IL95505A - Neuro-peptide containing erection-inducing compositions and use thereof - Google Patents

Neuro-peptide containing erection-inducing compositions and use thereof

Info

Publication number
IL95505A
IL95505A IL95505A IL9550590A IL95505A IL 95505 A IL95505 A IL 95505A IL 95505 A IL95505 A IL 95505A IL 9550590 A IL9550590 A IL 9550590A IL 95505 A IL95505 A IL 95505A
Authority
IL
Israel
Prior art keywords
erection
phm
vip
physiologically acceptable
acceptable solution
Prior art date
Application number
IL95505A
Other languages
English (en)
Inventor
Thomas Gerstenberg
Jan Fahrenkrug
Bent Ottesen
Original Assignee
Senetek Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senetek Plc filed Critical Senetek Plc
Publication of IL95505A publication Critical patent/IL95505A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Load-Engaging Elements For Cranes (AREA)
  • Revetment (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Detergent Compositions (AREA)
IL95505A 1989-09-18 1990-08-28 Neuro-peptide containing erection-inducing compositions and use thereof IL95505A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/408,754 US5236904A (en) 1989-09-18 1989-09-18 Erection-inducing methods and compositions

Publications (1)

Publication Number Publication Date
IL95505A true IL95505A (en) 1997-03-18

Family

ID=23617626

Family Applications (1)

Application Number Title Priority Date Filing Date
IL95505A IL95505A (en) 1989-09-18 1990-08-28 Neuro-peptide containing erection-inducing compositions and use thereof

Country Status (23)

Country Link
US (1) US5236904A (cs)
EP (1) EP0493485B1 (cs)
JP (1) JP3149946B2 (cs)
KR (1) KR100230720B1 (cs)
AT (1) ATE210994T1 (cs)
AU (1) AU641184B2 (cs)
BR (1) BR9007662A (cs)
CA (1) CA2065270C (cs)
CZ (1) CZ280446B6 (cs)
DE (1) DE69033881T2 (cs)
DK (1) DK0493485T3 (cs)
ES (1) ES2170050T3 (cs)
FI (1) FI104231B1 (cs)
GE (1) GEP19981264B (cs)
HU (1) HU208088B (cs)
IL (1) IL95505A (cs)
LT (1) LT3544B (cs)
LV (1) LV10198B (cs)
NO (1) NO307498B1 (cs)
RO (1) RO116346B1 (cs)
RU (1) RU2098120C1 (cs)
SK (1) SK279489B6 (cs)
WO (1) WO1991004039A1 (cs)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447912A (en) * 1989-09-18 1995-09-05 Senetek, Plc Erection-inducing methods and compositions
US5242391A (en) * 1990-04-25 1993-09-07 Alza Corporation Urethral insert for treatment of erectile dysfunction
DE4117249C2 (de) * 1991-05-27 1998-05-14 Christian Dr Stief Linsidomin zur Behandlung erektiler Dysfunktionen
US5565466A (en) * 1993-08-13 1996-10-15 Zonagen, Inc. Methods for modulating the human sexual response
US5482039A (en) * 1994-03-25 1996-01-09 Vivus, Inc. Process for diagnosing erectile dysfunction, and related methods of treatment
US5583144A (en) * 1995-02-24 1996-12-10 Kral; John G. Methods for treating erectile impotence
US5731339A (en) * 1995-04-28 1998-03-24 Zonagen, Inc. Methods and formulations for modulating the human sexual response
US5932538A (en) * 1996-02-02 1999-08-03 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
US6323211B1 (en) 1996-02-02 2001-11-27 Nitromed, Inc. Compositions and methods for treating sexual dysfunctions
US20050065161A1 (en) * 1996-02-02 2005-03-24 Nitromed, Inc. Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
US6294517B1 (en) 1996-02-02 2001-09-25 Nitromed, Inc. Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use
US6469065B1 (en) 1996-02-02 2002-10-22 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use
US5994294A (en) * 1996-02-02 1999-11-30 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
US20020143007A1 (en) * 1996-02-02 2002-10-03 Garvey David S. Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
US20030004170A1 (en) * 1997-05-19 2003-01-02 Zonagen, Inc. Combination therapy for modulating the human sexual response
US5947901A (en) 1997-09-09 1999-09-07 Redano; Richard T. Method for hemodynamic stimulation and monitoring
US5942545A (en) * 1998-06-15 1999-08-24 Macrochem Corporation Composition and method for treating penile erectile dysfunction
US6011043A (en) * 1998-06-19 2000-01-04 Schering Corporation Combination of phentolamine and apomorphine for the treatment of human sexual function and dysfunction
US6482426B1 (en) 1998-09-17 2002-11-19 Zonagen, Inc. Compositions for the treatment of male erectile dysfunction
US6706682B2 (en) * 1999-01-21 2004-03-16 The Trustees Of Columbia University In The City Of New York Uses of vascular endothelial growth factor in the treatment of erectile dysfunction
US6730065B1 (en) * 2000-09-15 2004-05-04 Ocularis Pharma, Inc. Night vision composition
US6211156B1 (en) * 1999-11-10 2001-04-03 Asta Medica A.G. Peptides for treatment of erectile dysfunction
US6650943B1 (en) 2000-04-07 2003-11-18 Advanced Bionics Corporation Fully implantable neurostimulator for cavernous nerve stimulation as a therapy for erectile dysfunction and other sexual dysfunction
JP2003532678A (ja) * 2000-05-12 2003-11-05 ノバラー ファーマシューティカルズ， インコーポレイテッド 局所麻酔の方法およびキット
US20060211753A1 (en) * 2000-11-03 2006-09-21 Ocularis Pharma, Inc. Method and composition which reduces stimulation of muscles which dilate the eye
US6885895B1 (en) * 2001-04-26 2005-04-26 Advanced Bionics Corporation Methods and systems for electrical and/or drug stimulation as a therapy for erectile dysfunction
EP1855661B1 (en) 2005-03-07 2011-05-04 mondoBIOTECH AG Formulation for aviptadil
US8841255B2 (en) 2005-12-20 2014-09-23 Duke University Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
US20130172274A1 (en) 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
CA2634034A1 (en) 2005-12-20 2007-06-28 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
CA2953975C (en) 2008-06-27 2019-11-26 Duke University Therapeutic agents comprising elastin-like peptides
IN2012DN02120A (cs) * 2009-08-14 2015-08-21 Phasebio Pharmaceuticals Inc
WO2011051928A1 (en) 2009-10-30 2011-05-05 Medispec Ltd Method and apparatus for treatment of erectile dysfunction with extracorporeal shockwaves
US9561262B2 (en) 2011-06-06 2017-02-07 Phasebio Pharmaceuticals, Inc. Use of modified vasoactive intestinal peptides in the treatment of hypertension
GB201221046D0 (en) * 2012-11-22 2013-01-09 Mens Health Ltd Method of diagnosis
GB201221032D0 (en) * 2012-11-22 2013-01-09 Mens Health Ltd Method of treatment
AU2015255752B2 (en) 2014-05-08 2020-07-23 Immunoforge Co., Ltd. Methods and compositions for treating Cystic Fibrosis
CN107427556B (zh) 2015-02-09 2022-02-25 费斯生物制药公司 用于治疗肌肉疾病和病症的方法和组合物
WO2019102310A1 (en) 2017-11-24 2019-05-31 Alaval (Pty) Ltd Vip formulation for management of inflammatory conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3898329A (en) * 1971-09-17 1975-08-05 Sami I Said Vasoactive intestinal peptide, composition and method
DE3637157A1 (de) * 1985-11-01 1987-05-21 Byk Gulden Lomberg Chem Fab Arzneimittel zur behandlung erektiler dysfunktionen
JPS62246595A (ja) * 1986-04-17 1987-10-27 Eisai Co Ltd 気菅支拡張作用・降圧作用ペプタイド
US4939224A (en) * 1987-02-26 1990-07-03 The Salk Institute Biotechnology/Industrial Associates, Inc. Vasoactive intestinal peptide analogs
IL87055A (en) * 1988-07-08 1994-06-24 Illana Gozes Conjugates of vasoactive intestinal peptide (vip) and of fragments thereof and pharmaceutical compositions comprising them
SE463851B (sv) * 1988-09-02 1991-02-04 Amsu Ltd Komposition foer behandling av erektil dysfunktion via uretra

Also Published As

Publication number Publication date
CZ452490A3 (en) 1995-09-13
JPH05500513A (ja) 1993-02-04
US5236904A (en) 1993-08-17
HU208088B (en) 1993-08-30
EP0493485A4 (en) 1993-08-18
RU2098120C1 (ru) 1997-12-10
KR100230720B1 (en) 1999-11-15
HU9200874D0 (en) 1992-05-28
FI104231B (fi) 1999-12-15
DE69033881T2 (de) 2002-09-12
DK0493485T3 (da) 2002-03-18
AU641184B2 (en) 1993-09-16
SK452490A3 (en) 1998-12-02
DE69033881D1 (de) 2002-01-31
FI921136A7 (fi) 1992-03-17
CZ280446B6 (cs) 1996-01-17
ES2170050T3 (es) 2002-08-01
LTIP1579A (en) 1995-06-26
RO116346B1 (ro) 2001-01-30
EP0493485A1 (en) 1992-07-08
CA2065270A1 (en) 1991-03-19
JP3149946B2 (ja) 2001-03-26
EP0493485B1 (en) 2001-12-19
HUT60633A (en) 1992-10-28
FI921136A0 (fi) 1992-03-17
CA2065270C (en) 2003-01-14
FI104231B1 (fi) 1999-12-15
ATE210994T1 (de) 2002-01-15
LT3544B (en) 1995-11-27
BR9007662A (pt) 1992-07-21
SK279489B6 (sk) 1998-12-02
AU6440490A (en) 1991-04-18
NO920915D0 (no) 1992-03-09
LV10198A (lv) 1994-10-20
WO1991004039A1 (en) 1991-04-04
GEP19981264B (en) 1998-07-07
NO920915L (no) 1992-03-09
LV10198B (en) 1995-08-20
HK1011292A1 (en) 1999-07-09
NO307498B1 (no) 2000-04-17

Similar Documents

Publication Publication Date Title
IL95505A (en) Neuro-peptide containing erection-inducing compositions and use thereof
GB2326093A (en) Avermectin formulation
KR930003912A (ko) 울혈성 심장 마비 치료법
UA39174C2 (uk) Асоціати депротонованої гіалуронової кислоти, спосіб одержання асоціатів депротонованої гіалуронової кислоти, фармацевтична композиція та спосіб одержання фармацевтичної композиції
KR910019618A (ko) 발기부전증 치료용 제약 조성물
DK0506778T3 (da) Substituerede 4-phenyl-4-piperidincarboxamider med både lokal anæstetisk og analgetisk virkning samt fremgangsmåder til deres fremstilling
MY117090A (en) Substituted benzamidines, their preparation and their use as pharmaceutical compounds
IE901683L (en) Compounds
GB1502873A (en) Pharmaceutical compositions with ulcer healing activity
EE03169B1 (et) Ravim erutusseisundite ja närvitalitlushäirete leevendamiseks või seiskamiseks
IL126175A0 (en) Method or treating heart failure with endothelin antagonists and pharmaceutical compositions containing the same
GB2209281B (en) Pharmaceutical compositions comprising an alpha-2 adrenoceptor antagonist
DK1058544T3 (da) Inhibition af TNF-aktivitet med præparater, der omfatter heparin og oplöselige TNF-receptorer
KR930003913A (ko) 덱스트로메토르판의 진해효과를 증진시키기 위한 방법 및 약제학적 조성물
KR880004810A (ko) 소화성 궤양 치료제
ATE175673T1 (de) Alkylidenanaloge von 1'-aminospiro-(isochinolin- 4(1h), 3'-pyrrolidin>-1,2',3,5'(2h)-tetronen, verwendbar als aldose reduktase-inhibitoren in vivo
GB1507643A (en) 4-(5-nitro-2-furyl)quinaldinic acid n-oxide and its use in the treatment of bovine mastitis
ES2126474A1 (es) Procedimiento para la preparacion de composiciones orales que contienn quinolonas
Tonini et al. Bicuculline but not SR 95531 and picrotoxinin enhances peristaltic activity of the guinea-pig ileum
EP0344981A3 (en) Alpha-adrenergic receptor antagonists
JPS56131516A (en) Immunochemotherapy, prevention of resistance to drug, and carcinostatic agent
KR920702623A (ko) 진해제
AU7370798A (en) Compositions and methods of therapy for igf-i-responsive conditions
HUT59597A (en) Process for producing pharmaceutical compositions contaiing pharmaceutically active tetrahydro-naphtalene derivatives
JO1531B1 (en) New near-compounds

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed