IL94777A - Cis-(-)-4-[1-(2)h-tetrazole-5-yl)methyl)-2-piperidinecarboxylic acid, salts thereof, process for their preparation and amino acid receptor antagonist composition containing them - Google Patents

Cis-(-)-4-[1-(2)h-tetrazole-5-yl)methyl)-2-piperidinecarboxylic acid, salts thereof, process for their preparation and amino acid receptor antagonist composition containing them

Info

Publication number
IL94777A
IL94777A IL9477790A IL9477790A IL94777A IL 94777 A IL94777 A IL 94777A IL 9477790 A IL9477790 A IL 9477790A IL 9477790 A IL9477790 A IL 9477790A IL 94777 A IL94777 A IL 94777A
Authority
IL
Israel
Prior art keywords
cis
compound
methyl
amino acid
mixture
Prior art date
Application number
IL9477790A
Other languages
English (en)
Other versions
IL94777A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL94777A0 publication Critical patent/IL94777A0/xx
Publication of IL94777A publication Critical patent/IL94777A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
IL9477790A 1989-06-26 1990-06-18 Cis-(-)-4-[1-(2)h-tetrazole-5-yl)methyl)-2-piperidinecarboxylic acid, salts thereof, process for their preparation and amino acid receptor antagonist composition containing them IL94777A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/371,568 US4968678A (en) 1988-02-19 1989-06-26 Tetrazole excitatory amino acid receptor antagonists

Publications (2)

Publication Number Publication Date
IL94777A0 IL94777A0 (en) 1991-04-15
IL94777A true IL94777A (en) 1994-05-30

Family

ID=23464503

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9477790A IL94777A (en) 1989-06-26 1990-06-18 Cis-(-)-4-[1-(2)h-tetrazole-5-yl)methyl)-2-piperidinecarboxylic acid, salts thereof, process for their preparation and amino acid receptor antagonist composition containing them

Country Status (17)

Country Link
US (1) US4968678A (de)
EP (1) EP0405834A3 (de)
JP (1) JPH0348679A (de)
KR (1) KR910000703A (de)
CN (1) CN1028024C (de)
AU (1) AU621498B2 (de)
CA (1) CA2019167A1 (de)
FI (1) FI903183A7 (de)
HU (1) HU206339B (de)
IE (1) IE902288A1 (de)
IL (1) IL94777A (de)
MX (1) MX21219A (de)
NZ (1) NZ234109A (de)
PH (1) PH26905A (de)
PT (1) PT94447B (de)
RU (2) RU1833385C (de)
ZA (1) ZA904717B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0330353B1 (de) * 1988-02-19 1993-04-07 Eli Lilly And Company Tetrazolverbindungen als Antagonisten der excitatorischen Aminosäurerezeptoren
US5594007A (en) * 1991-04-18 1997-01-14 Pfizer Inc. Method for treating spinal cord trauma with phenolic 2-piperidino-1-alkanols
US5196421A (en) * 1991-06-05 1993-03-23 Eli Lilly And Company Excitatory amino acid receptor antagonists in methods for the use thereof
US5153196A (en) * 1991-06-05 1992-10-06 Eli Lilly And Company Excitatory amino acid receptor antagonists and methods for the use thereof
EP0636130A1 (de) * 1992-04-15 1995-02-01 Merck Sharp & Dohme Ltd. Azaclyclische Verbindungen
US5192751A (en) * 1992-07-24 1993-03-09 Eli Lilly And Company Use of competitive NMDA receptor antagonists in the treatment of urinary incontinence
WO1994022437A2 (en) * 1993-03-29 1994-10-13 Queen's University At Kingston Method for treating amyloidosis
US20040208875A1 (en) 1995-03-15 2004-10-21 Queen's University At Kingston Method for treating amyloidosis
WO1995020587A1 (en) * 1994-01-31 1995-08-03 Pfizer Inc. Neuroprotective chroman compounds
MX9701282A (es) * 1994-08-18 1997-05-31 Pfizer Fenoles neuroprotectores.
US5880138A (en) * 1996-10-01 1999-03-09 Eli Lilly And Company NMDA receptor selective antagonists
US8043303B2 (en) * 2002-10-04 2011-10-25 Cook Medical Technologies Llc Handle for interchangeable medical device
CA2500853A1 (en) * 2002-10-04 2004-04-22 Cook Urological, Incorporated Rigid extractor with wire basket
EP1592684B1 (de) * 2003-02-04 2008-07-30 F. Hoffmann-La Roche Ag Malonamidderivate als gamma-secretaseinhibitoren
US7414076B2 (en) 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US7244764B2 (en) 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20070010573A1 (en) 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US20050192592A1 (en) * 2004-02-27 2005-09-01 Cook Urological Incorporated Self-tensioning handle for endoscopic device
BRPI0519243A2 (pt) 2004-12-22 2009-01-06 Neurochem Int Ltd mÉtodos e composiÇÕes para tratar doenÇas relacionadas a amilàide
TW200716088A (en) 2005-04-15 2007-05-01 Neurochem Int Ltd Formulations and methods for treating amyloidosis
EP3111866B1 (de) * 2005-11-03 2019-04-24 Cook Medical Technologies LLC Gelenkkorb mit gleichzeitiger korbextension und korbretraktion
MX2008008213A (es) 2005-12-22 2008-09-03 Neurochem Int Ltd Tratamiento de trastornos renales, nefropatia diabetica y dislipidemias.
DK2089417T3 (en) 2006-10-12 2015-03-23 Bhi Ltd Partnership Methods, Compounds, Compositions and Vehicles for Delivery of 3-Amion-1-Propanesulfonic Acid
EP3427729A1 (de) 2017-07-13 2019-01-16 Paris Sciences et Lettres - Quartier Latin Probenecid zur behandlung von epileptischen erkrankungen, störungen oder zuständen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536715A (en) * 1967-03-24 1970-10-27 Miles Lab 2-lower alkyl-5-(omega-(4-phenyl-1-piperazinyl) lower alkyl)-2h-tetrazoles
CA1248531A (en) * 1984-04-17 1989-01-10 Jeffrey C. Watkins 4-substituted piperazine-2-carboxylic acids
PH23848A (en) * 1985-05-24 1989-11-23 Ciba Geigy Ag Certain phosphonic acids and derivatives
US4746653A (en) * 1986-02-28 1988-05-24 Ciba-Geigy Corporation Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
DE3768000D1 (de) * 1986-11-21 1991-03-14 Ciba Geigy Ag Ungesaettigte phosphonsaeure und derivate.
EP0330353B1 (de) * 1988-02-19 1993-04-07 Eli Lilly And Company Tetrazolverbindungen als Antagonisten der excitatorischen Aminosäurerezeptoren

Also Published As

Publication number Publication date
ZA904717B (en) 1992-02-26
US4968678A (en) 1990-11-06
EP0405834A3 (en) 1991-12-27
CN1028024C (zh) 1995-03-29
CA2019167A1 (en) 1990-12-26
FI903183A7 (fi) 1990-12-27
RU1833385C (ru) 1993-08-07
NZ234109A (en) 1992-04-28
HU903976D0 (en) 1990-11-28
JPH0348679A (ja) 1991-03-01
HU206339B (en) 1992-10-28
IE902288L (en) 1990-12-26
FI903183A0 (fi) 1990-06-25
IE902288A1 (en) 1991-01-16
KR910000703A (ko) 1991-01-30
RU2089546C1 (ru) 1997-09-10
PT94447B (pt) 1997-02-28
MX21219A (es) 1993-11-01
CN1048385A (zh) 1991-01-09
AU5780890A (en) 1991-01-03
IL94777A0 (en) 1991-04-15
HUT54364A (en) 1991-02-28
AU621498B2 (en) 1992-03-12
PH26905A (en) 1992-12-03
EP0405834A2 (de) 1991-01-02
PT94447A (pt) 1991-02-08

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