IL81937A - Tissue plasminogen activator of a person who has changed the deficiency A functional sugar structure in the amino acid at position 711 has an extended period of half-life in the body, its preparation and medicinal preparation - Google Patents

Tissue plasminogen activator of a person who has changed the deficiency A functional sugar structure in the amino acid at position 711 has an extended period of half-life in the body, its preparation and medicinal preparation

Info

Publication number
IL81937A
IL81937A IL8193787A IL8193787A IL81937A IL 81937 A IL81937 A IL 81937A IL 8193787 A IL8193787 A IL 8193787A IL 8193787 A IL8193787 A IL 8193787A IL 81937 A IL81937 A IL 81937A
Authority
IL
Israel
Prior art keywords
human tissue
plasminogen activator
type plasminogen
amino acid
type
Prior art date
Application number
IL8193787A
Other languages
English (en)
Hebrew (he)
Other versions
IL81937A0 (en
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL81937A0 publication Critical patent/IL81937A0/xx
Publication of IL81937A publication Critical patent/IL81937A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL8193787A 1986-03-18 1987-03-18 Tissue plasminogen activator of a person who has changed the deficiency A functional sugar structure in the amino acid at position 711 has an extended period of half-life in the body, its preparation and medicinal preparation IL81937A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84107586A 1986-03-18 1986-03-18
US2189387A 1987-03-04 1987-03-04

Publications (2)

Publication Number Publication Date
IL81937A0 IL81937A0 (en) 1987-10-20
IL81937A true IL81937A (en) 1994-07-31

Family

ID=26695219

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8193787A IL81937A (en) 1986-03-18 1987-03-18 Tissue plasminogen activator of a person who has changed the deficiency A functional sugar structure in the amino acid at position 711 has an extended period of half-life in the body, its preparation and medicinal preparation

Country Status (19)

Country Link
EP (1) EP0238304B1 (ja)
JP (1) JP2972812B2 (ja)
AT (1) ATE139569T1 (ja)
AU (1) AU602510B2 (ja)
CA (1) CA1341597C (ja)
DD (1) DD258999A5 (ja)
DE (2) DE3708681C2 (ja)
DK (1) DK175490B1 (ja)
ES (1) ES2088860T3 (ja)
FI (1) FI100802B (ja)
FR (1) FR2597883B1 (ja)
GB (1) GB2189249B (ja)
GR (1) GR3020850T3 (ja)
HU (1) HU202276B (ja)
IE (1) IE81073B1 (ja)
IL (1) IL81937A (ja)
NO (1) NO172133C (ja)
NZ (1) NZ219654A (ja)
PT (1) PT84493B (ja)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2138824B (en) * 1982-10-29 1986-12-31 Mitsui Toatsu Chemicals Novel plasminogen activator process for its preparation and thrombolytic drug containing the same
IE81135B1 (en) * 1984-10-01 2000-03-22 Genzyme Corp Recombinant DNA techniques and the products thereof
US5108909A (en) * 1985-03-22 1992-04-28 Chiron Corporation Expression of TPA in mammalian cells
ATE74379T1 (de) * 1985-12-23 1992-04-15 Chiron Corp Peptidplasminogenaktivatoren.
EP0293394B2 (en) * 1986-01-31 2003-10-29 Genetics Institute, LLC Novel thrombolytic proteins
US4927630A (en) * 1986-02-26 1990-05-22 Monsanto Company Tissue plasminogen activator from normal human colon cells
US4851517A (en) * 1986-02-26 1989-07-25 Monsanto Company Tissue plasminogen activator oligosaccharide from normal human colon cells
JPH084501B2 (ja) * 1987-03-20 1996-01-24 エーザイ株式会社 糖鎖に関する変異ｔＰＡ
NO179754C (no) * 1987-06-04 1996-12-11 Zymogenetics Inc Fremgangsmåte for fremstilling av en t-PA-analog, DNA-sekveks som koder for t-PA-analogen, ekspresjonsvektor omfattende DNA-sekvensen samt vertscelle omfattende denne
NZ225215A (en) * 1987-07-01 1991-05-28 Beecham Group Plc Hybrid plasminogen activator and plasminogen derivatives and pharmaceutical compositions
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
IL88247A0 (en) * 1987-11-06 1989-06-30 Genentech Inc Novel human tissue-type plasminogen activator variant
IL90146A (en) * 1988-05-20 1994-10-07 Genentech Inc Glycosylation derivatives of tissue plasminogen activator
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3841296A1 (de) * 1988-12-08 1990-06-13 Bosch Gmbh Robert Antiblockierregelsystem
US5070021A (en) * 1989-01-10 1991-12-03 Monsanto Company Method of modifying oligosaccharide structure of tissue plasminogen activator
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
ATE155816T1 (de) * 1992-06-03 1997-08-15 Genentech Inc Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
CA2368797C (en) 1999-04-26 2010-08-17 Genentech, Inc. Cell culture process
US7084118B2 (en) 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR840004781A (ko) * 1982-05-05 1984-10-24 월터 에이치·드레거 인체의 조직 플라스미노겐 활성화제
WO1984001786A1 (en) * 1982-10-28 1984-05-10 Beecham Group Plc Enzyme derivatives and their use in the treatment of thrombosis
WO1984001960A1 (en) * 1982-11-11 1984-05-24 Beecham Group Plc Pharmaceutically active compounds
IE81135B1 (en) * 1984-10-01 2000-03-22 Genzyme Corp Recombinant DNA techniques and the products thereof
DE3537176C2 (de) * 1984-10-18 1994-06-09 Zymogenetics Inc Gewebeplasminogenaktivator und Verfahren zu seiner Herstellung
JPS61247384A (ja) * 1984-10-18 1986-11-04 チモ−ジエネテイツクス　インコ−ポレ−テツド 酵母中でプラスミノ−ゲン活性化因子を発現する方法
EP0199574B1 (en) * 1985-04-22 1991-10-23 Genentech, Inc. Human tissue plasminogen activator mutants, methods and intermediates therefor, and compositions using such mutants
JPH0811066B2 (ja) * 1985-09-30 1996-02-07 インテグレーテッド・ジエネティックス・インコーポレーテッド 組換えｄｎａが生産するヒト子宮プラスミノ−ゲンアクチベ−タ−
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
ATE74379T1 (de) * 1985-12-23 1992-04-15 Chiron Corp Peptidplasminogenaktivatoren.
EP0293394B2 (en) * 1986-01-31 2003-10-29 Genetics Institute, LLC Novel thrombolytic proteins

Also Published As

Publication number Publication date
NZ219654A (en) 1990-08-28
HUT43108A (en) 1987-09-28
DE3751842D1 (de) 1996-07-25
DE3708681C2 (de) 1995-08-17
DD258999A5 (de) 1988-08-10
AU602510B2 (en) 1990-10-18
EP0238304A2 (en) 1987-09-23
ES2088860T3 (es) 1996-10-01
EP0238304A3 (en) 1988-07-06
ATE139569T1 (de) 1996-07-15
HU202276B (en) 1991-02-28
DE3751842T2 (de) 1996-11-28
FI871175A (fi) 1987-09-19
FI100802B (fi) 1998-02-27
FR2597883B1 (fr) 1990-04-20
FR2597883A1 (fr) 1987-10-30
DK135887D0 (da) 1987-03-17
DE3708681A1 (de) 1987-10-01
JP2972812B2 (ja) 1999-11-08
GB2189249A (en) 1987-10-21
CA1341597C (en) 2009-06-23
IL81937A0 (en) 1987-10-20
PT84493A (en) 1987-04-01
GB2189249B (en) 1990-10-31
IE870691L (en) 1987-09-18
GB8706249D0 (en) 1987-04-23
AU7008887A (en) 1987-09-24
NO172133B (no) 1993-03-01
PT84493B (pt) 1989-11-10
EP0238304B1 (en) 1996-06-19
DK135887A (da) 1987-09-19
FI871175A0 (fi) 1987-03-18
IE81073B1 (en) 2000-01-12
JPS62282582A (ja) 1987-12-08
NO172133C (no) 1993-06-09
GR3020850T3 (en) 1996-11-30
DK175490B1 (da) 2004-11-08
NO871086D0 (no) 1987-03-17
NO871086L (no) 1987-09-21

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