6: a new member of the neurotrophin family
WO1995030434A1 (en) * 1994-05-06 1995-11-16 Regeneron Pharmaceuticals, Inc. Methods based on the role of neurotrophin 3 in female reproduction
US6303769B1 (en) 1994-07-08 2001-10-16 Immunex Corporation Lerk-5 dna
JP3738281B2 (ja) * 1994-07-22 2006-01-25 アベンティス ファーマ株式会社 新規な骨芽細胞増殖因子
US5770577A (en) * 1994-11-14 1998-06-23 Amgen Inc. BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
WO1996017865A2 (de) * 1994-12-05 1996-06-13 Boehringer Mannheim Gmbh Gene und genprodukte zur diagnostik von degenerativer nervenschädigung
US5859311A (en) * 1995-11-27 1999-01-12 University Of Kentucky Research Foundation Transgenic mice which overexpress neurotrophin-3 (NT-3) and methods of use
JP4383530B2 (ja) 1996-04-05 2009-12-16 ノバルティス バクシンズ アンド ダイアグノスティックス， インコーポレーテッド 細胞巨大分子合成の阻害が減少したアルファウイルスベクター
CZ250499A3 (cs) * 1997-01-17 1999-11-17 Rhone-Poulenc Rorer S. A. Použití nukleové kyseliny k indukci inervace svalů a růstu axonů motorických neuronů
KR20000070357A (ko) 1997-01-23 2000-11-25 다께우찌 마사야쓰 당뇨병 치료제
EP1173768B1 (en) * 1999-05-03 2006-10-25 Evotec AG Methods of diagnosing, prognosing, monitoring the progression or evaluating of a treatment of depression on basis of increased cerebrospinal fluid levels of neurotrophin 3
EP1050758A1 (en) * 1999-05-03 2000-11-08 Evotec BioSystems AG Methods of diagnosing or treating neuropsychiatric diseases on basis of increased cerebrospinal fluid levels of neurotrophin 3
CN1112215C (zh) * 1999-12-28 2003-06-25 潘晓东 神经生长因子在治疗有机溶剂中毒性周围神经病中的用途
WO2006108651A2 (en) * 2005-04-12 2006-10-19 Develogen Aktiengesellschaft Use of activin products for preventing and treating diabetes and/or metabolic syndrome
EP2776022A1 (en) 2011-11-08 2014-09-17 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research New treatment for neurodegenerative diseases
WO2013068432A1 (en) 2011-11-08 2013-05-16 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research Early diagnostic of neurodegenerative diseases
WO2014006114A1 (en) 2012-07-05 2014-01-09 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research New treatment for neurodegenerative diseases
CN110862447A (zh) * 2019-11-29 2020-03-06 武汉赛维尔生物科技有限公司 一种提高神经营养因子nt-3碱性蛋白产量的蛋白改造方法
CN113940308A (zh) * 2021-04-28 2022-01-18 重庆腾达牧业有限公司 大足黑山羊哺乳舍饲养管理方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4699875A (en) * 1982-11-24 1987-10-13 Baylor College Of Medicine Diagnosis of amyotrophic lateral sclerosis by neurotrophic factors
DK161152C (da) * 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US6709837B1 (en) * 1989-03-10 2004-03-23 Takeda Chemical Industries, Inc. Polypeptide and production thereof
US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
US7020718B2 (en) 2000-05-15 2006-03-28 Hewlett-Packard Development Company, L.P. System and method of aggregating discontiguous address ranges into addresses and masks using a plurality of repeating address blocks

Also Published As

Publication number Publication date
IE903129A1 (en) 1991-03-13
CZ286015B6 (cs) 1999-12-15
CZ423090A3 (cs) 1999-09-15
HK1006579A1 (en) 1999-03-05
IL95511A0 (en) 1991-06-30
GR1000980B (el) 1993-03-31
LV10792A (lv) 1995-08-20
CN1124342C (zh) 2003-10-15
KR100196203B1 (ko) 1999-06-15
WO1991003569A1 (en) 1991-03-21
PT95153B (pt) 1993-12-31
SK279660B6 (sk) 1999-02-11
AU6404990A (en) 1991-04-08
CN1052141A (zh) 1991-06-12
DE69030719T2 (de) 1997-09-25
GR900100647A (en) 1991-12-30
NZ235086A (en) 1993-10-26
EP0441947B1 (en) 1997-05-14
NO303694B1 (no) 1998-08-17
EP0441947A1 (en) 1991-08-21
FI105343B (fi) 2000-07-31
LV10792B (en) 1995-12-20
NO911688L (no) 1991-05-31
ATE153074T1 (de) 1997-05-15
PT95153A (pt) 1991-05-22
NO911688D0 (no) 1991-04-29
SK423090A3 (en) 1999-02-11
FI912105A0 (fi) 1991-04-30
AU643705B2 (en) 1993-11-25
KR920702865A (ko) 1992-10-28
ES2100891T3 (es) 1997-07-01
EP0441947A4 (en) 1992-05-13
CA2040437A1 (en) 1991-03-01
CA2040437C (en) 2002-10-22
DE69030719D1 (de) 1997-06-19
SG70560A1 (en) 2000-02-22

Similar Documents

Publication Publication Date Title
EP0441947A4 (en) Neurotrophin-3, a novel neurotrophic factor related to nerve growth factor and brain derived neurotrophic factor
DE59006837D1 (de) Verfahren zur fermentativen Herstellung von Aminosäuren, insbesondere L-Lysin, dafür geeignete Mikroorganismen und rekombinante DNA.
DE59611371D1 (de) Verfahren zur Herstellung von Erythropoietin frei von tierischen Proteinen
EP2258722A3 (en) Antibodies to fibroblast growth factor-like (FGF-like) polypeptides
BR8301918A (pt) Proteina,sequencia de dna,veiculo de expressao replicavel,microorganismo ou cultura celular,plasmideo,composicao,cultura de celulas,utilizacao de tal proteina,processo de expressao,processo para producao de um veiculo de expressao e processo para preparacao de uma proteina uroquinase
DE68929115D1 (de) Verfahren zur Herstellung von menschlichem Serumalbumin in Hefe
DE3884356D1 (de) Verfahren zur Herstellung von Fremdprotein in Hefe, Rekombinant DNS, Transformant.
DE69300158D1 (de) TGF-Beta induziertes Gen und Protein.
CA2092567A1 (en) Nt-4 neurotrophic factor
FI885679A0 (fi) Samuttryckning i eukariotiska celler.
UA48936C2 (uk) Спосіб одержання вірусу курячої анемії (cav) у дволанцюговій формі, рекомбінантна нуклеїнова кислота (варіанти), діагностичний набір (варіанти), вакцинний препарат (варіанти), культура клітин (варіанти), спосіб одержання діагностичного набору (варіанти)
AU8110487A (en) DNA molecules coding for proteins targeted to plant cell walls
AU2795989A (en) Production of gonorrheal pi proteins and vaccines
CA2128215A1 (en) Autotaxin: motility stimulating protein useful in cancer diagnosis and therapy
GB2171703B (en) Expression-secretion vector for gene expression and protein secretion, recombinant dna including the vector, and method of producing proteins by use of the re
ATE121419T1 (de) Protein l und ihre untereinheiten, mit immunglobulinbindender aktivität, verfahren zur herstellung, reagenssatz, pharmazeutische zubereitung und ein peptococcus-magnus-stamm.
WO1997035976A3 (en) Epidermal differentiation factor
EP0841399A3 (en) Mammalian fin-1 nucleic acid (a caspase) and protein sequences and uses therefor
ATE286509T1 (de) Interferon alpha/beta bindendes protein, seine herstellung und anwendung
ES2115208T3 (es) Proteina de la superficie celular de brevibacterium lactofermentum.
BR9508430A (pt) Sequência nucleotídica ADN recombinante vetor de expressão com replicação autônoma e/ou integrativo célula recombinante polipeptideo processo de produção de um polipeptideo topoismorase isolada e utilização de uma topoisomeras IV
DE3850933D1 (de) Anticoagulatorisches Protein PP4-X, seine Herstellung und Verwendung.
WO2001079525A3 (en) Purified and isolated potassium-chloride cotransporter nucleic acids and polypeptides and therapeutic and screening methods using same
TH14583EX (th) จีนที่มีรหัสของเมกะคาริโอไซท์โพเทนชิเอเตอร์

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees
KB Patent renewed