IL72833A - (pyrimidinyl,pyridazinyl and pyrazinyl)ethenyl phenyl oxamic acid derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

(pyrimidinyl,pyridazinyl and pyrazinyl)ethenyl phenyl oxamic acid derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL72833A
IL72833A IL72833A IL7283384A IL72833A IL 72833 A IL72833 A IL 72833A IL 72833 A IL72833 A IL 72833A IL 7283384 A IL7283384 A IL 7283384A IL 72833 A IL72833 A IL 72833A
Authority
IL
Israel
Prior art keywords
carbon atoms
alkoxy
hydrogen
pyridazinyl
pyrazinyl
Prior art date
Application number
IL72833A
Other languages
English (en)
Other versions
IL72833A0 (en
Original Assignee
Boehringer Ingelheim Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Ltd filed Critical Boehringer Ingelheim Ltd
Publication of IL72833A0 publication Critical patent/IL72833A0/xx
Publication of IL72833A publication Critical patent/IL72833A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/12—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/16—Halogen atoms; Nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Pyrrole Compounds (AREA)
IL72833A 1983-09-01 1984-08-31 (pyrimidinyl,pyridazinyl and pyrazinyl)ethenyl phenyl oxamic acid derivatives,their preparation and pharmaceutical compositions containing them IL72833A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52852283A 1983-09-01 1983-09-01

Publications (2)

Publication Number Publication Date
IL72833A0 IL72833A0 (en) 1984-11-30
IL72833A true IL72833A (en) 1987-09-16

Family

ID=24106021

Family Applications (1)

Application Number Title Priority Date Filing Date
IL72833A IL72833A (en) 1983-09-01 1984-08-31 (pyrimidinyl,pyridazinyl and pyrazinyl)ethenyl phenyl oxamic acid derivatives,their preparation and pharmaceutical compositions containing them

Country Status (22)

Country Link
EP (1) EP0137979B1 (fr)
JP (1) JPS60142968A (fr)
KR (1) KR900001217B1 (fr)
AT (1) ATE38224T1 (fr)
AU (1) AU569541B2 (fr)
CA (1) CA1219873A (fr)
CS (1) CS241100B2 (fr)
DD (1) DD227964A5 (fr)
DE (1) DE3474817D1 (fr)
DK (1) DK158725C (fr)
ES (1) ES8505934A1 (fr)
FI (1) FI84477C (fr)
GR (1) GR80245B (fr)
HU (1) HU192576B (fr)
IE (1) IE59035B1 (fr)
IL (1) IL72833A (fr)
NO (1) NO843477L (fr)
NZ (1) NZ209405A (fr)
PH (1) PH22753A (fr)
PT (1) PT79163B (fr)
SU (1) SU1342410A3 (fr)
ZA (1) ZA846826B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62145049A (ja) * 1985-12-18 1987-06-29 Mitsubishi Chem Ind Ltd アミノスチリル化合物及びそれを有効成分とするロイコトリエンきつ抗剤
WO1992000963A1 (fr) * 1990-07-12 1992-01-23 Yoshitomi Pharmaceutical Industries, Ltd. Composes de styryle et leur utilisation comme medicaments
JP2832923B2 (ja) * 1990-07-13 1998-12-09 吉富製薬株式会社 スチリル化合物およびその医薬用途
WO1999035140A1 (fr) * 1998-01-12 1999-07-15 Novartis Ag AMINES DE PYRIDINYLPYRIMIDINE AGISSANT COMME INHIBITEURS DE LA SYNTHESE DE L'IMMUNOGLOBULINE E (IgE)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1259685A (en) * 1969-04-03 1972-01-12 Soc D Etudes Prod Chimique Amino-pyrimidine derivatives
US3993679A (en) * 1972-12-20 1976-11-23 The Upjohn Company Cyano phenylene dioxamic molecules
US4054666A (en) * 1973-03-23 1977-10-18 American Home Products Corporation Compositions and methods of treating immediate hypersensitivity reactions with thiazolyl oxamic acid derivatives
US3953468A (en) * 1974-03-15 1976-04-27 The Upjohn Company 3-Cyano thiophen-2-yl oxamic acid and derivatives
CA1066714A (fr) * 1974-06-10 1979-11-20 John B. Wright Derives de l'acide phenyloxamique utilises en pharmacopee
DE2828091A1 (de) * 1978-06-27 1980-01-10 Boehringer Sohn Ingelheim 4-substituierte thiazoloxamsaeuren sowie ihre salze und ester
JPS5761028A (en) * 1980-09-30 1982-04-13 Sanyo Chem Ind Ltd Formation of heat-insulating primer layer and heat-insulating structure

Also Published As

Publication number Publication date
CS241100B2 (en) 1986-03-13
ATE38224T1 (de) 1988-11-15
IE59035B1 (en) 1993-12-15
KR850002258A (ko) 1985-05-10
CA1219873A (fr) 1987-03-31
AU3260084A (en) 1985-03-07
PH22753A (en) 1988-11-28
IE842237L (en) 1985-03-01
EP0137979B1 (fr) 1988-10-26
DE3474817D1 (en) 1988-12-01
FI843417A (fi) 1985-03-02
JPS60142968A (ja) 1985-07-29
PT79163A (en) 1984-09-01
IL72833A0 (en) 1984-11-30
SU1342410A3 (ru) 1987-09-30
CS654584A2 (en) 1985-07-16
ES535572A0 (es) 1985-06-16
FI843417A0 (fi) 1984-08-30
HU192576B (en) 1987-06-29
DD227964A5 (de) 1985-10-02
EP0137979A1 (fr) 1985-04-24
DK158725B (da) 1990-07-09
NO843477L (no) 1985-03-04
ZA846826B (en) 1986-04-30
KR900001217B1 (ko) 1990-02-28
NZ209405A (en) 1987-05-29
HUT37129A (en) 1985-11-28
PT79163B (en) 1986-11-18
ES8505934A1 (es) 1985-06-16
GR80245B (en) 1985-01-03
AU569541B2 (en) 1988-02-04
FI84477B (fi) 1991-08-30
FI84477C (fi) 1991-12-10
DK418484A (da) 1985-03-02
DK158725C (da) 1990-12-10
DK418484D0 (da) 1984-08-31

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Legal Events

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KB Patent renewed
RH Patent void
EXP Patent expired