ES2100891T3 - Neurotrofina-3, un nuevo factor neurotrofico relacionado con el factor de crecimiento nervioso y factor neurotrofico derivado del cerebro. - Google Patents
Neurotrofina-3, un nuevo factor neurotrofico relacionado con el factor de crecimiento nervioso y factor neurotrofico derivado del cerebro.Info
- Publication number
- ES2100891T3 ES2100891T3 ES90913954T ES90913954T ES2100891T3 ES 2100891 T3 ES2100891 T3 ES 2100891T3 ES 90913954 T ES90913954 T ES 90913954T ES 90913954 T ES90913954 T ES 90913954T ES 2100891 T3 ES2100891 T3 ES 2100891T3
- Authority
- ES
- Spain
- Prior art keywords
- neurotrophic factor
- neurotrofina
- brain
- factor
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
- F02B—INTERNAL-COMBUSTION PISTON ENGINES; COMBUSTION ENGINES IN GENERAL
- F02B75/00—Other engines
- F02B75/02—Engines characterised by their cycles, e.g. six-stroke
- F02B2075/022—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle
- F02B2075/027—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle four
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A LA NEUROTROFINA-3 (NT-3), MIEMBRO RECIENTEMENTE DESCUBIERTO DE LA FAMILIA DE GENES BDNF. ESTA BASADO, EN PARTE, EN LA IDENTIFICACION DE REGIONES DE LA SECUENCIA DE ACIDO NUCLEICO HOMOLOGAMENTE COMPARTIDA POR BDNF Y NGF (PATENTE DE LOS EEUU DE NUMERO DE SERIE 400.591, REGISTRADA EL 30 DE AGOSTO DE 1989, INCORPORADA POR REFERENCIA EN LA PRESENTE). DE ACUERDO CON LA PRESENTE INVENCION, ESTAS REGIONES DE HOMOLOGIA PUEDEN USARSE PARA IDENTIFICAR NUEVOS MIEMBROS DE LA FAMILIA DEL GEN BDNF/NGF; DICHA METODOLOGIA FUE USADA PARA IDENTIFICAR LA NT-3. LA PRESENTE INVENCION SUMINISTRA LOS GENES Y LOS PRODUCTOS DE GENE DEL NUEVO BDNF/NGF RELACIONADOS CON LOS FACTORES NEOTROFICOS IDENTIFICADOS POR ESTOS METODOS. DE ACUERDO CON LA INVENCION, LA NT-3 PUEDE USARSE EN EL DIAGNOSTICO Y/O TRATAMIENTO DE ENFERMEDADES NEUROLOGICAS, INCLUYENDO EL MAL DE ALZHEIMER Y LAS ENFERMEDADES DE PARKINSON. A CAUSA DE QUE SE HA OBSERVADO QUE LA NT-3 EXHIBE UN ESPECTRO DE ACTIVIDAD DIFERENTEDE LAS ESPECIFICACIONES DE BDNF O NGF, LA NT-3 SUMINISTRA NUEVAS Y VALORABLES OPCIONES PARA INDUCIR LA REGENERACION Y REPARACION EN EL SISTEMA NERVIOSO CENTRAL.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/400,591 US5180820A (en) | 1989-08-30 | 1989-08-30 | Brain-derived neurotrophic factor |
US49000490A | 1990-03-07 | 1990-03-07 | |
US57018990A | 1990-08-20 | 1990-08-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2100891T3 true ES2100891T3 (es) | 1997-07-01 |
Family
ID=27410411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90913954T Expired - Lifetime ES2100891T3 (es) | 1989-08-30 | 1990-08-29 | Neurotrofina-3, un nuevo factor neurotrofico relacionado con el factor de crecimiento nervioso y factor neurotrofico derivado del cerebro. |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0441947B1 (es) |
KR (1) | KR100196203B1 (es) |
CN (1) | CN1124342C (es) |
AT (1) | ATE153074T1 (es) |
AU (1) | AU643705B2 (es) |
CA (1) | CA2040437C (es) |
CZ (1) | CZ286015B6 (es) |
DE (1) | DE69030719T2 (es) |
ES (1) | ES2100891T3 (es) |
FI (1) | FI105343B (es) |
GR (1) | GR1000980B (es) |
HK (1) | HK1006579A1 (es) |
IE (1) | IE903129A1 (es) |
IL (1) | IL95511A (es) |
LV (1) | LV10792B (es) |
NO (1) | NO303694B1 (es) |
NZ (1) | NZ235086A (es) |
PT (1) | PT95153B (es) |
SG (1) | SG70560A1 (es) |
SK (1) | SK423090A3 (es) |
WO (1) | WO1991003569A1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5180820A (en) * | 1989-08-30 | 1993-01-19 | Barde Yves Alain | Brain-derived neurotrophic factor |
US5229500A (en) * | 1989-08-30 | 1993-07-20 | Regeneron Pharmaceuticals, Inc. | Brain derived neurotrophic factor |
US5986070A (en) * | 1990-04-06 | 1999-11-16 | Amgen Inc. | Production of biologically active NGF proteins |
US5606031A (en) * | 1990-04-06 | 1997-02-25 | Lile; Jack | Production and purification of biologically active recombinant neurotrophic protein in bacteria |
US5235043A (en) * | 1990-04-06 | 1993-08-10 | Synergen, Inc. | Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins |
ATE154389T1 (de) * | 1991-02-18 | 1997-06-15 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von menschlichem ngf-2 |
US5389529A (en) * | 1991-06-12 | 1995-02-14 | Regeneron Pharmaceuticals, Inc. | Modified lamβ signal sequence and processes for producing recombinant neurotrophins |
ZA923639B (en) * | 1991-07-10 | 1993-02-24 | Regeneron Pharma | Methods of treatment of motor neuron diseases using members of the bdnf/nt-3/ngf family of molecules |
DE4237047A1 (en) * | 1991-11-04 | 1993-05-06 | I N R O Handels-Gmbh, 8750 Aschaffenburg, De | Drug contg. polypeptide homologous to nerve growth factor and slow virus sequence - for treating amyotrophic lateral sclerosis, spinal muscle atrophy or Parkinson's disease |
ATE206056T1 (de) * | 1992-06-08 | 2001-10-15 | Takeda Chemical Industries Ltd | Therapeutisches agens für neutropenie |
JPH07509600A (ja) * | 1992-06-12 | 1995-10-26 | リジェネロン ファーマシューティカルズ,インコーポレーテッド | ニューロトロフィン−4発現に基づく治療および診断法 |
ES2149823T3 (es) * | 1992-09-03 | 2000-11-16 | Univ California | Factor y composiciones que afectan al tejido dorsal. |
NZ258697A (en) * | 1992-11-13 | 1996-03-26 | Immunex Corp | Elk-l polypeptide, coding sequence and vector therefor |
JPH07509002A (ja) * | 1993-02-11 | 1995-10-05 | エルツィーヒュングスディレクション オブ ザ キャントン チューリッヒ | ニューロトロフィンとミエリン−関連の軸索成長阻害タンパク質に対する抗体との組み合わせが中枢神経系の再生を促進する |
JPH07246040A (ja) * | 1993-07-06 | 1995-09-26 | Takeda Chem Ind Ltd | ニューロトロフィン−3遺伝子が不活性化された胚幹細胞および該遺伝子発現不全動物 |
WO1995026363A1 (en) * | 1994-03-29 | 1995-10-05 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Neurotrophin-6: a new member of the neurotrophin family |
AU2460595A (en) * | 1994-05-06 | 1995-11-29 | Regeneron Pharmaceuticals, Inc. | Methods based on the role of neurotrophin 3 in female reproduction |
US6303769B1 (en) | 1994-07-08 | 2001-10-16 | Immunex Corporation | Lerk-5 dna |
JP3738281B2 (ja) * | 1994-07-22 | 2006-01-25 | アベンティス ファーマ株式会社 | 新規な骨芽細胞増殖因子 |
US5770577A (en) * | 1994-11-14 | 1998-06-23 | Amgen Inc. | BDNF and NT-3 polypeptides selectively linked to polyethylene glycol |
EP0796275A2 (de) * | 1994-12-05 | 1997-09-24 | Roche Diagnostics GmbH | Gene und genprodukte zur diagnostik degenerativer nervenschädigungen |
US5859311A (en) * | 1995-11-27 | 1999-01-12 | University Of Kentucky Research Foundation | Transgenic mice which overexpress neurotrophin-3 (NT-3) and methods of use |
AU2800797A (en) | 1996-04-05 | 1997-10-29 | Chiron Corporation | Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis |
CZ250499A3 (cs) * | 1997-01-17 | 1999-11-17 | Rhone-Poulenc Rorer S. A. | Použití nukleové kyseliny k indukci inervace svalů a růstu axonů motorických neuronů |
KR20000070357A (ko) | 1997-01-23 | 2000-11-25 | 다께우찌 마사야쓰 | 당뇨병 치료제 |
EP1050758A1 (en) * | 1999-05-03 | 2000-11-08 | Evotec BioSystems AG | Methods of diagnosing or treating neuropsychiatric diseases on basis of increased cerebrospinal fluid levels of neurotrophin 3 |
AU4753800A (en) * | 1999-05-03 | 2000-11-17 | Evotec Biosystems Ag | Methods of diagnosing or treating depression |
CN1112215C (zh) * | 1999-12-28 | 2003-06-25 | 潘晓东 | 神经生长因子在治疗有机溶剂中毒性周围神经病中的用途 |
WO2006108651A2 (en) * | 2005-04-12 | 2006-10-19 | Develogen Aktiengesellschaft | Use of activin products for preventing and treating diabetes and/or metabolic syndrome |
EP2776838A1 (en) | 2011-11-08 | 2014-09-17 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Early diagnostic of neurodegenerative diseases |
WO2013068431A1 (en) | 2011-11-08 | 2013-05-16 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | New treatment for neurodegenerative diseases |
EP2870242A1 (en) | 2012-07-05 | 2015-05-13 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | New treatment for neurodegenerative diseases |
CN110862447A (zh) * | 2019-11-29 | 2020-03-06 | 武汉赛维尔生物科技有限公司 | 一种提高神经营养因子nt-3碱性蛋白产量的蛋白改造方法 |
CN113940308A (zh) * | 2021-04-28 | 2022-01-18 | 重庆腾达牧业有限公司 | 大足黑山羊哺乳舍饲养管理方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4699875A (en) * | 1982-11-24 | 1987-10-13 | Baylor College Of Medicine | Diagnosis of amyotrophic lateral sclerosis by neurotrophic factors |
DK161152C (da) * | 1983-03-03 | 1991-11-11 | Genentech Inc | Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat |
US6709837B1 (en) * | 1989-03-10 | 2004-03-23 | Takeda Chemical Industries, Inc. | Polypeptide and production thereof |
US5229500A (en) * | 1989-08-30 | 1993-07-20 | Regeneron Pharmaceuticals, Inc. | Brain derived neurotrophic factor |
US7020718B2 (en) | 2000-05-15 | 2006-03-28 | Hewlett-Packard Development Company, L.P. | System and method of aggregating discontiguous address ranges into addresses and masks using a plurality of repeating address blocks |
-
1990
- 1990-08-28 IL IL9551190A patent/IL95511A/xx not_active IP Right Cessation
- 1990-08-28 GR GR900100647A patent/GR1000980B/el not_active IP Right Cessation
- 1990-08-29 EP EP90913954A patent/EP0441947B1/en not_active Expired - Lifetime
- 1990-08-29 WO PCT/US1990/004916 patent/WO1991003569A1/en active IP Right Grant
- 1990-08-29 CA CA002040437A patent/CA2040437C/en not_active Expired - Lifetime
- 1990-08-29 IE IE312990A patent/IE903129A1/en not_active IP Right Cessation
- 1990-08-29 ES ES90913954T patent/ES2100891T3/es not_active Expired - Lifetime
- 1990-08-29 KR KR1019910700433A patent/KR100196203B1/ko not_active IP Right Cessation
- 1990-08-29 NZ NZ235086A patent/NZ235086A/en unknown
- 1990-08-29 AT AT90913954T patent/ATE153074T1/de not_active IP Right Cessation
- 1990-08-29 AU AU64049/90A patent/AU643705B2/en not_active Expired
- 1990-08-29 DE DE69030719T patent/DE69030719T2/de not_active Expired - Lifetime
- 1990-08-29 SG SG1996007705A patent/SG70560A1/en unknown
- 1990-08-30 PT PT95153A patent/PT95153B/pt not_active IP Right Cessation
- 1990-08-30 SK SK4230-90A patent/SK423090A3/sk not_active IP Right Cessation
- 1990-08-30 CZ CS904230A patent/CZ286015B6/cs not_active IP Right Cessation
- 1990-08-30 CN CN90108379A patent/CN1124342C/zh not_active Expired - Lifetime
-
1991
- 1991-04-29 NO NO911688A patent/NO303694B1/no not_active IP Right Cessation
- 1991-04-30 FI FI912105A patent/FI105343B/fi active
-
1993
- 1993-10-06 LV LVP-93-1135A patent/LV10792B/en unknown
-
1998
- 1998-06-20 HK HK98105814A patent/HK1006579A1/xx not_active IP Right Cessation
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