IL75738A - נגזרות פוליפפטיד של ז - אינטרפרון של בני אדם - Google Patents
נגזרות פוליפפטיד של ז - אינטרפרון של בני אדםInfo
- Publication number
- IL75738A IL75738A IL7573885A IL7573885A IL75738A IL 75738 A IL75738 A IL 75738A IL 7573885 A IL7573885 A IL 7573885A IL 7573885 A IL7573885 A IL 7573885A IL 75738 A IL75738 A IL 75738A
- Authority
- IL
- Israel
- Prior art keywords
- ifn
- dna
- cys
- ser
- plasmid
- Prior art date
Links
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- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 description 1
- 210000004897 n-terminal region Anatomy 0.000 description 1
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- 208000019585 progressive encephalomyelitis with rigidity and myoclonus Diseases 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14395084A JPS6124599A (ja) | 1984-07-11 | 1984-07-11 | 新規ヒトインタ−フエロン−ｒポリペプチド誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL75738A0 IL75738A0 (en) | 1985-11-29 |
| IL75738A true IL75738A (he) | 1995-06-29 |
Family
ID=15350817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL7573885A IL75738A (he) | 1984-07-11 | 1985-07-08 | נגזרות פוליפפטיד של ז - אינטרפרון של בני אדם |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4898931A (he) |
| EP (1) | EP0170917B1 (he) |
| JP (1) | JPS6124599A (he) |
| AT (1) | ATE63923T1 (he) |
| AU (1) | AU586822B2 (he) |
| CA (1) | CA1303529C (he) |
| DE (2) | DE170917T1 (he) |
| DK (1) | DK164108C (he) |
| ES (1) | ES8609484A1 (he) |
| IL (1) | IL75738A (he) |
| NO (1) | NO175487C (he) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8334102D0 (en) * | 1983-12-21 | 1984-02-01 | Searle & Co | Interferons with cysteine pattern |
| CA1340265C (en) * | 1985-01-18 | 1998-12-15 | Kirston E. Koths | Oxidation resistant muteins |
| GB8619725D0 (en) * | 1986-08-13 | 1986-09-24 | Hoffmann La Roche | Homogenous interferon fragments |
| JP2653061B2 (ja) * | 1986-12-27 | 1997-09-10 | 武田薬品工業株式会社 | 新規ポリペプチドおよびその製造法 |
| AT393690B (de) * | 1987-10-08 | 1991-11-25 | Hoffmann La Roche | Homogene, rekombinante immun-interferonfragmente |
| DE3829180A1 (de) * | 1988-08-29 | 1990-03-08 | Boehringer Ingelheim Int | Neues arzneimittel zur vorbeugung und behandlung von durch primaere immundefekte verursachte krankheiten |
| DE4036856C1 (he) * | 1990-11-19 | 1992-05-27 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De | |
| HUP9801746A3 (en) * | 1995-01-26 | 2000-11-28 | Biogen Idec Ma Inc Cambridge | Lymphotoxin-alfa/beta complexes and anti-lymphotoxin-beta receptor antibodies as anti-tumor agents |
| DE19535853C2 (de) * | 1995-09-18 | 1999-04-01 | Fraunhofer Ges Forschung | Varianten des rekombinanten humanen Interferon-gamma, Verfahren zu ihrer Herstellung und ihre Verwendung |
| AU782635B2 (en) * | 1999-11-12 | 2005-08-18 | Maxygen Holdings Ltd. | Interferon gamma conjugates |
| HUP0203409A3 (en) | 1999-11-12 | 2005-06-28 | Maxygen Holdings Ltd Redwood C | Interferon gamma conjugates |
| CN1309423C (zh) | 1999-11-12 | 2007-04-11 | 马克西根控股公司 | 干扰素γ偶联物 |
| US6958388B2 (en) | 2001-04-06 | 2005-10-25 | Maxygen, Aps | Interferon gamma polypeptide variants |
| US7038015B2 (en) | 2001-04-06 | 2006-05-02 | Maxygen Holdings, Ltd. | Interferon gamma polypeptide variants |
| EP1539814A2 (en) | 2002-07-03 | 2005-06-15 | Maxygen Holdings Ltd. c/o Close Brothers (Cayman) Limited | Full-length interferon gamma polypeptide variants |
| CA2553040A1 (en) * | 2004-02-02 | 2005-08-18 | Ambrx, Inc. | Modified human four helical bundle polypeptides and their uses |
| CN101247821B (zh) * | 2005-06-03 | 2013-01-23 | Ambrx公司 | 经改良人类干扰素分子和其用途 |
| FR2898359B1 (fr) * | 2006-03-08 | 2011-07-15 | Biomethodes | Variants ameliores de l'interferon-gamma humain (ifn gamma) |
| JP2009529027A (ja) * | 2006-03-08 | 2009-08-13 | ビオメトード | ヒトインターフェロンガンマ（ＩＦＮγ）変異体 |
| CN101939443B (zh) | 2008-02-08 | 2014-01-29 | Ambrx公司 | 经修饰瘦素多肽和其用途 |
| US20210309707A1 (en) * | 2018-07-30 | 2021-10-07 | The Board Of Trustees Of The Leland Stanford Junior University | Interferon-gamma biased agonists |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU561343B2 (en) * | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
| JPS58110548A (ja) * | 1981-12-24 | 1983-07-01 | Asahi Chem Ind Co Ltd | 新規な生理活性ペプチド |
| US6936694B1 (en) * | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| JPH0787797B2 (ja) * | 1982-05-20 | 1995-09-27 | サントリー株式会社 | ヒト・ガンマ・インタ−フエロン様ポリペプチドの製造法 |
| US4681848A (en) * | 1982-09-22 | 1987-07-21 | Takeda Chemical Industries, Ltd. | Novel peptide and use thereof |
| IL69851A0 (en) * | 1982-09-30 | 1983-12-30 | Japan Found Cancer | Novel dna and recombinant plasmid containing the same |
| US4758656A (en) * | 1983-12-26 | 1988-07-19 | Kyowa Hakko Kogyo Co., Ltd. | Novel human interferon-gamma polypeptide derivative |
| AU582574B2 (en) * | 1984-04-19 | 1989-04-06 | Hoechst Aktiengesellschaft | The preparation of polypeptides having human gamma interferon activity |
| IL75302A0 (en) * | 1984-06-06 | 1985-09-29 | Takeda Chemical Industries Ltd | Novel polypeptide and production thereof |
-
1984
- 1984-07-11 JP JP14395084A patent/JPS6124599A/ja active Pending
-
1985
- 1985-07-04 CA CA000486327A patent/CA1303529C/en not_active Expired - Lifetime
- 1985-07-08 IL IL7573885A patent/IL75738A/he not_active IP Right Cessation
- 1985-07-09 EP EP85108541A patent/EP0170917B1/en not_active Expired - Lifetime
- 1985-07-09 DE DE198585108541T patent/DE170917T1/de active Pending
- 1985-07-09 DE DE8585108541T patent/DE3582973D1/de not_active Expired - Lifetime
- 1985-07-09 AT AT85108541T patent/ATE63923T1/de not_active IP Right Cessation
- 1985-07-10 ES ES545052A patent/ES8609484A1/es not_active Expired
- 1985-07-10 US US06/751,205 patent/US4898931A/en not_active Expired - Fee Related
- 1985-07-10 NO NO852776A patent/NO175487C/no unknown
- 1985-07-10 DK DK314485A patent/DK164108C/da not_active IP Right Cessation
- 1985-07-10 AU AU44749/85A patent/AU586822B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ES8609484A1 (es) | 1986-09-01 |
| IL75738A0 (en) | 1985-11-29 |
| NO175487B (no) | 1994-07-11 |
| DK164108B (da) | 1992-05-11 |
| JPS6124599A (ja) | 1986-02-03 |
| DE170917T1 (de) | 1986-09-04 |
| CA1303529C (en) | 1992-06-16 |
| DK164108C (da) | 1992-10-12 |
| NO175487C (no) | 1994-10-19 |
| DK314485D0 (da) | 1985-07-10 |
| ES545052A0 (es) | 1986-09-01 |
| AU586822B2 (en) | 1989-07-27 |
| ATE63923T1 (de) | 1991-06-15 |
| EP0170917B1 (en) | 1991-05-29 |
| DK314485A (da) | 1986-01-12 |
| AU4474985A (en) | 1986-01-16 |
| US4898931A (en) | 1990-02-06 |
| DE3582973D1 (de) | 1991-07-04 |
| EP0170917A1 (en) | 1986-02-12 |
| NO852776L (no) | 1986-01-13 |
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Legal Events
| Date | Code | Title | Description |
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| KB | Patent renewed | ||
| RH | Patent void |