IL94482A - Transdominant repressor mutant of retroviral protein, dna encoding the protein and process for their preparation and use thereof - Google Patents
Transdominant repressor mutant of retroviral protein, dna encoding the protein and process for their preparation and use thereofInfo
- Publication number
- IL94482A IL94482A IL9448290A IL9448290A IL94482A IL 94482 A IL94482 A IL 94482A IL 9448290 A IL9448290 A IL 9448290A IL 9448290 A IL9448290 A IL 9448290A IL 94482 A IL94482 A IL 94482A
- Authority
- IL
- Israel
- Prior art keywords
- viral
- protein
- transdominant
- htlv
- hiv
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title 2
- 230000001177 retroviral effect Effects 0.000 title 1
- 101710150336 Protein Rex Proteins 0.000 abstract 3
- 230000014509 gene expression Effects 0.000 abstract 3
- 230000003612 virological effect Effects 0.000 abstract 3
- 241000714260 Human T-lymphotropic virus 1 Species 0.000 abstract 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 2
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 206010020460 Human T-cell lymphotropic virus type I infection Diseases 0.000 abstract 1
- 241000714259 Human T-lymphotropic virus 2 Species 0.000 abstract 1
- 101710150344 Protein Rev Proteins 0.000 abstract 1
- 108700005077 Viral Genes Proteins 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 238000013459 approach Methods 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 230000002939 deleterious effect Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000010195 expression analysis Methods 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 230000000754 repressing effect Effects 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000001052 transient effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
- C12N2740/14022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- AIDS & HIV (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35687889A | 1989-05-25 | 1989-05-25 | |
| GB898915602A GB8915602D0 (en) | 1989-07-07 | 1989-07-07 | Multivalent repressor of gene function |
| GB898924396A GB8924396D0 (en) | 1989-10-30 | 1989-10-30 | Multivalent repressor of gene function |
| US44267089A | 1989-11-29 | 1989-11-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL94482A0 IL94482A0 (en) | 1991-03-10 |
| IL94482A true IL94482A (en) | 2003-09-17 |
Family
ID=27450368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9448290A IL94482A (en) | 1989-05-25 | 1990-05-23 | Transdominant repressor mutant of retroviral protein, dna encoding the protein and process for their preparation and use thereof |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0406557B1 (da) |
| JP (2) | JP3126378B2 (da) |
| KR (1) | KR100215949B1 (da) |
| AT (1) | ATE207122T1 (da) |
| AU (2) | AU648256B2 (da) |
| CA (1) | CA2032158C (da) |
| DE (1) | DE69033829T2 (da) |
| DK (1) | DK0406557T3 (da) |
| ES (1) | ES2166748T3 (da) |
| FI (1) | FI110437B (da) |
| HU (2) | HU217091B (da) |
| IL (1) | IL94482A (da) |
| WO (1) | WO1990014427A2 (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992006990A1 (en) * | 1990-10-17 | 1992-04-30 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Molecular clones of hiv-1 and uses thereof |
| US5534408A (en) * | 1993-09-24 | 1996-07-09 | University Of Massachusetts Medical Center | 2-deoxystreptamine aminoglycoside inhibition of HIV RRE/Rev binding |
| US5650306A (en) * | 1993-06-07 | 1997-07-22 | University Of Michigan | Recombinant nucleic acids for inhibiting HIV gene expression |
| WO1995004546A1 (en) * | 1993-08-06 | 1995-02-16 | Kai Juhani Ernst Krohn | Novel mutated human and simian immunodeficiency viruses and vaccines containing said viruses |
| US6228369B1 (en) | 1993-12-13 | 2001-05-08 | Transgene S.A. | Composition of trans-dominant variants of viral proteins for obtaining an anti-viral effect |
