ATE59042T1 - Immunomodulatoren auf basis von pyrrolo(1,2a)imidazol und imidazo(1,2-a)pyridin. - Google Patents

Immunomodulatoren auf basis von pyrrolo(1,2a)imidazol und imidazo(1,2-a)pyridin.

Info

Publication number
ATE59042T1
ATE59042T1 AT84107006T AT84107006T ATE59042T1 AT E59042 T1 ATE59042 T1 AT E59042T1 AT 84107006 T AT84107006 T AT 84107006T AT 84107006 T AT84107006 T AT 84107006T AT E59042 T1 ATE59042 T1 AT E59042T1
Authority
AT
Austria
Prior art keywords
imidazo
pyrrolo
imidazole
pyridin
aryl
Prior art date
Application number
AT84107006T
Other languages
English (en)
Inventor
Thomas A Davidson
Robert J Murray
Original Assignee
Fisons Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Corp filed Critical Fisons Corp
Application granted granted Critical
Publication of ATE59042T1 publication Critical patent/ATE59042T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Detergent Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AT84107006T 1983-07-29 1984-06-20 Immunomodulatoren auf basis von pyrrolo(1,2a)imidazol und imidazo(1,2-a)pyridin. ATE59042T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/518,514 US4507481A (en) 1983-07-29 1983-07-29 Pyrrolo[1,2-a]imidazoles and imidazo[1,2-a]pyridines
EP84107006A EP0150255B1 (de) 1983-07-29 1984-06-20 Immunomodulatoren auf Basis von Pyrrolo(1,2-a)imidazol und Imidazo(1,2-a)pyridin

Publications (1)

Publication Number Publication Date
ATE59042T1 true ATE59042T1 (de) 1990-12-15

Family

ID=24064258

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84107006T ATE59042T1 (de) 1983-07-29 1984-06-20 Immunomodulatoren auf basis von pyrrolo(1,2a)imidazol und imidazo(1,2-a)pyridin.

Country Status (15)

Country Link
US (1) US4507481A (de)
EP (1) EP0150255B1 (de)
JP (1) JPS6042384A (de)
KR (1) KR910002837B1 (de)
AT (1) ATE59042T1 (de)
AU (1) AU562722B2 (de)
CA (1) CA1250295A (de)
DE (1) DE3483745D1 (de)
DK (1) DK367084A (de)
FI (1) FI78090C (de)
IL (1) IL71943A (de)
NO (1) NO161741C (de)
NZ (1) NZ208266A (de)
PH (1) PH19437A (de)
ZA (1) ZA844299B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728645A (en) * 1982-12-21 1988-03-01 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives and other substituted bicyclic derivatives, useful as aromatase inhibitors
US4551535A (en) * 1983-07-29 1985-11-05 Pennwalt Corporation Process for preparing novel 7-thioester derivatives of 3H pyrrolo [1,2-a]-imidazole and 8-thioester derivatives of imidazo [1,2-a] pyridine
US4670445A (en) * 1984-03-05 1987-06-02 Eli Lilly And Company Inotropic agents
US5134150A (en) * 1985-12-12 1992-07-28 Smithkline Beecham Corporation Inhibition of the 5-lipoxygenase pathway
US5145858A (en) * 1985-12-12 1992-09-08 Smithkline Beecham Corp. Pyrrolo [1,2-a] imidazole and imidazo [1,2a] pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
US4751310A (en) * 1985-12-12 1988-06-14 Smithkline Beckman Corporation Inhibition of the 5-lipoxygenase pathway
US4719218A (en) * 1985-12-12 1988-01-12 Smithkline Beckman Corporation Pyrrolo[1,2-a]imidazole and pyrrolo[1,2-a]pyridine derivatives and their use as 5-lipoxygenase pathway inhibitor
US5002941A (en) * 1985-12-12 1991-03-26 Smithkline Beecham Corporation Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
US4794114A (en) * 1986-08-19 1988-12-27 Smithkline Beckman Corporation Inhibition of interleukin-1 production by monocytes and/or macrophages
AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
EP0565582A4 (de) * 1990-12-13 1995-01-11 Smithkline Beecham Corp Cytokinin-suppresoren als neue entzündungshemmende medikamente.
AU686115B2 (en) * 1992-11-02 1998-02-05 Fujisawa Pharmaceutical Co., Ltd. Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation
US5574042A (en) * 1992-11-02 1996-11-12 Fujisawa Pharmaceutical Co., Ltd Imidazo [1,2-a] pyridines and their pharmaceutical use
CA2134009C (en) * 1993-11-11 2005-03-08 Oleg Werbitzky Bicyclic amidines, process for their preparation, and their use as catalyst
US5840732A (en) * 1994-06-20 1998-11-24 Takeda Chemical Industries Ltd. Imidazopyridine or imidazopyrimidine compounds, their production and use
US10738035B2 (en) 2015-05-13 2020-08-11 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10179131B2 (en) 2015-07-13 2019-01-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10301255B2 (en) 2015-07-22 2019-05-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2017136403A1 (en) 2016-02-02 2017-08-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
KR102398439B1 (ko) 2016-03-07 2022-05-16 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
AU2017277664A1 (en) * 2016-06-10 2019-01-24 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
SG11202001685TA (en) 2017-08-28 2020-03-30 Enanta Pharm Inc Hepatitis b antiviral agents
US10428070B2 (en) 2017-12-06 2019-10-01 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10723733B2 (en) 2017-12-06 2020-07-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US11058678B2 (en) 2018-01-22 2021-07-13 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2019191166A1 (en) 2018-03-29 2019-10-03 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
MX2021003253A (es) 2018-09-21 2021-08-11 Enanta Pharm Inc Heterociclos funcionalizados como agentes antivirales.
AU2019385477A1 (en) 2018-11-21 2021-06-10 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
US11236111B2 (en) 2019-06-03 2022-02-01 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US11760755B2 (en) 2019-06-04 2023-09-19 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US11472808B2 (en) 2019-06-04 2022-10-18 Enanta Pharmaceuticals, Inc. Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents
US11738019B2 (en) 2019-07-11 2023-08-29 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2021055425A2 (en) 2019-09-17 2021-03-25 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2984665A (en) * 1958-05-14 1961-05-16 Rohm & Haas Condensed heterocyclic compounds
US4126685A (en) * 1975-01-31 1978-11-21 Imperial Chemical Industries Limited 6-Aryl-pyrrolo[1,2,9]imidazole derivatives which possess anti-hypertensive activity
US4096264A (en) * 1975-12-09 1978-06-20 Merck & Co., Inc. Certain substituted imidazo [1,2-a] pyridines
DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
IL71943A0 (en) 1984-09-30
NZ208266A (en) 1987-03-31
ZA844299B (en) 1985-01-30
NO843053L (no) 1985-01-30
KR910002837B1 (ko) 1991-05-06
DK367084A (da) 1985-01-30
CA1250295A (en) 1989-02-21
EP0150255A2 (de) 1985-08-07
KR850001210A (ko) 1985-03-16
AU562722B2 (en) 1987-06-18
JPS6042384A (ja) 1985-03-06
DK367084D0 (da) 1984-07-27
NO161741B (no) 1989-06-12
IL71943A (en) 1987-07-31
FI78090B (fi) 1989-02-28
FI843001A (fi) 1985-01-30
PH19437A (en) 1986-04-15
EP0150255A3 (en) 1988-01-07
AU2885284A (en) 1985-01-31
NO161741C (no) 1989-09-20
FI78090C (fi) 1989-06-12
EP0150255B1 (de) 1990-12-12
DE3483745D1 (de) 1991-01-24
FI843001A0 (fi) 1984-07-27
US4507481A (en) 1985-03-26

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee