IL88034A - Causes of a mutant acid fibroblast growth, its preparation and pharmaceutical preparations containing it - Google Patents

Causes of a mutant acid fibroblast growth, its preparation and pharmaceutical preparations containing it

Info

Publication number
IL88034A
IL88034A IL8803488A IL8803488A IL88034A IL 88034 A IL88034 A IL 88034A IL 8803488 A IL8803488 A IL 8803488A IL 8803488 A IL8803488 A IL 8803488A IL 88034 A IL88034 A IL 88034A
Authority
IL
Israel
Prior art keywords
growth factor
fibroblast growth
leu
acidic fibroblast
ser
Prior art date
Application number
IL8803488A
Other languages
English (en)
Hebrew (he)
Other versions
IL88034A0 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL88034A0 publication Critical patent/IL88034A0/xx
Publication of IL88034A publication Critical patent/IL88034A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]
    • C07K14/501Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL8803488A 1987-10-22 1988-10-13 Causes of a mutant acid fibroblast growth, its preparation and pharmaceutical preparations containing it IL88034A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11260087A 1987-10-22 1987-10-22
US24443188A 1988-09-16 1988-09-16

Publications (2)

Publication Number Publication Date
IL88034A0 IL88034A0 (en) 1989-06-30
IL88034A true IL88034A (en) 1994-06-24

Family

ID=26810140

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8803488A IL88034A (en) 1987-10-22 1988-10-13 Causes of a mutant acid fibroblast growth, its preparation and pharmaceutical preparations containing it

Country Status (13)

Country Link
EP (1) EP0319052B1 (fr)
JP (1) JPH082309B2 (fr)
KR (1) KR970009340B1 (fr)
AT (1) ATE117723T1 (fr)
AU (1) AU623351B2 (fr)
CA (1) CA1340363C (fr)
DE (1) DE3852870T2 (fr)
DK (1) DK174961B1 (fr)
ES (1) ES2070125T3 (fr)
IE (1) IE65360B1 (fr)
IL (1) IL88034A (fr)
NZ (1) NZ226543A (fr)
PT (1) PT88824B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0392605A1 (fr) * 1989-04-13 1990-10-17 Merck & Co. Inc. Méthode pour augmenter l'expression du facteur de croissance acide de fibroblastes
EP0406738A3 (en) * 1989-07-03 1991-08-14 Takeda Chemical Industries, Ltd. Production of acidic fgf protein
CA2020720A1 (fr) * 1989-07-13 1991-01-14 Shigeko Yamazaki Methode de purification d'un facteur de croissance de fibroblaste acide recombinant ayant une action therapeutique
US5126323A (en) * 1989-11-16 1992-06-30 Genetics Institute, Inc. Homogeneous purified k-fgf and compositions containing the same
CA2098484A1 (fr) * 1990-12-18 1992-06-19 Tsutomu Arakawa Analogues du facteur croissance fibroblaste acide a stabilite et activite biologique accrues
US5348941A (en) * 1992-04-01 1994-09-20 Merck & Co., Inc. Stabilizers for fibroblast growth factors
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
JP4088111B2 (ja) * 2002-06-28 2008-05-21 日立電線株式会社 多孔質基板とその製造方法、GaN系半導体積層基板とその製造方法
EP2172550B1 (fr) 2007-06-29 2014-08-06 Daiichi Sankyo Company, Limited DÉRIVÉ D'ENZYME RECOMBINANTE C-TERMINAL-alpha-AMIDÉE
PL221356B1 (pl) * 2012-04-21 2016-03-31 Wrocławskie Ct Badań Eit & Spółka Z Ograniczoną Odpowiedzialności Zmodyfikowany genetycznie, rekombinowany czynnik wzrostu fibroblastów (FGF1) skoniugowany z nanocząsteczkami metalu lub tlenku metalu, jego sekwencja DNA i aminokwasowa oraz zastosowanie
CH717226B1 (it) * 2020-07-14 2021-09-30 Contrad Swiss Sa Idrogel per applicazione topica efficace nel limitare la degenerazione di tendini e muscoli.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL90047A (en) * 1982-10-19 1992-12-01 Cetus Oncology Corp Cysteine-depleted biologically active muteins other than interferon - '
US4711848A (en) * 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin
DE3650774T2 (de) * 1985-09-12 2003-05-28 Scios Inc Rekombinante Fibroblasten-Wachstums-Faktoren
US4868113A (en) * 1986-03-03 1989-09-19 Rorer Biotechnology, Inc. Recombinant DNA vector encoding human endothelial cell growth factor

Also Published As

Publication number Publication date
JPH082309B2 (ja) 1996-01-17
ES2070125T3 (es) 1995-06-01
JPH02484A (ja) 1990-01-05
PT88824B (pt) 1993-04-30
CA1340363C (fr) 1999-02-02
DK587488D0 (da) 1988-10-21
AU623351B2 (en) 1992-05-14
DE3852870T2 (de) 1995-08-17
AU2430588A (en) 1989-04-27
ATE117723T1 (de) 1995-02-15
EP0319052A2 (fr) 1989-06-07
DE3852870D1 (de) 1995-03-09
KR890006815A (ko) 1989-06-16
EP0319052B1 (fr) 1995-01-25
IE65360B1 (en) 1995-10-18
DK587488A (da) 1989-06-06
KR970009340B1 (en) 1997-06-10
IE883188L (en) 1989-04-22
NZ226543A (en) 1992-02-25
IL88034A0 (en) 1989-06-30
DK174961B1 (da) 2004-03-29
EP0319052A3 (en) 1990-04-25

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