| US5981258A (en) * | 1993-12-13 | 1999-11-09 | Transgene S.A. | Composition of trans-dominant variants of viral proteins for obtaining an antiviral effect |
| FR2713651B1 (fr) * | 1993-12-13 | 1996-04-19 | Transgene Sa | Nouvelle composition pour un effet antiviral. |
| CN1991365A (zh) | 1996-01-26 | 2007-07-04 | 沃尔科股份有限公司 | 根据人类hiv病毒株的表型药物敏感性控制hiv阳性病人化疗的方法 |
| CA2254819A1 (en) * | 1996-06-06 | 1997-12-11 | Novartis Ag | Inhibition of hiv-1 replication by antisense rna expression |
| NZ333188A (en) * | 1996-06-06 | 2001-06-29 | Systemix Inc | Use of DNA scaffold attachments regions to modify expression of a heterologous gene |
| US6776986B1 (en) | 1996-06-06 | 2004-08-17 | Novartis Ag | Inhibition of HIV-1 replication by antisense RNA expression |
| AU770885B2 (en) * | 1998-12-22 | 2004-03-04 | Ppd Development, Lp | Genetic suppressor elements against human immunodeficiency virus |
| AU2493300A (en) * | 1999-01-06 | 2000-07-24 | Regents Of The University Of California, The | Modulation of hiv replication using sam68 |
| US7300790B2 (en) | 2003-01-23 | 2007-11-27 | Iogenetics, Llc | Transgenic animals expressing transdominant negative retroviral nucleic acids and proteins |
| JP5653549B1 (ja) | 2014-05-30 | 2015-01-14 | 株式会社松風 | イオン徐放性歯科用レジン系仮封材組成物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4935372A (en) * | 1986-05-20 | 1990-06-19 | Dana Farber Cancer Institute | Art nucleotide segments, vectors, cell lines methods of preparation and use |
-
1990
- 1990-05-23 CA CA002032158A patent/CA2032158C/en not_active Expired - Lifetime
- 1990-05-23 AT AT90109892T patent/ATE207122T1/de not_active IP Right Cessation
- 1990-05-23 ES ES90109892T patent/ES2166748T3/es not_active Expired - Lifetime
- 1990-05-23 WO PCT/EP1990/000831 patent/WO1990014427A2/en active IP Right Grant
- 1990-05-23 KR KR1019910700090A patent/KR100215949B1/ko not_active IP Right Cessation
- 1990-05-23 JP JP02507933A patent/JP3126378B2/ja not_active Expired - Lifetime
- 1990-05-23 DK DK90109892T patent/DK0406557T3/da active
- 1990-05-23 AU AU57388/90A patent/AU648256B2/en not_active Expired
- 1990-05-23 HU HU904245A patent/HU217091B/hu unknown
- 1990-05-23 EP EP90109892A patent/EP0406557B1/en not_active Expired - Lifetime
- 1990-05-23 DE DE69033829T patent/DE69033829T2/de not_active Expired - Lifetime
- 1990-05-23 IL IL9448290A patent/IL94482A/xx not_active IP Right Cessation
-
1991
- 1991-01-24 FI FI910371A patent/FI110437B/fi active
-
1994
- 1994-07-20 AU AU67573/94A patent/AU678478B2/en not_active Expired
-
1995
- 1995-06-19 HU HU95P/P00249P patent/HU211530A9/hu unknown
-
1997
- 1997-11-19 JP JP31805597A patent/JP3159671B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU678478B2 (en) | 1997-05-29 |
| CA2032158A1 (en) | 1990-11-26 |
| AU5738890A (en) | 1990-12-18 |
| CA2032158C (en) | 2009-09-15 |
| HUT56135A (en) | 1991-07-29 |
| ES2166748T3 (es) | 2002-05-01 |
| IL94482A0 (en) | 1991-03-10 |
| EP0406557B1 (en) | 2001-10-17 |
| DK0406557T3 (da) | 2002-02-11 |
| KR100215949B1 (ko) | 1999-08-16 |
| AU6757394A (en) | 1994-11-17 |
| WO1990014427A3 (en) | 1991-01-10 |
| EP0406557A3 (en) | 1991-05-02 |
| FI110437B (fi) | 2003-01-31 |
| DE69033829D1 (de) | 2001-11-22 |
| JP3126378B2 (ja) | 2001-01-22 |
| HU904245D0 (en) | 1991-06-28 |
| KR920701440A (ko) | 1992-08-11 |
| DE69033829T2 (de) | 2002-04-04 |
| HU217091B (hu) | 1999-11-29 |
| FI910371A0 (fi) | 1991-01-24 |
| JPH10165188A (ja) | 1998-06-23 |
| JPH04500009A (ja) | 1992-01-09 |
| ATE207122T1 (de) | 2001-11-15 |
| JP3159671B2 (ja) | 2001-04-23 |
| WO1990014427A2 (en) | 1990-11-29 |
| HU211530A9 (en) | 1995-11-28 |
| EP0406557A2 (en) | 1991-01-09 |
| AU648256B2 (en) | 1994-04-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |