IL86847A - Purified fsh, its preparation and use - Google Patents

Purified fsh, its preparation and use

Info

Publication number
IL86847A
IL86847A IL86847A IL8684788A IL86847A IL 86847 A IL86847 A IL 86847A IL 86847 A IL86847 A IL 86847A IL 8684788 A IL8684788 A IL 8684788A IL 86847 A IL86847 A IL 86847A
Authority
IL
Israel
Prior art keywords
preparation
purified fsh
fsh
purified
Prior art date
Application number
IL86847A
Other languages
English (en)
Other versions
IL86847A0 (en
Inventor
Giuseppe Arpaia
Serenella Serani
Antonino Sirna
Stefano Villa
Original Assignee
Serono Cesare Ist Ricerca
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11264576&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL86847(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Serono Cesare Ist Ricerca filed Critical Serono Cesare Ist Ricerca
Publication of IL86847A0 publication Critical patent/IL86847A0/xx
Publication of IL86847A publication Critical patent/IL86847A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/11—Gonadotropin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
IL86847A 1987-06-26 1988-06-23 Purified fsh, its preparation and use IL86847A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8748110A IT1206302B (it) 1987-06-26 1987-06-26 Ormone follicolo-stimolante urinario

Publications (2)

Publication Number Publication Date
IL86847A0 IL86847A0 (en) 1988-11-30
IL86847A true IL86847A (en) 1997-11-20

Family

ID=11264576

Family Applications (1)

Application Number Title Priority Date Filing Date
IL86847A IL86847A (en) 1987-06-26 1988-06-23 Purified fsh, its preparation and use

Country Status (26)

Country Link
US (3) US5128453A (da)
EP (1) EP0322438B1 (da)
JP (1) JP2523843B2 (da)
KR (1) KR0156565B1 (da)
CN (2) CN1031714C (da)
AR (1) AR243241A1 (da)
AT (1) ATE115148T1 (da)
AU (1) AU615930B2 (da)
CA (1) CA1340649C (da)
DE (1) DE3852383T2 (da)
DK (1) DK173349B1 (da)
ES (1) ES2009948A6 (da)
FI (1) FI96608C (da)
GE (2) GEP19971042B (da)
GR (1) GR1003186B (da)
HK (1) HK143195A (da)
IL (1) IL86847A (da)
IT (1) IT1206302B (da)
LT (2) LT4018B (da)
LV (2) LV10628B (da)
MX (1) MX9203471A (da)
NO (1) NO177498C (da)
RU (2) RU2105012C1 (da)
UA (1) UA19101A (da)
WO (1) WO1988010270A1 (da)
ZA (1) ZA884492B (da)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
US5087615A (en) * 1989-03-17 1992-02-11 Applied Research Systems Ars Holding N.V. Novel method of ovulation induction in humans
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
IT1270866B (it) * 1993-03-10 1997-05-13 Eniricerche Spa Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis
US6737515B2 (en) * 1993-11-19 2004-05-18 Washington University Follicle stimulating hormone-glycosylation analogs
US6162905A (en) * 1996-11-07 2000-12-19 Ibsa Institut Biochimique S.A. FSH and LH separation and purification process
TW518235B (en) * 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
US5990288A (en) * 1997-10-21 1999-11-23 Vitro Diagnostics, Inc. Method for purifying FSH
US6414123B1 (en) * 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
US20030166525A1 (en) * 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
WO2000004913A1 (en) * 1998-07-23 2000-02-03 Eli Lilly And Company Fsh and fsh variant formulations, products and methods
CA2369262A1 (en) 1999-04-13 2000-10-19 Sudha Nagarajan Pulmonary administration of dry powder formulations for treating infertility
GB9924351D0 (en) * 1999-10-14 1999-12-15 Brennan Frank Immunomodulation methods and compositions
JP2001349892A (ja) * 2000-04-03 2001-12-21 Unilever Nv 検査方法及びデバイス
JP4371295B2 (ja) * 2000-05-19 2009-11-25 メルク セローノ ソシエテ アノニム 医薬として活性な化合物およびその使用方法
ATE355849T1 (de) * 2000-12-21 2007-03-15 Nektar Therapeutics Lagerstabile pulverzusammensetzungen mit interleukin-4 rezeptor
PL369606A1 (en) * 2001-10-22 2005-05-02 Applied Research Systems Ars Holding N.V. Gonadotrophins for folliculogenesis
ES2389835T3 (es) 2001-10-22 2012-11-02 Merck Serono Sa Glicoproteínas mutantes
CA2499732A1 (en) * 2002-09-20 2004-04-15 Applied Research Systems Ars Holding N.V. Piperazine derivatives and methods of use
AU2004226353A1 (en) * 2003-04-01 2004-10-14 Laboratoires Serono Sa Inhibitors of phosphodiesterases in infertility
US7741268B2 (en) * 2003-04-02 2010-06-22 Ares Trading S.A. Liquid pharmaceutical formulations of FSH and LH together with a non-ionic surfactant
WO2004112826A1 (en) * 2003-06-20 2004-12-29 Ares Trading Sa Freeze-dried fsh / lh formulations
CN100554277C (zh) * 2003-12-22 2009-10-28 阿雷斯贸易股份有限公司 Fsh的纯化方法
US20070270339A1 (en) * 2004-04-23 2007-11-22 Serono, Inc. Use of GPCR54 Ligands for the Treatment of Infertility
DE602005009856D1 (de) * 2004-11-09 2008-10-30 Ares Trading Sa Verfahren zur reinigung von fsh
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
RS57549B1 (sr) 2005-08-26 2018-10-31 Ares Trading Sa Proces za pripremu glikoziliranog interferona beta
EA200800755A1 (ru) 2005-09-07 2008-10-30 Лаборатуар Сероно С.А. Ikk ингибиторы, предназначенные для лечения эндометриоза
EA014585B1 (ru) * 2005-09-14 2010-12-30 Арес Трейдинг С.А. Способ определения полоксамеров
EP1960419B1 (en) 2005-12-09 2016-03-16 Ares Trading S.A. Method for purifying fsh or a fsh mutant
CN101784655A (zh) * 2007-04-27 2010-07-21 菲尼克斯股份有限公司 可溶性重组二十面体病毒样颗粒的改良生成和体内装配
NZ581702A (en) 2007-06-28 2011-10-28 Biogenerix Ag Follicle stimulating hormone producing cell clone
CN101970010A (zh) 2008-02-08 2011-02-09 拜奥吉耐里克斯股份公司 促卵泡激素的液体制剂
TWI488640B (zh) 2008-04-16 2015-06-21 菲瑞茵國際中心股份有限公司 藥學製劑
CN101269215B (zh) * 2008-05-15 2011-03-23 上海天伟生物制药有限公司 一种糖蛋白激素组合物
JP2009273427A (ja) 2008-05-16 2009-11-26 Jcr Pharmaceuticals Co Ltd 組換え体ヒトｆｓｈの製造方法
PL2414380T3 (pl) 2009-04-01 2016-01-29 Theramex Hq Uk Ltd Sposób oczyszczania rekombinowanego FSH
TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2325194A1 (en) 2009-11-24 2011-05-25 Glycotope GmbH Process for the purification of glycoproteins
RU2438680C1 (ru) * 2010-10-07 2012-01-10 Федеральное государственное образовательное учреждение высшего профессионального образования Курская государственная сельскохозяйственная академия имени профессора И.И. Иванова Министерства сельского хозяйства Российской Федерации Способ получения препарата фолликулостимулирующего гормона из аденогипофизов животных
CA3163525A1 (en) 2011-03-31 2012-10-04 Ferring Bv. Pharmaceutical preparation
CN103509121B (zh) 2012-11-22 2015-01-28 苏州康宁杰瑞生物科技有限公司 一种fsh融合蛋白及其制备方法和用途
KR102169536B1 (ko) 2014-09-11 2020-10-23 히사미쓰 세이야꾸 가부시키가이샤 마이크로니들 디바이스
WO2016067956A1 (ja) 2014-10-27 2016-05-06 久光製薬株式会社 遺伝子組換型卵胞刺激ホルモンを含有するマイクロニードルデバイス
KR102636093B1 (ko) * 2016-10-11 2024-02-13 온코그린 테라퓨틱스 에스아 종양의 진단 및 치료에서 fsh 호르몬 수용체의 리간드
CN111349154A (zh) * 2018-12-21 2020-06-30 江苏众红生物工程创药研究院有限公司 一种重组人促卵泡激素及其制备方法和药物应用
KR102752765B1 (ko) * 2019-12-26 2025-01-14 주식회사 엘지화학 여포 자극 호르몬의 정제 방법
CN113583125B (zh) * 2021-07-09 2022-09-20 苏州晟济药业有限公司 抗体以及包含其的结合剂、免疫吸附材料及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3852422A (en) * 1971-06-26 1974-12-03 Serono Ist Farm Long-active gonadotropins
SU618113A1 (ru) * 1976-11-19 1978-08-05 Всесоюзный научно-исследовательский институт технологии кровезаменителей и гормональных препаратов Способ получени фолликулостимулирующего гормона
US4923805A (en) * 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
US4845077A (en) * 1984-04-03 1989-07-04 Serono Laboratories, Inc. Method of inducing ovulation
DE3583528D1 (de) * 1984-04-03 1991-08-29 Serono Lab Verfahren zur herbeifuehrung der ovulation.
GB8510177D0 (en) * 1985-04-22 1985-05-30 Public Health Laborotory Servi Isolating pituitary glycoprotein hormones
GB2174600B (en) * 1985-05-10 1989-12-20 Univ Melbourne Induction of ovulation in mares
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario

Also Published As

Publication number Publication date
LV10196A (lv) 1994-10-20
RU2105012C1 (ru) 1998-02-20
GR880100418A (el) 1989-03-08
LT4018B (en) 1996-08-26
EP0322438B1 (en) 1994-12-07
JPH02500840A (ja) 1990-03-22
FI890893A0 (fi) 1989-02-24
GR1003186B (el) 1999-09-01
US5128453A (en) 1992-07-07
ATE115148T1 (de) 1994-12-15
DE3852383T2 (de) 1995-04-20
WO1988010270A1 (en) 1988-12-29
DK89989A (da) 1989-02-24
CN1031714C (zh) 1996-05-01
HK143195A (en) 1995-09-15
KR890701626A (ko) 1989-12-21
JP2523843B2 (ja) 1996-08-14
ES2009948A6 (es) 1989-10-16
US5767067A (en) 1998-06-16
CN1117873A (zh) 1996-03-06
NO890805D0 (no) 1989-02-24
NO177498B (no) 1995-06-19
MX9203471A (es) 1992-09-01
CN1069062C (zh) 2001-08-01
IL86847A0 (en) 1988-11-30
IT8748110A0 (it) 1987-06-26
DK89989D0 (da) 1989-02-24
NO890805L (no) 1989-02-24
CA1340649C (en) 1999-07-13
FI96608C (fi) 1996-07-25
KR0156565B1 (ko) 1998-10-15
GEP19971042B (en) 1997-06-13
LV10628A (lv) 1995-04-20
LTIP1654A (en) 1995-08-25
NO177498C (no) 1995-09-27
UA19101A (uk) 1997-12-25
IT1206302B (it) 1989-04-14
AR243241A1 (es) 1993-07-30
LT3999B (en) 1996-06-25
FI96608B (fi) 1996-04-15
LTIP1652A (en) 1995-08-25
DK173349B1 (da) 2000-08-07
AU1962088A (en) 1989-01-19
CN1030589A (zh) 1989-01-25
AU615930B2 (en) 1988-06-24
LV10196B (en) 1995-04-20
US5840857A (en) 1998-11-24
FI890893L (fi) 1989-02-24
LV10628B (en) 1995-10-20
ZA884492B (en) 1989-05-30
EP0322438A1 (en) 1989-07-05
DE3852383D1 (de) 1995-01-19
RU2059412C1 (ru) 1996-05-10
GEP19981274B (en) 1998-05-06

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