IL93136A - History of tetrahydroimidazo [1,4] benzodiazepine-2-thione, their preparation and pharmaceutical preparations containing them - Google Patents

History of tetrahydroimidazo [1,4] benzodiazepine-2-thione, their preparation and pharmaceutical preparations containing them

Info

Publication number
IL93136A
IL93136A IL9313690A IL9313690A IL93136A IL 93136 A IL93136 A IL 93136A IL 9313690 A IL9313690 A IL 9313690A IL 9313690 A IL9313690 A IL 9313690A IL 93136 A IL93136 A IL 93136A
Authority
IL
Israel
Prior art keywords
formula
hydrogen
parts
amino
methyl
Prior art date
Application number
IL9313690A
Other languages
English (en)
Hebrew (he)
Other versions
IL93136A0 (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898904108A external-priority patent/GB8904108D0/en
Priority claimed from GB898920354A external-priority patent/GB8920354D0/en
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL93136A0 publication Critical patent/IL93136A0/xx
Publication of IL93136A publication Critical patent/IL93136A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL9313690A 1989-02-23 1990-01-23 History of tetrahydroimidazo [1,4] benzodiazepine-2-thione, their preparation and pharmaceutical preparations containing them IL93136A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898904108A GB8904108D0 (en) 1989-02-23 1989-02-23 Antiviral tetrahydroimidazo(1,4)benzodiazepin-2-thiones
GB898920354A GB8920354D0 (en) 1989-09-08 1989-09-08 Antiviral tetrahydroimidazo(1,4)benzodiazepin-2-thiones
US40662689A 1989-09-13 1989-09-13

Publications (2)

Publication Number Publication Date
IL93136A0 IL93136A0 (en) 1990-11-05
IL93136A true IL93136A (en) 1995-01-24

Family

ID=27264337

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9313690A IL93136A (en) 1989-02-23 1990-01-23 History of tetrahydroimidazo [1,4] benzodiazepine-2-thione, their preparation and pharmaceutical preparations containing them

Country Status (28)

Country Link
EP (1) EP0384522B1 (fr)
JP (1) JP2588624B2 (fr)
AP (1) AP139A (fr)
AT (1) ATE84534T1 (fr)
AU (1) AU617926B2 (fr)
CA (1) CA2010639C (fr)
CY (1) CY1868A (fr)
DE (1) DE69000743T2 (fr)
DK (1) DK0384522T3 (fr)
EG (1) EG19674A (fr)
ES (1) ES2046671T3 (fr)
FI (1) FI92830C (fr)
GR (1) GR3006855T3 (fr)
HK (1) HK114995A (fr)
HU (2) HU204831B (fr)
IE (1) IE63155B1 (fr)
IL (1) IL93136A (fr)
JO (1) JO1610B1 (fr)
LV (1) LV5782B4 (fr)
MA (1) MA21748A1 (fr)
MY (1) MY106231A (fr)
NO (1) NO173503C (fr)
NZ (1) NZ232548A (fr)
OA (1) OA09196A (fr)
PH (1) PH27113A (fr)
PT (1) PT93227B (fr)
TN (1) TNSN90021A1 (fr)
YU (1) YU47219B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8806449D0 (en) * 1988-03-18 1988-04-20 Janssen Pharmaceutica Nv Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones
NZ235137A (en) * 1989-09-13 1992-02-25 Janssen Pharmaceutica Nv Tetrahydroimidazo(1,4)benzodiazepine derivatives, preparation and pharmaceutical compositions thereof
NZ238664A (en) * 1990-07-06 1992-12-23 Janssen Pharmaceutica Nv Substituted tetrahydroimidazo(1,4)benzodiazepin-2-(thi)ones and pharmaceutical anti-viral compositions
DE4036552C1 (fr) * 1990-11-16 1992-02-06 Boehringer Mannheim Gmbh, 6800 Mannheim, De
DE4103803A1 (de) * 1991-02-08 1992-08-13 Boehringer Mannheim Gmbh Neue 4,5,6,7-tetrahydro-imidazo-(4,5,ljk)(1,4)- benzodiazepin-2-(1h)-thione, verfahren zu ihrer herstellung sowie arzneimittel und zwischenprodukte zur herstellung dieser verbindungen
GB9109557D0 (en) * 1991-05-02 1991-06-26 Wellcome Found Chemical compounds
AU1787492A (en) * 1991-05-16 1992-12-30 Glaxo Group Limited Antiviral combinations containing nucleoside analogs
IL102548A (en) * 1991-08-02 1998-08-16 Medivir Ab Use of painting derivatives in the preparation of drugs for VIH inhibition and treatment of SDIA and new compounds
US5593993A (en) * 1991-08-02 1997-01-14 Medivir Ab Method for inhibition of HIV related viruses
WO1993006106A1 (fr) * 1991-09-24 1993-04-01 Janssen Pharmaceutica N.V. PROCEDE DE PREPARATION D'IMIDAZO[4,5,1-jk][1,4]-BENZODIAZEPIN-2(1H^_)-THIONES A PURETE ENANTIOMERE
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
AU4079593A (en) * 1992-05-13 1993-12-13 Wellcome Foundation Limited, The Therapeutic combinations
GR920100326A (el) * 1992-07-21 1994-03-31 Medivir Ag Ενώσεις και μέ?οδοι αναστολής του HIV και των σχετικών ιών.
US5519021A (en) * 1992-08-07 1996-05-21 Merck & Co., Inc. Benzoxazinones as inhibitors of HIV reverse transcriptase
DE19946289A1 (de) * 1999-09-28 2001-03-29 Basf Ag Benzodiazepin-Derivate, deren Herstellung und Anwendung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4075206A (en) * 1977-02-25 1978-02-21 Eli Lilly And Company Substituted pyrroloquinoxalinones and diones
FR2534257A1 (fr) * 1982-10-12 1984-04-13 Roussel Uclaf Nouveaux derives de la 6-amino 7-hydroxy 4,5,6,7-tetrahydro-imidazo/4,5,1-j-k/ /1/ benzazepin-2(1h)-one, leurs sels, application a titre de medicaments, compositions les renfermant et un intermediaire
GB8333581D0 (en) * 1983-12-16 1984-01-25 Wyeth John & Brother Ltd Heterocyclic compounds
GB8806449D0 (en) * 1988-03-18 1988-04-20 Janssen Pharmaceutica Nv Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones

Also Published As

Publication number Publication date
EP0384522A1 (fr) 1990-08-29
JO1610B1 (en) 1990-07-01
NZ232548A (en) 1991-03-26
DE69000743D1 (de) 1993-02-25
PH27113A (en) 1993-03-16
PT93227B (pt) 1996-01-31
AP139A (en) 1991-10-15
TNSN90021A1 (fr) 1991-03-05
NO900848D0 (no) 1990-02-22
CA2010639A1 (fr) 1990-08-23
OA09196A (en) 1992-06-30
NO173503B (no) 1993-09-13
HK114995A (en) 1995-07-21
MY106231A (en) 1995-04-29
AU5003890A (en) 1990-08-30
GR3006855T3 (fr) 1993-06-30
YU33490A (sh) 1992-09-07
PT93227A (pt) 1990-08-31
IE900650L (en) 1990-08-23
IL93136A0 (en) 1990-11-05
EG19674A (en) 1996-06-30
FI92830B (fi) 1994-09-30
LV5782A4 (lv) 1996-12-20
CA2010639C (fr) 2001-04-17
HU900896D0 (en) 1990-05-28
DE69000743T2 (de) 1993-05-13
EP0384522B1 (fr) 1993-01-13
JP2588624B2 (ja) 1997-03-05
LV5782B4 (lv) 1997-06-20
NO900848L (no) 1990-08-24
ATE84534T1 (de) 1993-01-15
HUT54158A (en) 1991-01-28
MA21748A1 (fr) 1990-10-01
NO173503C (no) 1993-12-22
YU47219B (sh) 1995-01-31
IE63155B1 (en) 1995-03-22
HU204831B (en) 1992-02-28
AU617926B2 (en) 1991-12-05
JPH02270876A (ja) 1990-11-05
FI92830C (fi) 1995-01-10
ES2046671T3 (es) 1994-02-01
FI900897A0 (fi) 1990-02-22
AP9000166A0 (en) 1990-04-30
DK0384522T3 (da) 1993-04-19
CY1868A (en) 1996-04-05
HU211250A9 (en) 1995-11-28

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Publication Publication Date Title
AP139A (en) Antiviral tetrahydroimidazo[1,4]benzodiazepin-2-thiones.
EP0336466B1 (fr) Tetrahydroimidazo (1,4) benzodiazépin-2-ones antivirales
US6201119B1 (en) Antiretroviral tetrahydroimidazo[1,4]benzodiazepin-2(thi) ones
EP0538297B9 (fr) Tetrahydroimidazo 1,4]benzodiazepine-2-(thio)ones antivirales
AU635328B2 (en) Antiviral tetrahydroimidazo (1,4) benzodiazepines
HRP930480A2 (en) Antiviral tetrahydroimidazo (1,4) benzodiazepine-2-thiones

Legal Events

Date Code Title Description
KB Patent renewed
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees