ES2170050T3 - Metodos y composiciones para inducir la ereccion. - Google Patents
Metodos y composiciones para inducir la ereccion.Info
- Publication number
- ES2170050T3 ES2170050T3 ES90914620T ES90914620T ES2170050T3 ES 2170050 T3 ES2170050 T3 ES 2170050T3 ES 90914620 T ES90914620 T ES 90914620T ES 90914620 T ES90914620 T ES 90914620T ES 2170050 T3 ES2170050 T3 ES 2170050T3
- Authority
- ES
- Spain
- Prior art keywords
- male
- peptide
- impotence
- terminal
- methionineamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
Abstract
ESTA INVENCION PROPORCIONA METODOS Y COMPOSICIONES PARA INDUCIR A UN HOMBRE QUE SUFRE DE IMPOTENCIA, ERECCIONES DEL PENE SUFICIENTES PARA LA PENETRACION VAGINAL. CUANDO LA IMPOTENCIA SOLO ES SUSTANCIALMENTE NEUROGENICA SICOGENICA O NEUROGENICA Y SICOGENICA, UN METODO DE LA INVENCION COMPRENDE (A) ADMINISTRAR AL HOMBRE MEDIANTE UNA INYECCION INTRACAVERNOSA PEPTIDO N-TERMINAL HISTIDINA C-TERMINAL METIONINEAMIDA Y (B) ESTIMULAR AL HOMBRE SEXUALMENTE. CUANDO LA IMPOTENCIA ESTA CAUSADA POR UNA ARTEROESCLEROSIS SEVERA, UN METODO DE LA INVENCION COMPRENDE (A) ADMINISTRAR AL HOMBRE MEDIANTE UNA INYECCION INTRACAVERNOSA UNA CANTIDAD DE UNA COMPOSICION FISIOLOGICAMENTE ACEPTABLE QUE COMPRENDE (I) UN NEUROPEPTIDO SELECCIONADO DEL GRUPO QUE CONSISTE EN PEPTIDO INTESTINAL VASOACTIVO HUMANO Y PEPTIDO N-TERMINAL HISTIDINE C-TERMINAL METIONINEAMIDA Y (2) UN BLOQUEADOR ALFA-ADRENERGICO, TAL COMO FEUTOLAMINA O PRAZOSINA, Y (B) ESTIMULAR SEXUALMENTE AL HOMBRE. LA INVENCION INCLUYE TAMBIEN UNA COMPOSICION FISIOLOGICAMENTE ACEPTABLE APROPIADA PARA UTILIZAR EN LA INDUCCION, DESPUES DE LA ADMINISTRACION A UN HOMBRE QUE SUFRE DE IMPOTENCIA INYECCION INTRACAVERNOSA, DE UNA ERECCION, SUFICIENTE PARA LA PENETRACION VAGINAL, CUANDO LA IMPOTENCIA ES OCASIONADA POR UNA SEVERA ARTEROESCLEROSIS, CUYA COMPOSICION COMPRENDE (I) UN NEUROPEPTIDO SELECCIONADO DEL GRUPO QUE CONSISTE EN PEPTIDO INTESTINAL VASOACTIVO Y PEPTIDO N-TERMINAL HISTIDINA C-TERMINAL METIONINEAMIDA Y (2) UN BLOQUEADOR ALFA-ADRENERGICO, TAL COMO FEUTOLAMINA O PAROSINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/408,754 US5236904A (en) | 1989-09-18 | 1989-09-18 | Erection-inducing methods and compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2170050T3 true ES2170050T3 (es) | 2002-08-01 |
Family
ID=23617626
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90914620T Expired - Lifetime ES2170050T3 (es) | 1989-09-18 | 1990-09-14 | Metodos y composiciones para inducir la ereccion. |
Country Status (24)
Country | Link |
---|---|
US (1) | US5236904A (es) |
EP (1) | EP0493485B1 (es) |
JP (1) | JP3149946B2 (es) |
KR (1) | KR100230720B1 (es) |
AT (1) | ATE210994T1 (es) |
AU (1) | AU641184B2 (es) |
BR (1) | BR9007662A (es) |
CA (1) | CA2065270C (es) |
CZ (1) | CZ280446B6 (es) |
DE (1) | DE69033881T2 (es) |
DK (1) | DK0493485T3 (es) |
ES (1) | ES2170050T3 (es) |
FI (1) | FI104231B1 (es) |
GE (1) | GEP19981264B (es) |
HK (1) | HK1011292A1 (es) |
HU (1) | HU208088B (es) |
IL (1) | IL95505A (es) |
LT (1) | LT3544B (es) |
LV (1) | LV10198B (es) |
NO (1) | NO307498B1 (es) |
RO (1) | RO116346B1 (es) |
RU (1) | RU2098120C1 (es) |
SK (1) | SK279489B6 (es) |
WO (1) | WO1991004039A1 (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5447912A (en) * | 1989-09-18 | 1995-09-05 | Senetek, Plc | Erection-inducing methods and compositions |
US5242391A (en) * | 1990-04-25 | 1993-09-07 | Alza Corporation | Urethral insert for treatment of erectile dysfunction |
DE4117249C2 (de) * | 1991-05-27 | 1998-05-14 | Christian Dr Stief | Linsidomin zur Behandlung erektiler Dysfunktionen |
US5565466A (en) * | 1993-08-13 | 1996-10-15 | Zonagen, Inc. | Methods for modulating the human sexual response |
US5482039A (en) * | 1994-03-25 | 1996-01-09 | Vivus, Inc. | Process for diagnosing erectile dysfunction, and related methods of treatment |
US5583144A (en) * | 1995-02-24 | 1996-12-10 | Kral; John G. | Methods for treating erectile impotence |
US5731339A (en) * | 1995-04-28 | 1998-03-24 | Zonagen, Inc. | Methods and formulations for modulating the human sexual response |
US6294517B1 (en) | 1996-02-02 | 2001-09-25 | Nitromed, Inc. | Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use |
US5932538A (en) * | 1996-02-02 | 1999-08-03 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
US6469065B1 (en) | 1996-02-02 | 2002-10-22 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use |
US20050065161A1 (en) * | 1996-02-02 | 2005-03-24 | Nitromed, Inc. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses |
US20020143007A1 (en) * | 1996-02-02 | 2002-10-03 | Garvey David S. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use |
US6323211B1 (en) | 1996-02-02 | 2001-11-27 | Nitromed, Inc. | Compositions and methods for treating sexual dysfunctions |
US5994294A (en) * | 1996-02-02 | 1999-11-30 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
US20030004170A1 (en) * | 1997-05-19 | 2003-01-02 | Zonagen, Inc. | Combination therapy for modulating the human sexual response |
US5947901A (en) | 1997-09-09 | 1999-09-07 | Redano; Richard T. | Method for hemodynamic stimulation and monitoring |
US5942545A (en) * | 1998-06-15 | 1999-08-24 | Macrochem Corporation | Composition and method for treating penile erectile dysfunction |
US6011043A (en) * | 1998-06-19 | 2000-01-04 | Schering Corporation | Combination of phentolamine and apomorphine for the treatment of human sexual function and dysfunction |
US6482426B1 (en) | 1998-09-17 | 2002-11-19 | Zonagen, Inc. | Compositions for the treatment of male erectile dysfunction |
US6706682B2 (en) * | 1999-01-21 | 2004-03-16 | The Trustees Of Columbia University In The City Of New York | Uses of vascular endothelial growth factor in the treatment of erectile dysfunction |
US6730065B1 (en) * | 2000-09-15 | 2004-05-04 | Ocularis Pharma, Inc. | Night vision composition |
US6650943B1 (en) | 2000-04-07 | 2003-11-18 | Advanced Bionics Corporation | Fully implantable neurostimulator for cavernous nerve stimulation as a therapy for erectile dysfunction and other sexual dysfunction |
AU2001259848B2 (en) * | 2000-05-12 | 2005-10-13 | Septodont Holding Sas | Local anesthetic methods and kits |
US20060211753A1 (en) * | 2000-11-03 | 2006-09-21 | Ocularis Pharma, Inc. | Method and composition which reduces stimulation of muscles which dilate the eye |
US6885895B1 (en) * | 2001-04-26 | 2005-04-26 | Advanced Bionics Corporation | Methods and systems for electrical and/or drug stimulation as a therapy for erectile dysfunction |
AU2006222233B2 (en) * | 2005-03-07 | 2011-05-12 | Mondobiotech Ag | Formulation for aviptadil |
US8334257B2 (en) | 2005-12-20 | 2012-12-18 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
US20130172274A1 (en) | 2005-12-20 | 2013-07-04 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
US8841255B2 (en) | 2005-12-20 | 2014-09-23 | Duke University | Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides |
EP3412300A1 (en) | 2008-06-27 | 2018-12-12 | Duke University | Therapeutic agents comprising elastin-like peptides |
EP2464370B1 (en) * | 2009-08-14 | 2017-03-29 | Phasebio Pharmaceuticals, Inc. | Modified vasoactive intestinal peptides |
EP2493434A1 (en) | 2009-10-30 | 2012-09-05 | Medispec Ltd | Method and apparatus for treatment of erectile dysfunction with extracorporeal shockwaves |
CA2873553C (en) | 2011-06-06 | 2020-01-28 | Phasebio Pharmaceuticals, Inc. | Use of modified vasoactive intestinal peptides in the treatment of hypertension |
GB201221046D0 (en) * | 2012-11-22 | 2013-01-09 | Mens Health Ltd | Method of diagnosis |
GB201221032D0 (en) * | 2012-11-22 | 2013-01-09 | Mens Health Ltd | Method of treatment |
ES2818824T3 (es) | 2014-05-08 | 2021-04-14 | Phasebio Pharmaceuticals Inc | Composiciones que comprenden una proteína de fusión de VIP-ELP para su uso en el tratamiento de fibrosis quística |
CA2976038A1 (en) | 2015-02-09 | 2016-08-18 | Phasebio Pharmaceuticals, Inc. | Methods and compositions for treating muscle disease and disorders |
WO2019102310A1 (en) | 2017-11-24 | 2019-05-31 | Alaval (Pty) Ltd | Vip formulation for management of inflammatory conditions |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3898329A (en) * | 1971-09-17 | 1975-08-05 | Sami I Said | Vasoactive intestinal peptide, composition and method |
DE3637157A1 (de) * | 1985-11-01 | 1987-05-21 | Byk Gulden Lomberg Chem Fab | Arzneimittel zur behandlung erektiler dysfunktionen |
JPS62246595A (ja) * | 1986-04-17 | 1987-10-27 | Eisai Co Ltd | 気菅支拡張作用・降圧作用ペプタイド |
US4939224A (en) * | 1987-02-26 | 1990-07-03 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Vasoactive intestinal peptide analogs |
IL87055A (en) * | 1988-07-08 | 1994-06-24 | Illana Gozes | Conjugates of vasoactive intestinal peptide (vip) and of fragments thereof and pharmaceutical compositions comprising them |
SE463851B (sv) * | 1988-09-02 | 1991-02-04 | Amsu Ltd | Komposition foer behandling av erektil dysfunktion via uretra |
-
1989
- 1989-09-18 US US07/408,754 patent/US5236904A/en not_active Expired - Lifetime
-
1990
- 1990-08-28 IL IL95505A patent/IL95505A/xx active IP Right Grant
- 1990-09-14 HU HU92874A patent/HU208088B/hu unknown
- 1990-09-14 CA CA002065270A patent/CA2065270C/en not_active Expired - Lifetime
- 1990-09-14 WO PCT/US1990/005237 patent/WO1991004039A1/en active IP Right Grant
- 1990-09-14 ES ES90914620T patent/ES2170050T3/es not_active Expired - Lifetime
- 1990-09-14 DE DE69033881T patent/DE69033881T2/de not_active Expired - Lifetime
- 1990-09-14 DK DK90914620T patent/DK0493485T3/da active
- 1990-09-14 AU AU64404/90A patent/AU641184B2/en not_active Expired
- 1990-09-14 AT AT90914620T patent/ATE210994T1/de not_active IP Right Cessation
- 1990-09-14 JP JP51377290A patent/JP3149946B2/ja not_active Expired - Lifetime
- 1990-09-14 EP EP90914620A patent/EP0493485B1/en not_active Expired - Lifetime
- 1990-09-14 BR BR909007662A patent/BR9007662A/pt not_active Application Discontinuation
- 1990-09-14 RU SU925011648A patent/RU2098120C1/ru active
- 1990-09-14 RO RO92-200339A patent/RO116346B1/ro unknown
- 1990-09-17 CZ CS904524A patent/CZ280446B6/cs not_active IP Right Cessation
- 1990-09-17 SK SK4524-90A patent/SK279489B6/sk not_active IP Right Cessation
-
1992
- 1992-03-09 NO NO920915A patent/NO307498B1/no not_active IP Right Cessation
- 1992-03-10 KR KR1019920700543A patent/KR100230720B1/ko not_active IP Right Cessation
- 1992-03-17 FI FI921136A patent/FI104231B1/fi active
-
1993
- 1993-06-29 LV LVP-93-740A patent/LV10198B/lv unknown
- 1993-08-25 GE GEAP19931497A patent/GEP19981264B/en unknown
- 1993-12-10 LT LTIP1579A patent/LT3544B/lt not_active IP Right Cessation
-
1998
- 1998-11-30 HK HK98112509A patent/HK1011292A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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