IL93118A0 - Expression vectors,cells transformed thereby and their use in the production of chimeric monoclonal antibodies - Google Patents
Expression vectors,cells transformed thereby and their use in the production of chimeric monoclonal antibodiesInfo
- Publication number
- IL93118A0 IL93118A0 IL93118A IL9311890A IL93118A0 IL 93118 A0 IL93118 A0 IL 93118A0 IL 93118 A IL93118 A IL 93118A IL 9311890 A IL9311890 A IL 9311890A IL 93118 A0 IL93118 A0 IL 93118A0
- Authority
- IL
- Israel
- Prior art keywords
- monoclonal antibodies
- chimeric monoclonal
- production
- expression vectors
- cells transformed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30121689A | 1989-01-24 | 1989-01-24 | |
US44170289A | 1989-12-04 | 1989-12-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL93118A0 true IL93118A0 (en) | 1990-11-05 |
Family
ID=26972226
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL93118A IL93118A0 (en) | 1989-01-24 | 1990-01-22 | Expression vectors,cells transformed thereby and their use in the production of chimeric monoclonal antibodies |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0380068B1 (xx) |
JP (1) | JPH02295487A (xx) |
AT (1) | ATE81153T1 (xx) |
AU (1) | AU641907B2 (xx) |
CA (1) | CA2008259A1 (xx) |
DE (1) | DE69000338T2 (xx) |
DK (1) | DK0380068T3 (xx) |
ES (1) | ES2052077T3 (xx) |
FI (1) | FI900332A0 (xx) |
IL (1) | IL93118A0 (xx) |
NZ (1) | NZ232201A (xx) |
PT (1) | PT92900A (xx) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6051231A (en) * | 1988-09-01 | 2000-04-18 | Bayer Corporation | Antiviral methods and prepations |
US6143298A (en) * | 1988-09-01 | 2000-11-07 | Bayer Corporation | Soluble truncated forms of ICAM-1 |
ZA896668B (en) * | 1988-09-01 | 1990-06-27 | Molecular Therapeutics Inc | A human rhinovirus receptor protein that inhibits virus infectivity |
US6514936B1 (en) | 1988-09-01 | 2003-02-04 | Bayer Corporation | Antiviral methods using human rhinovirus receptor (ICAM-1) |
DE68929096T2 (de) | 1988-09-01 | 2000-05-11 | Bayer Corp., Pittsburgh | Menschliches Rhinovirusrezeptorprotein, das die Virusinfektionsanfälligkeit hemmt |
US5674982A (en) * | 1990-07-20 | 1997-10-07 | Bayer Corporation | Multimeric form of human rhinovirus receptor protein |
ES2134762T3 (es) * | 1990-07-20 | 1999-10-16 | Bayer Ag | Formas multimericas de proteinas receptoras de rinovirus humanos. |
US6107461A (en) * | 1990-07-20 | 2000-08-22 | Bayer Corporation | Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use |
US5871733A (en) * | 1990-07-20 | 1999-02-16 | Bayer Corporation | Multimeric forms of human rhinovirus receptor protein |
GB2279077B (en) * | 1990-12-21 | 1995-06-14 | Celltech Ltd | Therapeutic compositions comprising recombinant antibodies specific for the TNFalpha |
US5656272A (en) * | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
US6284471B1 (en) | 1991-03-18 | 2001-09-04 | New York University Medical Center | Anti-TNFa antibodies and assays employing anti-TNFa antibodies |
DE69231828T3 (de) * | 1991-03-18 | 2008-06-19 | New York University | Spezifisch gegen menschlichen Tumornekrosefaktor gerichtete monoklonale und chimäre Antikörper |
US5919452A (en) * | 1991-03-18 | 1999-07-06 | New York University | Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies |
US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
US7192584B2 (en) | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
US5698195A (en) * | 1991-03-18 | 1997-12-16 | New York University Medical Center | Methods of treating rheumatoid arthritis using chimeric anti-TNF antibodies |
NZ269735A (en) * | 1993-07-30 | 1998-01-26 | Oravax Inc | Monoclonal iga antibody against respiratory syncytial virus (rsv) |
JP4731683B2 (ja) * | 1997-08-22 | 2011-07-27 | ユニバーシティ・オブ・グエルフ | 卵中でのタンパク質の産生 |
GB0013810D0 (en) * | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
UA81743C2 (uk) | 2000-08-07 | 2008-02-11 | Центокор, Инк. | МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ |
TWI334439B (en) | 2001-08-01 | 2010-12-11 | Centocor Inc | Anti-tnf antibodies, compositions, methods and uses |
US8415291B2 (en) | 2008-10-31 | 2013-04-09 | Centocor Ortho Biotech Inc. | Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses |
FR3004184B1 (fr) | 2013-02-26 | 2016-03-18 | Agronomique Inst Nat Rech | Anticorps anti-gluten desamide et utilisations. |
GB201522394D0 (en) | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibodies |
US10465003B2 (en) | 2016-02-05 | 2019-11-05 | Janssen Biotech, Inc. | Anti-TNF antibodies, compositions, methods and use for the treatment or prevention of type 1 diabetes |
MA47362A (fr) | 2017-01-30 | 2019-12-04 | Janssen Biotech Inc | Anticorps anti-tnf, compositions et méthodes pour le traitement du rhumatisme psoriasique actif |
MA47442A (fr) | 2017-02-07 | 2019-12-18 | Janssen Biotech Inc | Anticorps anti-tnf, compositions et méthodes pour le traitement de la spondylarthrite ankylosante active |
BR112021023295A2 (pt) | 2019-05-23 | 2022-02-08 | Janssen Biotech Inc | Método de tratamento de doença inflamatória intestinal com uma terapia de combinação de anticorpos para il-23 e tnf-alfa |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2188941B (en) * | 1986-04-14 | 1990-06-06 | Bayer Ag | Monoclonal antibodies recognizing human interleukin-2-receptor |
DE3751908T2 (de) * | 1986-07-07 | 1997-02-06 | Centocor Inc | Chimärisches Murine-Mensch-Immunoglobulin, spezifisch für tumorassoziertes 17-1A Antigen |
JPH02503867A (ja) * | 1988-04-15 | 1990-11-15 | プロテイン デザイン ラブズ インコーポレーテッド | Il‐2レセプター特異的キメラ抗体 |
JP3105898B2 (ja) * | 1988-04-16 | 2000-11-06 | セルテック リミテッド | 組換えdnaタンパクの製造方法 |
-
1990
- 1990-01-18 PT PT199092900A patent/PT92900A/pt not_active Application Discontinuation
- 1990-01-22 IL IL93118A patent/IL93118A0/xx unknown
- 1990-01-22 FI FI900332A patent/FI900332A0/fi not_active Application Discontinuation
- 1990-01-22 CA CA002008259A patent/CA2008259A1/en not_active Abandoned
- 1990-01-23 NZ NZ232201A patent/NZ232201A/en unknown
- 1990-01-24 DE DE9090101351T patent/DE69000338T2/de not_active Expired - Fee Related
- 1990-01-24 JP JP2014743A patent/JPH02295487A/ja active Pending
- 1990-01-24 AT AT90101351T patent/ATE81153T1/de not_active IP Right Cessation
- 1990-01-24 AU AU48766/90A patent/AU641907B2/en not_active Ceased
- 1990-01-24 DK DK90101351.6T patent/DK0380068T3/da active
- 1990-01-24 EP EP90101351A patent/EP0380068B1/en not_active Expired - Lifetime
- 1990-01-24 ES ES90101351T patent/ES2052077T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU4876690A (en) | 1990-08-02 |
DE69000338T2 (de) | 1993-02-25 |
EP0380068A1 (en) | 1990-08-01 |
PT92900A (pt) | 1990-07-31 |
ES2052077T3 (es) | 1994-07-01 |
AU641907B2 (en) | 1993-10-07 |
NZ232201A (en) | 1992-04-28 |
FI900332A0 (fi) | 1990-01-22 |
DE69000338D1 (de) | 1992-11-05 |
JPH02295487A (ja) | 1990-12-06 |
DK0380068T3 (da) | 1992-11-02 |
EP0380068B1 (en) | 1992-09-30 |
CA2008259A1 (en) | 1990-07-24 |
ATE81153T1 (de) | 1992-10-15 |
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