IL87657A - Preparation of methylene derivatives of androsta-1,4-diene-3,17-dione and pharmaceutical compositions containing them - Google Patents

Preparation of methylene derivatives of androsta-1,4-diene-3,17-dione and pharmaceutical compositions containing them

Info

Publication number
IL87657A
IL87657A IL87657A IL8765788A IL87657A IL 87657 A IL87657 A IL 87657A IL 87657 A IL87657 A IL 87657A IL 8765788 A IL8765788 A IL 8765788A IL 87657 A IL87657 A IL 87657A
Authority
IL
Israel
Prior art keywords
preparation
androsta
dione
diene
pharmaceutical compositions
Prior art date
Application number
IL87657A
Other languages
English (en)
Other versions
IL87657A0 (en
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of IL87657A0 publication Critical patent/IL87657A0/xx
Publication of IL87657A publication Critical patent/IL87657A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
IL87657A 1987-09-11 1988-09-02 Preparation of methylene derivatives of androsta-1,4-diene-3,17-dione and pharmaceutical compositions containing them IL87657A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878721383A GB8721383D0 (en) 1987-09-11 1987-09-11 Preparation of methylene derivatives

Publications (2)

Publication Number Publication Date
IL87657A0 IL87657A0 (en) 1989-02-28
IL87657A true IL87657A (en) 1993-02-21

Family

ID=10623618

Family Applications (1)

Application Number Title Priority Date Filing Date
IL87657A IL87657A (en) 1987-09-11 1988-09-02 Preparation of methylene derivatives of androsta-1,4-diene-3,17-dione and pharmaceutical compositions containing them

Country Status (16)

Country Link
US (1) US4876045A (ko)
EP (1) EP0307134B1 (ko)
JP (1) JP2791046B2 (ko)
KR (1) KR970005315B1 (ko)
AT (1) ATE78488T1 (ko)
AU (1) AU602608B2 (ko)
CA (1) CA1316914C (ko)
DE (1) DE3872995T2 (ko)
ES (1) ES2051858T3 (ko)
FI (1) FI884087A (ko)
GB (1) GB8721383D0 (ko)
GR (1) GR3005296T3 (ko)
HU (1) HU199156B (ko)
IL (1) IL87657A (ko)
SU (1) SU1681731A3 (ko)
UA (1) UA6044A1 (ko)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
WO2001004342A1 (en) * 1999-07-07 2001-01-18 Pharmacia & Upjohn Company Process to prepare exemestane
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
ES2382609T3 (es) * 2004-01-16 2012-06-11 Cedarburg Pharmaceuticals, Inc. Exemestano y sus productos intermedios y métodos de preparación de los mismos
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US20070225354A1 (en) * 2006-03-21 2007-09-27 Eric Marchewitz Use of dihydrolipoamide for enhancing physical performance
US7569719B1 (en) * 2006-10-25 2009-08-04 Loctite (R&D) Limited Method of preparing electron deficient olefins
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
CA2691772A1 (en) * 2007-06-25 2008-12-31 Scinopharm Taiwan Ltd. Crystalline polymorph of exemestane
SI2170329T1 (sl) * 2007-06-25 2015-03-31 Scinopharm Taiwan Ltd. Postopek za izdelavo kristaliničnega polimorfa 7-etil-10-hidroksikamptotecina
CA2703596A1 (en) * 2007-10-24 2009-04-30 Loctite (R&D) Limited Activated methylene reagents and curable compositions prepared therefrom
US8686105B2 (en) 2007-10-24 2014-04-01 Henkel IP & Holding GmbH Adhesive systems using imines and salts thereof, precursors to electron deficient olefins and coreactants therefor
US7973119B1 (en) 2007-10-24 2011-07-05 Loctite (R&D) Limited Adhesive systems using imines and salts thereof and precursurs to electron deficient olefins
US8053589B1 (en) * 2007-10-24 2011-11-08 Henkel Ireland Limited Imines and methods of preparing electron deficient olefins using such novel imines
WO2009053484A2 (en) 2007-10-24 2009-04-30 Loctite (R & D) Limited Electron deficient olefins and curable compositions prepared therefrom
US8399698B1 (en) 2008-10-24 2013-03-19 Henkel Ireland Limited Substituted activated methylene reagents and methods of using such reagents to form electron deficient olefins
US10196471B1 (en) 2008-10-24 2019-02-05 Henkel IP & Holding GmbH Curable composition having an electron deficient olefin
ES2587977T3 (es) 2009-05-01 2016-10-28 Celloxess Llc Tratamiento de la infertilidad masculina secundaria al estrés oxidativo de esperma
EP2616477B1 (en) 2010-09-14 2016-11-09 Endece, LLC 6-substituted demethyl-estradiol derivatives as er-beta agonists
CN105085599A (zh) * 2014-05-16 2015-11-25 绍兴文理学院 一种依西美坦中间体17,17-乙二氧基-6-亚甲基雄甾-1,4-二烯-3-酮及其制备方法和应用
CN105294807A (zh) * 2014-06-26 2016-02-03 浙江医药股份有限公司新昌制药厂 一种依西美坦中间体肟化合物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3004508C2 (de) * 1980-02-05 1981-12-10 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von 6-Methylensteroiden
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Also Published As

Publication number Publication date
IL87657A0 (en) 1989-02-28
GR3005296T3 (ko) 1993-05-24
CA1316914C (en) 1993-04-27
HUT48273A (en) 1989-05-29
JPH01104095A (ja) 1989-04-21
DE3872995D1 (de) 1992-08-27
UA6044A1 (uk) 1994-12-29
ES2051858T3 (es) 1994-07-01
FI884087A (fi) 1989-03-12
FI884087A0 (fi) 1988-09-06
DE3872995T2 (de) 1992-12-10
AU602608B2 (en) 1990-10-18
ATE78488T1 (de) 1992-08-15
GB8721383D0 (en) 1987-10-21
US4876045A (en) 1989-10-24
EP0307134B1 (en) 1992-07-22
JP2791046B2 (ja) 1998-08-27
AU2198088A (en) 1989-03-16
EP0307134A1 (en) 1989-03-15
KR890005141A (ko) 1989-05-13
HU199156B (en) 1990-01-29
KR970005315B1 (ko) 1997-04-15
SU1681731A3 (ru) 1991-09-30

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AU589269B2 (en) New 6- or 7-methylenandrosta-1,4-diene-3,17-dione derivatives and process for their preparation
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PT83061A (en) Process for the preparation of steroidic aromatase inhibitors
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Legal Events

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