IL71943A - Ether and thioether derivatives of arylpyrrolo(1,2-a)-imidazole and arylimidazo(1,2-a)pyridine and their preparation - Google Patents
Ether and thioether derivatives of arylpyrrolo(1,2-a)-imidazole and arylimidazo(1,2-a)pyridine and their preparationInfo
- Publication number
- IL71943A IL71943A IL71943A IL7194384A IL71943A IL 71943 A IL71943 A IL 71943A IL 71943 A IL71943 A IL 71943A IL 7194384 A IL7194384 A IL 7194384A IL 71943 A IL71943 A IL 71943A
- Authority
- IL
- Israel
- Prior art keywords
- ether
- pyridine
- imidazole
- arylpyrrolo
- arylimidazo
- Prior art date
Links
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical class CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 title abstract 4
- VNHBYKHXBCYPBJ-UHFFFAOYSA-N 5-ethynylimidazo[1,2-a]pyridine Chemical compound C#CC1=CC=CC2=NC=CN12 VNHBYKHXBCYPBJ-UHFFFAOYSA-N 0.000 title 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 150000003568 thioethers Chemical class 0.000 title 1
- SDIVEYBYOHLVIP-UHFFFAOYSA-N 8,8-dimethoxy-2-phenyl-3,5,6,7-tetrahydro-2h-imidazo[1,2-a]pyridine;hydrochloride Chemical compound Cl.N1=C2C(OC)(OC)CCCN2CC1C1=CC=CC=C1 SDIVEYBYOHLVIP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/518,514 US4507481A (en) | 1983-07-29 | 1983-07-29 | Pyrrolo[1,2-a]imidazoles and imidazo[1,2-a]pyridines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL71943A0 IL71943A0 (en) | 1984-09-30 |
| IL71943A true IL71943A (en) | 1987-07-31 |
Family
ID=24064258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL71943A IL71943A (en) | 1983-07-29 | 1984-05-28 | Ether and thioether derivatives of arylpyrrolo(1,2-a)-imidazole and arylimidazo(1,2-a)pyridine and their preparation |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4507481A (ja) |
| EP (1) | EP0150255B1 (ja) |
| JP (1) | JPS6042384A (ja) |
| KR (1) | KR910002837B1 (ja) |
| AT (1) | ATE59042T1 (ja) |
| AU (1) | AU562722B2 (ja) |
| CA (1) | CA1250295A (ja) |
| DE (1) | DE3483745D1 (ja) |
| DK (1) | DK367084A (ja) |
| FI (1) | FI78090C (ja) |
| IL (1) | IL71943A (ja) |
| NO (1) | NO161741C (ja) |
| NZ (1) | NZ208266A (ja) |
| PH (1) | PH19437A (ja) |
| ZA (1) | ZA844299B (ja) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4728645A (en) * | 1982-12-21 | 1988-03-01 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives and other substituted bicyclic derivatives, useful as aromatase inhibitors |
| US4551535A (en) * | 1983-07-29 | 1985-11-05 | Pennwalt Corporation | Process for preparing novel 7-thioester derivatives of 3H pyrrolo [1,2-a]-imidazole and 8-thioester derivatives of imidazo [1,2-a] pyridine |
| US4670445A (en) * | 1984-03-05 | 1987-06-02 | Eli Lilly And Company | Inotropic agents |
| US4719218A (en) * | 1985-12-12 | 1988-01-12 | Smithkline Beckman Corporation | Pyrrolo[1,2-a]imidazole and pyrrolo[1,2-a]pyridine derivatives and their use as 5-lipoxygenase pathway inhibitor |
| US5002941A (en) * | 1985-12-12 | 1991-03-26 | Smithkline Beecham Corporation | Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors |
| US4751310A (en) * | 1985-12-12 | 1988-06-14 | Smithkline Beckman Corporation | Inhibition of the 5-lipoxygenase pathway |
| US5134150A (en) * | 1985-12-12 | 1992-07-28 | Smithkline Beecham Corporation | Inhibition of the 5-lipoxygenase pathway |
| US5145858A (en) * | 1985-12-12 | 1992-09-08 | Smithkline Beecham Corp. | Pyrrolo [1,2-a] imidazole and imidazo [1,2a] pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors |
| US4794114A (en) * | 1986-08-19 | 1988-12-27 | Smithkline Beckman Corporation | Inhibition of interleukin-1 production by monocytes and/or macrophages |
| AU622330B2 (en) * | 1989-06-23 | 1992-04-02 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides |
| JPH06504779A (ja) * | 1990-12-13 | 1994-06-02 | スミスクライン・ビーチャム・コーポレイション | 新規ｃｓａｉｄｓ |
| US5574042A (en) * | 1992-11-02 | 1996-11-12 | Fujisawa Pharmaceutical Co., Ltd | Imidazo [1,2-a] pyridines and their pharmaceutical use |
| AU686115B2 (en) * | 1992-11-02 | 1998-02-05 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation |
| CA2134009C (en) | 1993-11-11 | 2005-03-08 | Oleg Werbitzky | Bicyclic amidines, process for their preparation, and their use as catalyst |
| CA2191979A1 (en) * | 1994-06-20 | 1995-12-28 | Muneo Takatani | Condensed imidazole compounds, their production and use |
| US10738035B2 (en) | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2017011552A1 (en) | 2015-07-13 | 2017-01-19 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| US10301255B2 (en) | 2015-07-22 | 2019-05-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2017136403A1 (en) | 2016-02-02 | 2017-08-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| KR102398439B1 (ko) | 2016-03-07 | 2022-05-16 | 이난타 파마슈티칼스, 인코포레이티드 | B형 간염 항바이러스제 |
| EP3468561A4 (en) | 2016-06-10 | 2019-12-04 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| SG11202001685TA (en) | 2017-08-28 | 2020-03-30 | Enanta Pharm Inc | Hepatitis b antiviral agents |
| WO2019113173A1 (en) | 2017-12-06 | 2019-06-13 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| US10723733B2 (en) | 2017-12-06 | 2020-07-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US11058678B2 (en) | 2018-01-22 | 2021-07-13 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| US10729688B2 (en) | 2018-03-29 | 2020-08-04 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| TW202024093A (zh) | 2018-09-21 | 2020-07-01 | 美商安塔製藥公司 | 作為抗病毒劑之官能化雜環 |
| EP3883570A4 (en) | 2018-11-21 | 2022-07-13 | Enanta Pharmaceuticals, Inc. | FUNCTIONALIZED HETEROCYCLES AS ANTIVIRAL AGENTS |
| WO2020247444A1 (en) | 2019-06-03 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| US11472808B2 (en) | 2019-06-04 | 2022-10-18 | Enanta Pharmaceuticals, Inc. | Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents |
| WO2020247561A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| WO2021007488A1 (en) | 2019-07-11 | 2021-01-14 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| WO2021055425A2 (en) | 2019-09-17 | 2021-03-25 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| US11802125B2 (en) | 2020-03-16 | 2023-10-31 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2984665A (en) * | 1958-05-14 | 1961-05-16 | Rohm & Haas | Condensed heterocyclic compounds |
| US4126685A (en) * | 1975-01-31 | 1978-11-21 | Imperial Chemical Industries Limited | 6-Aryl-pyrrolo[1,2,9]imidazole derivatives which possess anti-hypertensive activity |
| US4096264A (en) * | 1975-12-09 | 1978-06-20 | Merck & Co., Inc. | Certain substituted imidazo [1,2-a] pyridines |
| EP0068378B1 (en) * | 1981-06-26 | 1986-03-05 | Schering Corporation | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
-
1983
- 1983-07-29 US US06/518,514 patent/US4507481A/en not_active Expired - Fee Related
-
1984
- 1984-05-23 NZ NZ208266A patent/NZ208266A/en unknown
- 1984-05-28 IL IL71943A patent/IL71943A/xx unknown
- 1984-05-30 CA CA000455455A patent/CA1250295A/en not_active Expired
- 1984-05-30 AU AU28852/84A patent/AU562722B2/en not_active Ceased
- 1984-06-07 ZA ZA844299A patent/ZA844299B/xx unknown
- 1984-06-20 EP EP84107006A patent/EP0150255B1/en not_active Expired - Lifetime
- 1984-06-20 DE DE8484107006T patent/DE3483745D1/de not_active Expired - Fee Related
- 1984-06-20 AT AT84107006T patent/ATE59042T1/de not_active IP Right Cessation
- 1984-07-10 PH PH30953A patent/PH19437A/en unknown
- 1984-07-23 JP JP59151489A patent/JPS6042384A/ja active Pending
- 1984-07-27 DK DK367084A patent/DK367084A/da not_active Application Discontinuation
- 1984-07-27 FI FI843001A patent/FI78090C/fi not_active IP Right Cessation
- 1984-07-27 NO NO843053A patent/NO161741C/no unknown
- 1984-07-28 KR KR1019840004509A patent/KR910002837B1/ko not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| KR850001210A (ko) | 1985-03-16 |
| KR910002837B1 (ko) | 1991-05-06 |
| EP0150255A2 (en) | 1985-08-07 |
| FI78090B (fi) | 1989-02-28 |
| AU2885284A (en) | 1985-01-31 |
| CA1250295A (en) | 1989-02-21 |
| NZ208266A (en) | 1987-03-31 |
| FI843001A7 (fi) | 1985-01-30 |
| AU562722B2 (en) | 1987-06-18 |
| JPS6042384A (ja) | 1985-03-06 |
| EP0150255B1 (en) | 1990-12-12 |
| NO161741C (no) | 1989-09-20 |
| DE3483745D1 (de) | 1991-01-24 |
| DK367084A (da) | 1985-01-30 |
| IL71943A0 (en) | 1984-09-30 |
| NO161741B (no) | 1989-06-12 |
| ATE59042T1 (de) | 1990-12-15 |
| EP0150255A3 (en) | 1988-01-07 |
| NO843053L (no) | 1985-01-30 |
| PH19437A (en) | 1986-04-15 |
| FI843001A0 (fi) | 1984-07-27 |
| ZA844299B (en) | 1985-01-30 |
| DK367084D0 (da) | 1984-07-27 |
| FI78090C (fi) | 1989-06-12 |
| US4507481A (en) | 1985-03-26 |
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