IL81420A - Phenolic thioethers and pharmaceutical compositions containing them - Google Patents

Phenolic thioethers and pharmaceutical compositions containing them

Info

Publication number
IL81420A
IL81420A IL8781420A IL8142087A IL81420A IL 81420 A IL81420 A IL 81420A IL 8781420 A IL8781420 A IL 8781420A IL 8142087 A IL8142087 A IL 8142087A IL 81420 A IL81420 A IL 81420A
Authority
IL
Israel
Prior art keywords
substituted
alkyl
methylene
phenyl
compounds
Prior art date
Application number
IL8781420A
Other languages
English (en)
Other versions
IL81420A0 (en
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/824,984 external-priority patent/US4711903A/en
Application filed by Searle & Co filed Critical Searle & Co
Publication of IL81420A0 publication Critical patent/IL81420A0/xx
Publication of IL81420A publication Critical patent/IL81420A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/22—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/36—Esters of dithiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/02—Thiocyanates
    • C07C331/10—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lubricants (AREA)
  • Polymerisation Methods In General (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Steroid Compounds (AREA)
IL8781420A 1986-01-31 1987-01-29 Phenolic thioethers and pharmaceutical compositions containing them IL81420A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/824,984 US4711903A (en) 1986-01-31 1986-01-31 Phenolic thioethers as inhibitors of 5-lipoxygenase
US07/001,259 US4755524A (en) 1986-01-31 1987-01-15 Novel phenolic thioethers as inhibitors of 5-lipoxygenase

Publications (2)

Publication Number Publication Date
IL81420A0 IL81420A0 (en) 1987-08-31
IL81420A true IL81420A (en) 1991-11-21

Family

ID=26668781

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8781420A IL81420A (en) 1986-01-31 1987-01-29 Phenolic thioethers and pharmaceutical compositions containing them

Country Status (17)

Country Link
US (1) US4755524A (de)
EP (1) EP0235575B1 (de)
JP (1) JPH085852B2 (de)
KR (1) KR910002948B1 (de)
AT (1) ATE56702T1 (de)
AU (1) AU593606B2 (de)
CA (1) CA1302424C (de)
DE (1) DE3764976D1 (de)
DK (1) DK50487A (de)
ES (1) ES2017647B3 (de)
FI (1) FI87922C (de)
GR (1) GR3000864T3 (de)
IL (1) IL81420A (de)
NO (1) NO165191C (de)
NZ (1) NZ219104A (de)
PH (1) PH24624A (de)
PT (1) PT84229B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
AU584669B2 (en) * 1985-02-04 1989-06-01 G.D. Searle & Co. Novel disubstituted 4-hydroxyphenylthio anilides
US5157053A (en) * 1985-02-04 1992-10-20 G. D. Searle & Co. Bicycloalky, tricycloalkyl, azabicycloalkyl, and azatricycloalkyl thio amides used to treat inflammation, allergy, asthma and skin disorders
US5002967A (en) * 1987-06-05 1991-03-26 G. D. Searle & Co. Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase
JPS63310821A (ja) * 1987-06-05 1988-12-19 ジー．ディー．サール　アンド　カンパニー ５−リポキシゲナーゼの阻害剤としてのフエノール性チオエーテル、スルホキサイドおよびジスルフアイド
US4847305A (en) * 1987-06-05 1989-07-11 G. D. Searle & Co. Phenolic thioethers as inhibitors of 5-lipoxygenase
AU610528B2 (en) * 1987-10-29 1991-05-23 Smithkline Beckman Corporation Leukotriene antagonists
US4968710A (en) * 1987-11-13 1990-11-06 Riker Laboratories, Inc. Substituted di-t-butylphenols and anti-allergic use thereof
NZ226621A (en) * 1987-11-13 1991-12-23 Riker Laboratories Inc Di-tert butyl phenols substituted by alkoxy, benzyloxy, or benzylthio groups; pharmaceutical compositions containing them
US5066822A (en) * 1987-11-13 1991-11-19 Riker Laboratories, Inc Di-t-butylphenols substituted by an alkoxy or benzyloxy group or a benzylthio group
US5006542A (en) * 1988-10-31 1991-04-09 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use
US4959383A (en) * 1988-10-31 1990-09-25 E. R. Squibb & Sons, Inc. Phenylsulfone alkenoic acids, derivatives thereof, compositions containing same and method of use
US5070099A (en) * 1988-10-31 1991-12-03 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use
JP2627003B2 (ja) * 1989-01-25 1997-07-02 塩野義製薬株式会社 ジーｔｅｒｔ―ブチルヒドロキシフェニルチオ誘導体
US5013864A (en) * 1989-12-08 1991-05-07 G. D. Searle & Co. Process for preparation of α-alkoxy acetic acids and their salts
US4952724A (en) * 1989-12-08 1990-08-28 G. D. Searle & Co. Process for preparation of alpha-aryloxy acetic acids and their salts
JPH0629236B2 (ja) * 1990-05-02 1994-04-20 ナショナル サイエンス カウンシル ２，６―ジメトキシヒドロキノン―３―メルカプトプロピオン酸および２，６―ジメトキシヒドロキノン―３―メルカプト酢酸およびその抗癌用途
US5064860A (en) * 1990-09-07 1991-11-12 G. D. Searle & Co. Method of inhibiting superoxide generation
AU8440991A (en) * 1990-09-07 1992-03-30 G.D. Searle & Co. Phenolic thioetheramides as 5-lipoxygenase inhibitors
CA2051229A1 (en) * 1990-09-14 1992-03-15 Sing-Yuen Sit Hypocholesterolemic unsymmetrical dithiol ketals
US5145992A (en) * 1991-05-06 1992-09-08 G. D. Searle & Co. Process and preparation of α-alkoxy acetic acids and their salts
US5250567A (en) * 1991-05-09 1993-10-05 G. D. Searle & Co. Cyclic phenolic thioethers
US5147893A (en) * 1991-05-09 1992-09-15 G. D. Searle & Co. Cyclic phenolic thioethers
US5442111A (en) * 1991-05-24 1995-08-15 Warner-Lambert Company 3,5-di-tetriary-4-butyl-4-hydroxyphenyloxy- or tioalkylene N-hydroxyamides, N-hydroxythioamides, N-hydroxyureas, and N-hydroxythioureas as 5-lipoxygenase inhibitors
US5476944A (en) * 1991-11-18 1995-12-19 G. D. Searle & Co. Derivatives of cyclic phenolic thioethers
US5272178A (en) * 1991-11-18 1993-12-21 G. D. Searle & Co. Compounds of cyclic phenolic thioethers which are useful in stimulating and inhibiting superoxide generation
US5326907A (en) * 1992-12-18 1994-07-05 G. D. Searle & Co. 2-aminoethanesulfonic acid derivatives of 3,5-disubstituted-4-hydroxyphenolic thioethers
ES2087019B1 (es) * 1994-02-08 1997-03-16 Bobel246 S L Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.
US5420343A (en) * 1994-08-31 1995-05-30 G. D. Searle & Co. Derivatives of aromatic cyclic alkylethers
EP1695959A1 (de) * 1997-05-14 2006-08-30 Atherogenics, Inc. Verbindungen und Methoden zur Hemmung der VCAM-1 Expression
US6852878B2 (en) * 1998-05-14 2005-02-08 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of VCAM-1
AU2006202461B2 (en) * 1997-05-14 2009-12-03 Atherogenics, Inc. Compositions and methods for the inhibition of the expression of VCAM-1
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
CN1275596C (zh) 1997-05-14 2006-09-20 阿特罗吉尼克斯公司 普罗布考单酯在制备用于治疗心血管疾病和炎性疾病的药物中的应用
DE69938192D1 (en) * 1998-11-03 2008-04-03 Nycomed Gmbh Imidazonaphthyridine
CA2444429A1 (en) * 2001-04-11 2002-11-07 Atherogenics, Inc. Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
WO2004064781A2 (en) * 2003-01-14 2004-08-05 Adam Heller Anti-inflammatory substituted phenols and elastomeric compositions for oral delivery of drugs
JP2007512262A (ja) * 2003-11-25 2007-05-17 ノボ　ノルディスク　アクティーゼルスカブ 肥満症の治療のための新規な化合物
WO2005102323A2 (en) 2004-04-20 2005-11-03 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
CA2682258A1 (en) * 2007-03-26 2008-10-02 Salutria Pharmaceuticals Llc Methods and compositions of derivatives of probucol for the treatment of diabetes
US20080280985A1 (en) * 2007-03-27 2008-11-13 Scott Robert A D Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes
KR101357438B1 (ko) 2009-04-29 2014-02-06 아마린 코포레이션 피엘씨 Ｅｐａ 및 심혈관 제제를 포함하는 제약 조성물 및 그의 사용 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1936463A1 (de) * 1969-07-17 1971-02-04 Boehringer Sohn Ingelheim Substituierte Phenole
US3674857A (en) * 1970-03-02 1972-07-04 Dow Chemical Co (((alkylthio) alkyl)thio)phenols
CA1037964A (en) * 1973-02-14 1978-09-05 Eugene R. Wagner 2-((3,5-di-tert-buryl-4-hydroxyphenyl)thio)alkanoic acids and derivatives and esters
AT353776B (de) * 1973-12-27 1979-12-10 Siegfried Ag Verfahren zur herstellung von neuen alkan- saeuren, deren estern und salzen
US4029812A (en) * 1976-02-18 1977-06-14 The Dow Chemical Company Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides
EP0079855A1 (de) * 1981-11-12 1983-05-25 Ciba-Geigy Ag Alkylierte Hydroxyphenylthioalkansäureester
DE3324916A1 (de) * 1983-07-09 1985-01-17 Boehringer Mannheim Gmbh, 6800 Mannheim Thioether, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
US4551279A (en) 1984-01-09 1985-11-05 G. D. Searle & Co. Protease inhibitors
EP0190684B1 (de) * 1985-02-04 1990-07-25 G.D. Searle & Co. Bicycloalkyl-, Tricycloalkyl-, Azabicycloalkyl- und Azatricycloalkyl-Amide

Also Published As

Publication number Publication date
KR870007113A (ko) 1987-08-14
NZ219104A (en) 1989-09-27
EP0235575B1 (de) 1990-09-19
DE3764976D1 (en) 1990-10-25
IL81420A0 (en) 1987-08-31
NO165191B (no) 1990-10-01
NO870384L (no) 1987-08-03
PT84229A (en) 1987-02-01
ATE56702T1 (de) 1990-10-15
PH24624A (en) 1990-08-17
CA1302424C (en) 1992-06-02
FI87922C (fi) 1993-03-10
DK50487A (da) 1987-08-01
DK50487D0 (da) 1987-01-30
JPS62228054A (ja) 1987-10-06
GR3000864T3 (en) 1991-11-15
PT84229B (pt) 1989-03-30
NO165191C (no) 1991-01-09
US4755524A (en) 1988-07-05
FI87922B (fi) 1992-11-30
FI870417A0 (fi) 1987-01-30
AU6810387A (en) 1987-08-06
AU593606B2 (en) 1990-02-15
NO870384D0 (no) 1987-01-30
ES2017647B3 (es) 1991-03-01
EP0235575A1 (de) 1987-09-09
FI870417A (fi) 1987-08-01
KR910002948B1 (ko) 1991-05-11
JPH085852B2 (ja) 1996-01-24

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