IL81055A - Alkoxyalkyl isonitriles and their radiolabeled technetium-99m complexes,preparation of said isonitriles and kits containing them - Google Patents

Alkoxyalkyl isonitriles and their radiolabeled technetium-99m complexes,preparation of said isonitriles and kits containing them

Info

Publication number
IL81055A
IL81055A IL81055A IL8105586A IL81055A IL 81055 A IL81055 A IL 81055A IL 81055 A IL81055 A IL 81055A IL 8105586 A IL8105586 A IL 8105586A IL 81055 A IL81055 A IL 81055A
Authority
IL
Israel
Prior art keywords
isonitriles
alkoxyalkyl
complexes
preparation
kits containing
Prior art date
Application number
IL81055A
Other languages
English (en)
Other versions
IL81055A0 (en
Inventor
Paul Louis Bergstein
Vinayakam Subramanyam
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27123612&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL81055(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Du Pont filed Critical Du Pont
Publication of IL81055A0 publication Critical patent/IL81055A0/xx
Publication of IL81055A publication Critical patent/IL81055A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/10—Isocyanides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Position Fixing By Use Of Radio Waves (AREA)
IL81055A 1985-12-23 1986-12-22 Alkoxyalkyl isonitriles and their radiolabeled technetium-99m complexes,preparation of said isonitriles and kits containing them IL81055A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81247085A 1985-12-23 1985-12-23
US92509186A 1986-11-06 1986-11-06

Publications (2)

Publication Number Publication Date
IL81055A0 IL81055A0 (en) 1987-03-31
IL81055A true IL81055A (en) 1991-07-18

Family

ID=27123612

Family Applications (1)

Application Number Title Priority Date Filing Date
IL81055A IL81055A (en) 1985-12-23 1986-12-22 Alkoxyalkyl isonitriles and their radiolabeled technetium-99m complexes,preparation of said isonitriles and kits containing them

Country Status (20)

Country Link
US (1) US4988827A (da)
EP (1) EP0233368B1 (da)
JP (2) JPH0755914B2 (da)
KR (1) KR940011456B1 (da)
CN (1) CN1057470C (da)
AU (1) AU594407B2 (da)
CA (1) CA1305160C (da)
DE (1) DE3673000D1 (da)
DK (1) DK173003B1 (da)
ES (1) ES2036171T3 (da)
FI (1) FI91747C (da)
GR (1) GR3000681T3 (da)
HU (1) HU201301B (da)
ID (1) ID1037B (da)
IE (1) IE59758B1 (da)
IL (1) IL81055A (da)
MX (1) MX168821B (da)
NO (1) NO166640C (da)
PT (1) PT83996B (da)
SU (1) SU1635903A3 (da)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028699A (en) * 1987-09-11 1991-07-02 E. I. Du Pont De Nemours And Company Process for preparing Tc-99m tris(isonitrile) copper complexes
US4885100A (en) * 1987-09-11 1989-12-05 E. I. Du Pont De Nemours And Company Tris(isonitrile)copper(I) adducts for preparing radionuclide complexes
US5008418A (en) * 1987-09-11 1991-04-16 E. I. Du Pont De Nemours And Company Tris(isonitrile)copper(I) adducts for preparing radionuclide complexes
US4864051A (en) * 1988-09-02 1989-09-05 E. R. Squibb & Sons, Inc. Process for preparing 2-methoxyisobutylisonitrile
CA2085364A1 (en) * 1990-06-18 1991-12-19 Alfons M. Verbruggen Metal-radionuclide complex comprising isonitrile ligands
US5210270A (en) * 1991-11-25 1993-05-11 Institute Of Nuclear Energy Research Method for synthesis and 99m C labelling of 2-alkoxyisobutylisonitrile
US5420321A (en) * 1993-08-03 1995-05-30 The Du Pont Merck Pharmaceutical Company Tris(isonitrile)copper(i) sulfates for preparing radionuclide complexes
DE4445004A1 (de) * 1994-12-16 1996-06-20 Consortium Elektrochem Ind Zusammensetzung zur delokalisierten Kennzeichnung von Gegenständen, ihre Herstellung und Verwendung
US5961952A (en) * 1996-01-24 1999-10-05 Dupont Pharmaceuticals Company 99m Tc-tertiary-butyl isonitrile as breast tumor imaging agents
US6416733B1 (en) 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
US20030124053A1 (en) * 1996-10-07 2003-07-03 Barrett John Andrew Radiopharmaceuticals for imaging infection and inflammation
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
US6524553B2 (en) * 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
JP2002510705A (ja) 1998-04-03 2002-04-09 デュポン ファーマシューティカルズ カンパニー 感染および炎症の撮像、ならびに癌の撮像および治療のための放射性医薬品
TR200101757T2 (tr) 1998-12-18 2001-12-21 Dupont Pharmaceuticais Company Vitronektin reseptör antagonisti farmasötikler
US6794518B1 (en) * 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6511649B1 (en) * 1998-12-18 2003-01-28 Thomas D. Harris Vitronectin receptor antagonist pharmaceuticals
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6511648B2 (en) 1998-12-18 2003-01-28 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6656448B1 (en) 2000-02-15 2003-12-02 Bristol-Myers Squibb Pharma Company Matrix metalloproteinase inhibitors
WO2001087354A2 (en) * 2000-05-17 2001-11-22 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands for diagnostic imaging
MXPA02000862A (es) * 2000-06-01 2003-07-14 Bristol Myers Squibb Pharma Co Lactamas substituidas por succinatos ciclicos como inhibidores de la produccion de proteina abeta.
EP1347784A2 (en) 2000-11-03 2003-10-01 Bristol-Myers Squibb Pharma Company Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation
CN1136921C (zh) * 2001-04-27 2004-02-04 北京师范大学 一种心肌显像剂及其制备方法
US20090062256A1 (en) * 2001-06-01 2009-03-05 Bristol-Myers Squibb Pharma Company LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION
RU2186834C1 (ru) * 2001-06-22 2002-08-10 Быстров Владимир Николаевич Металлоплакирующая присадка к смазочным композициям
US6838074B2 (en) 2001-08-08 2005-01-04 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
EP1423152A4 (en) * 2001-08-08 2006-12-27 Bristol Myers Squibb Pharma Co SIMULTANEOUS PRESENTATION OF THE HEART PERFUSION AND IMAGING MEDICINE WITH VITRONECTIN RECEPTOR AS TARGET
US20050106100A1 (en) * 2003-09-03 2005-05-19 Harris Thomas D. Compounds containing matrix metalloproteinase substrates and methods of their use
KR20080022588A (ko) * 2005-06-30 2008-03-11 브리스톨-마이어스 스퀴브 파마 컴퍼니 영상화제로서의 히드라지드 컨쥬게이트
WO2007123934A2 (en) * 2006-04-19 2007-11-01 The General Hospital Corporation Aryl bidentate isonitriles and their uses
US7563920B2 (en) 2006-10-30 2009-07-21 Draximage Limited Methods for preparing 2-methoxyisobutylisonitrile and tetrakis(2-methoxyisobutylisonitrile)copper(I) tetrafluoroborate
EP2821394A1 (en) * 2013-07-01 2015-01-07 Fundacion MEDINA. Centro de Excelencia en Investigacion de Medicamentos Innovadores en Andalucia Compounds with antibacterial activity

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1215142B (de) * 1964-07-09 1966-04-28 Bayer Ag Verfahren zur Herstellung von araliphatischen Isonitrilen
GB1187755A (en) * 1968-02-24 1970-04-15 Bayer Ag A Process for the Production of Isonitriles
DE1962898A1 (de) * 1969-12-16 1971-06-24 Bayer Ag Verfahren zur Herstellung von Isonitrilen
JPS57165370A (en) * 1981-03-18 1982-10-12 Ici Ltd Triazole or imidazole compounds, manufacture and fungicidal or plant growth regulant agent
US4347251A (en) * 1981-07-13 1982-08-31 American Cyanamid Company Novel 3-substituted amino-1-substituted heteroaryl-2-pyrazolines
US4452774A (en) * 1982-04-30 1984-06-05 President And Fellows Of Harvard College Isonitrile radionuclide complexes for labelling and imaging agents
DE3343673A1 (de) * 1983-12-02 1985-09-05 Basf Ag, 6700 Ludwigshafen Verfahren zur gleichzeitigen herstellung von nitrilen und acrylamid bzw. methacrylamid
US4707544A (en) * 1984-11-28 1987-11-17 President And Fellows Of Harvard College Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents
US4735793A (en) * 1985-08-30 1988-04-05 Massachusetts Institute Of Technology Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes

Also Published As

Publication number Publication date
NO166640C (no) 1991-08-21
HUT43557A (en) 1987-11-30
US4988827A (en) 1991-01-29
CA1305160C (en) 1992-07-14
KR940011456B1 (ko) 1994-12-15
IL81055A0 (en) 1987-03-31
ES2036171T3 (es) 1996-07-16
PT83996B (pt) 1989-07-31
DK623886A (da) 1987-06-24
NO865247D0 (no) 1986-12-22
FI865260A0 (fi) 1986-12-22
KR870005976A (ko) 1987-07-08
JP2774940B2 (ja) 1998-07-09
EP0233368B1 (en) 1990-07-25
GR3000681T3 (en) 1991-09-27
PT83996A (en) 1987-01-01
HU201301B (en) 1990-10-28
DE3673000D1 (de) 1990-08-30
JPS62201363A (ja) 1987-09-05
NO865247L (no) 1987-06-24
MX168821B (es) 1993-06-10
JPH0755914B2 (ja) 1995-06-14
ID1037B (id) 1996-10-24
IE863353L (en) 1987-06-23
FI91747C (fi) 1994-08-10
DK173003B1 (da) 1999-11-01
SU1635903A3 (ru) 1991-03-15
AU594407B2 (en) 1990-03-08
EP0233368A1 (en) 1987-08-26
FI865260L (fi) 1987-06-24
NO166640B (no) 1991-05-13
IE59758B1 (en) 1994-03-23
AU6684286A (en) 1987-06-25
CN1057470C (zh) 2000-10-18
FI91747B (fi) 1994-04-29
JPH07242615A (ja) 1995-09-19
CN1057585A (zh) 1992-01-08
DK623886D0 (da) 1986-12-22

Similar Documents

Publication Publication Date Title
IL81055A (en) Alkoxyalkyl isonitriles and their radiolabeled technetium-99m complexes,preparation of said isonitriles and kits containing them
IL79523A (en) Avermectin-analogous antiparasitic agents,their preparation and compositions containing them
EP0207581A3 (en) Thiazolidine derivatives, their preparation and use
EP0206998A3 (en) Lubricant compositions, glucamin derivatives and complex compounds containing them
PH22659A (en) Paf-antagonistic diazepines, methods of use
GB2155914B (en) Treatment of technetium containing solns
GB8426845D0 (en) Complexes of technetium-99m
PH24451A (en) New pteridines and their use as pharmaceuticla agents
IL79678A0 (en) Preparation of urea
GB8615927D0 (en) Sliding ring seal
AU6667786A (en) Cationic complex of technetium-99m
DE3664781D1 (en) Metal complex pigments
EP0193656A3 (en) Hair-dyeing composition
DE3266694D1 (en) Beta-lactam compounds, their preparation and their use
ZA869618B (en) Ether isonitriles and radiolabeled complexes thereof
GB8514171D0 (en) Cream powder
ZA867343B (en) Use of thienylamines as production-promoting agents,new thienylamine
JPS57200393A (en) Beta-lactam derivatives, manufacture and composition containing them
ZA81483B (en) Beta-lactam containing compounds,their preparation and use
DE3473608D1 (en) Metal complex compounds, their preparation and use
GB8506249D0 (en) Complexes of technetium-99m
GB8624272D0 (en) Cationic complexes of tc-99m
GB8506522D0 (en) Technetium-99m complexes
IL79164A0 (en) Herbicidal compositions containing triazolo-pyrimidine derivatives,their preparation,certain new such derivatives and their preparation
GB8430767D0 (en) Technetium-99m complex

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired